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Volumn 33, Issue 4, 2015, Pages 1113-1129

Direct Nkx2-5 transcriptional repression of isl1 controls cardiomyocyte subtype identity

Author keywords

Cardiac differentiation; Cardiac progenitors; Embryonic stem cells; Heart development; Isl1; Nkx2 5

Indexed keywords

TRANSCRIPATION FACTOR ISL1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NKX2.5; UNCLASSIFIED DRUG; HOMEODOMAIN PROTEIN; INSULIN GENE ENHANCER BINDING PROTEIN ISL-1; LIM HOMEODOMAIN PROTEIN; NKX2-5 PROTEIN, MOUSE; PROTEIN BINDING;

EID: 84925622556     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1923     Document Type: Article
Times cited : (76)

References (97)
  • 1
    • 38949168086 scopus 로고    scopus 로고
    • Islet1 cardiovascular progenitors: A single source for heart lineages?
    • Laugwitz K-L, Moretti A, Caron L, et al. Islet1 cardiovascular progenitors: A single source for heart lineages? Development 2008; 135 (2): 193-205.
    • (2008) Development , vol.135 , Issue.2 , pp. 193-205
    • Laugwitz, K.-L.1    Moretti, A.2    Caron, L.3
  • 2
    • 77955334500 scopus 로고    scopus 로고
    • How to make a heart: The origin and regulation of cardiac progenitor cells
    • Vincent SD, Buckingham ME,. How to make a heart: The origin and regulation of cardiac progenitor cells. Curr Top Dev Biol 2010; 90: 1-41.
    • (2010) Curr Top Dev Biol , vol.90 , pp. 1-41
    • Vincent, S.D.1    Buckingham, M.E.2
  • 3
    • 0346783332 scopus 로고    scopus 로고
    • Isl1 Identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart
    • Cai C-L, Liang X, Shi Y, et al. Isl1 Identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell 2003; 5 (6): 877-889.
    • (2003) Dev Cell , vol.5 , Issue.6 , pp. 877-889
    • Cai, C.-L.1    Liang, X.2    Shi, Y.3
  • 4
    • 33847344204 scopus 로고    scopus 로고
    • An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation
    • Prall OWJ, Menon MK, Solloway MJ, et al. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell 2007; 128 (5): 947-959.
    • (2007) Cell , vol.128 , Issue.5 , pp. 947-959
    • Prall, O.W.J.1    Menon, M.K.2    Solloway, M.J.3
  • 5
    • 53649094995 scopus 로고    scopus 로고
    • Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity
    • Ma Q, Zhou B, Pu WT,. Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity. Dev Biol 2008; 323 (1): 98-104.
    • (2008) Dev Biol , vol.323 , Issue.1 , pp. 98-104
    • Ma, Q.1    Zhou, B.2    Pu, W.T.3
  • 6
    • 33845457194 scopus 로고    scopus 로고
    • Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification
    • Moretti A, Caron L, Nakano A, et al. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell 2006; 127 (6): 1151-1165.
    • (2006) Cell , vol.127 , Issue.6 , pp. 1151-1165
    • Moretti, A.1    Caron, L.2    Nakano, A.3
  • 7
    • 33845442108 scopus 로고    scopus 로고
    • Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart
    • Wu SM, Fujiwara Y, Cibulsky SM, et al. Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell 2006; 127 (6): 1137-1150.
    • (2006) Cell , vol.127 , Issue.6 , pp. 1137-1150
    • Wu, S.M.1    Fujiwara, Y.2    Cibulsky, S.M.3
  • 8
    • 0029090829 scopus 로고
    • Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5
    • Lyons I, Parsons LM, Hartley L, et al. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev 1995; 9 (13): 1654-1666.
    • (1995) Genes Dev , vol.9 , Issue.13 , pp. 1654-1666
    • Lyons, I.1    Parsons, L.M.2    Hartley, L.3
  • 9
    • 0032543267 scopus 로고    scopus 로고
    • Cardiac and extracardiac expression of Csx/Nkx2.5 homeodomain protein
    • Kasahara H, Bartunkova S, Schinke M, et al. Cardiac and extracardiac expression of Csx/Nkx2.5 homeodomain protein. Circ Res 1998; 82 (9): 936-946.
    • (1998) Circ Res , vol.82 , Issue.9 , pp. 936-946
    • Kasahara, H.1    Bartunkova, S.2    Schinke, M.3
  • 10
    • 0027383023 scopus 로고
    • Nkx-2.5: A novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants
    • Lints TJ, Parsons LM, Hartley L, et al. Nkx-2.5: A novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 1993; 119 (2): 419-431.
    • (1993) Development , vol.119 , Issue.2 , pp. 419-431
    • Lints, T.J.1    Parsons, L.M.2    Hartley, L.3
  • 11
    • 11144357335 scopus 로고    scopus 로고
    • Nkx2-5 pathways and congenital heart disease; Loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block
    • Pashmforoush M, Lu JT, Chen H, et al. Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. Cell 2004; 117 (3): 373-386.
