CD3- CD56+ CD16+ natural killer cells and improvement of pregnancy outcome in IVF/ICSI failure after additional IVIG-treatment

American Journal of Reproductive Immunology

Volumn 63, Issue 3, 2010, Pages 263-265

  Heilmann, Lothar ^a   Schorsch, Martin ^a   Hahn, Thomas ^a  

^a Institute of Reproduction   (Germany)

Author keywords

Implantation failure; IVIG therapy; Natural killer cells (CD3 CD56+ CD16+)

Indexed keywords

IMMUNOGLOBULIN;

ADULT; ARTICLE; CD16+ T LYMPHOCYTE; CD3- T LYMPHOCYTE; CD56+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG EFFECT; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; FETUS WASTAGE; HUMAN; IMMUNOMODULATION; MAJOR CLINICAL STUDY; NATURAL KILLER CELL; NIDATION; PREGNANCY OUTCOME; PREGNANCY RATE; PREGNANCY TEST; PRIORITY JOURNAL; REPEAT PROCEDURE;

ABORTION, SPONTANEOUS; ADULT; ANTIGENS, CD3; ANTIGENS, CD56; EMBRYO IMPLANTATION; EMBRYO TRANSFER; FEMALE; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; KILLER CELLS, NATURAL; PREGNANCY; PREGNANCY OUTCOME; PREGNANCY RATE; RECEPTORS, IGG; SPERM INJECTIONS, INTRACYTOPLASMIC; YOUNG ADULT;

EID: 76549085120     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2009.00790.x     Document Type: Article

References (12)

1. van den Heuvel M, Peralta CG, Hatta K, Han VK, Clark DA. Decline in number of elevated blood CD3+ CD56+NKT cells in response to intravenous immunoglobulin treatment correlates with successful pregnancy. AJRI 2007, 57:447-459.
2. Clark DA, Coulam CB, Stricker RB. Is intravenous immunoglobulins (IVIG) efficacious in early pregnancy failure? A critical review and meta-analysis for patients who fail in vitro fertilization and embryo transfer (IVF). J Assist Reprod Genetic 2006, 23:1-13.
3. Leong H, Stachnik J, Bonk ME, Matuszewski KA. Unlabeled uses of intravenous immune globulin. Am J Health-Syst Pharm 2008, 65:1815-1824.
4. Clark DA, Wong K, Banwatt D, Chen Z, Liu J, Lee L, Gorczynski RM, Blajchman MA. CD200-dependent and nonCD200-dependent pathways of NK cells suppression by human IVIG. J Ass Reprod Genet 2008, 25:67-72.
5. Caspi RR. Expanding Tregs with IVIg. Blood 2008, 111:481-482.
6. Ola B, Li T-C. Implantation failure following in-vitro fertilization. Curr Opin Obstet Gynecol 2006, 18:440-445.
7. Stricker RB, Steinleitner A, Winger EE. Intravenous immunoglobulin (IVIG) therapy for immunologic abortion. Clin Appl Immunol Rev 2002, 2:187-199.
8. Nelson SM, Greer IA. The potential role of heparin in assisted conception. Hum Reprod update 2008, 14:623-645.
9. Hatam L, Schuval S, Bonagura VR. Flow cytometric, analysis of NK cell function as a clinical assay. Cytometry 1994, 16:59-68.
10. Coulam CB, Goodman C, Roussev RG, Thomason EJ, Beaman KD. Systemic CD56+ cells can predict pregnancy outcome. AJRI 1995, 33:40-45.
11. Kwak JYH, Kwak FMY, Ainbinder SW, Ruiz AM, Beer AE. Elevated peripheral blood natural killer cells are effectively suppressed by immunoglobulin G infusions in women with recurrent spontaneous abortion. AJRI 1996, 35:363-369.
12. Winger EE, Reed JL, Ashoud S, Ahuja S, El-Toukhy T, Taranissi M. Treatment with adalimumab (Humira) and intravenous immunglobulin improves pregnancy rates in women undergoing IVF. AJRI 2009, 61:113-120.