메뉴 건너뛰기




Volumn 37, Issue 2, 2015, Pages 265-279

Recent developments in therapeutic protein expression technologies in plants

Author keywords

Antibodies; Bacterial cells; Biopharmaceuticals; Mammalian cells; Protein expression; Vaccines

Indexed keywords

ANTIBODIES; DISEASES; MAMMALS; VACCINES;

EID: 84925518115     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-014-1699-7     Document Type: Review
Times cited : (59)

References (109)
  • 1
    • 33846805740 scopus 로고    scopus 로고
    • Amplicon-plus targeting technology (APTT) for rapid production of a highly unstable vaccine protein in tobacco plants
    • COI: 1:CAS:528:DC%2BD2sXhtFygsr4%3D, PID: 17221361
    • Azhakanandam K, Weissinger SM, Nicholson JS, Qu R, Weissinger AK (2007) Amplicon-plus targeting technology (APTT) for rapid production of a highly unstable vaccine protein in tobacco plants. Plant Mol Biol 63:393–404
    • (2007) Plant Mol Biol , vol.63 , pp. 393-404
    • Azhakanandam, K.1    Weissinger, S.M.2    Nicholson, J.S.3    Qu, R.4    Weissinger, A.K.5
  • 2
    • 0023359272 scopus 로고
    • Why do chloroplasts and mitochondria contain so many copies of their genome?
    • COI: 1:STN:280:DyaL2s3pvVCmsg%3D%3D, PID: 3619888
    • Bendich AJ (1987) Why do chloroplasts and mitochondria contain so many copies of their genome? BioEssays 6:279–282
    • (1987) BioEssays , vol.6 , pp. 279-282
    • Bendich, A.J.1
  • 5
    • 65349164119 scopus 로고    scopus 로고
    • Geminivirus AL2 and L2 proteins suppress transcriptional gene silencing and cause genome-wide reductions in cytosine methylation
    • COI: 1:CAS:528:DC%2BD1MXlvVGht7w%3D, PID: 19279102
    • Buchmann RC, Asad S, Wolf JN, Mohannath G, Bisaro DM (2009) Geminivirus AL2 and L2 proteins suppress transcriptional gene silencing and cause genome-wide reductions in cytosine methylation. J Virol 83:5005–5013
    • (2009) J Virol , vol.83 , pp. 5005-5013
    • Buchmann, R.C.1    Asad, S.2    Wolf, J.N.3    Mohannath, G.4    Bisaro, D.M.5
  • 6
    • 20444371584 scopus 로고    scopus 로고
    • Use of viral vectors for vaccine production in plants
    • COI: 1:CAS:528:DC%2BD2MXmtVSit7w%3D, PID: 15877604
    • Canizares MC, Nicholson L, Lomonossoff GP (2005) Use of viral vectors for vaccine production in plants. Immunol Cell Biol 83:263–270
    • (2005) Immunol Cell Biol , vol.83 , pp. 263-270
    • Canizares, M.C.1    Nicholson, L.2    Lomonossoff, G.P.3
  • 7
    • 84859744586 scopus 로고    scopus 로고
    • Transient expression of Human papilloma virus type 16 L2 epitope fused to N- and C-terminus of coat protein of Potato virus X in plants
    • COI: 1:CAS:528:DC%2BC38Xls12lsro%3D, PID: 22357210
    • Cerovska N, Hoffmeisterova H, Moravec T, Plchova H, Folwarczna J, Synkova H, Ryslava H, Ludvikova V, Smahel M (2012) Transient expression of Human papilloma virus type 16 L2 epitope fused to N- and C-terminus of coat protein of Potato virus X in plants. J Biosci 37:125–133
    • (2012) J Biosci , vol.37 , pp. 125-133
    • Cerovska, N.1    Hoffmeisterova, H.2    Moravec, T.3    Plchova, H.4    Folwarczna, J.5    Synkova, H.6    Ryslava, H.7    Ludvikova, V.8    Smahel, M.9
  • 8
    • 67849122688 scopus 로고    scopus 로고
    • Chloroplast-derived vaccine antigens and biopharmaceuticals: expression, folding, assembly and functionality
    • COI: 1:CAS:528:DC%2BC3cXjvV2juw%3D%3D
    • Chebolu S, Daniell H (2009) Chloroplast-derived vaccine antigens and biopharmaceuticals: expression, folding, assembly and functionality. Curr Top Microbiol 332:33–54
    • (2009) Curr Top Microbiol , vol.332 , pp. 33-54
    • Chebolu, S.1    Daniell, H.2
  • 9
    • 84870622077 scopus 로고    scopus 로고
    • Safety and immunogenicity of a plant-produced recombinant hemagglutinin-based influenza vaccine (HAI-05) derived from A/Indonesia/05/2005 (H5N1) influenza virus: a phase 1 randomized, double-blind, placebo-controlled, dose-escalation study in healthy adults
    • COI: 1:CAS:528:DC%2BC38XhvVSrtrjF, PID: 23202523
    • Chichester JA, Jones RM, Green BJ, Stow M, Miao F, Moonsammy G, Streatfield SJ, Yusibov V (2012) Safety and immunogenicity of a plant-produced recombinant hemagglutinin-based influenza vaccine (HAI-05) derived from A/Indonesia/05/2005 (H5N1) influenza virus: a phase 1 randomized, double-blind, placebo-controlled, dose-escalation study in healthy adults. Viruses 4:3227–3244
    • (2012) Viruses , vol.4 , pp. 3227-3244
    • Chichester, J.A.1    Jones, R.M.2    Green, B.J.3    Stow, M.4    Miao, F.5    Moonsammy, G.6    Streatfield, S.J.7    Yusibov, V.8
  • 10
    • 85067722733 scopus 로고    scopus 로고
    • Clinical trials for autologous vaccine for follicular lymphoma (2014) clinicaltrials.gov/ct2/show/NCT01022255. Accessed 26 June 2014
    • Clinical trials for autologous vaccine for follicular lymphoma (2014) clinicaltrials.gov/ct2/show/NCT01022255. Accessed 26 June 2014
  • 11
  • 12
    • 0031979072 scopus 로고    scopus 로고
    • Containment of herbicide resistance through genetic engineering of the chloroplast genome
    • COI: 1:CAS:528:DyaK1cXisVSmtrc%3D, PID: 9555724
    • Daniell H, Datta R, Varma S, Gray S, Lee SB (1998) Containment of herbicide resistance through genetic engineering of the chloroplast genome. Nat Biotechnol 16:345–348
    • (1998) Nat Biotechnol , vol.16 , pp. 345-348
    • Daniell, H.1    Datta, R.2    Varma, S.3    Gray, S.4    Lee, S.B.5
  • 14