    • (2004) Cell , vol.117 , Issue.3 , pp. 373-386
    • Pashmforoush, M.1    Lu, J.T.2    Chen, H.3
  • 12
    • 33646680831 scopus 로고    scopus 로고
    • Isl1Cre reveals a common Bmp pathway in heart and limb
    • Yang L, Cai C-L, Lin L, et al. Isl1Cre reveals a common Bmp pathway in heart and limb. Development 2006; 133 (8): 1575-1585.
    • (2006) Development , vol.133 , Issue.8 , pp. 1575-1585
    • Yang, L.1    Cai, C.-L.2    Lin, L.3
  • 14
    • 35748933898 scopus 로고    scopus 로고
    • The amphibian second heart field: Xenopus islet-1 is required for cardiovascular development
    • Brade T, Gessert S, Kühl M, et al. The amphibian second heart field: Xenopus islet-1 is required for cardiovascular development. Dev Biol 2007; 311 (2): 297-310.
    • (2007) Dev Biol , vol.311 , Issue.2 , pp. 297-310
    • Brade, T.1    Gessert, S.2    Kühl, M.3
  • 15
    • 70349287525 scopus 로고    scopus 로고
    • Comparative gene expression analysis and fate mapping studies suggest an early segregation of cardiogenic lineages in Xenopus laevis
    • Gessert S, Kühl M,. Comparative gene expression analysis and fate mapping studies suggest an early segregation of cardiogenic lineages in Xenopus laevis. Dev Biol 2009; 334 (2): 395-408.
    • (2009) Dev Biol , vol.334 , Issue.2 , pp. 395-408
    • Gessert, S.1    Kühl, M.2
  • 16
    • 34548835772 scopus 로고    scopus 로고
    • Pescadillo is required for Xenopus laevis eye development and neural crest migration
    • Gessert S, Maurus D, Rössner A, et al. Pescadillo is required for Xenopus laevis eye development and neural crest migration. Dev Biol 2007; 310 (1): 99-112.
    • (2007) Dev Biol , vol.310 , Issue.1 , pp. 99-112
    • Gessert, S.1    Maurus, D.2    Rössner, A.3
  • 17
    • 80855124280 scopus 로고    scopus 로고
    • Tbx5 overexpression favors a first heart field lineage in murine embryonic stem cells and in Xenopus laevis embryos
    • Herrmann F, Bundschu K, Kühl SJ, et al. Tbx5 overexpression favors a first heart field lineage in murine embryonic stem cells and in Xenopus laevis embryos. Dev Dyn 2011; 240(12): 2634-2645.
    • (2011) Dev Dyn , vol.240 , Issue.12 , pp. 2634-2645
    • Herrmann, F.1    Bundschu, K.2    Kühl, S.J.3
  • 18
    • 84864003888 scopus 로고    scopus 로고
    • The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity
    • Witzel HR, Jungblut B, Choe CP, et al. The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity. Dev Cell 2012; 23 (1): 58-70.
    • (2012) Dev Cell , vol.23 , Issue.1 , pp. 58-70
    • Witzel, H.R.1    Jungblut, B.2    Choe, C.P.3
  • 19
    • 30344478870 scopus 로고    scopus 로고
    • A global map of p53 transcription-factor binding sites in the human genome
    • Wei C-L, Wu Q, Vega VB, et al. A global map of p53 transcription-factor binding sites in the human genome. Cell 2006; 124 (1): 207-219.
    • (2006) Cell , vol.124 , Issue.1 , pp. 207-219
    • Wei, C.-L.1    Wu, Q.2    Vega, V.B.3
  • 20
    • 33847409199 scopus 로고    scopus 로고
    • Transcriptional pathways in second heart field development
    • Black BL,. Transcriptional pathways in second heart field development. Semin Cell Dev Biol 2007; 18 (1): 67-76.
    • (2007) Semin Cell Dev Biol , vol.18 , Issue.1 , pp. 67-76
    • Black, B.L.1
  • 21
    • 0029857502 scopus 로고    scopus 로고
    • Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips
    • Kispert A, Vainio S, Shen L, et al. Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips. Development 1996; 122 (11): 3627-3637.
    • (1996) Development , vol.122 , Issue.11 , pp. 3627-3637
    • Kispert, A.1    Vainio, S.2    Shen, L.3
  • 22
    • 0035461911 scopus 로고    scopus 로고
    • The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm
    • Kelly RG, Brown NA, Buckingham ME,. The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. Dev Cell 2001; 1 (3): 435-440.
    • (2001) Dev Cell , vol.1 , Issue.3 , pp. 435-440
    • Kelly, R.G.1    Brown, N.A.2    Buckingham, M.E.3
  • 23
    • 77649172161 scopus 로고    scopus 로고
    • Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries
    • Watanabe Y, Miyagawa-Tomita S, Vincent SD, et al. Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. Circ Res 2010; 106 (3): 495-503.
    • (2010) Circ Res , vol.106 , Issue.3 , pp. 495-503
    • Watanabe, Y.1    Miyagawa-Tomita, S.2    Vincent, S.D.3
  • 24
    • 0033168070 scopus 로고    scopus 로고
    • Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome
    • Bruneau BG, Logan M, Davis N, et al. Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome. Dev Biol 1999; 211 (1): 100-108.
