Selective COX-2 inhibitor versus indomethacin for the prevention of heterotopic ossification after hip replacement: A double-blind randomized trial of 100 patients with 1-year follow-up

Acta Orthopaedica

Volumn 78, Issue 1, 2007, Pages 95-98

  Grohs, Josef G ^a   Schmidt, Maximilian ^a   Wanivenhaus, Axel ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; ROFECOXIB;

ADULT; AGED; ARTICLE; BRAIN ISCHEMIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG WITHDRAWAL; DYSPEPSIA; FEMALE; HETEROTOPIC OSSIFICATION; HUMAN; MAJOR CLINICAL STUDY; MALE; OSSIFICATION; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; TOTAL HIP PROSTHESIS; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHROPLASTY, REPLACEMENT, HIP; CYCLOOXYGENASE 2 INHIBITORS; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; INDOMETHACIN; LACTONES; MALE; MIDDLE AGED; OSSIFICATION, HETEROTOPIC; SULFONES;

EID: 34147155238     PISSN: 17453674     EISSN: 17453682     Source Type: Journal    
DOI: 10.1080/17453670610013484     Document Type: Article

References (13)

1. Allen H L, Wase A, Bear W T. Indomethacin and Aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat. Acta Orthop Scand 1980; 51: 595-600.
2. Bombardier C, Laine L, Reicin A, Shapiro D, Burgos-Vargas R, Davis B, Day R, Ferraz M B, Hawkey C J, Hochberg M C, Kvien T K, Schnitzer T J. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. N Engl J Med 2000; 343: 1520-8.
3. Brooker A F, Bowerman J W, Robinson R A, Riley H Jr. Ectopic ossification following total hip replacement. Incidence and a method of classification. J Bone Joint Surg (Am) 1973; 55: 1629-32.
4. Dekel S, Lenthall G, Francis M J. Release of prostaglandins from bone and muscle after tibial fracture: an experimental study in rabbits. J Bone Joint Surg (Br) 1981; 63: 185-9.
5. Fijn R, Koorevaar R T, Brouwers J R. Prevention of heterotopic ossification after total hip replacement with NSAIDs. Pharm World Sci 2003; 25: 138-45.
6. Gislason G H, Jacobsen S, Rasmussen J N, Rasmussen S, Buch P, Friberg J, Schramm T K, Abildstrom S Z, Kober L, Madsen M, Torp-Pedersen C. Risk of death or reinfarction associated with the use of selective cyclooxygenase-2 inhibitors and nonselective nonsteroidal antiinflammatory drugs after acute myocardial infarction. Circulation 2006; 113: 2906-13.
7. Keller J C, Trancik T M, Young F A, St Mary E. Effects of Indomethacin on bone ingrowth. J Orthop Res 1989; 7: 28-34.
8. Reuben S S, Bhopatkar S, Maciolek H, Joshi W, Sklar J. The preemptive Analgesic effect of rofecoxib after ambulatory arthroscopic knee surgery. Anesth Analg 2002; 94: 55-9.
9. Romano C L, Duci D, Romano D, Mazza M, Meani E. Celecoxib versus Indomethacin in the prevention of heterotopic ossification after total hip arthroplasty. J Arthroplasty 2004; 19: 14-8.
10. Ruvanendran A, Kroin J S, Tuman K J, Lubenov T R, Elmofty D, Moric M, Rosenberg A. Effects of perioperative administration of a selective cyclooxygenase 2 inhibitor on pain management and recovery of function after knee replacement. JAMA 2003; 290: 2411-8.
11. Schmidt S A, Kjaersgaard-Andersen P, Pedersen N W, Kristensen S S, Pedersen P, Nielsen J B. The use of Indomethacin to prevent the formation of heterotopic bone after total hip replacement. J Bone Joint Surg (Am) 1988; 70: 834-8.
12. Wurnig C, Schwameis E, Bitzan P, Kainberger F. Six-years results of a cementless stem with prophylaxis against heterotopic bone. Clin Orthop 1999; (361): 150-8.
13. Zacher J, Walther E, Gursche A. Prevention of periarticular ossification (PAO) after total hip replacement (THR) with Rofecoxib 25mg. Annals of the Rheumatic Diseases (Suppl 1): 2001; 60: 79.