    • 84902247056 scopus 로고    scopus 로고
    • Disease resistance in rice and the role of molecular breeding in protecting rice crops against diseases
    • Fahad S, Nie L, Khan FA, Chen Y, Hussain S, Wu C et al (2014) Disease resistance in rice and the role of molecular breeding in protecting rice crops against diseases. Biotechnol Lett. doi:10.1007/s10529-014-1510-9
    • (2014) Biotechnol Lett
    • Fahad, S.1    Nie, L.2    Khan, F.A.3    Chen, Y.4    Hussain, S.5    Wu, C.6
  • 15
    • 84855180534 scopus 로고    scopus 로고
    • Safety and immunogenicity of a modified process hepatitis B vaccine in healthy adults >50 years
    • Gilbert CL, Klopfer SO, Martin JC, Schödel FP, Bhuyan PK (2012) Safety and immunogenicity of a modified process hepatitis B vaccine in healthy adults >50 years. Hum Vaccine 7:1336–1342
    • (2012) Hum Vaccine , vol.7 , pp. 1336-1342
    • Gilbert, C.L.1    Klopfer, S.O.2    Martin, J.C.3    Schödel, F.P.4    Bhuyan, P.K.5
  • 16
    • 14844293838 scopus 로고    scopus 로고
    • Magnifection: a new platform for expressing recombinant vaccines in plants
    • COI: 1:CAS:528:DC%2BD2MXitVCgsLw%3D, PID: 15755568
    • Gleba Y, Klimyuk V, Marillonnet S (2005) Magnifection: a new platform for expressing recombinant vaccines in plants. Vaccine 23:2042–2048
    • (2005) Vaccine , vol.23 , pp. 2042-2048
    • Gleba, Y.1    Klimyuk, V.2    Marillonnet, S.3
  • 17
    • 0018369605 scopus 로고
    • Expression in Escherichia coli of chemically synthesized genes for human insulin
    • COI: 1:CAS:528:DyaE1MXhtFOrtrk%3D, PID: 85300
    • Goeddel DV et al (1979) Expression in Escherichia coli of chemically synthesized genes for human insulin. Proc Natl Acad Sci USA 76:106–110
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 106-110
    • Goeddel, D.V.1
  • 18
    • 79958112109 scopus 로고    scopus 로고
    • A plant based protective antigen [PA(dIV)] vaccine expressed in chloroplasts demonstrates protective immunity in mice against anthrax
    • COI: 1:CAS:528:DC%2BC3MXntlGgt70%3D, PID: 21504775
    • Gorantala J, Grover S, Goel D, Rahi A, Jayadev Magani SK, Chandra S, Bhatnagar R (2011) A plant based protective antigen [PA(dIV)] vaccine expressed in chloroplasts demonstrates protective immunity in mice against anthrax. Vaccine 29:4521–4533
    • (2011) Vaccine , vol.29 , pp. 4521-4533
    • Gorantala, J.1    Grover, S.2    Goel, D.3    Rahi, A.4    Jayadev Magani, S.K.5    Chandra, S.6    Bhatnagar, R.7
  • 19
    • 84869855268 scopus 로고    scopus 로고
    • Using transgenic plants as bioreactors to produce edible vaccines
    • COI: 1:CAS:528:DC%2BC3sXhtFej
    • Gunn KS, Singh N, Giambrone J, Wu H (2012) Using transgenic plants as bioreactors to produce edible vaccines. J Biotechnol Res 4:92–99
    • (2012) J Biotechnol Res , vol.4 , pp. 92-99
    • Gunn, K.S.1    Singh, N.2    Giambrone, J.3    Wu, H.4
  • 20
    • 12444286371 scopus 로고    scopus 로고
    • The sexual inheritance of plant organelles
    • Daniell H, Chase C, (eds), Springer, Netherlands:
    • Hagemann R (2004) The sexual inheritance of plant organelles. In: Daniell H, Chase C (eds) Molecular biology and biotechnology of plant organelles. Springer, Netherlands, pp 93–113
    • (2004) Molecular biology and biotechnology of plant organelles , pp. 93-113
    • Hagemann, R.1
  • 21
    • 0029055060 scopus 로고
    • Oral immunization with a recombinant bacterial antigen produced in transgenic plants
    • COI: 1:CAS:528:DyaK2MXlsVGitrw%3D, PID: 7732379
    • Haq TA, Mason HS, Clements JD, Arntzen CJ (1995) Oral immunization with a recombinant bacterial antigen produced in transgenic plants. Science 268:714–716
    • (1995) Science , vol.268 , pp. 714-716
    • Haq, T.A.1    Mason, H.S.2    Clements, J.D.3    Arntzen, C.J.4
  • 22
    • 0022977872 scopus 로고
    • Development of a genetically-engineered, candidate polio vaccine employing the self-assembling properties of the tobacco mosaic virus coat protein
    • COI: 1:CAS:528:DyaL28XkvFGqtbc%3D
    • Haynes JR, Cunningham J, Seefried AV, Lennick M, Garvin RT, Shen S (1986) Development of a genetically-engineered, candidate polio vaccine employing the self-assembling properties of the tobacco mosaic virus coat protein. Nat Biotechnol 4:637–641
    • (1986) Nat Biotechnol , vol.4 , pp. 637-641
    • Haynes, J.R.1    Cunningham, J.2    Seefried, A.V.3    Lennick, M.4    Garvin, R.T.5    Shen, S.6
  • 23
    • 84957933738 scopus 로고    scopus 로고
    • Recent advances in virus expression vector strategies for vaccine production in plants
    • Hefferon KL (2012) Recent advances in virus expression vector strategies for vaccine production in plants. Virol Mycol 1:105–124
    • (2012) Virol Mycol , vol.1 , pp. 105-124
    • Hefferon, K.L.1
  • 24
    • 0024959945 scopus 로고
    • Production of antibodies in transgenic plants
    • COI: 1:CAS:528:DyaK3cXkvF2isA%3D%3D, PID: 2509938
    • Hiatt A, Cafferkey R, Bowdish K (1989) Production of antibodies in transgenic plants. Nature 342:76–78
    • (1989) Nature , vol.342 , pp. 76-78
    • Hiatt, A.1    Cafferkey, R.2    Bowdish, K.3
  • 25
    • 33750798367 scopus 로고    scopus 로고
    • Peptide immunotherapy for allergic diseases using a rice-based edible vaccine
    • COI: 1:CAS:528:DC%2BD2sXisl2mtw%3D%3D, PID: 17088651
    • Hiroi T, Takaiwa F (2006) Peptide immunotherapy for allergic diseases using a rice-based edible vaccine. Curr Opin Allergy Clin Immunol 6:455–460
