Degree of TNF-α/IL-10 Cytokine Elevation Correlates With IVF Success Rates in Women Undergoing Treatment With Adalimumab (Humira) and IVIG

American Journal of Reproductive Immunology

Volumn 65, Issue 6, 2011, Pages 610-618

  Winger, Edward E ^a   Reed, Jane L ^a   Ashoush, Sherif ^b   El Toukhy, Tarek ^b   Ahuja, Sapha ^b   Taranissi, Mohamed ^b  

^a Laboratory for Reproductive Medicine and Immunology   (United States)

^b Assisted Reproduction and Gynaecology Centre   (United Kingdom)

Author keywords

Egg; Implantation; Infertility; Pregnancy; Th1 Th2 ratio; TNF inhibitor

Indexed keywords

ADALIMUMAB; CD3 ANTIGEN; CD8 ANTIGEN; ENOXAPARIN; IMMUNOGLOBULIN; INTERLEUKIN 10; IONOMYCIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BIRTH RATE; CONTROLLED STUDY; DELIVERY; EMBRYO; EMBRYO TRANSFER; ENDOMETRIUM; FEMALE; FERTILIZATION IN VITRO; FETUS HEART RATE; HUMAN; IMMUNOMODULATION; IMMUNOPHENOTYPING; IMMUNOTHERAPY; INTRACYTOPLASMIC SPERM INJECTION; MAJOR CLINICAL STUDY; NIDATION; OBSERVATIONAL STUDY; PREGNANCY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK ASSESSMENT; TH2 CELL;

ADULT; ANTI-INFLAMMATORY AGENTS; ANTIBODIES, MONOCLONAL; FEMALE; FERTILIZATION IN VITRO; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS; INFERTILITY, FEMALE; INTERLEUKIN-10; RETROSPECTIVE STUDIES; T-LYMPHOCYTES; TH1-TH2 BALANCE; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 79955148665     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2010.00946.x     Document Type: Article

References (26)