    • (1999) Dev Biol , vol.211 , Issue.1 , pp. 100-108
    • Bruneau, B.G.1    Logan, M.2    Davis, N.3
  • 25
    • 0034234753 scopus 로고    scopus 로고
    • Ventricular expression of tbx5 inhibits normal heart chamber development
    • Liberatore CM, Searcy-Schrick RD, Yutzey KE,. Ventricular expression of tbx5 inhibits normal heart chamber development. Dev Biol 2000; 223 (1): 169-180.
    • (2000) Dev Biol , vol.223 , Issue.1 , pp. 169-180
    • Liberatore, C.M.1    Searcy-Schrick, R.D.2    Yutzey, K.E.3
  • 26
    • 84881661799 scopus 로고    scopus 로고
    • HCN4 dynamically marks the first heart field and conduction system precursors
    • Liang X, Wang G, Lin L, et al. HCN4 dynamically marks the first heart field and conduction system precursors. Circ Res 2013; 113 (4): 399-407.
    • (2013) Circ Res , vol.113 , Issue.4 , pp. 399-407
    • Liang, X.1    Wang, G.2    Lin, L.3
  • 27
    • 84883740296 scopus 로고    scopus 로고
    • A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells
    • Später D, Abramczuk MK, Buac K, et al. A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells. Nat Cell Biol 2013; 15 (9): 1098-1106.
    • (2013) Nat Cell Biol , vol.15 , Issue.9 , pp. 1098-1106
    • Später, D.1    Abramczuk, M.K.2    Buac, K.3
  • 28
    • 0031932209 scopus 로고    scopus 로고
    • A common precursor for hematopoietic and endothelial cells
    • Choi K, Kennedy M, Kazarov A, et al. A common precursor for hematopoietic and endothelial cells. Development 1998; 125 (4): 725-732.
    • (1998) Development , vol.125 , Issue.4 , pp. 725-732
    • Choi, K.1    Kennedy, M.2    Kazarov, A.3
  • 29
    • 33750456216 scopus 로고    scopus 로고
    • Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages
    • Kattman SJ, Huber TL, Keller GM,. Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Dev Cell 2006; 11 (5): 723-732.
    • (2006) Dev Cell , vol.11 , Issue.5 , pp. 723-732
    • Kattman, S.J.1    Huber, T.L.2    Keller, G.M.3
  • 30
    • 79955521591 scopus 로고    scopus 로고
    • Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis
    • Caprioli A, Koyano-Nakagawa N, Iacovino M, et al. Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis. Circulation 2011; 123 (15): 1633-1641.
    • (2011) Circulation , vol.123 , Issue.15 , pp. 1633-1641
    • Caprioli, A.1    Koyano-Nakagawa, N.2    Iacovino, M.3
  • 31
    • 79960192126 scopus 로고    scopus 로고
    • Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators
    • Simões FC, Peterkin T, Patient R,. Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators. Development 2011; 138 (15): 3235-3245.
    • (2011) Development , vol.138 , Issue.15 , pp. 3235-3245
    • Simões, F.C.1    Peterkin, T.2    Patient, R.3
  • 32
    • 13544272476 scopus 로고    scopus 로고
    • Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
    • Laugwitz K-L, Moretti A, Lam J, et al. Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature 2005; 433 (7026): 647-653.
    • (2005) Nature , vol.433 , Issue.7026 , pp. 647-653
    • Laugwitz, K.-L.1    Moretti, A.2    Lam, J.3
  • 33
    • 84904640769 scopus 로고    scopus 로고
    • Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3
    • Cambier L, Plate M, Sucov HM, et al. Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development 2014; 141 (15): 2959-2971.
    • (2014) Development , vol.141 , Issue.15 , pp. 2959-2971
    • Cambier, L.1    Plate, M.2    Sucov, H.M.3
  • 34
    • 77957270888 scopus 로고    scopus 로고
    • Neuregulin/ErbB signaling regulates cardiac subtype specification in differentiating human embryonic stem cells
    • Zhu W-Z, Xie Y, Moyes KW, et al. Neuregulin/ErbB signaling regulates cardiac subtype specification in differentiating human embryonic stem cells. Circ Res 2010; 107 (6): 776-786.
    • (2010) Circ Res , vol.107 , Issue.6 , pp. 776-786
    • Zhu, W.-Z.1    Xie, Y.2    Moyes, K.W.3
  • 35
    • 0037123990 scopus 로고    scopus 로고
    • Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function
    • Schram G, Pourrier M, Melnyk P, et al. Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function. Circ Res 2002; 90(9): 939-950.
    • (2002) Circ Res , vol.909 , pp. 939-950
    • Schram, G.1    Pourrier, M.2    Melnyk, P.3
  • 36
    • 0033538398 scopus 로고    scopus 로고
    • Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues
    • Shi W, Wymore R, Yu H, et al. Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Circ Res 1999; 85 (1): e1-e6.
    • (1999) Circ Res , vol.85 , Issue.1 , pp. e1-e6
    • Shi, W.1    Wymore, R.2    Yu, H.3
  • 37
    • 0034623369 scopus 로고    scopus 로고
    • Expression of T- and L-type calcium channel mRNA in murine sinoatrial node
    • Bohn G, Moosmang S, Conrad H, et al. Expression of T- and L-type calcium channel mRNA in murine sinoatrial node. FEBS Lett 2000; 481 (1): 73-76.
