Identification of Fat4 and Tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas

Cancer Research

Volumn 71, Issue 17, 2011, Pages 5779-5791

  Berndt, Annerose ^a   Cario, Clinton L ^a   Silva, Kathleen A ^b   Kennedy, Victoria E ^b   Harrison, David E ^b   Paigen, Beverly ^b   Sundberg, John P ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; GLUTAMIC ACID; HISTIDINE; PROLINE;

ALLELE; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CCDC122 GENE; CHROMOSOME 1; CHROMOSOME 10; CHROMOSOME 11; CHROMOSOME 12; CHROMOSOME 15; CHROMOSOME 16; CHROMOSOME 17; CHROMOSOME 18; CHROMOSOME 19; CHROMOSOME 2; CHROMOSOME 3; CHROMOSOME 4; CHROMOSOME 6; CHROMOSOME 7; CONTROLLED STUDY; DISEASE SEVERITY; FAT TUMOR SUPPRESSOR HOMOLOG 4 GENE; FAT4 GENE; FBXO38 GENE; FEMALE; GENE; GENE FREQUENCY; GENE IDENTIFICATION; GENE LOCATION; GENE LOCUS; GENE MAPPING; INBRED STRAIN; LUNG ADENOMA; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SPONTANEOUS PULMONARY ADENOMA; STRAIN DIFFERENCE; TSC22D1 GENE; TUMOR SUPPRESSOR GENE;

ADENOMA; AGE FACTORS; AGING; ANIMALS; CADHERINS; FEMALE; GENETIC LOCI; GENOME-WIDE ASSOCIATION STUDY; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED STRAINS; REPRESSOR PROTEINS; SEVERITY OF ILLNESS INDEX;

EID: 80052244375     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-1418     Document Type: Article

References (46)