1. Winger EE, Reed JL, Ashoush S, Ahuja S, El-Toukhy T, Taranissi M: Treatment with adalimumab (Humira) and intravenous immunoglobulin improves pregnancy rates in women undergoing IVF. Am J Reprod Immunol 2009; 61:113-120. Epub 2008 Dec 3.
2. Kwak-Kim J, Yang KM, Gilman-Sachs A: Recurrent pregnancy loss: a disease of inflammation and coagulation. J Obstet Gynaecol Res 2009; 35:609-622.
3. Clark DA, Chaouat G, Arck PC, Mittruecker HW, Levy GA: Cytokine-dependent abortion in CBA xDBA/2 mice is mediated by the procoagulant fgl2prothrombinase. J Immunol 1998; 160:545-549.
4. Esmon CT: The impact of the inflammatory response on coagulation. Thromb Res 2004; 114:321-327.
5. Ng SC, Thaker P, Gilman-Sachs A, Beaman KD, Beer AE, Kwak-Kim JYH: Expression of intracellular Th1 and Th2 cytokines in women with recurrent spontaneous abortion, implantation failures after IVF/ET or normal pregnancy. Am J Reprod Immunol 2002; 48:77-86.
6. Beer AE, Kwak JYH: Intravenous immunoglobulin G (IVIG) Dream or reality? Presented at ART Symposium, Maui, HA, 1997.
7. Kwak JY, Gilman-Sachs A, Moretti M, Beaman KD, Beer AE: Natural killer cell cytotoxicity and paternal lymphocyte immunization in women with recurrent spontaneous abortions. Am J Reprod Immunol 1998; 40:352-358.
8. Gilman-Sachs A, DuChateau BK, Aslakson CJ, Wohlgemuth GP, Kwak JY, Beer AE, Beaman KD: Natural Killer (NK) cell subsets and NK cell cytotoxicity in women with histories of recurrent spontaneous abortions. Am J Reprod Immunol 1999; 41:99-105.
9. Coulam CB, Goodman C, Roussev RG, Thomasen EJ, Beaman KD: Systemic CD56+ cells can predict pregnancy outcome. Am J Reprod Immunol 1995; 33:40-46.
10. Beer AE, Kwak JY, Ruiz JE: Immunophenotypic profiles of peripheral blood lymphocytes in women with recurrent pregnancy losses and in infertile women with multiple failed in vitro fertilization cycles. Am J Reprod Immunol 1996; 35:376-382.
11. Kwak JY, Beaman KD, Gilman-Sachs A, Ruiz JE, Schewitz D, Beer AE: Up-regulated expression of CD56+, CD56+/CD16+, and CD19+ cells in peripheral blood lymphocytes in pregnant women with recurrent pregnancy losses. Am J Reprod Immunol 1995; 34:93-99.
12. Humira prescribing Information. Prescribing Info.pdf, last accessed, January 3, 2010.
13. Saito S, Nakashima A, Shima T, Ito M: Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am J Reprod Immunol 2010; 63:601-610.
14. Clark DA, Coulam CB, Stricker RB: Is intravenous immunoglobulins (IVIG) efficacious in early pregnancy failure? A critical review and meta-analysis for patients who fail in vitro fertilization and embryo transfer (IVF). J Assist Reprod Genet 2006; 19:1-13.
15. Chaouat G, Ledee-Bataille N, Dubanchet S, Zourbas S, Sandra O, Martal J: Reproductive immunology 2003: reassessing the Th1/Th2 paradigm? Immunol Lett 2004; 92:207-214.
16. Gougeon A: Dynamics of follicular growth in the human: a model from preliminary results. Hum Reprod 1986; 1:81.
17. Austgulen R, Arntzen KJ, Vatten LJ, Kahn J, Sunde A: Detection of cytokines (interleukin-1, interleukin-6, transforming growth factor-beta) and soluble tumour necrosis factor receptors in embryo culture fluids during in-vitro fertilization. Hum Reprod 1995; 10:171-176.
18. Cianci A, Calogero AE, Palumbo MA, Burrello N, Ciotta L, Palumbo G, Bernardini R: Relationship between tumour necrosis factor alpha and sex steroid concentrations in the follicular fluid of women with immunological infertility. Hum Reprod 1996; 11:265-268.
19. Leisa J, Morrison LJ, Jennifer L, Marcinkiewicz JL: Tumor necrosis factor α enhances oocyte/follicle apoptosis in the neonatal rat ovary. Biol Reprod, 2002; 66:450-457.
20. Guerin LR, Prins JR, Robertson SA: Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? Hum Reprod Update 2009; 15:517-535. Epub 2009 Mar 11.
21. Jasper MJ, Tremellen KP, Robertson SA: Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue. Mol Hum Reprod 2006; 12:301-308.
22. Zenclussen AC, Gerlof K, Zenclussen ML, Ritschel S, Zambon Bertoja A, Fest S, Hontsu S, Ueha S, Matsushima K, Leber J, Volk HD: Regulatory T cells induce a privileged tolerant microenvironment at the fetal-maternal interface. Eur J Immunol 2006; 36:82-94.
23. Leber A, Teles A, Zenclussen AC: Regulatory T cells and their role in pregnancy. Am J Reprod Immunol 2010; 63:445-459.
24. Moldenhauer LM, Diener KR, Thring DM, Brown MP, Hayball JD, Robertson SA: Cross-presentation of male seminal fluid antigens elicits T cell activation to initiate the female immune response to pregnancy. J Immunol 2009; 182:8080-8093.
25. Bayry J, Sibéril S, Triebel F, Tough DF, Kaveri SV: Rescuing CD4+CD25+ regulatory T-cell functions in rheumatoid arthritis by cytokine-targeted monoclonal antibody therapy. Drug Discov Today 2007; 12:548-552.
26. Haider S, Knöfler M: Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. Placenta 2009; 30:111-123.