    • (2000) FEBS Lett , vol.481 , Issue.1 , pp. 73-76
    • Bohn, G.1    Moosmang, S.2    Conrad, H.3
  • 38
    • 13444304421 scopus 로고    scopus 로고
    • Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart
    • Marionneau C, Couette B, Liu J, et al. Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart. J Physiol 2005; 562 (Pt 1): 223-234.
    • (2005) J Physiol , vol.562 , pp. 223-234
    • Marionneau, C.1    Couette, B.2    Liu, J.3
  • 39
    • 0037093383 scopus 로고    scopus 로고
    • Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: Implications for cardiac chamber formation
    • Habets PEMH, Moorman AFM, Clout DEW, et al. Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: Implications for cardiac chamber formation. Genes Dev 2002; 16 (10): 1234-1246.
    • (2002) Genes Dev , vol.16 , Issue.10 , pp. 1234-1246
    • Habets, P.1    Moorman, A.F.M.2    Clout, D.E.W.3
  • 40
    • 1842561719 scopus 로고    scopus 로고
    • T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers
    • Christoffels VM, Hoogaars WMH, Tessari A, et al. T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers. Dev Dyn 2004; 229 (4): 763-770.
    • (2004) Dev Dyn , vol.229 , Issue.4 , pp. 763-770
    • Christoffels, V.M.1    Hoogaars, W.M.H.2    Tessari, A.3
  • 41
    • 0033582685 scopus 로고    scopus 로고
    • Regulation of chamber-specific gene expression in the developing heart by Irx4
    • Bao ZZ, Bruneau BG, Seidman JG, et al. Regulation of chamber-specific gene expression in the developing heart by Irx4. Science 1999; 283 (5405): 1161-1164.
    • (1999) Science , vol.283 , Issue.5405 , pp. 1161-1164
    • Bao, Z.Z.1    Bruneau, B.G.2    Seidman, J.G.3
  • 42
    • 0035133913 scopus 로고    scopus 로고
    • Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression
    • Bruneau BG, Bao ZZ, Fatkin D, et al. Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression. Mol Cell Biol 2001; 21 (5): 1730-1736.
    • (2001) Mol Cell Biol , vol.21 , Issue.5 , pp. 1730-1736
    • Bruneau, B.G.1    Bao, Z.Z.2    Fatkin, D.3
  • 43
    • 34147188988 scopus 로고    scopus 로고
    • CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression
    • Koibuchi N, Chin MT,. CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression. Circ Res 2007; 100 (6): 850-855.
    • (2007) Circ Res , vol.100 , Issue.6 , pp. 850-855
    • Koibuchi, N.1    Chin, M.T.2
  • 44
    • 34249932672 scopus 로고    scopus 로고
    • Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function
    • Xin M, Small EM, van Rooij E, et al. Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc Natl Acad Sci USA 2007; 104 (19): 7975-7980.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.19 , pp. 7975-7980
    • Xin, M.1    Small, E.M.2    Van Rooij, E.3
  • 45
    • 0027301056 scopus 로고
    • Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube
    • O'Brien TX, Lee KJ, Chien KR,. Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube. Proc Natl Acad Sci USA 1993; 90 (11): 5157-5161.
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.11 , pp. 5157-5161
    • O'Brien, T.X.1    Lee, K.J.2    Chien, K.R.3
  • 46
    • 78649666101 scopus 로고    scopus 로고
    • Differential gene expressions in atrial and ventricular myocytes: Insights into the road of applying embryonic stem cell-derived cardiomyocytes for future therapies
    • Ng SY, Wong CK, Tsang SY,. Differential gene expressions in atrial and ventricular myocytes: Insights into the road of applying embryonic stem cell-derived cardiomyocytes for future therapies. Am J Physiol Cell Physiol 2010; 299 (6): C1234-C1249.
    • (2010) Am J Physiol Cell Physiol , vol.299 , Issue.6 , pp. C1234-C1249
    • Ng, S.Y.1    Wong, C.K.2    Tsang, S.Y.3
  • 48
    • 0034662018 scopus 로고    scopus 로고
    • Chamber formation and morphogenesis in the developing mammalian heart
    • Christoffels VM, Habets PE, Franco D, et al. Chamber formation and morphogenesis in the developing mammalian heart. Dev Biol 2000; 223 (2): 266-278.
    • (2000) Dev Biol , vol.223 , Issue.2 , pp. 266-278
    • Christoffels, V.M.1    Habets, P.E.2    Franco, D.3
  • 49
    • 22744442083 scopus 로고    scopus 로고
    • Expression and regulation of the atrial natriuretic factor encoding gene Nppa during development and disease
    • Houweling AC, van Borren MM, Moorman AFM, et al. Expression and regulation of the atrial natriuretic factor encoding gene Nppa during development and disease. Cardiovasc Res 2005; 67 (4): 583-593.
    • (2005) Cardiovasc Res , vol.67 , Issue.4 , pp. 583-593
    • Houweling, A.C.1    Van Borren, M.M.2    Moorman, A.F.M.3
  • 50
    • 33748489726 scopus 로고    scopus 로고
    • Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis
    • Mori AD, Zhu Y, Vahora I, et al. Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis. Dev Biol 2006; 297 (2): 566-586.
