Observation of reduced cytotoxicity of aggregated amyloidogenic peptides with chaperone-like molecules

ACS Nano

Volumn 5, Issue 7, 2011, Pages 6001-6007

  Liu, Lei ^a   Zhang, Lan ^a   Niu, Lin ^a   Xu, Meng ^a   Mao, Xiaobo ^a   Yang, Yanlian ^a   Wang, Chen ^a  

^a NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

Author keywords

amyloidogenic peptide; chaperone like molecules; modulation; neuronal cytotoxicity; peptide aggregation

Indexed keywords

AGGREGATION BEHAVIOR; AGGREGATION PROCESS; AMYLOIDOGENIC PEPTIDES; BIOLOGICAL EFFECTS; CHAPERONE-LIKE MOLECULES; HYDROGEN-BOND FORMATION; NEURONAL CYTOTOXICITY; PEPTIDE AGGREGATION; PROTOFIBRILS; PYRIDYL; SENILE PLAQUES;

AGGLOMERATION; CYTOTOXICITY; HYDROGEN; HYDROGEN BONDS; MOLECULES; NEURODEGENERATIVE DISEASES; OLIGOMERS; SCANNING PROBE MICROSCOPY;

PEPTIDES;

AMYLOID BETA PROTEIN; PYRIDINE; PYRIDINE DERIVATIVE;

ARTICLE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; HUMAN; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; SOLUTION AND SOLUBILITY; TUMOR CELL LINE;

AMYLOID BETA-PEPTIDES; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PYRIDINES; SOLUTIONS;

EID: 79961063205     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn201773x     Document Type: Conference Paper

References (47)

