Tbx5 overexpression favors a first heart field lineage in murine embryonic stem cells and in Xenopus laevis embryos

Developmental Dynamics

Volumn 240, Issue 12, 2011, Pages 2634-2645

  Herrmann, Franziska ^a   Bundschu, Karin ^a   Kühl, Susanne J ^a   Kühl, Michael ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Cardiogenesis; First heart field; Murine ES cells; Tbx5; Xenopus laevis

Indexed keywords

BIOLOGICAL MARKER; BONE MORPHOGENETIC PROTEIN 4; HAND2 PROTEIN; PROTEIN; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR TBX5; TROPONIN T; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; DOWN REGULATION; EMBRYO; EMBRYONIC STEM CELL; FIRST HEARTFIELD LINEAGE; GENE OVEREXPRESSION; HEART ATRIUM; HEART BEAT; HEART CONTRACTION; HEART DEVELOPMENT; HEART MUSCLE CELL; MOUSE; MOUSE EMBRYO; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; XENOPUS LAEVIS;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BONE MORPHOGENETIC PROTEIN 4; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; DOWN-REGULATION; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART ATRIA; HOMEODOMAIN PROTEINS; MICE; MYOCYTES, CARDIAC; T-BOX DOMAIN PROTEINS; TRANSCRIPTION FACTORS; TROPONIN T; XENOPUS LAEVIS; XENOPUS PROTEINS;

MURINAE; XENOPUS LAEVIS;

EID: 80855124280     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.22776     Document Type: Article

References (43)

