Current trends in edible vaccine development using transgenic plants

Biotechnology and Bioprocess Engineering

Volumn 15, Issue 1, 2010, Pages 61-65

  Kim, Tae Geum ^a   Yang, Moon Sik ^a  

^a Chonbuk National University   (South Korea)

Author keywords

Edible vaccine; Plant based vaccine; Transgenic plant

Indexed keywords

CLINICAL TRIAL; CURRENT TRENDS; EDIBLE VACCINE; EDIBLE VACCINES; IMMUNE RESPONSE; IMMUNE STIMULATION; IMMUNE TOLERANCES; TRANSGENIC PLANTS;

AGRICULTURE; ANIMALS; GENETICALLY MODIFIED PLANTS; IMMUNOLOGY;

VACCINES;

ANTIGEN; EDIBLE VACCINE;

CLINICAL TRIAL; DENTAL CARIES; DIARRHEA; HEPATITIS B; HUMAN; IMMUNE RESPONSE; MAIZE; MUCOSAL IMMUNITY; NEWCASTLE DISEASE; NONHODGKIN LYMPHOMA; PLANT VIRUS; POTATO; RABIES; REVIEW; SPINACH; TOBACCO; TRANSGENIC PLANT; VIRUS INFECTION;

ANIMALIA;

EID: 77953598981     PISSN: 12268372     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12257-009-3084-2     Document Type: Review

References (32)