    • (2006) Curr Opin Allergy Clin Immunol , vol.6 , pp. 455-460
    • Hiroi, T.1    Takaiwa, F.2
  • 26
  • 27
    • 58849122869 scopus 로고    scopus 로고
    • Production of pharmaceutical proteins by transgenic animals
    • PID: 18243312
    • Houdebine LM (2009) Production of pharmaceutical proteins by transgenic animals. Comp Immunol Microbiol Infect Dis 32:107–121
    • (2009) Comp Immunol Microbiol Infect Dis , vol.32 , pp. 107-121
    • Houdebine, L.M.1
  • 28
    • 67650156117 scopus 로고    scopus 로고
    • A DNA replicon system for rapid high-level production of virus-like particles in plants
    • COI: 1:CAS:528:DC%2BD1MXnslejtbg%3D, PID: 19309755
    • Huang Z, Chen Q, Hjelm B, Arntzen C, Mason H (2009) A DNA replicon system for rapid high-level production of virus-like particles in plants. Biotechnol Bioeng 103:706–714
    • (2009) Biotechnol Bioeng , vol.103 , pp. 706-714
    • Huang, Z.1    Chen, Q.2    Hjelm, B.3    Arntzen, C.4    Mason, H.5
  • 30
    • 84866491765 scopus 로고    scopus 로고
    • Bipartite and tripartite cucumber mosaic virus-based vectors for producing the Acidothermus cellulolyticusendo-1,4-β-glucanase and other proteins in non-transgenic plants
    • COI: 1:CAS:528:DC%2BC3sXmt1GksrY%3D, PID: 22999234
    • Hwang MS, Lindenmut BE, McDonald KA, Falk BW (2012) Bipartite and tripartite cucumber mosaic virus-based vectors for producing the Acidothermus cellulolyticusendo-1,4-β-glucanase and other proteins in non-transgenic plants. BMC Biotechnol 12:66
    • (2012) BMC Biotechnol , vol.12 , pp. 66
    • Hwang, M.S.1    Lindenmut, B.E.2    McDonald, K.A.3    Falk, B.W.4
  • 31
    • 0017697097 scopus 로고
    • Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin
    • COI: 1:CAS:528:DyaE1cXjsVCjtQ%3D%3D, PID: 412251
    • Itakura K, Hirose T, Crea R, Riggs AD, Heyneker HL, Bolivar F, Boyer HW (1977) Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin. Science 198:1056–1063
    • (1977) Science , vol.198 , pp. 1056-1063
    • Itakura, K.1    Hirose, T.2    Crea, R.3    Riggs, A.D.4    Heyneker, H.L.5    Bolivar, F.6    Boyer, H.W.7
  • 32
    • 75949109975 scopus 로고    scopus 로고
    • Hydrophobin fusions for high-level transient protein expression and purification in Nicotiana benthamiana
    • PID: 20018596
    • Joensuu JJ, Conley AJ, Lienemann M, Brandle JE, Linder MB, Menassa R (2009) Hydrophobin fusions for high-level transient protein expression and purification in Nicotiana benthamiana. Plant Physiol 152:622–633
    • (2009) Plant Physiol , vol.152 , pp. 622-633
    • Joensuu, J.J.1    Conley, A.J.2    Lienemann, M.3    Brandle, J.E.4    Linder, M.B.5    Menassa, R.6
  • 33
    • 84870790110 scopus 로고    scopus 로고
    • TMV-gate vectors: gateway compatible tobacco mosaic virus based expression vectors for functional analysis of proteins
    • PID: 23166857
    • Kagale S, Uzuhashi S, Wigness M, Bender T, Yang W, Borhan MH, Rozwadowski K (2012) TMV-gate vectors: gateway compatible tobacco mosaic virus based expression vectors for functional analysis of proteins. Sci Rep 2:874
    • (2012) Sci Rep , vol.2 , pp. 874
    • Kagale, S.1    Uzuhashi, S.2    Wigness, M.3    Bender, T.4    Yang, W.5    Borhan, M.H.6    Rozwadowski, K.7
  • 34
    • 84858603408 scopus 로고    scopus 로고
    • Transient expression of hemagglutinin antigen from low pathogenic avian influenza A (H7N7) in Nicotiana benthamiana
    • COI: 1:CAS:528:DC%2BC38XltVers7c%3D, PID: 22442675
    • Kanagarajan S, Tolf C, Lundgren A, Waldenström J, Brodelius PE (2012) Transient expression of hemagglutinin antigen from low pathogenic avian influenza A (H7N7) in Nicotiana benthamiana. PLoS ONE 7:e33010
    • (2012) PLoS ONE , vol.7 , pp. e33010
    • Kanagarajan, S.1    Tolf, C.2    Lundgren, A.3    Waldenström, J.4    Brodelius, P.E.5
  • 35
    • 84868548651 scopus 로고    scopus 로고
    • A 28 nt long synthetic 5′UTR (synJ) as an enhancer of transgene expression in dicotyledonous plants
    • Kanoria S, Burma PK (2012) A 28 nt long synthetic 5′UTR (synJ) as an enhancer of transgene expression in dicotyledonous plants. BMC Biotechnol 12:1472–6750
    • (2012) BMC Biotechnol , vol.12 , pp. 1472-6750
    • Kanoria, S.1    Burma, P.K.2
  • 36
    • 0000146626 scopus 로고    scopus 로고
    • An Agrobacterium-mediated transient gene expression system for intact leaves
    • COI: 1:CAS:528:DyaK2sXhslCktQ%3D%3D
    • Kapila J, DeRycke R, Van Montagu M, Angenon G (1997) An Agrobacterium-mediated transient gene expression system for intact leaves. Plant Sci 122:101
    • (1997) Plant Sci , vol.122 , pp. 101
    • Kapila, J.1    DeRycke, R.2    Van Montagu, M.3    Angenon, G.4
  • 37
    • 34247204915 scopus 로고    scopus 로고
    • Plastid marker gene excision by the phiC31 phage site-specific recombinase
    • COI: 1:CAS:528:DC%2BD2sXktFagu7w%3D, PID: 17294253
    • Kittiwongwattana C, Lutz K, Clark M, Maliga P (2007) Plastid marker gene excision by the phiC31 phage site-specific recombinase. Plant Mol Biol 64:137–143
    • (2007) Plant Mol Biol , vol.64 , pp. 137-143
    • Kittiwongwattana, C.1    Lutz, K.2    Clark, M.3    Maliga, P.4
  • 38
    • 39049156949 scopus 로고    scopus 로고
    • Expression of HPV-11 L1 protein in transgenic Arabidopsis thaliana and Nicotiana tabacum
    • PID: 17850660
    • Kohl TO, Hitzeroth II, Christensen ND, Rybicki EP (2007) Expression of HPV-11 L1 protein in transgenic Arabidopsis thaliana and Nicotiana tabacum. BMC Biotechnol 7:56
