Immunogenicity and virus-like particle formation of rotavirus capsid proteins produced in transgenic plants

Science China Life Sciences

Volumn 54, Issue 1, 2011, Pages 82-89

  Yang, Yan Mei ^a,b,c   Li, Xia ^d   Yang, Hui ^d   Qian, Yuan ^e   Zhang, You ^e   Fang, Rong Xiang ^a,b   Chen, Xiao Ying ^a,b  

^a INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

^b National Plant Gene Research Center   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^d INSTITUTE OF PLANT AND ENVIRONMENT PROTECTION   (China)

^e CAPITAL INSTITUTE OF PEDIATRICS   (China)

Author keywords

immunogenicity; oral vaccine; rotavirus; transgenic plant; virus like particles

Indexed keywords

MIRIDAE; MUS; NICOTIANA OBTUSIFOLIA; NICOTIANA TABACUM; ROTAVIRUS; ROTAVIRUS A;

EID: 78751648047     PISSN: 16747305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11427-010-4104-3     Document Type: Article

References (43)

1. O'Ryan M, Prado V, Pickering L K. A millennium update on pediatric diarrheal illness in the developing world. Semin Pediatr Infect Dis, 2005, 16: 125-136.
2. Banos D M, Lopez S, Arias C F, et al. Identification of a T-helper cell epitope on the rotavirus VP6 protein. J Virol, 1997, 71: 419-426.
3. Estes M K, Crawford S E, Penaranda M E, et al. Synthesis and immunogenicity of the rotavirus major capsid antigen using a baculovirus expression system. J Virol, 1987, 61: 1488-1494.
4. Offit P A, Shaw R D, Greenberg H B. Passive protection against rotavirus-induced diarrhea by monoclonal antibodies to surface proteins vp3 and vp7. J Virol, 1986, 58: 700-703.
5. Matsui S M, Offit P A, Vo P T, et al. Passive protection against rotavirus-induced diarrhea by monoclonal antibodies to the heterotypic neutralization domain of VP7 and the VP8 fragment of VP4. J Clin Microbiol, 1989, 27: 780-782.
6. Mackow E R, Vo P T, Broome R, et al. Immunization with baculovirus-expressed VP4 protein passively protects against simian and murine rotavirus challenge. J Virol, 1990, 64: 1698-1703.
7. Andrew M E, Boyle D B, Coupar B E, et al. Vaccinia-rotavirus VP7 recombinants protect mice against rotavirus-induced diarrhoea. Vaccine, 1992, 10: 185-191.
8. Both G W, Lockett L J, Janardhana V, et al. Protective immunity to rotavirus-induced diarrhoea is passively transferred to newborn mice from naive dams vaccinated with a single dose of a recombinant adenovirus expressing rotavirus VP7sc. Virol, 1993, 193: 940-950.
9. Kapikian A Z, Hoshino Y, Chanock R M, et al. Efficacy of a quadrivalent rhesus rotavirus-based human rotavirus vaccine aimed at preventing severe rotavirus diarrhea in infants and young children. J Infect Dis, 1996, 174: S65-72.
10. Centers for Disease Control and Prevention. Withdrawal of rotavirus vaccine recommendation. Jama, 1999, 282: 2113-2114.
11. Madhi S A, Cunliffe N A, Steele D, et al. Effect of human rotavirus vaccine on severe diarrhea in African infants. N Engl J Med, 2010, 362: 289-298.
12. Richardson V, Hernandez-Pichardo J, Quintanar-Solares M, et al. Effect of rotavirus vaccination on death from childhood diarrhea in Mexico. N Engl J Med, 2010, 362: 299-305.
13. Vesikari T, Karvonen A, Korhonen T, et al. Safety and immunogenicity of RIX4414 live attenuated human rotavirus vaccine in adults, toddlers and previously uninfected infants. Vaccine, 2004, 22: 2836-2842.
14. Ruiz-Palacios G M, Perez-Schael I, Velazquez F R, et al. Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. N Engl J Med, 2006, 354: 11-22.
15. Vesikari T, Clark H F, Offit P A, et al. Effects of the potency and composition of the multivalent human-bovine (WC3) reassortant rotavirus vaccine on efficacy, safety and immunogenicity in healthy infants. Vaccine, 2006, 24: 4821-4829.
16. Choi A H, Basu M, Rae M N, et al. Particle-bombardment-mediated DNA vaccination with rotavirus VP4 or VP7 induces high levels of serum rotavirus IgG but fails to protect mice against challenge. Virol, 1998, 250: 230-240.
17. Bachmann M F, Rohrer U H, Kundig T M, et al. The influence of antigen organization on B cell responsiveness. Science, 1993, 262: 1448-1451.
18. Bachmann M F, Zinkernagel R M, Oxenius A. Immune responses in the absence of costimulation: Viruses know the trick. J Immunol, 1998, 161: 5791-5794.