1. Yusibov, V., S. Rabindran, U. Commandeur, R. M. Twyman, and R. Fischer (2006) The potential of plant virus vectors for vaccine production. Drugs R. D. 7: 203-217.
2. Gleba, Y., V. Klimyuk, and S. Marillonnet (2007) Viral vectors for the expression of proteins in plants. Curr. Opin. Biotechnol. 18: 134-141.
3. Marillonnet, S., C. Thoeringer, R. Kandzia, V. Klimyuk, and Y. Gleba (2005) Systemic Agrobacterium tumefaciens- mediated transfection of viral replicons for efficient transient expression in plants. Nat. Biotechnol. 23: 718-723.
4. Fischer, R., E. Stoger, S. Schillberg, P. Christou, and R. M. Twyman (2004) Plant-based production of biopharmaceuticals. Curr. Opin. Plant Biol. 7: 152-158.
5. Rybicki, E. P. (2009) Plant-produced vaccines: promise and reality. Drug Discov. Today 14: 16-24.
6. Daniell, H., S. Chebolu, S. Kumar, M. Singleton, and R. Falconer (2005) Chloroplast-derived vaccine antigens and other therapeutic proteins. Vaccine 23: 1779-1783.
7. Yu, J. and W. H. R. Langridge (2001) A plant-based multicomponent vaccine protects mice from enteric diseases. Nat. Biotechnol. 19: 548-552.
8. Hiatt, A., R. Cafferkey, and K. Bowdish (1989) Production of antibodies in transgenic plants. Nature 342: 76-78.
9. Haq, T. A., H. S. Mason, J. D. Clements, and C. J. Arntzen (1995) Oral immunization with a recombinant bacterial antigen produced in transgenic plants. Science 268: 714-716.
10. Dalsgaard, K., A. Uttenthal, T. D. Jones, F. Xu, A. Merryweather, W. D. Hamilton, J. P. Langeveld, R. S. Boshuizen, S. Kamstrup, G. P. Lomonossoff, C. Porta, C. Vela, J. I. Casal, R. H. Meloen, and P. B. Rodgers (1997) Plant-derived vaccine protects target animals against a viral disease. Nat. Biotechnol. 15: 248-252.
11. Castanon, S., M. S. Marin, J. M. Martin-Alonso, J. A. Boga, R. Casais, J. M. Humara, R. J. Ordas, and F. Parra (1999) Immunization with potato plants expressing VP60 protein protects against rabbit hemorrhagic disease virus. J. Virol. 73: 4452-4455.
12. Wigdorovitz, A., D. M. Perez Filgueira, N. Robertson, C. Carrillo, M. V. Borca, T. J. Morris, and A. M. Sadir (1999) Protection of mice against challenge with foot and mouth disease virus (FMDV) by immunization with foliar extracts from plants infected with recombinant tobacco mosaic virus expressing the FMDV structural protein VP1. Virology 264: 85-91.
13. Lamphear, B. J., J. M. Jilka, L. Kesl, M. Welter, J. A. Howard, and S. J. Streatfield (2004) A corn-based delivery system for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine. Vaccine 22: 2420-2424.
14. Turpen, T. H., S. J. Reinl, Y. Charoenvit, S. L. Hoffman, V. Fallarme, and L. K. Grill (1995) Malarial epitopes expressed on the surface of recombinant tobacco mosaic virus. Biotechnology 13: 53-57.
15. Mason, H. S., J. M. Ball, J. J. Shi, X. Jiang, M. K. Estes, and C. J. Arntzen (1996) Expression of norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proc. Natl. Acad. Sci. USA 93: 5335-5340.
16. Arakawa, T., D. K. Chong, and W. H. Langridge (1998) Efficacy of a food plant-based oral cholera toxin B subunit vaccine. Nat. Biotechnol. 16: 292-297.
17. Mason, H. S., J. M. Ball, J. J. Shi, X. Jiang, M. K. Estes, and C. J. Arntzen (1998) Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene. Vaccine 16: 1336-1343.
18. Rose, R. C., C. Lane, S. Wilson, J. A. Suzich, E. Rybicki, and A. L. Williamson (1999) Oral vaccination of mice with human papillomavirus virus-like particles induces systemic virus-neutralizing antibodies. Vaccine 17: 2129-2135.
19. Tacket, C. O., H. S. Mason, G. Losonsky, M. K. Estes, M. M. Levine, and C. J. Arntzen (2000) Human immune responses to a novel norwalk virus vaccine delivered in transgenic potatoes. J. Infect. Dis. 182: 302-305.
20. Kong, Q., L. Richter, Y. F. Yang, C. J. Arntzen, H. S. Mason, and Y. Thanavala (2001) Oral immunization with hepatitis B surface antigen expressed in transgenic plants. Proc. Natl. Acad. Sci. USA 98: 11539-11544.
21. Horn, M. E., K. M. Pappu, M. R. Bailey, R. C. Clough, M. Barker, J. M. Jilka, J. A. Howard, and S. J. Streatfield (2003) Advantageous features of plant-based systems for the development of HIV vaccines. J. Drug Target. 11: 539-545.
22. Choi, N. W., M. K. Estes, and W. H. Langridge (2005) Synthesis and assembly of a cholera toxin B subunitrotavirus VP7 fusion protein in transgenic potato. Mol. Biotechnol. 31: 193-202.
23. Thanavala, Y., M. Mahoney, S. Pal, A. Scott, Richter, N. Natarajan, P. Goodwin, C. J. Arntzen, and H. S. Mason (2005) Immunogenicity in humans of an edible vaccine for hepatitis B. Proc. Natl. Acad. Sci. USA 102: 3378-3382.
24. Wu, Y. Z., J. T. Li, Z. R. Mou, L. Fei, B. Ni, M. Geng, Z. C. Jia, W. Zhou, L. Y. Zou, and Y. Tang (2003) Oral immunization with rotavirus VP7 expressed in transgenic potatoes induced high titers of mucosal neutralizing IgA. Virology 313: 337-342.
25. Tregoning, J. S., S. Clare, F. Bowe, L. Edwards, N. Fairweather, O. Qazi, P. J. Nixon, P. Maliga, G. Dougan, and T. Hussell (2005) Protection against tetanus toxin using a plant-based vaccine. Eur. J. Immunol. 35: 1320-1326.
26. Hiroi, T. and F. Takaiwa (2006) Peptide immunotherapy for allergic diseases using a rice-based edible vaccine. Curr. Opin. Allergy Clin. Immunol. 6: 455-460.
27. Golovkin, M., S. Spitsin, S., V. Andrianov, Y. Smirnov, Y. Xiao, N. Pogrebnyak, K. Markley, R. Brodzik, Y. Gleba, S. N. Isaacs, and H. Koprowski (2007) Smallpox subunit vaccine produced in planta confers protection in mice. Proc. Natl. Acad. Sci. USA 104: 6864-6869.
28. Li, J.T., L. Fei, Z. R. Mou, J. Wei, Y. Tang, H. Y. He, L. Wang, and Y. Z. Wu (2006) Immunogenicity of a plantderived edible rotavirus subunit vaccine transformed over fifty generations. Virology 356: 171-178.
29. Massa, S., R. Franconi, R. Brandi, A. Muller, V. Mett, V. Yusibo, and A. Venuti (2007) Anti-cancer activity of plant-produced HPV16 E7 vaccine. Vaccine 25: 3018-3021.
30. McCormick, A. A., S. Reddy, S. J. Reinl, T. I. Cameron, D. K. Czerwinski, F. Vojdani, K. M. Hanley, S. J. Garger, E. L. White, J. Novak, J. Barrett, R. B. Holtz, D. Tuse, and R. Levy (2008) Plant-produced idiotype vaccines for the treatment of non-Hodgkin's lymphoma: safety and immunogenicity in a phase I clinical study. Proc. Natl. Acad. Sci. USA 105: 10131-10136.
31. Tiwari, S., P. C. Verma, P. K. Singh, and R. Tuli (2009) Plants as bioreactors for the production of vaccine antigens. Biotechnol. Adv. 27: 449-467.
32. Kaiser, J. (2008) Is the drought over for pharming?. Science 320: 473-475.