1. Abu-Issa R, Kirby ML. 2007. Heart field: from mesoderm to heart tube. Annu Rev Cell Dev Biol 23: 45-68.
2. Anton R, Kestler HA, Kühl M. 2007. Beta-catenin signaling contributes to stemness and regulates early differentiation in murine embryonic stem cells. FEBS letters 581: 5247-5254.
3. Banach K, Halbach MD, Hu P, Hescheler J, Egert U. 2003. Development of electrical activity in cardiac myocyte aggregates derived from mouse embryonic stem cells. Am J Physiol Heart Circ Physiol 284: H2114-H2123.
4. Basson CT, Bachinsky DR, Lin RC, Levi T, Elkins JA, Soults J, Grayzel D, Kroumpouzou E, Traill TA, Leblanc-Straceski J, Renault B, Kucherlapati R, Seidman JG, Seidman CE. 1997. Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome. Nat Genet 15: 30-35.
5. Bruneau BG, Logan M, Davis N, Levi T, Tabin CJ, Seidman JG, Seidman CE. 1999. Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome. Dev Biol 211: 100-108.
6. Bruneau BG, Nemer G, Schmitt JP, Charron F, Robitaille L, Caron S, Conner DA, Gessler M, Nemer M, Seidman CE, Seidman JG. 2001. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell 106: 709-721.
7. Buckingham M, Meilhac S, Zaffran S. 2005. Building the mammalian heart from two sources of myocardial cells. Nat Rev Genet 6: 826-835.
8. Cai CL, Liang X, Shi Y, Chu PH, Pfaff SL, Chen J, Evans S. 2003. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell 5: 877-889.
9. Chapman DL, Garvey N, Hancock S, Alexiou M, Agulnik SI, Gibson-Brown JJ, Cebra-Thomas J, Bollag RJ, Silver LM, Papaioannou VE. 1996. Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development. Dev Dyn 206: 379-390.
10. Coppen SR, Dupont E, Rothery S, Severs NJ. 1998. Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart. Circ Res 82: 232-243.
11. David R, Brenner C, Stieber J, Schwarz F, Brunner S, Vollmer M, Mentele E, Muller-Hocker J, Kitajima S, Lickert H, Rupp R, Franz WM. 2008. MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling. Nat Cell Biol 10: 338-345.
12. Espinoza-Lewis RA, Yu L, He F, Liu H, Tang R, Shi J, Sun X, Martin JF, Wang D, Yang J, Chen Y. 2009. Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5. Dev Biol 327: 376-385.
13. Firulli AB, McFadden DG, Lin Q, Srivastava D, Olson EN. 1998. Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nat Genet 18: 266-270.
14. Gessert S, Kühl M. 2009. Comparative gene expression analysis and fate mapping studies suggest an early segregation of cardiogenic lineages in Xenopus laevis. Dev Biol 334: 395-408.
15. Gessert S, Maurus D, Brade T, Walther P, Pandur P, Kühl M. 2008. DM-GRASP/ALCAM/CD166 is required for cardiac morphogenesis and maintenance of cardiac identity in first heart field derived cells. Dev Biol 321: 150-161.
16. Goetz SC, Brown DD, Conlon FL. 2006. TBX5 is required for embryonic cardiac cell cycle progression. Development 133: 2575-2584.
17. Grepin C, Nemer G, Nemer M. 1997. Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor. Development 124: 2387-2395.
18. Hiroi Y, Kudoh S, Monzen K, Ikeda Y, Yazaki Y, Nagai R, Komuro I. 2001. Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nat Genet 28: 276-280.
19. Hoogaars WM, Tessari A, Moorman AF, de Boer PA, Hagoort J, Soufan AT, Campione M, Christoffels VM. 2004. The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart. Cardiovasc Res 62: 489-499.
20. Hoogaars WM, Engel A, Brons JF, Verkerk AO, de Lange FJ, Wong LY, Bakker ML, Clout DE, Wakker V, Barnett P, Ravesloot JH, Moorman AF, Verheijck EE, Christoffels VM. 2007. Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. Genes Dev 21: 1098-1112.
21. Horb ME, Thomsen GH. 1999. Tbx5 is essential for heart development. Development 126: 1739-1751.
22. Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D. 2010. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142: 375-386.
23. Ilagan R, Abu-Issa R, Brown D, Yang YP, Jiao K, Schwartz RJ, Klingensmith J, Meyers EN. 2006. Fgf8 is required for anterior heart field development. Development 133: 2435-2445.
24. Kattman SJ, Huber TL, Keller GM. 2006. Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Dev Cell 11: 723-732.
25. Kreuzberg MM, Sohl G, Kim JS, Verselis VK, Willecke K, Bukauskas FF. 2005. Functional properties of mouse connexin30.2 expressed in the conduction system of the heart. Circ Res 96: 1169-1177.
26. Laugwitz KL, Moretti A, Caron L, Nakano A, Chien KR. 2008. Islet1 cardiovascular progenitors: a single source for heart lineages? Development 135: 193-205.
27. Liberatore CM, Searcy-Schrick RD, Yutzey KE. 2000. Ventricular expression of tbx5 inhibits normal heart chamber development. Dev Biol 223: 169-180.
28. Lin Q, Schwarz J, Bucana C, Olson EN. 1997. Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 276: 1404-1407.
29. Liu W, Selever J, Wang D, Lu MF, Moses KA, Schwartz RJ, Martin JF. 2004. Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling. Proc Natl Acad Sci U S A 101: 4489-4494.
30. Milanesi R, Baruscotti M, Gnecchi-Ruscone T, DiFrancesco D. 2006. Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel. N Engl J Med 354: 151-157.
31. Mommersteeg MT, Hoogaars WM, Prall OW, de Gier-de Vries C, Wiese C, Clout DE, Papaioannou VE, Brown NA, Harvey RP, Moorman AF, Christoffels VM. 2007. Molecular pathway for the localized formation of the sinoatrial node. Circ Res 100: 354-362.
32. Moretti A, Caron L, Nakano A, Lam JT, Bernshausen A, Chen Y, Qyang Y, Bu L, Sasaki M, Martin-Puig S, Sun Y, Evans SM, Laugwitz KL, Chien KR. 2006. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell 127: 1151-1165.
33. Moskowitz IP, Pizard A, Patel VV, Bruneau BG, Kim JB, Kupershmidt S, Roden D, Berul CI, Seidman CE, Seidman JG. 2004. The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system. Development 131: 4107-4116.
34. Moskowitz IP, Kim JB, Moore ML, Wolf CM, Peterson MA, Shendure J, Nobrega MA, Yokota Y, Berul C, Izumo S, Seidman JG, Seidman CE. 2007. A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development. Cell 129: 1365-1376.
35. Risebro CA, Smart N, Dupays L, Breckenridge R, Mohun TJ, Riley PR. 2006. Hand1 regulates cardiomyocyte proliferation versus differentiation in the developing heart. Development 133: 4595-4606.
36. Seo S, Kume T. 2006. Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. Dev Biol 296: 421-436.
37. Skerjanc IS, Petropoulos H, Ridgeway AG, Wilton S. 1998. Myocyte enhancer factor 2C and Nkx2-5 up-regulate each other's expression and initiate cardiomyogenesis in P19 cells. J Biol Chem 273: 34904-34910.
38. Sun G, Lewis LE, Huang X, Nguyen Q, Price C, Huang T. 2004. TBX5, a gene mutated in Holt-Oram syndrome, is regulated through a GC box and T-box binding elements (TBEs). J Cell Biochem 92: 189-199.
39. Tabibiazar R, Wagner RA, Liao A, Quertermous T. 2003. Transcriptional profiling of the heart reveals chamber-specific gene expression patterns. Circ Res 93: 1193-1201.
40. Takeuchi JK, Bruneau BG. 2009. Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors. Nature 459: 708-711.
41. Takeuchi JK, Mileikovskaia M, Koshiba-Takeuchi K, Heidt AB, Mori AD, Arruda EP, Gertsenstein M, Georges R, Davidson L, Mo R, Hui CC, Henkelman RM, Nemer M, Black BL, Nagy A, Bruneau BG. 2005. Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development 132: 2463-2474.
42. Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM. 2008. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature 453: 524-528.
43. Zhao XS, Gallardo TD, Lin L, Schageman JJ, Shohet RV. 2002. Transcriptional mapping and genomic analysis of the cardiac atria and ventricles. Physiol Genom 12: 53-60.