    • (2007) BMC Biotechnol , vol.7 , pp. 56
    • Kohl, T.O.1    Hitzeroth, I.I.2    Christensen, N.D.3    Rybicki, E.P.4
  • 39
    • 84864565209 scopus 로고    scopus 로고
    • Production of a subunit vaccine candidate against porcine post-weaning diarrhea in high-biomass transplastomic tobacco
    • COI: 1:CAS:528:DC%2BC38XhtFOls7bE, PID: 22879967
    • Kolotilin I, Kaldis A, Devriendt B, Joensuu J, Cox E, Menassa R (2012) Production of a subunit vaccine candidate against porcine post-weaning diarrhea in high-biomass transplastomic tobacco. PLoS ONE 7:e42405
    • (2012) PLoS ONE , vol.7 , pp. e42405
    • Kolotilin, I.1    Kaldis, A.2    Devriendt, B.3    Joensuu, J.4    Cox, E.5    Menassa, R.6
  • 41
    • 34347404687 scopus 로고    scopus 로고
    • Suppressor of RNA silencing encoded by the monopartite tomato leaf curl Java begomovirus
    • COI: 1:CAS:528:DC%2BD2sXntVOlt7s%3D, PID: 17385070
    • Kon T, Sharma P, Ikegami M (2007) Suppressor of RNA silencing encoded by the monopartite tomato leaf curl Java begomovirus. Arch Virol 152:1273–1282
    • (2007) Arch Virol , vol.152 , pp. 1273-1282
    • Kon, T.1    Sharma, P.2    Ikegami, M.3
  • 42
    • 28444439874 scopus 로고    scopus 로고
    • Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal, toxin challenge
    • COI: 1:CAS:528:DC%2BD2MXhtlertr%2FL, PID: 16299323
    • Koya V, Moayeri M, Leppla SH, Daniell H (2005) Plant-based vaccine: mice immunized with chloroplast-derived anthrax protective antigen survive anthrax lethal, toxin challenge. Infect Immun 73:8266–8274
    • (2005) Infect Immun , vol.73 , pp. 8266-8274
    • Koya, V.1    Moayeri, M.2    Leppla, S.H.3    Daniell, H.4
  • 43
    • 79955162419 scopus 로고    scopus 로고
    • New plant expression systems drive vaccine innovation and opportunity
    • Laanger E (2011) New plant expression systems drive vaccine innovation and opportunity. BioProcess Int 9:16–20
    • (2011) BioProcess Int , vol.9 , pp. 16-20
    • Laanger, E.1
  • 44
    • 77954560597 scopus 로고    scopus 로고
    • Effect of codon optimization and subcellular targeting on Toxoplasma gondii antigen SAG1 expression in tobacco leaves to use in subcutaneous and oral immunization in mice
    • PID: 20633272
    • Laguía-Becher M, Martín V, Kraemer M, Corigliano M, Yacono ML, Goldman A, Clemente M (2010) Effect of codon optimization and subcellular targeting on Toxoplasma gondii antigen SAG1 expression in tobacco leaves to use in subcutaneous and oral immunization in mice. BMC Biotechnol 10:52
    • (2010) BMC Biotechnol , vol.10 , pp. 52
    • Laguía-Becher, M.1    Martín, V.2    Kraemer, M.3    Corigliano, M.4    Yacono, M.L.5    Goldman, A.6    Clemente, M.7
  • 45
    • 78650981716 scopus 로고    scopus 로고
    • Preclinical and clinical development of plant-made virus-like particle vaccine against avian H5N1 influenza
    • Landry N, Ward BJ, Trépanier S, Montomoli E, Dargis M, Lapini G, Vézina LP (2010) Preclinical and clinical development of plant-made virus-like particle vaccine against avian H5N1 influenza. PLoS One 5:0015559
    • (2010) PLoS One , vol.5 , pp. 0015559
    • Landry, N.1    Ward, B.J.2    Trépanier, S.3    Montomoli, E.4    Dargis, M.5    Lapini, G.6    Vézina, L.P.7
  • 46
    • 84860539720 scopus 로고    scopus 로고
    • RNA viral vectors for improved Agrobacterium-mediated transient expression of heterologous proteins in Nicotiana benthamiana cell suspensions and hairy roots
    • COI: 1:CAS:528:DC%2BC38XhtFamsrnL, PID: 22559055
    • Larsen JS, Curtis WR (2012) RNA viral vectors for improved Agrobacterium-mediated transient expression of heterologous proteins in Nicotiana benthamiana cell suspensions and hairy roots. BMC Biotechnol 12:21
    • (2012) BMC Biotechnol , vol.12 , pp. 21
    • Larsen, J.S.1    Curtis, W.R.2
  • 47
    • 46049083590 scopus 로고    scopus 로고
    • Viral vectors for production of recombinant proteins in plants
    • COI: 1:CAS:528:DC%2BD1cXotFyrt7o%3D, PID: 18330886
    • Lico C, Chen Q, Santi L (2008) Viral vectors for production of recombinant proteins in plants. J Cell Physiol 216:366–377
    • (2008) J Cell Physiol , vol.216 , pp. 366-377
    • Lico, C.1    Chen, Q.2    Santi, L.3
  • 48
    • 35248832984 scopus 로고    scopus 로고
    • High-efficiency protein expression in plants from agroinfection: compatible tobacco mosaic virus expression vectors
    • PID: 17723150
    • Lindbo JA (2007a) High-efficiency protein expression in plants from agroinfection: compatible tobacco mosaic virus expression vectors. BMC Biotechnol 7:52
    • (2007) BMC Biotechnol , vol.7 , pp. 52
    • Lindbo, J.A.1
  • 49
    • 37249086137 scopus 로고    scopus 로고
    • TRBO: a high-efficiency tobacco mosaic virus rna-based overexpression Vector
    • Lindbo JA (2007b) TRBO: a high-efficiency tobacco mosaic virus rna-based overexpression Vector. Plant Physiol 145:1161–1170
    • (2007) Plant Physiol , vol.145 , pp. 1161-1170
    • Lindbo, J.A.1
  • 50
    • 84886092842 scopus 로고    scopus 로고
    • Advanced genetic tools for plant biotechnology
    • COI: 1:CAS:528:DC%2BC3sXhsFOlsb%2FN, PID: 24105275
    • Liu W, Yuan JS, Stewart CN Jr (2013) Advanced genetic tools for plant biotechnology. Nat Rev Genet 14:781–793
    • (2013) Nat Rev Genet , vol.14 , pp. 781-793
    • Liu, W.1    Yuan, J.S.2    Stewart, C.N.3
  • 51