1. Chiti, F.; Dobson, C. M. Protein Misfolding, Functional Amyloid, and Human Disease Annu. Rev. Biochem. 2006, 75, 333-366 (Pubitemid 44118036)
2. Dobson, C. M. Protein Folding and Misfolding Nature 2003, 426, 884-890 (Pubitemid 38056880)
3. Goedert, M.; Spillantini, M. G. A Century of Alzheimer's Disease Science 2006, 314, 777-781 (Pubitemid 44706636)
4. Roberson, E. D.; Mucke, L. 100 Years and Counting: Prospects for Defeating Alzheimer's Disease Science 2006, 314, 781-784 (Pubitemid 44706637)
5. Brody, D. L.; Magnoni, S.; Schwetye, K. E.; Spinner, M. L.; Esparza, T. J.; Stocchetti, N.; Zipfel, G. J.; Holtzman, D. M. Amyloid-Beta Dynamics Correlate with Neurological Status in the Injured Human Brain Science 2008, 321, 1221-1224
6. Forloni, G.; Angeretti, N.; Chiesa, R.; Monzani, E.; Salmona, M.; Bugiani, O.; Tagliavini, F. Neurotoxicity of a Prion Protein-Fragment Nature 1993, 362, 543-546
7. Kahn, S. E.; Andrikopoulos, S.; Verchere, C. B. Islet Amyloid: A Long-Recognized but Underappreciated Pathological Feature of Type 2 Diabetes Diabetes 1999, 48, 241-253 (Pubitemid 29061094)
8. Westermark, P.; Wilander, E. Influence of Amyloid Deposits on Islet Volume in Maturity Onset Diabetes-Mellitus Diabetologia 1978, 15, 417-421 (Pubitemid 9046993)
9. Young, A. A.; Gedulin, B.; Vine, W.; Percy, A.; Rink, T. J. Gastric-Emptying Is Accelerated in Diabetic Bb Rats and Is Slowed by Subcutaneous Injections of Amylin Diabetologia 1995, 38, 642-648
10. Maloy, A. L.; Longnecker, D. S.; Greenberg, E. R. The Relation of Islet Amyloid to the Clinical Type of Diabetes Hum. Pathol. 1981, 12, 917-922 (Pubitemid 12227621)
11. Lorenzo, A.; Razzaboni, B.; Weir, G. C.; Yankner, B. A. Pancreatic-Islet Cell Toxicity of Amylin Associated with Type-2 Diabetes-Mellitus Nature 1994, 368, 756-760 (Pubitemid 24153418)
12. Kelly, J. W. Towards an Understanding of Amyloidogenesis Nat. Struct. Mol. Biol. 2002, 9, 323-325 (Pubitemid 34462546)
13. Dobson, C. M. Protein Misfolding, Evolution and Disease Trends Biochem. Sci. 1999, 24, 329-332 (Pubitemid 29421804)
14. Selkoe, D. J. Folding Proteins in Fatal Ways Nature 2003, 426, 900-904 (Pubitemid 38056883)
15. Klein, W. L. A-Beta Toxicity in Alzheimer's Disease: Globular Oligomers (ADDLs) as New Vaccine and Drug Targets Neurochem. Int. 2002, 41, 345-352
16. Lambert, M. P.; Barlow, A. K.; Chromy, B. A.; Edwards, C.; Freed, R.; Liosatos, M.; Morgan, T. E.; Rozovsky, I.; Trommer, B.; Viola, K. L. et al. Diffusible, Nonfibrillar Ligands Derived from A Beta(1-42) Are Potent Central Nervous System Neurotoxins Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 6448-6453
17. Bucciantini, M.; Giannoni, E.; Chiti, F.; Baroni, F.; Formigli, L.; Zurdo, J. S.; Taddei, N.; Ramponi, G.; Dobson, C. M.; Stefani, M. Inherent Toxicity of Aggregates Implies a Common Mechanism for Protein Misfolding Diseases Nature 2002, 416, 507-511 (Pubitemid 34288846)
18. Frid, P.; Anisimov, S. V.; Popovic, N. Congo Red and Protein Aggregation in Neurodegenerative Diseases Brain Res. Rev. 2007, 53, 135-160 (Pubitemid 44854214)
19. Klunk, W. E.; Debnath, M. L.; Pettegrew, J. W. Development of Small-Molecule Probes for the Beta-Amyloid Protein of Alzheimers-Disease Neurobiol. Aging 1994, 15, 691-698 (Pubitemid 24360159)
20. Gestwicki, J. E.; Crabtree, G. R.; Graef, I. A. Harnessing Chaperones To Generate Small-Molecule Inhibitors of Amyloid Beta Aggregation Science 2004, 306, 865-869 (Pubitemid 39446994)
21. Ono, K.; Naiki, H.; Yamada, M. The Development of Preventives and Therapeutics for Alzheimer's Disease That Inhibit the Formation of Beta-Amyloid Fibrils (fA beta), as Well as Destabilize Preformed fA Beta Curr. Pharm. Des. 2006, 12, 4357-4375 (Pubitemid 44718294)
22. Hamaguchi, T.; Ono, K.; Murase, A.; Yamada, M. Phenolic Compounds Prevent Alzheimer's Pathology through Different Effects on the Amyloid-Beta Aggregation Pathway Am. J. Pathol. 2009, 175, 2557-2565
23. Yang, F. S.; Lim, G. P.; Begum, A. N.; Ubeda, O. J.; Simmons, M. R.; Ambegaokar, S. S.; Chen, P. P.; Kayed, R.; Glabe, C. G.; Frautschy, S. A. et al. Curcumin Inhibits Formation of Amyloid Beta Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid In Vivo J. Biol. Chem. 2005, 280, 5892-5901 (Pubitemid 40280072)
24. Gibson, T. J.; Murphy, R. M. Design of Peptidyl Compounds That Affect Beta-Amyloid Aggregation: Importance of Surface Tension and Contex Biochemistry 2005, 44, 8898-8907 (Pubitemid 40840456)
25. Pallitto, M. M.; Ghanta, J.; Heinzelman, P.; Kiessling, L. L.; Murphy, R. M. Recognition Sequence Design for Peptide Modulators of Beta-Amyloid Aggregation and Toxicity Biochemistry 1999, 38, 3570-3578
