Neural HO-1/sterol interactions in vivo: Implications for Alzheimer's disease

Neuroscience

Volumn 280, Issue , 2014, Pages 40-49

  Hascalovici, J R ^a,b   Song, W ^a   Liberman, A ^a   Vaya, J ^c   Khatib, S ^c   Holcroft, C ^b   Laferla, F ^d   Schipper, H M ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MIGAL GALILEE TECHNOLOGY CENTER   (Israel)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; Astrocyte; Cholesterol; Heme oxygenase 1; Lipid; Oxysterol

Indexed keywords

24 HYDROXYCHOLESTEROL; 4BETA HYDROXYCHOLESTEROL; 7 OXOCHOLESTEROL; 7ALPHA HYDROXYCHOLESTEROL; 7BETA HYDROXYCHOLESTEROL; CHOLESTEROL; DESMOSTEROL; GLIAL FIBRILLARY ACIDIC PROTEIN; HEME OXYGENASE 1; LANOSTEROL; OXYSTEROL; STEROL; UNCLASSIFIED DRUG; AMYLOID PRECURSOR PROTEIN; APP PROTEIN, HUMAN; GLIAL FIBRILLARY ASTROCYTIC PROTEIN, MOUSE; HMOX1 PROTEIN, HUMAN; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN; NERVE PROTEIN;

ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HO 1 GENE; IN VIVO STUDY; LINEAR REGRESSION ANALYSIS; MASS FRAGMENTOGRAPHY; METABOLITE; MOLECULAR INTERACTION; MOUSE; NEUROPATHOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN EXPRESSION; TRANSGENIC MOUSE; UPREGULATION; AGING; ANIMAL; BRAIN; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; HOMEOSTASIS; HUMAN; METABOLISM; MUTATION; OXIDATION REDUCTION REACTION; RAT;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ASTROCYTES; BRAIN; HEK293 CELLS; HEME OXYGENASE-1; HOMEOSTASIS; HUMANS; MEMBRANE PROTEINS; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; OXIDATION-REDUCTION; RATS; STEROLS;

EID: 84925872431     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.09.001     Document Type: Article

References (62)

