Molecular tethering effect of c-terminus of amyloid peptide aβ42

ACS Nano

Volumn 8, Issue 9, 2014, Pages 9503-9510

  Liu, Lei ^a,b   Niu, Lin ^a   Xu, Meng ^a   Han, Qiusen ^a   Duan, Hongyang ^a   Dong, Mingdong ^c   Besenbacher, Flemming ^c   Wang, Chen ^a   Yang, Yanlian ^a  

^a NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^b JIANGSU UNIVERSITY   (China)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

amyloid peptide; membrane disruption; modulation; molecular tethering effect; peptide aggregation

Indexed keywords

AMINO ACIDS; GLYCOPROTEINS; MODULATION; MOLECULES; PROTEINS; SCANNING TUNNELING MICROSCOPY; SELF ASSEMBLY;

AMYLOID PEPTIDES; BETA AMYLOID PEPTIDES; DEGENERATIVE DISEASE; FEATURE VARIATIONS; MEMBRANE DISRUPTION; MOLECULAR TETHERING EFFECT; PEPTIDE AGGREGATION; SINGLE MOLECULE LEVEL;

PEPTIDES;

4,4'-BIPYRIDYL; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); PEPTIDE FRAGMENT; PROTEIN AGGREGATE; PROTEIN BINDING; PYRIDINE DERIVATIVE;

CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HUMAN; KINETICS; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; TUMOR CELL LINE;

AMYLOID BETA-PEPTIDES; CELL LINE, TUMOR; CELL MEMBRANE; HUMANS; KINETICS; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PROTEIN AGGREGATES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PYRIDINES;

EID: 84925603237     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn503737r     Document Type: Article

References (39)