26. Takahashi, T.; Ohta, K.; Mihara, H. Embedding the Amyloid Beta-Peptide Sequence in Green Fluorescent Protein Inhibits A Beta Oligomerization ChemBioChem 2007, 8, 985-988 (Pubitemid 47183614)
27. Wu, W. H.; Lei, P.; Liu, Q.; Hu, J.; Gunn, A. P.; Chen, M. S.; Rui, Y. F.; Su, X. Y.; Xie, Z. P.; Zhao, Y. F. et al. Sequestration of Copper from Beta-Amyloid Promotes Selective Lysis by Cyclen-Hybrid Cleavage Agents J. Biol. Chem. 2008, 283, 31657-31664
28. Liu, L.; Zhang, L.; Mao, X. B.; Niu, L.; Yang, Y. L.; Wang, C. Chaperone-Mediated Single Molecular Approach toward Modulating Aβ Peptide Aggregation Nano Lett. 2009, 9, 4066-4072
29. Stains, C. I.; Mondal, K.; Ghosh, I. Molecules That Target Beta-Amyloid ChemMedChem 2007, 2, 1675-1692
30. Bush, A. I.; Pettingell, W. H.; Multhaup, G.; Paradis, M. D.; Vonsattel, J. P.; Gusella, J. F.; Beyreuther, K.; Masters, C. L.; Tanzi, R. E. Rapid Induction of Alzheimer A-Beta Amyloid Formation by Zinc Science 1994, 265, 1464-1467 (Pubitemid 24306803)
31. Lovell, M. A.; Robertson, J. D.; Teesdale, W. J.; Campbell, J. L.; Markesbery, W. R. Copper, Iron and Zinc in Alzheimer's Disease Senile Plaques J. Neurol. Sci. 1998, 158, 47-52 (Pubitemid 28277534)
32. Cherny, R. A.; Legg, J. T.; McLean, C. A.; Fairlie, D. P.; Huang, X. D.; Atwood, C. S.; Beyreuther, K.; Tanzi, R. E.; Masters, C. L.; Bush, A. I. Aqueous Dissolution of Alzheimer's Disease A Beta Amyloid Deposits by Biometal Depletion J. Biol. Chem. 1999, 274, 23223-23228
33. White, D. A.; Buell, A. K.; Knowles, T. P. J.; Welland, M. E.; Dobson, C. M. Protein Aggregation in Crowded Environments J. Am. Chem. Soc. 2010, 132, 5170-5175
34. Ma, X. J.; Liu, L.; Mao, X. B.; Niu, L.; Deng, K.; Wu, W. H.; Li, Y. M.; Yang, Y. L.; Wang, C. Amyloid Beta (1-42) Folding Multiplicity and Single-Molecule Binding Behavior Studied with STM J. Mol. Biol. 2009, 388, 894-901
35. Mao, X. B.; Ma, X. J.; Liu, L.; Niu, L.; Yang, Y. L.; Wang, C. Structural Characteristics of the Beta-Sheet-like Human and Rat Islet Amyloid Polypeptides As Determined by Scanning Tunneling Microscopy J. Struct. Biol. 2009, 167, 209-215
36. Yang, Y. L.; Wang, C. Hierarchical Construction of Self-Assembled Low-Dimensional Molecular Architectures Observed by Using Scanning Tunneling Microscopy Chem. Soc. Rev. 2009, 38, 2576-2589
37. Kudernac, T.; Lei, S. B.; Elemans, J.; De Feyter, S. Two-Dimensional Supramolecular Self-Assembly: Nanoporous Networks on Surfaces Chem. Soc. Rev. 2009, 38, 402-421
38. Lingenfelder, M.; Tomba, G.; Costantini, G.; Ciacchi, L. C.; De Vita, A.; Kern, K. Tracking the Chiral Recognition of Adsorbed Dipeptides at the Single-Molecule Level Angew. Chem., Int. Ed. 2007, 46, 4492-4495 (Pubitemid 46954602)
39. Wang, Y.; Lingenfelder, M.; Classen, T.; Costantini, G.; Kern, K. Ordering of Dipeptide Chains on Cu Surfaces through 2D Cocrystallization J. Am. Chem. Soc. 2007, 129, 15742-15743
40. 1-42 Oligomers to Fibrils Nat. Struct. Mol. Biol. 2010, 17, 561-568
41. Mastrangelo, I. A.; Ahmed, M.; Sato, T.; Liu, W.; Wang, C. P.; Hough, P.; Smith, S. O. High-Resolution Atomic Force Microscopy of Soluble Aβ42 Oligomers J. Mol. Biol. 2006, 358, 106-119
42. Quist, A.; Doudevski, L.; Lin, H.; Azimova, R.; Ng, D.; Frangione, B.; Kagan, B.; Ghiso, J.; Lal, R. Amyloid Ion Channels: A Common Structural Link for Protein-Misfolding Disease Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 10427-10432 (Pubitemid 41061570)
43. Mucke, L.; Masliah, E.; Yu, G. Q.; Mallory, M.; Rockenstein, E. M.; Tatsuno, G.; Hu, K.; Kholodenko, D.; Johnson-Wood, K.; McConlogue, L. High-Level Neuronal Expression of A Beta(1-42) in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation J. Neurosci. 2000, 20, 4050-4058 (Pubitemid 30365675)
44. Naslund, J.; Haroutunian, V.; Mohs, R.; Davis, K. L.; Davies, P.; Greengard, P.; Buxbaum, J. D. Correlation between Elevated Levels of Amyloid Beta-Peptide in the Brain and Cognitive Decline JAMA 2000, 283, 1571-1577 (Pubitemid 30161512)
45. Kuo, Y. M.; Emmerling, M. R.; VigoPelfrey, C.; Kasunic, T. C.; Kirkpatrick, J. B.; Murdoch, G. H.; Ball, M. J.; Roher, A. E. Water-Soluble A Beta (N-40, N-42) Oligomers in Normal and Alzheimer Disease Brains J. Biol. Chem. 1996, 271, 4077-4081
46. Lue, L. F.; Kuo, Y. M.; Roher, A. E.; Brachova, L.; Shen, Y.; Sue, L.; Beach, T.; Kurth, J. H.; Rydel, R. E.; Rogers, J. Soluble Amyloid Beta Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease Am. J. Pathol. 1999, 155, 853-862 (Pubitemid 29426831)
47. Takahashi, T.; Mihara, H. Peptide and Protein Mimetics Inhibiting Amyloid Beta-Peptide Aggregation Acc. Chem. Res. 2008, 41, 1309-1318