Islet amyloid-induced cell death and bilayer integrity loss share a molecular origin targetable with oligopyridylamide-based α-helical mimetics

Chemistry and Biology

Volumn 22, Issue 3, 2015, Pages 369-378

  Kumar, Sunil ^a   Schlamadinger, Diana E ^a   Brown, Mark A ^a   Dunn, Joanna M ^a   Mercado, Brandon ^a   Hebda, James A ^b   Saraogi, Ishu ^c   Rhoades, Elizabeth ^a   Hamilton, Andrew D ^d   Miranker, Andrew D ^a  

^a YALE UNIVERSITY   (United States)

^b AMHERST COLLEGE   (United States)

^c INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH BHOPAL   (India)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; AMYLIN; LIPID; OLIGOMER; OLIGOPYRIDYLAMIDE; UNCLASSIFIED DRUG; BIOMIMETIC MATERIAL; LIPID BILAYER; LIPOSOME; PYRIDINE DERIVATIVE;

ALKYLATION; ALPHA HELIX; ANIMAL CELL; ARTICLE; CARBONYLATION; CATALYST; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; HUMAN; LIPID BILAYER; MEMBRANE TRANSPORT; MICROWAVE RADIATION; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; SYNTHESIS; AMINO ACID SEQUENCE; ANIMAL; APOPTOSIS; CHEMISTRY; DRUG DESIGN; INSULINOMA; MEMBRANE FLUIDITY; METABOLISM; MOLECULAR GENETICS; MOLECULAR MODEL; PANCREAS TUMOR; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

AMIDES; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BIOMIMETIC MATERIALS; CELL LINE, TUMOR; DRUG DESIGN; HUMANS; INSULINOMA; ISLET AMYLOID POLYPEPTIDE; LIPID BILAYERS; LIPOSOMES; MEMBRANE FLUIDITY; MICROWAVES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PANCREATIC NEOPLASMS; PROTEIN STRUCTURE, SECONDARY; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84925538053     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2015.01.006     Document Type: Article

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