    • (2006) Dev Biol , vol.297 , Issue.2 , pp. 566-586
    • Mori, A.D.1    Zhu, Y.2    Vahora, I.3
  • 51
    • 33847294241 scopus 로고    scopus 로고
    • Nkx2.5-negative myocardium of the posterior heart field and its correlation with podoplanin expression in cells from the developing cardiac pacemaking and conduction system
    • Gittenberger-de Groot AC, Mahtab EAF, Hahurij ND, et al. Nkx2.5-negative myocardium of the posterior heart field and its correlation with podoplanin expression in cells from the developing cardiac pacemaking and conduction system. Anat Rec (Hoboken) 2007; 290 (1): 115-122.
    • (2007) Anat Rec (Hoboken) , vol.290 , Issue.1 , pp. 115-122
    • Gittenberger-De Groot, A.C.1    Mahtab, E.A.F.2    Hahurij, N.D.3
  • 52
    • 0344735848 scopus 로고    scopus 로고
    • The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart
    • Stieber J, Herrmann S, Feil S, et al. The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci USA 2003; 100 (25): 15235-15240.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.25 , pp. 15235-15240
    • Stieber, J.1    Herrmann, S.2    Feil, S.3
  • 53
    • 79953769339 scopus 로고    scopus 로고
    • Optical action potential screening on adult ventricular myocytes as an alternative QT-screen
    • Tian Q, Oberhofer M, Ruppenthal S, et al. Optical action potential screening on adult ventricular myocytes as an alternative QT-screen. Cell Physiol Biochem 2011; 27 (3-4): 281-290.
    • (2011) Cell Physiol Biochem , vol.27 , Issue.34 , pp. 281-290
    • Tian, Q.1    Oberhofer, M.2    Ruppenthal, S.3
  • 54
    • 77649274601 scopus 로고    scopus 로고
    • A system for optical high resolution screening of electrical excitable cells
    • Müller O, Tian Q, Zantl R, et al. A system for optical high resolution screening of electrical excitable cells. Cell Calcium 2010; 47 (3): 224-233.
    • (2010) Cell Calcium , vol.47 , Issue.3 , pp. 224-233
    • Müller, O.1    Tian, Q.2    Zantl, R.3
  • 55
    • 84893779887 scopus 로고    scopus 로고
    • Rapid cellular phenotyping of human pluripotent stem cell-derived cardiomyocytes using a genetically encoded fluorescent voltage sensor
    • Leyton-Mange JS, Mills RW, Macri VS, et al. Rapid cellular phenotyping of human pluripotent stem cell-derived cardiomyocytes using a genetically encoded fluorescent voltage sensor. Stem Cell Rep 2014; 2 (2): 163-170.
    • (2014) Stem Cell Rep , vol.2 , Issue.2 , pp. 163-170
    • Leyton-Mange, J.S.1    Mills, R.W.2    MacRi, V.S.3
  • 56
    • 84908375059 scopus 로고    scopus 로고
    • A near-infrared fluorescent voltage-sensitive dye allows for moderate-throughput analyses of human induced pluripotent stem cell-derived cardiomyocytes
    • Lopez-Izquierdo A, Warren M, Riedel M, et al. A near-infrared fluorescent voltage-sensitive dye allows for moderate-throughput analyses of human induced pluripotent stem cell-derived cardiomyocytes. Am J Physiol Heart Circ Physiol 2014; 307: H1370-H1377.
    • (2014) Am J Physiol Heart Circ Physiol , vol.307 , pp. H1370-H1377
    • Lopez-Izquierdo, A.1    Warren, M.2    Riedel, M.3
  • 57
    • 0029144367 scopus 로고
    • Development of cardiomyocytes expressing cardiac-specific genes, action potentials, and ionic channels during embryonic stem cell-derived cardiogenesis
    • Wobus AM, Rohwedel J, Maltsev V, et al. Development of cardiomyocytes expressing cardiac-specific genes, action potentials, and ionic channels during embryonic stem cell-derived cardiogenesis. Ann N Y Acad Sci 1995; 752: 460-469.
    • (1995) Ann N y Acad Sci , vol.752 , pp. 460-469
    • Wobus, A.M.1    Rohwedel, J.2    Maltsev, V.3
  • 58
    • 77957729169 scopus 로고    scopus 로고
    • Patient-specific induced pluripotent stem-cell models for long-QT syndrome
    • Moretti A, Bellin M, Welling A, et al. Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N Engl J Med 2010; 363 (15): 1397-1409.
    • (2010) N Engl J Med , vol.363 , Issue.15 , pp. 1397-1409
    • Moretti, A.1    Bellin, M.2    Welling, A.3
  • 59
    • 33645513944 scopus 로고    scopus 로고
    • Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels
    • Bucchi A, Tognati A, Milanesi R, et al. Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels. J Physiol 2006; 572 (Pt 2): 335-346.
    • (2006) J Physiol , vol.572 , pp. 335-346
    • Bucchi, A.1    Tognati, A.2    Milanesi, R.3
  • 60
    • 84879186921 scopus 로고    scopus 로고
    • 2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development
    • 2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development. J Cell Biochem 2013; 114 (8): 1852-1862.
    • (2013) J Cell Biochem , vol.114 , Issue.8 , pp. 1852-1862
    • Wang, P.1    Tang, M.2    Gao, L.3
  • 61
    • 0036020147 scopus 로고    scopus 로고
    • Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine
    • Bucchi A, Baruscotti M, DiFrancesco D,. Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine. J Gen Physiol 2002; 120 (1): 1-13.
