Do inflammatory markers portend heterotopic ossification and wound failure in combat wounds?

Clinical Orthopaedics and Related Research

Volumn 472, Issue 9, 2014, Pages 2845-2854

  Forsberg, Jonathan A ^a,b,c,d,e   Potter, Benjamin K ^a,b,c,e   Polfer, Elizabeth M ^a,b,c   Safford, Shawn D ^b,c   Elster, Eric A ^b,c,e  

^a NAVAL MEDICAL RESEARCH CENTER   (United States)

^b WALTER REED ARMY MEDICAL CENTER   (United States)

^c Uniformed Services University of the Health Sciences   (United States)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^e Surgical Critical Care Initiative (SC2i)   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CHEMOKINE; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 3; PROCALCITONIN;

ADULT; AMPUTATION; ARTICLE; BATTLE INJURY; BODY SURFACE; BONE RADIOGRAPHY; CYTOKINE PRODUCTION; DEBRIDEMENT; DEMOGRAPHY; EFFLUENT; FEMALE; FOLLOW UP; GUNSHOT INJURY; HETEROTOPIC OSSIFICATION; HUMAN; INFLAMMATION; INJURY SCALE; MAJOR CLINICAL STUDY; MALE; OPEN FRACTURE; PENETRATING TRAUMA; PRIORITY JOURNAL; SCORING SYSTEM; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TRAUMATIC AMPUTATION; UPREGULATION; WOUND CLOSURE; WOUND COMPLICATION; WOUND HEALING IMPAIRMENT;

BIOLOGICAL MARKERS; CYTOKINES; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFLAMMATION; INJURY SEVERITY SCORE; MALE; MILITARY PERSONNEL; OSSIFICATION, HETEROTOPIC; RETROSPECTIVE STUDIES; UNITED STATES; WAR; WOUNDS AND INJURIES; YOUNG ADULT;

EID: 84905976527     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1007/s11999-014-3694-7     Document Type: Article

References (25)