1. Seizinger, B. R.; Liebisch, D. C.; Gramsch, C.; Herz, A.; Weber, E.; Evans, C. J.; Esch, F. S.; Bohlen, P. Isolation and Structure of a Novel C-Terminally Amidated Opioid Peptide, Amidorphin, from Bovine Adrenal Medulla Nature 1985, 313, 57-59
2. Abraha, A.; Kuret, J.; Binder, L. I. C-Terminus Truncation and Phosphorylation of the Human Tau Protein Enhances Tau Polymerization: An In Vitro Study Using Laser Light Scattering and Electron Microscopy J. Neurochem. 2000, 74, S15-S15
3. Rivka. Ofir; Dwarki, V. J.; Rashid, D.; Verma, I. M. Phosphorylation of the C Terminus of Fos Protein Is Required for Transcriptional Transrepression of the C-Fos Promoter Nature 1990, 348, 80-82
4. Piers, K. L.; Brown, M. H.; Hancock, R. E. Improvement of Outer Membrane-Permeabilizing and Lipopolysaccharide-Binding Activities of an Antimicrobial Cationic Peptide by C-Terminal Modification Antimicrob. Agents Chemother. 1994, 38, 2311-2316
5. Seppala, S.; Slusky, J. S.; Lloris-Garcera, P.; Rapp, M.; von Heijne, G. Control of Membrane Protein Topology by a Single C-Terminal Residue Science 2010, 328, 1698-1700
6. Lashuel, H. A.; Hartley, D.; Petre, B. M.; Walz, T.; Lansbury, P. T. Neurodegenerative Disease-Amyloid Pores from Pathogenic Mutations Nature 2002, 418, 291-291
7. Quist, A.; Doudevski, L.; Lin, H.; Azimova, R.; Ng, D.; Frangione, B.; Kagan, B.; Ghiso, J.; Lal, R. Amyloid Ion Channels: A Common Structural Link for Protein-Misfolding Disease Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 10427-10432
8. Butterfield, S. M.; Lashuel, H. A. Amyloidogenic Protein Membrane Interactions: Mechanistic Insight from Model Systems Angew. Chem., Int. Ed. 2010, 49, 5628-5654
9. Laganowsky, A.; Liu, C.; Sawaya, M. R.; Whitelegge, J. P.; Park, J.; Zhao, M. L.; Pensalfini, A.; Soriaga, A. B.; Landau, M.; Teng, P. K. et al. Atomic View of a Toxic Amyloid Small Oligomer Science 2012, 335, 1228-1231
10. Roberson, E. D.; Mucke, L. 100 Years and Counting: Prospects for Defeating Alzheimers Disease Science 2006, 314, 781-784
11. Goedert, M.; Spillantini, M. G. A Century of Alzheimers Disease Science 2006, 314, 777-781
12. Brody, D. L.; Magnoni, S.; Schwetye, K. E.; Spinner, M. L.; Esparza, T. J.; Stocchetti, N.; Zipfel, G. J.; Holtzman, D. M. Amyloid-Beta Dynamics Correlate with Neurological Status in the Injured Human Brain Science 2008, 321, 1221-1224
13. Hardy, J.; Selkoe, D. J. Medicine-the Amyloid Hypothesis of Alzheimers Disease: Progress and Problems on the Road to Therapeutics Science 2002, 297, 353-356
14. Joseph, T.; Jarrett, E. P.; Berger, P. T.; Lansbury, J. The Carboxy Terminus of the Amyloid Protein Is Critical for the Seeding of Amyloid Formation: Implications for the Pathogenesis of Alzheimers Disease Biochemistry 1993, 32, 4693-4697
15. Lansbury, P. T., Jr.; Costa, P. R.; Griffiths, J. M.; Simon, E. J.; Auger, M.; Halverson, K. J.; Kocisko, D. A.; Hendsch, Z. S.; Ashburn, T. T.; Spencer, R. G. et al. Structural Model for the Beta-Amyloid Fibril Based on Interstrand Alignment of an Antiparallel-Sheet Comprising a C-Terminal Peptide Nat. Struct. Mol. Biol. 1995, 2, 990-998
16. Lambert, M. P.; Barlow, A. K.; Chromy, B. A.; Edwards, C.; Freed, R.; Liosatos, M.; Morgan, T. E.; Rozovsky, I.; Trommer, B.; Viola, K. L. et al. Diffusible, Nonfibrillar Ligands Derived from a Beta(1-42) Are Potent Central Nervous System Neurotoxins Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 6448-6453
17. Stroud, J. C.; Liu, C.; Teng, P. K.; Eisenberg, D. Toxic Fibrillar Oligomers of Amyloid-Beta Have Cross-Beta Structure Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 7717-7722
18. Irie, K.; Murakami, K.; Masuda, Y.; Morimoto, A.; Ohigashi, H.; Ohashi, R.; Takegoshi, K.; Nagao, M.; Shimizu, T.; Shirasawa, T. Structure of Beta-Amyloid Fibrils and Its Relevance to Their Neurotoxicity: Implications for the Pathogenesis of Alzheimers Disease J. Biosci. Bioeng. 2005, 99, 437-447
19. Frid, P.; Anisimov, S. V.; Popovic, N. Congo Red and Protein Aggregation in Neurodegenerative Diseases Brain Res. Rev. 2007, 53, 135-160
20. Klunk, W. E.; Debnath, M. L.; Pettegrew, J. W. Development of Small-Molecule Probes for the Beta-Amyloid Protein of Alzheimers Disease Neurobio. Aging. 1994, 15, 691-698