    • (2002) J Gen Physiol , vol.120 , Issue.1 , pp. 1-13
    • Bucchi, A.1    Baruscotti, M.2    Difrancesco, D.3
  • 62
    • 84908648441 scopus 로고    scopus 로고
    • Functional expression and regulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in mouse iPS cell-derived cardiomyocytes after UTF1-neo selection
    • Semmler J, Lehmann M, Pfannkuche K, et al. Functional expression and regulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in mouse iPS cell-derived cardiomyocytes after UTF1-neo selection. Cell Physiol Biochem 2014; 34 (4): 1199-1215.
    • (2014) Cell Physiol Biochem , vol.34 , Issue.4 , pp. 1199-1215
    • Semmler, J.1    Lehmann, M.2    Pfannkuche, K.3
  • 63
    • 71549150302 scopus 로고    scopus 로고
    • Forward programming of pluripotent stem cells towards distinct cardiovascular cell types
    • David R, Stieber J, Fischer E, et al. Forward programming of pluripotent stem cells towards distinct cardiovascular cell types. Cardiovasc Res 2009; 84 (2): 263-272.
    • (2009) Cardiovasc Res , vol.84 , Issue.2 , pp. 263-272
    • David, R.1    Stieber, J.2    Fischer, E.3
  • 65
    • 41149107746 scopus 로고    scopus 로고
    • Identification of downstream genetic pathways of Tbx1 in the second heart field
    • Liao J, Aggarwal VS, Nowotschin S, et al. Identification of downstream genetic pathways of Tbx1 in the second heart field. Dev Biol 2008; 316 (2): 524-537.
    • (2008) Dev Biol , vol.316 , Issue.2 , pp. 524-537
    • Liao, J.1    Aggarwal, V.S.2    Nowotschin, S.3
  • 66
    • 33745390405 scopus 로고    scopus 로고
    • Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling
    • Park EJ, Ogden LA, Talbot A, et al. Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development 2006; 133 (12): 2419-2433.
    • (2006) Development , vol.133 , Issue.12 , pp. 2419-2433
    • Park, E.J.1    Ogden, L.A.2    Talbot, A.3
  • 67
    • 84874349047 scopus 로고    scopus 로고
    • Islet1 is a direct transcriptional target of the homeodomain transcription factor Shox2 and rescues the Shox2-mediated bradycardia
    • Hoffmann S, Berger IM, Glaser A, et al. Islet1 is a direct transcriptional target of the homeodomain transcription factor Shox2 and rescues the Shox2-mediated bradycardia. Basic Res Cardiol 2013; 108 (2): 339.
    • (2013) Basic Res Cardiol , vol.108 , Issue.2 , pp. 339
    • Hoffmann, S.1    Berger, I.M.2    Glaser, A.3
  • 68
    • 70349270571 scopus 로고    scopus 로고
    • Isl1 is a direct transcriptional target of Forkhead transcription factors in second-heart-field-derived mesoderm
    • Kang J, Nathan E, Xu S-M, et al. Isl1 is a direct transcriptional target of Forkhead transcription factors in second-heart-field-derived mesoderm. Dev Biol 2009; 334 (2): 513-522.
    • (2009) Dev Biol , vol.334 , Issue.2 , pp. 513-522
    • Kang, J.1    Nathan, E.2    Xu, S.-M.3
  • 69
    • 70350007320 scopus 로고    scopus 로고
    • Identification of regulatory elements in the Isl1 gene locus
    • Kappen C, Salbaum JM,. Identification of regulatory elements in the Isl1 gene locus. Int J Dev Biol 2009; 53 (7): 935-946.
    • (2009) Int J Dev Biol , vol.53 , Issue.7 , pp. 935-946
    • Kappen, C.1    Salbaum, J.M.2
  • 70
    • 79958242694 scopus 로고    scopus 로고
    • POU homeodomain protein OCT1 modulates islet 1 expression during cardiac differentiation of P19CL6 cells
    • Liu Y, Li Y, Li T, et al. POU homeodomain protein OCT1 modulates islet 1 expression during cardiac differentiation of P19CL6 cells. Cell Mol Life Sci 2011; 68 (11): 1969-1982.
    • (2011) Cell Mol Life Sci , vol.68 , Issue.11 , pp. 1969-1982
    • Liu, Y.1    Li, Y.2    Li, T.3
  • 71
    • 21044454606 scopus 로고    scopus 로고
    • T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis
    • Cai C-L, Zhou W, Yang L, et al. T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development 2005; 132 (10): 2475-2487.
    • (2005) Development , vol.132 , Issue.10 , pp. 2475-2487
    • Cai, C.-L.1    Zhou, W.2    Yang, L.3
  • 72
    • 84868573870 scopus 로고    scopus 로고
    • Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium
    • Watanabe Y, Zaffran S, Kuroiwa A, et al. Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium. Proc Natl Acad Sci USA 2012; 109 (45): 18273-18280.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.45 , pp. 18273-18280
    • Watanabe, Y.1    Zaffran, S.2    Kuroiwa, A.3
  • 73
  • 74
    • 43049087055 scopus 로고    scopus 로고
    • Promoter-dependent EGFP expression during embryonic stem cell propagation and differentiation
    • Wang R, Liang J, Jiang H, et al. Promoter-dependent EGFP expression during embryonic stem cell propagation and differentiation. Stem Cells Dev 2008; 17 (2): 279-289.