1. Adibhatla R.M., Hatcher J.F. Altered lipid metabolism in brain injury and disorders. Subcell Biochem 2008, 48. nihpa41041.
2. Arca M., et al. Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: reduction during atorvastatin and fenofibrate therapy. Free Radic Biol Med 2007, 42:698-705.
3. Baranano D.E., Snyder S.H. Neural roles for heme oxygenase: contrasts to nitric oxide synthase. Proc Natl Acad Sci USA 2001, 98:10996-11002.
4. Benarroch E.E. Brain cholesterol metabolism and neurologic disease. Neurology 2008, 71:1368-1373.
5. Bjorkhem I., et al. Oxysterols and neurodegenerative diseases. Mol Aspects Med 2009, 30:171-179.
6. Bjorkhem I., Diczfalusy U. Oxysterols: friends, foes, or just fellow passengers?. Arterioscler Thromb Vasc Biol 2002, 22:734-742.
7. Bogdanovic N., et al. On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells. Neurosci Lett 2001, 314:45-48.
8. Bosco D.A., et al. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nat Chem Biol 2006, 2:249-253.
9. Chen K., et al. Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death. J Neurochem 2000, 75:304-313.
10. Cheng C., et al. Heme oxygenase 1 determines atherosclerotic lesion progression into a vulnerable plaque. Circulation 2009, 119:3017-3027.
11. Cummings J.L. Alzheimer's disease. N Engl J Med 2004, 351:56-67.
12. Dennery P.A. Regulation and role of heme oxygenase in oxidative injury. Curr Top Cell Regul 2000, 36:181-199.
13. Dietschy J.M., Turley S.D. Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res 2004, 45:1375-1397.
14. Dore S., et al. Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. Proc Natl Acad Sci USA 1999, 96:2445-2450.
15. Florent-Bechard S., et al. The essential role of lipids in Alzheimer's disease. Biochimie 2009, 91:804-809.
16. Frank R.N., et al. Antioxidant enzymes in the macular retinal pigment epithelium of eyes with neovascular age-related macular degeneration. Am J Ophthalmol 1999, 127:694-709.
17. Galbraith R. Heme oxygenase: who needs it?. Proc Soc Exp Biol Med 1999, 222:299-305.
18. Garcia-Cruset S., et al. Oxysterols in cap and core of human advanced atherosclerotic lesions. Free Radic Res 1999, 30:341-350.
19. Hascalovici J.R., et al. Impact of heme oxygenase-1 on cholesterol synthesis, cholesterol efflux and oxysterol formation in cultured astroglia. J Neurochem 2009, 108:72-81.
20. Hascalovici J.R., et al. Brain sterol dysregulation in sporadic AD and MCI: relationship to heme oxygenase-1. J Neurochem 2009, 110:1241-1253.
21. Hebert L.E., et al. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol 2003, 60:1119-1122.
22. Hung S.Y., et al. The mechanism of heme oxygenase-1 action involved in the enhancement of neurotrophic factor expression. Neuropharmacology 2009, 58:321-329.
23. Jurevics H., Morell P. Cholesterol for synthesis of myelin is made locally, not imported into brain. J Neurochem 1995, 64:895-901.
24. Kadoya C., et al. Preischemic but not postischemic zinc protoporphyrin treatment reduces infarct size and edema accumulation after temporary focal cerebral ischemia in rats. Stroke 1995, 26:1035-1038.
25. Kim D.E., et al. Glycyrrhizin prevents 7-ketocholesterol toxicity against differentiated PC12 cells by suppressing mitochondrial membrane permeability change. Neurochem Res 2009, 34:1433-1442.
26. Koudinov A.R., Koudinova N.V. Cholesterol, synaptic function and Alzheimer's disease. Pharmacopsychiatry 2003, 36(suppl. 2):S107-S112.
27. Le W.D., et al. Protective role of heme oxygenase-1 in oxidative stress-induced neuronal injury. J Neurosci Res 1999, 56:652-658.
28. Lemaire-Ewing S., et al. Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. Cell Biol Toxicol 2005, 21:97-114.
29. Leoni V., et al. Levels of 7-oxocholesterol in cerebrospinal fluid are more than one thousand times lower than reported in multiple sclerosis. J Lipid Res 2005, 46:191-195.
30. Llesuy S.F., Tomaro M.L. Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage. Biochim Biophys Acta 1994, 1223:9-14.
31. Malvitte L., et al. Analogies between atherosclerosis and age-related maculopathy: expected roles of oxysterols. J Fr Ophtalmol 2006, 29:570-578.
32. Mehindate K., et al. Proinflammatory cytokines promote glial heme oxygenase-1 expression and mitochondrial iron deposition: implications for multiple sclerosis. J Neurochem 2001, 77:1386-1395.
33. Miao L., et al. From lanosterol to cholesterol: structural evolution and differential effects on lipid bilayers. Biophys J 2002, 82:1429-1444.
34. Nakagami T., et al. A beneficial role of bile pigments as an endogenous tissue protector: anti-complement effects of biliverdin and conjugated bilirubin. Biochim Biophys Acta 1993, 1158:189-193.
35. Nelson T.J., Alkon D.L. Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide. J Biol Chem 2005, 280:7377-7387.
36. Oddo S., et al. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 2003, 39:409-421.
37. Ohyama Y., et al. Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes. J Biol Chem 2006, 281:3810-3820.
38. Panahian N., et al. Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice. J Neurochem 1999, 72:1187-1203.
39. Pfrieger F.W. Cholesterol homeostasis and function in neurons of the central nervous system. Cell Mol Life Sci 2003, 60:1158-1171.
40. Piantadosi C.A., et al. Carbon monoxide, oxidative stress, and mitochondrial permeability pore transition. Free Radic Biol Med 2006, 40:1332-1339.
41. Rantham Prabhakara J.P., et al. Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells. J Neurochem 2008, 107:1722-1729.
42. Refolo L.M., et al. A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol Dis 2001, 8:890-899.
43. Resende R., et al. Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease. Free Radic Biol Med 2008, 44:2051-2057.
44. Schipper H.M. Heme oxygenase expression in human central nervous system disorders. Free Radic Biol Med 2004, 37:1995-2011.
45. Schipper H.M., et al. Suppression of glial HO-1 activity as a potential neurotherapeutic intervention in AD. Curr Alzheimer Res 2009, 6:424-430.
46. Schipper H.M., et al. Neural heme oxygenase-1 expression in idiopathic Parkinson's disease. Exp Neurol 1998, 150:60-68.
47. Schipper H.M., et al. Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement. J Neurochem 2009, 110:469-485.
48. Selkoe D.J. Alzheimer's disease. In the beginning. Nature 1991, 354:432-433.
49. Shobab L.A., et al. Cholesterol in Alzheimer's disease. Lancet Neurol 2005, 4:841-852.
50. Song W., et al. Over-expression of heme oxygenase-1 promotes oxidative mitochondrial damage in rat astroglia. J Cell Physiol 2006, 206:655-663.
51. Song W., et al. Schizophrenia-like features in transgenic mice overexpressing human HO-1 in the astrocytic compartment. J Neurosci 2012, 32:10841-10853.
52. Song W., et al. Unregulated brain iron deposition in transgenic mice over-expressing HMOX1 in the astrocytic compartment. J Neurochem 2012, 123:325-336.
53. Stahnke T., et al. Differential upregulation of heme oxygenase-1 (HSP32) in glial cells after oxidative stress and in demyelinating disorders. J Mol Neurosci 2007, 32:25-37.
54. Suttner D.M., Dennery P.A. Reversal of HO-1 related cytoprotection with increased expression is due to reactive iron. FASEB J 1999, 13:1800-1809.
55. Vaya J., et al. Selective distribution of oxysterols in atherosclerotic lesions and human plasma lipoproteins. Free Radic Res 2001, 34:485-497.
56. Vaya J., Schipper H.M. Oxysterols, cholesterol homeostasis, and Alzheimer disease. J Neurochem 2007, 102:1727-1737.
57. Vaya J., et al. Effects of heme oxygenase-1 expression on sterol homeostasis in rat astroglia. Free Radic Biol Med 2007, 42:864-871.
58. Vejux A., et al. Side effects of oxysterols: cytotoxicity, oxidation, inflammation, and phospholipidosis. Braz J Med Biol Res 2008, 41:545-556.
59. Wang J., Dore S. Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage. Brain 2007, 130:1643-1652.
60. Wang Y., et al. Analysis of neurosterols and neurosteroids by mass spectrometry. Biochimie 2007, 89:182-191.
61. Zhao C., Dahlman-Wright K. Liver X receptor in cholesterol metabolism. J Endocrinol 2010, 204:233-240.
62. Zwerina J., et al. Heme oxygenase 1 (HO-1) regulates osteoclastogenesis and bone resorption. FASEB J 2005, 19:2011-2013.