21. Yang, F. S.; Lim, G. P.; Begum, A. N.; Ubeda, O. J.; Simmons, M. R.; Ambegaokar, S. S.; Chen, P. P.; Kayed, R.; Glabe, C. G.; Frautschy, S. A. et al. Curcumin Inhibits Formation of Amyloid Beta Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo J. Biol. Chem. 2005, 280, 5892-5901
22. Hamaguchi, T.; Ono, K.; Murase, A.; Yamada, M. Phenolic Compounds Prevent Alzheimers Pathology through Different Effects on the Amyloid-Beta Aggregation Pathway Am. J. Pathol. 2009, 175, 2557-2565
23. Gestwicki, J. E.; Crabtree, G. R.; Graef, I. A. Harnessing Chaperones to Generate Small-Molecule Inhibitors of Amyloid Beta Aggregation Science 2004, 306, 865-869
24. Wu, W. H.; Lei, P.; Liu, Q.; Hu, J.; Gunn, A. P.; Chen, M. S.; Rui, Y. F.; Su, X. Y.; Xie, Z. P.; Zhao, Y. F. et al. Sequestration of Copper from Beta-Amyloid Promotes Selective Lysis by Cyclen-Hybrid Cleavage Agents J. Biol. Chem. 2008, 283, 31657-31664
25. Takahashi, T.; Ohta, K.; Mihara, H. Embedding the Amyloid Beta-Peptide Sequence in Green Fluorescent Protein Inhibits Abeta Oligomerization ChemBioChem 2007, 8, 985-988
26. Biancalana, M.; Makabe, K.; Koide, A.; Koide, S. Molecular Mechanism of Thioflavin-T Binding to the Surface of Beta-Rich Peptide Self-Assemblies J. Mol. Biol. 2009, 385, 1052-1063
27. Biancalana, M.; Koide, S. Molecular Mechanism of Thioflavin-T Binding to Amyloid Fibrils Biochim. Biophys. Acta, Proteins Proteomics 2010, 1804, 1405-1412
28. Childers, W. S.; Mehta, A. K.; Lu, K.; Lynn, D. G. Templating Molecular Arrays in Amyloids Cross-Beta Grooves J. Am. Chem. Soc. 2009, 131, 10165-10172
29. Claridge, S. A.; Thomas, J. C.; Silverman, M. A.; Schwartz, J. J.; Yang, Y. L.; Wang, C.; Weiss, P. S. Differentiating Amino Acid Residues and Side Chain Orientations in Peptides Using Scanning Tunneling Microscopy J. Am. Chem. Soc. 2013, 135, 18528-18535
30. Ma, X. J.; Liu, L.; Mao, X. B.; Niu, L.; Deng, K.; Wu, W. H.; Li, Y. M.; Yang, Y. L.; Wang, C. Amyloid Beta (1-42) Folding Multiplicity and Single-Molecule Binding Behavior Studied with STM J. Mol. Biol. 2009, 388, 894-901
31. Liu, L.; Zhang, L.; Niu, L.; Xu, M.; Mao, X. B.; Yang, Y. L.; Wang, C. Observation of Reduced Cytotoxicity of Aggregated Amyloidogenic Peptides with Chaperone-Like Molecules ACS Nano 2011, 5, 6001-6007
32. Liu, L.; Zhang, L.; Mao, X. B.; Niu, L.; Yang, Y. L.; Wang, C. Chaperon-Mediated Single Molecular Approach toward Modulating a Beta Peptide Aggregation Nano Lett. 2009, 9, 4066-4072
33. Luhrs, T.; Ritter, C.; Adrian, M.; Riek-Loher, D.; Bohrmann, B.; Doeli, H.; Schubert, D.; Riek, R. 3D Structure of Alzheimers Amyloid-Beta(1-42) Fibrils Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 17342-17347
34. Mao, X. B.; Wang, C. X.; Wu, X. K.; Ma, X. J.; Liu, L.; Zhang, L.; Niu, L.; Guo, Y. Y.; Li, D. H.; Yang, Y. L. et al. Beta Structure Motifs of Islet Amyloid Polypeptides Identified through Surface-Mediated Assemblies Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 19605-19610
35. Petkova, A. T.; Ishii, Y.; Balbach, J. J.; Antzutkin, O. N.; Leapman, R. D.; Delaglio, F.; Tycko, R. A Stru ctural Model for Alzheimers Beta-Amyloid Fibrils Based on Experimental Constraints from Solid State NMR Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 16742-16747
36. Pauling, L.; Corey, R. B. Two Rippled-Sheet Configurations of Polypeptide Chains, and a Note about the Pleated Sheets Proc. Natl. Acad. Sci. U.S.A. 1953, 39, 253-256
37. Liu, R.; Barkhordarian, H.; Emadi, S.; Park, C. B.; Sierks, M. R. Trehalose Differentially Inhibits Aggregation and Neurotoxicity of Beta-Amyloid 40 and 42 Neurobiol. Dis. 2005, 20, 74-81
38. Vad, B.; Thomsen, L. A.; Bertelsen, K.; Franzmann, M.; Pedersen, J. M.; Nielsen, S. B.; Vosegaard, T.; Valnickova, Z.; Skrydstrup, T.; Enghild, J. J. et al. Divorcing Folding from Function: How Acylation Affects the Membrane-Perturbing Properties of an Antimicrobial Peptide Biochim. Biophys. Acta, Proteins Proteomics 2010, 1804, 806-820
39. Vad, B. S.; Bertelsen, K.; Johansen, C. H.; Pedersen, J. M.; Skrydstrup, T.; Nielsen, N. C.; Otzen, D. E. Pardaxin Permeabilizes Vesicles More Efficiently by Pore Formation than by Disruption Biophys. J. 2010, 98, 576-585