    • 79955661319 scopus 로고    scopus 로고
    • Chloroplast-derived vaccines against human diseases: achievements, challenges and scopes
    • PID: 21447052
    • Lossl AG, Waheed MT (2011) Chloroplast-derived vaccines against human diseases: achievements, challenges and scopes. Plant Biotechnol J 9:527–539
    • (2011) Plant Biotechnol J , vol.9 , pp. 527-539
    • Lossl, A.G.1    Waheed, M.T.2
  • 52
    • 84858450806 scopus 로고    scopus 로고
    • Production, characterization and immunogenicity of a plant-made plasmodium antigen-the 19 kDa C-terminal fragment of plasmodium yoelii merozoite surface protein 1
    • COI: 1:CAS:528:DC%2BC38XjvFKku7g%3D, PID: 22170105
    • Ma C, Wang L, Webster DE, Campbell AE, Coppel RL (2012a) Production, characterization and immunogenicity of a plant-made plasmodium antigen-the 19 kDa C-terminal fragment of plasmodium yoelii merozoite surface protein 1. Appl Microbiol Biotechnol 94:151–161
    • (2012) Appl Microbiol Biotechnol , vol.94 , pp. 151-161
    • Ma, C.1    Wang, L.2    Webster, D.E.3    Campbell, A.E.4    Coppel, R.L.5
  • 53
    • 84864798781 scopus 로고    scopus 로고
    • Virus-induced gene-silencing in wheat spikes and grains and its application in functional analysis of HMW-GS-encoding genes
    • COI: 1:CAS:528:DC%2BC38Xhslals7zJ, PID: 22882902
    • Ma M, Yan Y, Huang L, Chen M, Zhao H (2012b) Virus-induced gene-silencing in wheat spikes and grains and its application in functional analysis of HMW-GS-encoding genes. BMC Plant Biol 12:141
    • (2012) BMC Plant Biol , vol.12 , pp. 141
    • Ma, M.1    Yan, Y.2    Huang, L.3    Chen, M.4    Zhao, H.5
  • 55
    • 1542368230 scopus 로고    scopus 로고
    • Plastid transformation in higher plants
    • COI: 1:CAS:528:DC%2BD2cXlvFeisL4%3D, PID: 15377222
    • Maliga P (2004) Plastid transformation in higher plants. Annu Rev Plant Biol 55:289–313
    • (2004) Annu Rev Plant Biol , vol.55 , pp. 289-313
    • Maliga, P.1
  • 56
    • 2342525801 scopus 로고    scopus 로고
    • In planta engineering of viral RNA replicons: efficient assembly by recombination of DNA modules delivered by Agrobacterium
    • COI: 1:CAS:528:DC%2BD2cXktFeruro%3D, PID: 15103020
    • Marillonnet S, Giritch A, Gils M, Kandzia R, Klimyuk V, Gleba Y (2004) In planta engineering of viral RNA replicons: efficient assembly by recombination of DNA modules delivered by Agrobacterium. Proc Natl Acad Sci USA 101:6852–6857
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6852-6857
    • Marillonnet, S.1    Giritch, A.2    Gils, M.3    Kandzia, R.4    Klimyuk, V.5    Gleba, Y.6
  • 57
    • 24944498904 scopus 로고    scopus 로고
    • Systemic Agrobacterium tumefaciens-mediated transfection of viral replicons for efficient transient expression in plants
    • COI: 1:CAS:528:DC%2BD2MXkvVShsrY%3D
    • Marillonnet S, Thoeringer C, Kandzia R, Klimyuk V, Gleba Y (2005) Systemic Agrobacterium tumefaciens-mediated transfection of viral replicons for efficient transient expression in plants. Nat Biotech 23:718–723
    • (2005) Nat Biotech , vol.23 , pp. 718-723
    • Marillonnet, S.1    Thoeringer, C.2    Kandzia, R.3    Klimyuk, V.4    Gleba, Y.5
  • 59
    • 0027048769 scopus 로고
    • Expression of hepatitis B surface antigen in transgenic plants
    • COI: 1:CAS:528:DyaK3sXpsFakug%3D%3D, PID: 1465391
    • Mason HS, Lam DM, Arntzen CJ (1992) Expression of hepatitis B surface antigen in transgenic plants. Proc Natl Acad Sci USA 89:11745–11749
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11745-11749
    • Mason, H.S.1    Lam, D.M.2    Arntzen, C.J.3
  • 60
    • 0032146489 scopus 로고    scopus 로고
    • Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene
    • COI: 1:STN:280:DyaK1czkslehsw%3D%3D, PID: 9682399
    • Mason HS, Haq TA, Clements JD, Arntzen CJ (1998) Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene. Vaccine 16:1336–1343
    • (1998) Vaccine , vol.16 , pp. 1336-1343
    • Mason, H.S.1    Haq, T.A.2    Clements, J.D.3    Arntzen, C.J.4
  • 63
    • 84897553272 scopus 로고    scopus 로고
    • Comparative evaluation of recombinant protein production in different biofactories: the green perspective
    • Merlin M, Gecchele E, Capaldi S, Pezzotti M, Avesani L (2014) Comparative evaluation of recombinant protein production in different biofactories: the green perspective. BioMed Res Intern 2014:14. doi:10.1155/2014/136419
    • (2014) BioMed Res Intern , vol.2014 , pp. 14
    • Merlin, M.1    Gecchele, E.2    Capaldi, S.3    Pezzotti, M.4    Avesani, L.5
  • 64
    • 85067704676 scopus 로고    scopus 로고
    • Transforming tobacco cell line containing sequences encoding antigens (such as hemagglutinin/neuraminidase protein from Newcastle Disease Virus), culturing, washing, suspending in lysis buffer, disrupting cells, then separating debris; vaccines
    • Miller T, Fanton M, Webb S (2004) Transforming tobacco cell line containing sequences encoding antigens (such as hemagglutinin/neuraminidase protein from Newcastle Disease Virus), culturing, washing, suspending in lysis buffer, disrupting cells, then separating debris; vaccines. US Patent 0268442A1
    • (2004) US Patent 0268442A1
    • Miller, T.1    Fanton, M.2    Webb, S.3
  • 67
    • 33846210581 scopus 로고    scopus 로고
    • Production of Escherichia coli heat labile toxin (LT) B subunit in soybean seed and analysis of its immunogenicity as an oral vaccine
