Islet1 is a direct transcriptional target of the homeodomain transcription factor Shox2 and rescues the Shox2-mediated bradycardia

Basic Research in Cardiology

Volumn 108, Issue 2, 2013, Pages

  Hoffmann, Sandra ^a   Berger, Ina M ^b   Glaser, Anne ^a   Bacon, Claire ^a   Li, Li ^a   Gretz, Norbert ^a   Steinbeisser, Herbert ^a   Rottbauer, Wolfgang ^b   Just, Steffen ^b   Rappold, Gudrun ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

Arrhythmia; Gene regulation; Islet1; Shox2; Sinoatrial node; Transcription factors

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ISLET1; TRANSCRIPTION FACTOR SHOX2; UNCLASSIFIED DRUG; HOMEODOMAIN PROTEIN; INSULIN GENE ENHANCER BINDING PROTEIN ISL 1; INSULIN GENE ENHANCER BINDING PROTEIN ISL-1; LIM HOMEODOMAIN PROTEIN; SHOX2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRADYCARDIA; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EPISTASIS; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION; GENE LOCUS; GENE SILENCING; HEART BEAT; HEART DEVELOPMENT; HEART RATE; HEART RIGHT ATRIUM; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; INTRON; LUCIFERASE ASSAY; MICROARRAY ANALYSIS; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PHENOTYPE; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN TARGETING; SHOX2 GENE; SINUS NODE; WILD TYPE; ZEBRA FISH; ANIMAL; CELL CULTURE; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETIC TRANSCRIPTION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; BRADYCARDIA; CELLS, CULTURED; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIM-HOMEODOMAIN PROTEINS; MICE; MICROARRAY ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; SINOATRIAL NODE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; ZEBRAFISH;

MLCS; MLOWN;

EID: 84874349047     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-013-0339-z     Document Type: Article

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