1. Bartlett CS. Clinical update: gunshot wound ballistics. Clin Orthop Relat Res. 2003;408:28-57. (Pubitemid 36307487)
2. Belmont PJ Jr, McCriskin BJ, Hsiao MS, Burks R, Nelson KJ, Schoenfeld AJ. The nature and incidence of musculoskeletal combat wounds in Iraq and Afghanistan (2005-2009). J Orthop Trauma. 2013;27:e107-113.
3. Brown TS, Hawksworth JS, Sheppard FR, Tadaki DK, Elster E. Inflammatory response is associated with critical colonization in combat wounds. Surg Infect (Larchmt). 2011;12:351-357.
4. Davis TA, Lazdun Y, Potter BK, Forsberg JA. Ectopic bone formation in severely combat-injured orthopedic patients: a hematopoietic niche. Bone. 2013;56:119-126.
5. Ehrlich LA, Chung HY, Ghobrial I, Choi SJ, Morandi F, Colla S, Rizzoli V, Roodman GD, Giuliani N. IL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma. Blood. 2005;106:1407-1414. (Pubitemid 41129608)
6. Evans KN, Forsberg JA, Potter BK, Hawksworth JS, Brown TS, Andersen R, Dunne JR, Tadaki D, Elster EA. Inflammatory cytokine and chemokine expression is associated with heterotopic ossification in high-energy penetrating war injuries. J Orthop Trauma. 2012;26:e204-213.
7. Evans KN, Potter BK, Brown TS, Davis TA, Elster EA, Forsberg JA. Osteogenic gene expression correlates with development of heterotopic ossification in war wounds. Clin Orthop Relat Res. 2014;472:396-404.
8. Forsberg J, Elster E, Andersen R, Nylen E, Brown T, Rose M, Stojadinovic A, Becker K, McGuigan F. Correlation of procalcitonin and cytokine expression with dehiscence of wartime extremity wounds. J Bone Joint Surg Am. 2008;90:580-588. (Pubitemid 351341992)
9. Forsberg JA, Pepek JM, Wagner S, Wilson K, Flint J, Andersen RC, Tadaki D, Gage FA, Stojadinovic A, Elster EA. Heterotopic ossification in high-energy wartime extremity injuries: prevalence and risk factors. J Bone Joint Surg Am. 2009;91:1084-1091.
10. Gwinn DE, Tintle SM, Kumar AR, Andersen RC, Keeling JJ. Blast-induced lower extremity fractures with arterial injury: prevalence and risk factors for amputation after initial limb-preserving treatment. J Orthop Trauma. 2011;25:543-548.
11. Hawksworth JS, Stojadinovic A, Gage FA, Tadaki DK, Perdue PW, Forsberg J, Davis TA, Dunne JR, Denobile JW, Brown TS, Elster EA. Inflammatory biomarkers in combat wound healing. Ann Surg. 2009;250:1002-1007.
12. Lenarz CJ, Watson JT, Moed BR, Israel H, Mullen JD, Macdonald JB. Timing of wound closure in open fractures based on cultures obtained after debridement. J Bone Joint Surg Am. 2010;92:1921-1926.
13. Moorhead JJ. Surgical experience at Pearl Harbor. JAMA. 1942;118:712-714.
14. Pawitan Y, Michiels S, Koscielny S, Gusnanto A, Ploner A. False discovery rate, sensitivity and sample size for microarray studies. Bioinformatics . 2005;21:3017-3024. (Pubitemid 40916427)
15. Potter BK, Burns TC, Lacap AP, Granville RR, Gajewski DA. Heterotopic ossification following traumatic and combat-related amputations: prevalence, risk factors, and preliminary results of excision. J Bone Joint Surg Am. 2007;89:476-486. (Pubitemid 46365347)
16. Potter BK, Forsberg JA, Davis TA, Evans KN, Hawksworth JS, Tadaki D, Brown TS, Crane NJ, Burns TC, O'Brien FP, Elster EA. Heterotopic ossification following combat-related trauma. J Bone Joint Surg Am. 2010;92(suppl 2):74-89.
17. Robson MC, Heggers JP. Bacterial quantification of open wounds. Mil Med. 1969;134:19-24.
18. Selcer P. Standardizing wounds: Alexis Carrel and the scientific management of life in the First World War. Br J History Sci. 2008;41:73-107.
19. Stein NC, Kreutzmann C, Zimmermann S-P, Niebergall U, Hellmeyer L, Goettsch C, Schoppet M, Hofbauer LC. Interleukin-4 and interleukin-13 stimulate the osteoclast inhibitor osteoprotegerin by human endothelial cells through the STAT6 pathway. J Bone Miner Res. 2008;23:750-758. (Pubitemid 351575029)
20. Stromeyer L, Esmarch F. Gunshot Fractures. Resection in Gunshot Injuries. Translated by S.F. Statham. Philadelphia, PA: J.B. Lippincott & Co; 1862:20-32.
21. Tintle SM, Baechler MF, Nanos GP 3rd, Forsberg JA, Potter BK. Traumatic and trauma-related amputations: Part II. Upper extremity and future directions. J Bone Joint Surg Am. 2010;92:2934-2945.
22. Tintle SM, Baechler MF, Nanos GP 3rd, Forsberg JA, Potter BK. Reoperations following combat-related upper-extremity amputations. J Bone Joint Surg Am. 2012;94:e1191-1196.
23. Tintle SM, Keeling JJ, Forsberg JA, Shawen SB, Andersen RC, Potter BK. Operative complications of combat-related transtibial amputations: a comparison of the modified Burgess and modified Ertl tibiofibular synostosis techniques. J Bone Joint Surg Am. 2011;93:1016-1021.
24. Tintle SM, Keeling JJ, Shawen SB, Forsberg JA, Potter BK. Traumatic and trauma-related amputations: Part I. general principles and lower-extremity amputations. J Bone Joint Surg Am. 2010;92:2852-2868.
25. Utz ER, Elster EA, Tadaki DK, Gage F, Perdue PW, Forsberg JA, Stojadinovic A, Hawksworth JS, Brown TS. Metalloproteinase expression is associated with traumatic wound failure. J Surg Res. 2010;159:633-639.