    • COI: 1:CAS:528:DC%2BD2sXntlOqtQ%3D%3D, PID: 17188785
    • Moravec T, Schmidt MA, Herman EM, Woodford-Thomas T (2007) Production of Escherichia coli heat labile toxin (LT) B subunit in soybean seed and analysis of its immunogenicity as an oral vaccine. Vaccine 25:1647–1657
    • (2007) Vaccine , vol.25 , pp. 1647-1657
    • Moravec, T.1    Schmidt, M.A.2    Herman, E.M.3    Woodford-Thomas, T.4
  • 71
    • 57749209656 scopus 로고    scopus 로고
    • Structural and biological properties of cucumber mosaic virus particles carrying hepatitis C virus-derived epitopes
    • COI: 1:CAS:528:DC%2BD1cXhsFCnu7zE, PID: 18992770
    • Nuzzaci M, Bochicchio I, De Stradis A, Vitti A, Natilla A, Piazzolla P, Tamburro AM (2009) Structural and biological properties of cucumber mosaic virus particles carrying hepatitis C virus-derived epitopes. J Virol Methods 155:118–121
    • (2009) J Virol Methods , vol.155 , pp. 118-121
    • Nuzzaci, M.1    Bochicchio, I.2    De Stradis, A.3    Vitti, A.4    Natilla, A.5    Piazzolla, P.6    Tamburro, A.M.7
  • 72
    • 77950968711 scopus 로고    scopus 로고
    • In vitro stability of cucumber mosaic virus nanoparticles carrying a Hepatitis C virus-derived epitope under simulated gastrointestinal conditions and in vivo efficacy of an edible vaccine
    • COI: 1:CAS:528:DC%2BC3cXksVaqu78%3D, PID: 20132840
    • Nuzzaci M, Vitti A, Condelli V, Lanorte MT, Tortorella C, Boscia D, Piazzolla P, Piazzolla G (2010) In vitro stability of cucumber mosaic virus nanoparticles carrying a Hepatitis C virus-derived epitope under simulated gastrointestinal conditions and in vivo efficacy of an edible vaccine. J Virol Methods 165:211–215
    • (2010) J Virol Methods , vol.165 , pp. 211-215
    • Nuzzaci, M.1    Vitti, A.2    Condelli, V.3    Lanorte, M.T.4    Tortorella, C.5    Boscia, D.6    Piazzolla, P.7    Piazzolla, G.8
  • 73
    • 84883235221 scopus 로고    scopus 로고
    • The pEAQ vector series: the easy and quick way to produce recombinant proteins in plants
    • COI: 1:CAS:528:DC%2BC3sXhtlCgtrnI, PID: 23479085
    • Peyret H, Lomonossoff GP (2013) The pEAQ vector series: the easy and quick way to produce recombinant proteins in plants. Plant Mol Biol 83:51–58
    • (2013) Plant Mol Biol , vol.83 , pp. 51-58
    • Peyret, H.1    Lomonossoff, G.P.2
  • 74
    • 0035888373 scopus 로고    scopus 로고
    • Insulin therapies-past, present and future
    • COI: 1:CAS:528:DC%2BD3MXntF2qtLc%3D, PID: 11590034
    • Pillai O, Panchagnula R (2001) Insulin therapies-past, present and future. Drug Discov Today 6:1056–1061
    • (2001) Drug Discov Today , vol.6 , pp. 1056-1061
    • Pillai, O.1    Panchagnula, R.2
  • 77
    • 85067707275 scopus 로고    scopus 로고
    • Transient virus expression systems for recombinant protein expression in dicot- and monocotyledonous plants. In: Dhal NK. (Ed.) Plant Science, ISBN: 978-953-51-0905-1, InTech
    • Pogue GP, Holzberg S (2012) Transient virus expression systems for recombinant protein expression in dicot- and monocotyledonous plants. In: Dhal NK. (Ed.) Plant Science, ISBN: 978-953-51-0905-1, InTech. doi: 10.5772/54187
    • (2012) doi: 10.5772/54187
    • Pogue, G.P.1    Holzberg, S.2
  • 78
    • 27244432790 scopus 로고    scopus 로고
    • Characterization of heterologous multigene operons in transgenic chloroplasts: transcription, processing, and translation
    • COI: 1:CAS:528:DC%2BD2MXmvV2ksLk%3D, PID: 15980187
    • Quesada-Vargas T, Ruiz ON, Daniell H (2005) Characterization of heterologous multigene operons in transgenic chloroplasts: transcription, processing, and translation. Plant Physiol 138:1746–1762
    • (2005) Plant Physiol , vol.138 , pp. 1746-1762
    • Quesada-Vargas, T.1    Ruiz, O.N.2    Daniell, H.3
  • 79
    • 84876388914 scopus 로고    scopus 로고
    • FDA biopharmaceutical product approvals and trends in 2012
    • Rader RA (2013) FDA biopharmaceutical product approvals and trends in 2012. BioProcess Int 11:18–27
    • (2013) BioProcess Int , vol.11 , pp. 18-27
    • Rader, R.A.1
  • 80
    • 84875099976 scopus 로고    scopus 로고
    • Production of pharmaceutical proteins in solanaceae food crops
    • COI: 1:CAS:528:DC%2BC3sXisVyksbY%3D, PID: 23434646
    • Rigano MM, Guzman GD, Walmsley AM, Frusciante L, Barone A (2013) Production of pharmaceutical proteins in solanaceae food crops. Int J Mol Sci 14:2753–2773
    • (2013) Int J Mol Sci , vol.14 , pp. 2753-2773
    • Rigano, M.M.1    Guzman, G.D.2    Walmsley, A.M.3    Frusciante, L.4    Barone, A.5
  • 81
    • 36949021571 scopus 로고    scopus 로고
    • Ingestion of transgenic carrots expressing the Escherichia coli heat-labile enterotoxin B subunit protects mice against cholera toxin challenge
    • COI: 1:CAS:528:DC%2BD2sXhsVSls7jE, PID: 17874110
    • Rosales-Mendoza S, Soria-Guerra RE, López-Revilla R, Moreno-Fierros L, Alpuche-Solís AG (2008) Ingestion of transgenic carrots expressing the Escherichia coli heat-labile enterotoxin B subunit protects mice against cholera toxin challenge. Plant Cell Rep 27:79–84
    • (2008) Plant Cell Rep , vol.27 , pp. 79-84
    • Rosales-Mendoza, S.1    Soria-Guerra, R.E.2    López-Revilla, R.3    Moreno-Fierros, L.4    Alpuche-Solís, A.G.5
  • 84
    • 34249860016 scopus 로고    scopus 로고
    • Determining the transgene containment level provided by chloroplast transformation
    • COI: 1:CAS:528:DC%2BD2sXls1OktLY%3D, PID: 17420459