1. Hecht SS. Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer 2003;3:733-44. (Pubitemid 37328812)
2. Catelinois O, Rogel A, Laurier D, Billon S, Hemon D, Verger P, et al. Lung cancer attributable to indoor radon exposure in France: impact of the risk models and uncertainty analysis. Environ Health Perspect 2006;114:1361-6. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570096/?tool = pubmed.
3. Palmarini M, Fan H. Retrovirus-induced ovine pulmonary adenocarcinoma, an animal model for lung cancer. J Natl Cancer Inst 2001;93:1603-14. Available from: http://jnci.oxfordjournals.org/content/93/21/1603.long.
4. Cheng YW, Chiou HL, Sheu GT, Hsieh LL, Chen JT, Chen CY, et al. The association of human papillomavirus 16/18 infection with lung cancer among nonsmoking Taiwanese women. Cancer Res 2001;61:2799-803. Available from: http://cancerres.aacrjournals.org/content/61/7/2799.long.
5. Fenske TS, McMahon C, Edwin D, Jarvis JC, Cheverud JM, Minn M, et al. Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice. Cancer Res 2006;66:5029-38. Available from: http://cancerres.aacrjournals.org/content/66/10/5029.full.
6. Liu P, Wang Y, Vikis H, Maciag A, Wang D, Lu Y, et al. Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. Nat Genet 2006;38:888-95. Available from: http://www.nature.com/ ng/journal/v38/n8/abs/ng1849.html.
7. Manenti G, Galvan A, Pettinicchio A, Manenti G, Galvan A, Pettinicchio A, et al. Mouse genome-wide association mapping needs linkage analysis to avoid false-positive loci. PLoS Genet 2009;5:e1000331.
8. Available from: http://www.plosgenetics.org/article/info%3Adoi%2F10. 1371%2Fjournal.pgen.1000331.
9. Wang D, You M. Five loci, SLT1 to SLT5, controlling the susceptibility to spontaneously occurring lung cancer in mice. Cancer Res 2005;65:8158-65. Available from: http://cancerres.aacrjournals.org/content/65/18/8158.abstract.
10. Cervino AC, Darvasi A, Fallahi M, Mader CC, Tsinoremas NF. An integrated in silico gene mapping strategy in inbred mice. Genetics. 2007;175:321-33. Available from: http://www.genetics.org/content/175/1/321.long.
11. Devlin B, Roeder K. Genomic control for association studies. Biometrics 1999;55:997-1004.
12. Kang HM, Zaitlen NA, Wade CM, Kirby A, Heckerman D, Daly MJ, et al. Efficient control of population structure in model organism association mapping. Genetics 2008;178:17090-23. Available from: http://cancerres.aacrjournals.org/ content/65/18/8158.abstract.
13. Petkov PM, Ding Y, Cassell MA, Zhang W, Wagner G, Sargent EE, et al. An efficient SNP system for mouse genome scanning and elucidating strain relationships. Genome Res 2004;14:1806-11. Available from: http://genome.cshlp. org/content/14/9/1806.long.
14. Sundberg JP, Berndt A, Sundberg BA, Silva KA, Kennedy V, Bronson R, et al. The mouse as a model for understanding chronic diseases of aging: the histopathologic basis of aging in inbred mice. Pathobiol Aging Age Relat Dis 2011;1:7179 - DOI: 10.3402/pba.v1i0.7179.
15. Available from: http://www.pathobiologyofaging.net / index.php/pba/ article / viewArticle / 7179/html-161.
16. Seymour R, Ichiki T, Mikaelian I, Boggess D, Silva KA. Laboratory mouse: necropsy methods. London: Academic Press; 2004.
17. Schofield PN, Dubus P, Klein L, Moore M, McKerlie C, Ward JM, et al. Pathology of the laboratory mouse: an International Workshop on Challenges for High Throughput Phenotyping. Toxicol Pathol 2011;39:559-62. Available from: http://tpx.sagepub.com/content/39/3/559.long.
18. Austin CP, Battey JF, Bradley A, et al. The knockout mouse project. Nat Genet 2004;36:921-4. Available from: http://www.nature.com/ng/journal/v36/n9/ full/ng0904-921.html.
19. Grubb SC, Maddatu TP, Bult CJ, Bogue MA. Mouse phenome database. Nucleic Acids Res 2009;37:D720-30. Available from: http://nar.oxfordjournals.org/ content/37/suppl-1/D720.long.
20. Nikitin AY, Alcaraz A, Anver MR, Bronson RT, Cardiff RD, Dixon D, et al. Classification of proliferative pulmonary lesions of the mouse: recommendations of the mouse models of human cancers consortium. Cancer Res 2004;64:2307-16. (Pubitemid 38523879)
21. Hahn FF, Boorman GA. Neoplasia and preneoplasia of the lung. Bannasch P, Goessner W, editors. Pathology of neoplasia and preneoplasia in rodents. Stuttgart, Germany: Schattauer; 1997. p. 29-42.
22. Sundberg BA, Schofield PN, Gruenberger M, Sundberg JP. A datacapture tool for mouse pathology phenotyping. Vet Pathol 2009;46:1230-40. Available from: http://vet.sagepub.com/content/46/6/1230.short?rss = 1&ssource = mfc.
23. Sundberg JP, Sundberg BA, Schofield P. Integrating mouse anatomy and pathology ontologies into a phenotyping database: tools for data capture and training. Mamm Genome 2008;19:413-9. Available from: http://www.ncbi.nlm.nih. gov/pmc/articles/PMC2844541/.
24. Hutchins LN, Ding Y, Szatkiewicz JP, Von Smith R, Yang H, de Villena FP, et al. CGDSNPdb: a database resource for error-checked and imputed mouse SNPs. Database2010;2010:baq008. Available from: http://database.oxfordjournals.org/ content/2010/baq008.long.