    • (2008) Stem Cells Dev , vol.17 , Issue.2 , pp. 279-289
    • Wang, R.1    Liang, J.2    Jiang, H.3
  • 75
    • 84872927982 scopus 로고    scopus 로고
    • Islet1-expressing cardiac progenitor cells: A comparison across species
    • Pandur P, Sirbu IO, Kühl SJ, et al. Islet1-expressing cardiac progenitor cells: A comparison across species. Dev Genes Evol 2013; 223 (1-2): 117-129.
    • (2013) Dev Genes Evol , vol.223 , Issue.12 , pp. 117-129
    • Pandur, P.1    Sirbu, I.O.2    Kühl, S.J.3
  • 76
    • 62349131520 scopus 로고    scopus 로고
    • The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis
    • Mann T, Bodmer R, Pandur P,. The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis. Development 2009; 136 (2): 317-326.
    • (2009) Development , vol.136 , Issue.2 , pp. 317-326
    • Mann, T.1    Bodmer, R.2    Pandur, P.3
  • 77
    • 68249120547 scopus 로고    scopus 로고
    • A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate
    • Kwon C, Qian L, Cheng P, et al. A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat Cell Biol 2009; 11 (8): 951-957.
    • (2009) Nat Cell Biol , vol.11 , Issue.8 , pp. 951-957
    • Kwon, C.1    Qian, L.2    Cheng, P.3
  • 78
    • 79952374113 scopus 로고    scopus 로고
    • Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation
    • Bondue A, Tännler S, Chiapparo G, et al. Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation. J Cell Biol 2011; 192 (5): 751-765.
    • (2011) J Cell Biol , vol.192 , Issue.5 , pp. 751-765
    • Bondue, A.1    Tännler, S.2    Chiapparo, G.3
  • 79
    • 0031281873 scopus 로고    scopus 로고
    • Embryonic stem cells: A model to study structural and functional properties in cardiomyogenesis
    • Hescheler J, Fleischmann BK, Lentini S, et al. Embryonic stem cells: A model to study structural and functional properties in cardiomyogenesis. Cardiovasc Res 1997; 36 (2): 149-162.
    • (1997) Cardiovasc Res , vol.36 , Issue.2 , pp. 149-162
    • Hescheler, J.1    Fleischmann, B.K.2    Lentini, S.3
  • 80
    • 78349309061 scopus 로고    scopus 로고
    • Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells
    • Kleger A, Seufferlein T, Malan D, et al. Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells. Circulation 2010; 122 (18): 1823-1836.
    • (2010) Circulation , vol.122 , Issue.18 , pp. 1823-1836
    • Kleger, A.1    Seufferlein, T.2    Malan, D.3
  • 81
    • 0030051923 scopus 로고    scopus 로고
    • Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation
    • Pfaff SL, Mendelsohn M, Stewart CL, et al. Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell 1996; 84 (2): 309-320.
    • (1996) Cell , vol.84 , Issue.2 , pp. 309-320
    • Pfaff, S.L.1    Mendelsohn, M.2    Stewart, C.L.3
  • 82
    • 0036304223 scopus 로고    scopus 로고
    • Transcriptional codes and the control of neuronal identity
    • Shirasaki R, Pfaff SL,. Transcriptional codes and the control of neuronal identity. Annu Rev Neurosci 2002; 25: 251-281.
    • (2002) Annu Rev Neurosci , vol.25 , pp. 251-281
    • Shirasaki, R.1    Pfaff, S.L.2
  • 83
    • 0037178783 scopus 로고    scopus 로고
    • LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions
    • Thaler JP, Lee S-K, Jurata LW, et al. LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions. Cell 2002; 110 (2): 237-249.
    • (2002) Cell , vol.110 , Issue.2 , pp. 237-249
    • Thaler, J.P.1    Lee, S.-K.2    Jurata, L.W.3
  • 84
    • 0028580180 scopus 로고
    • Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
    • Tsuchida T, Ensini M, Morton SB, et al. Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Cell 1994; 79 (6): 957-970.
    • (1994) Cell , vol.79 , Issue.6 , pp. 957-970
    • Tsuchida, T.1    Ensini, M.2    Morton, S.B.3
  • 85
    • 67349190330 scopus 로고    scopus 로고
    • LIM family transcription factors regulate the subtype-specific morphogenesis of retinal horizontal cells at post-migratory stages
    • Suga A, Taira M, Nakagawa S,. LIM family transcription factors regulate the subtype-specific morphogenesis of retinal horizontal cells at post-migratory stages. Dev Biol 2009; 330 (2): 318-328.
    • (2009) Dev Biol , vol.330 , Issue.2 , pp. 318-328
    • Suga, A.1    Taira, M.2    Nakagawa, S.3
  • 86
    • 33847020703 scopus 로고    scopus 로고
    • Molecular pathway for the localized formation of the sinoatrial node
    • Mommersteeg MTM, Hoogaars WMH, Prall OWJ, et al. Molecular pathway for the localized formation of the sinoatrial node. Circ Res 2007; 100 (3): 354-362.