    • Ruf S, Karcher D, Bock R (2007) Determining the transgene containment level provided by chloroplast transformation. Proc Natl Acad Sci USA 104:6998–7002
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6998-7002
    • Ruf, S.1    Karcher, D.2    Bock, R.3
  • 85
    • 57749107463 scopus 로고    scopus 로고
    • Extremely high-level and rapid transient protein production in plants without the use of viral replication
    • COI: 1:CAS:528:DC%2BD1cXhsVSnurvM, PID: 18775971
    • Sainsbury F, Lomonossoff GP (2008) Extremely high-level and rapid transient protein production in plants without the use of viral replication. Plant Physiol 148:1212–1218
    • (2008) Plant Physiol , vol.148 , pp. 1212-1218
    • Sainsbury, F.1    Lomonossoff, G.P.2
  • 86
    • 84897097820 scopus 로고    scopus 로고
    • Transient expressions of synthetic biology in plants
    • COI: 1:CAS:528:DC%2BC2cXhtVemsb%2FF, PID: 24631883
    • Sainsbury F, Lomonossoff GP (2014) Transient expressions of synthetic biology in plants. Curr Opin Plant Biol 19:1–7. doi:10.1016/j.pbi.2014.02.003
    • (2014) Curr Opin Plant Biol , vol.19 , pp. 1-7
    • Sainsbury, F.1    Lomonossoff, G.P.2
  • 87
    • 79958081520 scopus 로고    scopus 로고
    • Efficient virus-induced gene silencing in apple, pear and Japanese pear using Apple latent spherical virus vectors
    • COI: 1:CAS:528:DC%2BC3MXotVWgu7w%3D, PID: 21658286
    • Sasaki S, Yamagishi N, Yoshikawa N (2011) Efficient virus-induced gene silencing in apple, pear and Japanese pear using Apple latent spherical virus vectors. Plant Methods 7:15
    • (2011) Plant Methods , vol.7 , pp. 15
    • Sasaki, S.1    Yamagishi, N.2    Yoshikawa, N.3
  • 88
    • 79952477083 scopus 로고    scopus 로고
    • Development of expression vectors based on pepino mosaic virus
    • COI: 1:CAS:528:DC%2BC3MXkt1SksLk%3D, PID: 21396092
    • Sempere RN, Gómez P, Truniger V, Aranda MA (2011) Development of expression vectors based on pepino mosaic virus. Plant Methods 7:6
    • (2011) Plant Methods , vol.7 , pp. 6
    • Sempere, R.N.1    Gómez, P.2    Truniger, V.3    Aranda, M.A.4
  • 89
    • 84885950753 scopus 로고    scopus 로고
    • Oral immunization of fish against iridovirus infection using recombinant antigen produced from rice callus
    • COI: 1:CAS:528:DC%2BC3sXhsFemsLnK, PID: 24021312
    • Shin YJ, Kwon TH, Seo JY, Kim TJ (2013) Oral immunization of fish against iridovirus infection using recombinant antigen produced from rice callus. Vaccine 31:5210–5215
    • (2013) Vaccine , vol.31 , pp. 5210-5215
    • Shin, Y.J.1    Kwon, T.H.2    Seo, J.Y.3    Kim, T.J.4
  • 91
    • 34548431801 scopus 로고    scopus 로고
    • Transgenic tomatoes express an antigenic polypeptide containing epitopes of the diphtheria, pertussis and tetanus exotoxins, encoded by a synthetic gene
    • COI: 1:CAS:528:DC%2BD2sXnsFaqurY%3D, PID: 17619922
    • Soria-Guerra RE, Rosales-Mendoza S, Márquez-Mercado C, López-Revilla R, Castillo-Collazo R, Alpuche-Solís AG (2007) Transgenic tomatoes express an antigenic polypeptide containing epitopes of the diphtheria, pertussis and tetanus exotoxins, encoded by a synthetic gene. Plant Cell Rep 26:961–968
    • (2007) Plant Cell Rep , vol.26 , pp. 961-968
    • Soria-Guerra, R.E.1    Rosales-Mendoza, S.2    Márquez-Mercado, C.3    López-Revilla, R.4    Castillo-Collazo, R.5    Alpuche-Solís, A.G.6
  • 92
    • 79751538411 scopus 로고    scopus 로고
    • Oral immunogenicity of tomato-derived sDPT polypeptide containing Corynebacterium diphtheriae, Bordetella pertussis and Clostridium tetaniexotoxin epitopes
    • COI: 1:CAS:528:DC%2BC3MXhslWmt7w%3D, PID: 21188384
    • Soria-Guerra RE, Rosales-Mendoza S, Moreno-Fierros L, López-Revilla R, Alpuche-Solís AG (2011) Oral immunogenicity of tomato-derived sDPT polypeptide containing Corynebacterium diphtheriae, Bordetella pertussis and Clostridium tetaniexotoxin epitopes. Plant Cell Rep 30:417–424
    • (2011) Plant Cell Rep , vol.30 , pp. 417-424
    • Soria-Guerra, R.E.1    Rosales-Mendoza, S.2    Moreno-Fierros, L.3    López-Revilla, R.4    Alpuche-Solís, A.G.5
  • 93
    • 34249860848 scopus 로고    scopus 로고
    • Exceptional transmission of plastids and mitochondria from the transplastomic pollen parent and its impact on transgene containment
    • COI: 1:CAS:528:DC%2BD2sXls1OktLc%3D, PID: 17420457
    • Svab Z, Maliga P (2007) Exceptional transmission of plastids and mitochondria from the transplastomic pollen parent and its impact on transgene containment. Proc Natl Acad Sci USA 104:7003–7008
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 7003-7008
    • Svab, Z.1    Maliga, P.2
  • 94
    • 65549134575 scopus 로고    scopus 로고
    • Plants as bioreactors for the production of vaccine antigens
    • COI: 1:CAS:528:DC%2BD1MXmtlKmu74%3D, PID: 19356740
    • Tiwari S, Verma PC, Singh PK, Tuli R (2009) Plants as bioreactors for the production of vaccine antigens. Biotechnol Adv 27:449–467
    • (2009) Biotechnol Adv , vol.27 , pp. 449-467
    • Tiwari, S.1    Verma, P.C.2    Singh, P.K.3    Tuli, R.4
  • 95
    • 84883532793 scopus 로고    scopus 로고
    • Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection
    • COI: 1:CAS:528:DC%2BC3sXhsVemsr7L, PID: 23925294
    • Tokuhara D et al (2013) Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection. J Clin Invest 123:3829–3838
    • (2013) J Clin Invest , vol.123 , pp. 3829-3838
    • Tokuhara, D.1
  • 96