19. Jiang X, Wang M, Graham D Y, et al. Expression, self-assembly, and antigenicity of the Norwalk virus capsid protein. J Virol, 1992, 66: 6527-6532.
20. Ciarlet M, Crawford S E, Barone C, et al. Subunit rotavirus vaccine administered parenterally to rabbits induces active protective immunity. J Virol, 1998, 72: 9233-9246.
21. McNeal M M, Rae M N, Conner M E, et al. Stimulation of local immunity and protection in mice by intramuscular immunization with triple- or double-layered rotavirus particles and QS-21. Virol, 1998, 243: 158-166.
22. O'Neal C M, Clements J D, Estes M K, et al. Rotavirus 2/6 viruslike particles administered intranasally with cholera toxin, Escherichia coli heat-labile toxin (LT), and LT-R192G induce protection from rotavirus challenge. J Virol, 1998, 72: 3390-3393.
23. Yuan L, Geyer A, Hodgins D C, et al. Intranasal administration of 2/6-rotavirus-like particles with mutant Escherichia coli heat-labile toxin (LT-R192G) induces antibody-secreting cell responses but not protective immunity in gnotobiotic pigs. J Virol, 2000, 74: 8843-8853.
24. Yuan L, Saif L J. Induction of mucosal immune responses and protection against enteric viruses: Rotavirus infection of gnotobiotic pigs as a model. Vet Immunol Immunopathol, 2002, 87: 147-160.
25. Conner M E, Crawford S E, Barone C, et al. Rotavirus subunit vaccines. Arch Virol, 1996, 12: 199-206.
26. Jiang B, Estes M K, Barone C, et al. Heterotypic protection from rotavirus infection in mice vaccinated with virus-like particles. Vaccine, 1999, 17: 1005-1013.
27. Coste A, Sirard J C, Johansen K, et al. Nasal immunization of mice with virus-like particles protects offspring against rotavirus diarrhea. J Virol, 2000, 74: 8966-8971.
28. Cimolai N. Do mycoplasmas cause human cancer? Can J Microbiol, 2001, 47: 691-697.
29. Streatfield S J, Howard J A. Plant production systems for vaccines. Expert Rev Vaccines, 2003, 2: 763-775.
30. Tacket C O. Plant-derived vaccines against diarrhoeal diseases. Expert Opin Biol Ther, 2004, 4: 719-728.
31. Streatfield S J. Oral hepatitis B vaccine candidates produced and delivered in plant material. Immunol Cell Biol, 2005, 83: 257-262.
32. Mason H S, Ball J M, Shi J J, et al. Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Proc Natl Acad Sci USA, 1996, 93: 5335-5340.
33. Warzecha H, Mason H S, Lane C, et al. Oral immunogenicity of human papillomavirus-like particles expressed in potato. J Virol, 2003, 77: 8702-8711.
34. Santi L, Batchelor L, Huang Z, et al. An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles. Vaccine, 2008, 26: 1846-1854.
35. Kohl T, Hitzeroth I I, Stewart D, et al. Plant-produced cottontail rabbit papillomavirus L1 protein protects against tumor challenge: A proof-of-concept study. Clin Vaccine Immunol, 2006, 13: 845-853.
36. Mason H S, Lam D M, Arntzen C J. Expression of hepatitis B surface antigen in transgenic plants. Proc Natl Acad Sci USA, 1992, 89: 11745-11749.
37. Huang Z, Elkin G, Maloney B J, et al. Virus-like particle expression and assembly in plants: Hepatitis B and Norwalk viruses. Vaccine, 2005, 23: 1851-1858.
38. Saldana S, Esquivel Guadarrama F, Olivera Flores T de J, et al. Production of rotavirus-like particles in tomato (Lycopersicon esculentum L.) fruit by expression of capsid proteins VP2 and VP6 and immunological studies. Viral immunol, 2006, 19: 42-53.
39. Greco R, Michel M, Guetard D, et al. Production of recombinant HIV-1/HBV virus-like particles in Nicotiana tabacum and Arabidopsis thaliana plants for a bivalent plant-based vaccine. Vaccine, 2007, 25: 8228-8240.
40. Vieira H L, Estevao C, Roldao A, et al. Triple layered rotavirus VLP production: Kinetics of vector replication, mRNA stability and recombinant protein production. J Biotechnol, 2005, 120: 72-82.
41. Roldao A, Vieira H L A, Alves P M, et al. Intracellular dynamics in rotavirus-like particles production: Evaluation of multigene and monocistronic infection strategies. Proc Biochem, 2006, 41: 2188-2199.
42. Petitpas I, Lepault J, Vachette P, et al. Crystallization and preliminary X-ray analysis of rotavirus protein VP6. J Virol, 1998, 72: 7615-7619.
43. Lepault J, Petitpas I, Erk I, et al. Structural polymorphism of the major capsid protein of rotavirus. EMBO J, 2001, 20: 1498-1507.