25. Szatkiewicz JP, Beane GL, Ding Y, Hutchins L, Pardo-Manuel de Villena F, Churchill GA. An imputed genotype resource for the laboratory mouse. Mamm Genome 2008;19:199-208. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/ PMC2725522/.
26. Ng PC, Henikoff S. SIFT: predicting amino acid changes that affect protein function. Nucleic Acids Res 2003;31:3812-4. Available from: http://nar.oxfordjournals.org/content/31/13/3812.long.
27. Krupke DM, Begley DA, Sundberg JP, Bult CJ, Eppig JT. The Mouse Tumor Biology database. Nat Rev Cancer 2008;8:459-65. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574871/.
28. Schofield PN, Bard JB, Boniver J, Covelli V, Delvenne P, Ellender M, et al. Pathbase: a new reference resource and database for laboratory mouse pathology. Radiat Prot Dosimetry 2004;112:525-8. Available from: http://rpd.oxfordjournals.org/content/112/4/525.full.
29. Schofield PN, Bard JB, Booth C, et al. Pathbase: a database of mutant mouse pathology. Nucleic Acids Res 2004;32:D512-5. Available from: http://nar.oxfordjournals.org/content/32/suppl-1/D512.full.
30. Devereux TR, Wiseman RW, Kaplan N, Garren S, Foley JF, White CM, et al. Assignment of a locus for mouse lung tumor susceptibility to proximal chromosome 19. Mamm Genome 1994;5:749-55.
31. Malkinson AM. The genetic basis of susceptibility to lung tumors in mice. Toxicology 1989;54:241-71. (Pubitemid 19084024)
32. Drinkwater NR, Bennett LM. Genetic control of carcinogenesis in experimental animals. Prog Exp Tumor Res 1991;33:1-20.
33. Engelhardt JA, Gries CL, Long GG. Incidence of spontaneous neoplastic and nonneoplastic lesions in Charles River CD-1 mice varies with breeding origin. Toxicol Pathol 1993;21:538-41. (Pubitemid 24266835)
34. Rehm S, Rapp KG, Deerberg F. Influence of food restriction and body fat on life span and tumour incidence in female outbred Han:NMRI mice and two sublines. Z Versuchstierk 1985;27:240-83.
35. Rittinghausen S, Dungworth DL, Ernst H, Mohr U. Pathobiology of the aging mouse. Washington, DC: Intl Life Sciences Inst. (International Life Sciences Institute); 1996.
36. Festing MFW, Yang A, Malkinson AM. At least four genes and sex are associated with susceptibility to urethan-induced pulmonary adenomas in mice. Genet Res 1994;64:99-106. (Pubitemid 24357660)
37. Zheng S, El-Naggar AK, Kim ES, Kurie JM, Lozano G. A genetic mouse model for metastatic lung cancer with gender differences in survival. Oncogene 2007;26:6896-904. Available from: http://www.nature.com/onc/journal/v26/n48/ full/1210493a.html.
38. Hammoud Z, Tan B, Badve S, Bigsby RM. Estrogen promotes tumor progression in a genetically defined mouse model of lung adenocarcinoma. Endocr Relat Cancer 2008;15:475-83. Available from: http://erc.endocrinology-journals.org/ content/15/2/475.abstract.
39. Xing S, Tsaih SW, Yuan R, Svenson KL, Jorgenson LM, So M, et al. Genetic influence on electrocardiogram time intervals and heart rate in aging mice. Am J Physiol Heart Circ Physiol 2009;296:H1907-13. Available from: http://ajpheart.physiology.org/content/296/6/H1907.abstract.
40. Tsaih SW, Pezzolesi MG, Yuan R, Warram JH, Krolewski AS, Korstanje R. Genetic analysis of albuminuria in aging mice and concordance with loci for human diabetic nephropathy found in a genomewide association scan. Kidney Int 2009;77:201-10. Available from: http://www.nature.com/ki/journal/v77/n3/full/ ki2009434a.html.
41. Yuan R, Tsaih SW, Petkova SB, Marin de Evsikova C, Xing S, Marion MA, et al. Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell 2009;8:277-87. Available from: http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2009.00478.x/abstract.
42. Qi C, Zhu YT, Hu L, Zhu YJ. Identification of Fat4 as a candidate tumor suppressor gene in breast cancers. Int J Cancer 2009;124:793-8. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667156/?tool = pubmed.
43. Doi Y, Kawamata H, Ono Y, Fujimori T, Imai Y. Expression and cellular localization of TSC-22 in normal salivary glands and salivary gland tumors: implications for tumor cell differentiation. Oncol Rep 2008;19:609-16. Available from: http://www.spandidos-publications. com/or/19/3/609.
44. Meijer D, Jansen MP, Look MP, Ruigrok-Ritstier K, van Staveren IL, Sieuwerts AM, et al. TSC22D1 and PSAP predict clinical outcome of tamoxifen treatment in patients with recurrent breast cancer. Breast Cancer Res Treat 2009;113:253-60. Available from: http://www.springerlink.com/content/ p5249g74850061hl/.
45. Rentsch CA, Cecchini MG, Schwaninger R, Germann M, Markwalder R, Heller M, et al. Differential expression of TGFbeta-stimulated clone 22 in normal prostate and prostate cancer. Int J Cancer 2006;118:899-906. Available from: http://onlinelibrary.wiley.com/doi/10.1002/ijc.21449/abstract.
46. Ohta S, Shimekake Y, Nagata K. Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter. Eur J Biochem 1996;242:460-6. (Pubitemid 27121124)