    • 80053600622 scopus 로고    scopus 로고
    • Protective efficacy of a trivalent recombinant hemagglutinin protein vaccine [FluBlok(R)] against influenza in healthy adults: a randomized, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BC3MXht12it7rM, PID: 21835220
    • Treanor JJ, El Sahly H, King J, Graham I, Izikson R, Kohberger R, Patriarca P, Cox M (2011) Protective efficacy of a trivalent recombinant hemagglutinin protein vaccine [FluBlok(R)] against influenza in healthy adults: a randomized, placebo-controlled trial. Vaccine 29:7733–7739
    • (2011) Vaccine , vol.29 , pp. 7733-7739
    • Treanor, J.J.1    El Sahly, H.2    King, J.3    Graham, I.4    Izikson, R.5    Kohberger, R.6    Patriarca, P.7    Cox, M.8
  • 99
    • 37249014420 scopus 로고    scopus 로고
    • Chloroplast vector systems for biotechnology applications
    • COI: 1:CAS:528:DC%2BD2sXhsVCntL3K, PID: 18056863
    • Verma D, Daniell H (2007) Chloroplast vector systems for biotechnology applications. Plant Physiol 145:1129–1143
    • (2007) Plant Physiol , vol.145 , pp. 1129-1143
    • Verma, D.1    Daniell, H.2
  • 101
    • 67651083472 scopus 로고    scopus 로고
    • Advances in chloroplast engineering
    • COI: 1:CAS:528:DC%2BD1MXpvFyntb0%3D, PID: 19631913
    • Wang HH, Yin WB, Hu ZM (2009) Advances in chloroplast engineering. J Genet Genomics 36:387–398
    • (2009) J Genet Genomics , vol.36 , pp. 387-398
    • Wang, H.H.1    Yin, W.B.2    Hu, Z.M.3
  • 102
    • 67849103582 scopus 로고    scopus 로고
    • Virus-induced gene silencing in soybean seeds and the emergence stage of soybean plants with apple latent spherical virus vectors
    • COI: 1:CAS:528:DC%2BD1MXptVGjtbs%3D, PID: 19495995
    • Yamagishi N, Yoshikawa N (2009) Virus-induced gene silencing in soybean seeds and the emergence stage of soybean plants with apple latent spherical virus vectors. Plant Mol Biol 71:15–24
    • (2009) Plant Mol Biol , vol.71 , pp. 15-24
    • Yamagishi, N.1    Yoshikawa, N.2
  • 103
    • 77953598981 scopus 로고    scopus 로고
    • Current trends in edible vaccine development using transgenic plants
    • Yang TG, Yang MS (2010) Current trends in edible vaccine development using transgenic plants. Biotechnol Bioprocess Eng 15:61–65
    • (2010) Biotechnol Bioprocess Eng , vol.15 , pp. 61-65
    • Yang, T.G.1    Yang, M.S.2
  • 104
    • 78751648047 scopus 로고    scopus 로고
    • Immunogenicity and virus-like particle formation of rotavirus capsid proteins produced in transgenic plants
    • COI: 1:CAS:528:DC%2BC3MXptFeksw%3D%3D, PID: 21104033
    • Yang Y, Li X, Yang H, Qian Y, Zhang Y, Fang R, Chen X (2011) Immunogenicity and virus-like particle formation of rotavirus capsid proteins produced in transgenic plants. Sci China Life Sci 54:82–89
    • (2011) Sci China Life Sci , vol.54 , pp. 82-89
    • Yang, Y.1    Li, X.2    Yang, H.3    Qian, Y.4    Zhang, Y.5    Fang, R.6    Chen, X.7
  • 105
    • 84873097320 scopus 로고    scopus 로고
    • Bacteriophage 5′ untranslated regions for control of plastid transgene expression
    • COI: 1:CAS:528:DC%2BC3sXhsFeitr0%3D, PID: 23053542
    • Yang H, Gray BN, Ahner BA, Hanson MR (2013) Bacteriophage 5′ untranslated regions for control of plastid transgene expression. Planta 237:517–527
    • (2013) Planta , vol.237 , pp. 517-527
    • Yang, H.1    Gray, B.N.2    Ahner, B.A.3    Hanson, M.R.4
  • 106
    • 84882646501 scopus 로고    scopus 로고
    • Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification
    • COI: 1:CAS:528:DC%2BC3sXhsFKlur7K, PID: 23601492
    • Yuki Y et al (2013) Induction of toxin-specific neutralizing immunity by molecularly uniform rice-based oral cholera toxin B subunit vaccine without plant-associated sugar modification. Plant Biotechnol J 11:799–808
    • (2013) Plant Biotechnol J , vol.11 , pp. 799-808
    • Yuki, Y.1
  • 107
    • 79953697416 scopus 로고    scopus 로고
    • Clinical development of plant-produced recombinant pharmaceuticals: vaccines, antibodies and beyond
    • COI: 1:CAS:528:DC%2BC38Xos1Whtw%3D%3D
    • Yusibov V, Streatfield SJ, Kushnir N (2011) Clinical development of plant-produced recombinant pharmaceuticals: vaccines, antibodies and beyond. Hum Vaccine 7(3):313–321
    • (2011) Hum Vaccine , vol.7 , Issue.3 , pp. 313-321
    • Yusibov, V.1    Streatfield, S.J.2    Kushnir, N.3
  • 108
    • 33644760771 scopus 로고    scopus 로고
    • A truncated hepatitis E virus ORF2 protein expressed in tobacco plastids is immunogenic in mice
    • COI: 1:CAS:528:DC%2BD28Xis1yitrg%3D, PID: 16482635
    • Zhou YX, Lee MY, Ng JM, Chye ML, Yip WK, Zee SY, Lam E (2006) A truncated hepatitis E virus ORF2 protein expressed in tobacco plastids is immunogenic in mice. World J Gastroenterol 12:306–312
    • (2006) World J Gastroenterol , vol.12 , pp. 306-312
    • Zhou, Y.X.1    Lee, M.Y.2    Ng, J.M.3    Chye, M.L.4    Yip, W.K.5    Zee, S.Y.6    Lam, E.7
  • 109
    • 84886882822 scopus 로고    scopus 로고
    • Engineering metabolic pathways in plants by multigene transformation
    • COI: 1:CAS:528:DC%2BC2cXksF2rtr0%3D, PID: 24166439
    • Zorrilla-Lopez U, Masip G, Arj´o G, Bai C, Banakar R et al (2013) Engineering metabolic pathways in plants by multigene transformation. Int J Dev Biol 57:565–576
    • (2013) Int J Dev Biol , vol.57 , pp. 565-576
    • Zorrilla-Lopez, U.1    Masip, G.2    Arj´o, G.3    Bai, C.4    Banakar, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.