    • (2007) Circ Res , vol.100 , Issue.3 , pp. 354-362
    • Mommersteeg, M.T.M.1    Hoogaars, W.M.H.2    Prall, O.W.J.3
  • 87
    • 77955138809 scopus 로고    scopus 로고
    • The sinus venosus progenitors separate and diversify from the first and second heart fields early in development
    • Mommersteeg MTM, Domínguez JN, Wiese C, et al. The sinus venosus progenitors separate and diversify from the first and second heart fields early in development. Cardiovasc Res 2010; 87 (1): 92-101.
    • (2010) Cardiovasc Res , vol.87 , Issue.1 , pp. 92-101
    • Mommersteeg, M.T.M.1    Domínguez, J.N.2    Wiese, C.3
  • 88
    • 33947165217 scopus 로고    scopus 로고
    • Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells
    • Sun Y, Liang X, Najafi N, et al. Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol 2007; 304 (1): 286-296.
    • (2007) Dev Biol , vol.304 , Issue.1 , pp. 286-296
    • Sun, Y.1    Liang, X.2    Najafi, N.3
  • 89
    • 79957850422 scopus 로고    scopus 로고
    • Distinction between two populations of islet-1-positive cells in hearts of different murine strains
    • Khattar P, Friedrich FW, Bonne G, et al. Distinction between two populations of islet-1-positive cells in hearts of different murine strains. Stem Cells Dev 2011; 20 (6): 1043-1052.
    • (2011) Stem Cells Dev , vol.20 , Issue.6 , pp. 1043-1052
    • Khattar, P.1    Friedrich, F.W.2    Bonne, G.3
  • 90
    • 84861100146 scopus 로고    scopus 로고
    • Localization of Islet-1-positive cells in the healthy and infarcted adult murine heart
    • Weinberger F, Mehrkens D, Friedrich FW, et al. Localization of Islet-1-positive cells in the healthy and infarcted adult murine heart. Circ Res 2012; 110 (10): 1303-1310.
    • (2012) Circ Res , vol.110 , Issue.10 , pp. 1303-1310
    • Weinberger, F.1    Mehrkens, D.2    Friedrich, F.W.3
  • 91
    • 84867584799 scopus 로고    scopus 로고
    • Identification and functional characterization of cardiac pacemaker cells in zebrafish
    • Tessadori F, van Weerd JH, Burkhard SB, et al. Identification and functional characterization of cardiac pacemaker cells in zebrafish. PLoS ONE 2012; 7 (10): e47644.
    • (2012) PLoS ONE , vol.7 , Issue.10 , pp. e47644
    • Tessadori, F.1    Van Weerd, J.H.2    Burkhard, S.B.3
  • 92
    • 68549119152 scopus 로고    scopus 로고
    • Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart
    • de Pater E, Clijsters L, Marques SR, et al. Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart. Development 2009; 136 (10): 1633-1641.
    • (2009) Development , vol.136 , Issue.10 , pp. 1633-1641
    • De Pater, E.1    Clijsters, L.2    Marques, S.R.3
  • 93
    • 79951727653 scopus 로고    scopus 로고
    • Differentiation induction of mouse embryonic stem cells into sinus node-like cells by suramin
    • Wiese C, Nikolova T, Zahanich I, et al. Differentiation induction of mouse embryonic stem cells into sinus node-like cells by suramin. Int J Cardiol 2011; 147 (1): 95-111.
    • (2011) Int J Cardiol , vol.147 , Issue.1 , pp. 95-111
    • Wiese, C.1    Nikolova, T.2    Zahanich, I.3
  • 94
    • 2442513900 scopus 로고    scopus 로고
    • The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart
    • Hoogaars WMH, Tessari A, Moorman AFM, et al. The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart. Cardiovasc Res 2004; 62 (3): 489-499.
    • (2004) Cardiovasc Res , vol.62 , Issue.3 , pp. 489-499
    • Hoogaars, W.M.H.1    Tessari, A.2    Moorman, A.F.M.3
  • 95
    • 34247590280 scopus 로고    scopus 로고
    • Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria
    • Hoogaars WMH, Engel A, Brons JF, et al. Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. Genes Dev 2007; 21 (9): 1098-1112.
    • (2007) Genes Dev , vol.21 , Issue.9 , pp. 1098-1112
    • Hoogaars, W.M.H.1    Engel, A.2    Brons, J.F.3
  • 96
    • 8444252934 scopus 로고    scopus 로고
    • Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development
    • Harrelson Z, Kelly RG, Goldin SN, et al. Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development. Development 2004; 131 (20): 5041-5052.
    • (2004) Development , vol.131 , Issue.20 , pp. 5041-5052
    • Harrelson, Z.1    Kelly, R.G.2    Goldin, S.N.3
  • 97
    • 84861354654 scopus 로고    scopus 로고
    • T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells
    • Bakker ML, Boink GJJ, Boukens BJ, et al. T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells. Cardiovasc Res 2012; 94 (3): 439-449.
    • (2012) Cardiovasc Res , vol.94 , Issue.3 , pp. 439-449
    • Bakker, M.L.1    Boink, G.J.J.2    Boukens, B.J.3


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