Proinflammatory cytokines promote glial heme oxygenase-1 expression and mitochondrial iron deposition: Implications for multiple sclerosis

Journal of Neurochemistry

Volumn 77, Issue 5, 2001, Pages 1386-1395

  Mehindate, K ^a   Sahlas, D J ^a,b   Frankel, D ^a,b   Mawal, Y ^a   Liberman, A ^a   Corcos, J ^b   Dion, S ^b   Schipper, H M ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Astrocyte; Cytokine; Heme oxygenase 1; Iron; Mitochondria; Multiple sclerosis

Indexed keywords

ANTIOXIDANT; CYTOKINE; DEXAMETHASONE; HEME OXYGENASE; INTERFERON BETA SERINE; INTERLEUKIN 1BETA; MESOPORPHYRIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN MITOCHONDRION; CONTROLLED STUDY; FEMALE; GENE INDUCTION; GLIA; IMMUNOHISTOCHEMISTRY; IRON STORAGE; MACROGLIA; MULTIPLE SCLEROSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD;

ANIMALS; BLOTTING, NORTHERN; CELLS, CULTURED; CYTOKINES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FERRIC COMPOUNDS; HEME OXYGENASE (DECYCLIZING); HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1; IRON; IRON RADIOISOTOPES; MITOCHONDRIA; MULTIPLE SCLEROSIS; NEUROGLIA; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SPINAL CORD; SUBCELLULAR FRACTIONS; TRANSFERRIN; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0034999085     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00354.x     Document Type: Article

References (54)

1. Multiple sclerosis: Altered expression of 70- and 27 kDa heat shock proteins in lesions and myelin
2. The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death
3. Inhibition of mitochondrial permeability transition by cyclosporin A during long time frame experiments: Relationship between pore opening and the activity of mitochondrial phospholipases
4. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chlorophorm extraction
5. Differential effects of cysteamine on heat shock protein and cytoplasmic granulation in astrocytes and glioma cells
6. Genomic sequencing
7. Iron deposits surrounding multiple sclerosis plaques
8. Heme oxygenase-1 and NADPH cytochrome P450 reductase expression in experimental allergic encephalomyelitis: An expanded view of the stress response
9. Inflammation in EAE: Role of chemokine/cytokine expression by resident and infiltrating cells
10. Rapid induction of heme oxygenase-1 mRNA and protein by hyperthermia in rat brain: Heme oxygenase-2 is not a heat shock protein
11. Normal and heat-induced patterns of expression of heme oxygenase-1 (HSP32) in rat brain; hyperthermia causes rapid induction of mRNA and protein
12. 125I-ferrotransferrin binding sites in the mesencephalon of control subjects and patients with Parkinson's disease
13. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity
14. Iron deposits in the central nervous system of SJL mice with experimental allergic encephalomyelitis
15. Role of heme oxygenase-1 in the regulation of manganese superoxide dismutase gene expression in oxidatively-challenged astroglia
16. Experimental autoimmune encephalomyelitis. Qualitative and semiquantitative differences in heat shock protein 60 expression in the central nervous system
17. Iron in CNS disease
18. Cytokines in relapsing experimental autoimmune encephalitis in DA rats: Persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-β
19. Transferrin receptors of rat and human brain and cerebral microvessels and their status in Alzheimer's disease
20. Receptor-mediated endocytosis of transferrin in K562 cells
21. Oral administration of the oxidant-scavenger N-acetyl-L-cysteine inhibits acute experimental autoimmune encephalomyelitis
22. Iron deposits in multiple sclerosis and Alzheimer's disease brains
23. Distribution and number of transferrin receptors in Parkinson's disease and in MPTP-treated mice
24. Iron content correlates with peroxidase activity in cysteamine-induced astroglial organelles
25. Redox perturbations in cysteamine-stressed astroglia: Implications for inclusion formation and gliosis in the aging brain
26. Purification of skeletal-muscle mitochondria by density gradient centrifugation with Percoll
27. Role of the cellular stress response in the biogenesis of cysteamine-induced astrocytic inclusions in primary culture
28. Detection of triplex-forming RNA oligonucleotides by triplex blotting
29. Management of multiple sclerosis and interpretation of clinical trials
30. Physiological effectors modify voltage sensing by the cyclosporin A-sensitive permeability transition pore of mitochondria
31. Heme oxygenase: Protective gene or Trojan horse?
32. Iron utilization in rabbit reticulocytes. A study using succinylacetone as an inhibitior of heme synthesis
33. Acquisition of iron from transferrin regulates reticulocyte heme synthesis
34. Multiple sclerosis
35. The uptake of inorganic iron complexes by human melanoma cells
36. Influence of nitric oxide on cellular and mitochondrial integrity in oxidatively stressed astrocytes
37. Reactive oxygen species are involved in the pathogenesis of experimental allergic encephalomyelitis in Lewis rats
38. Astrocytes, brain aging and neurodegeneration
39. Glial HO-1 expression, iron deposition and oxidative stress in neurodegenerative diseases
40. Identification of peroxidase-positive astrocytes by combined histochemical and immunolabelling techniques in situ and in cell culture
41. Gomori-positive astrocytes in primary culture: Effects of in vitro age and cysteamine exposure
42. Catechol oxidation by peroxidase-positive astrocytes in primary culture: An electron spin resonance study
43. Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain
44. Mitochondrial iron sequestration in dopamine-challenged astroglia: Role of heme oxygenase-1 and the permeability transition pore
45. Heme oxygenase-1 in lesions of rat experimental autoimmune encephalomyelitis and neuritis
46. Pretreatment of astrocytes with interferon-alpha/beta impairs interferon-gamma induction of nitric oxide synthase
47. Induction of heme oxygenase as a defence against oxidative stress
48. Evidence for increased lipid peroxidation in multiple sclerosis
49. Cellular mechanisms of demyelination in multiple sclerosis brains
50. The small heat-shock protein αB-crystallin as candidate autoantigen in multiple sclerosis
51. A cellular stress model for the sequestration of redox-active glial iron in the aging and degenerating nervous system
52. Possible protective mechanisms of tumor necrosis factors against oxidative stress
53. Inorganic neurotoxins in neurodegenerative disorders without primary dementia
54. Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain