Pathologic and molecular profiling of rapid-onset fibrosis and inflammation induced by multi-walled carbon nanotubes

Archives of Toxicology

Volumn 89, Issue 4, 2015, Pages 621-633

  Dong, Jie ^a   Porter, Dale W ^a   Batteli, Lori A ^a   Wolfarth, Michael G ^a   Richardson, Diana L ^a   Ma, Qiang ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

Animal model; Cytokine; Growth factor; Inflammation; Lung fibrosis; Nanotoxicity

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 1 A1; COLLAGEN TYPE 2; COLLAGEN TYPE 2 A2; FIBRONECTIN; FN1 PROTEIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MULTI WALLED NANOTUBE; PLATELET DERIVED GROWTH FACTOR A; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ALPHA 2(I) COLLAGEN; CARBON NANOTUBE; COLLAGEN TYPE I, ALPHA 1 CHAIN; CYTOKINE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLLAGEN FIBER; FIBROSING ALVEOLITIS; GENE EXPRESSION; LUNG PARENCHYMA; MACROPHAGE; MALE; MOLECULAR PATHOLOGY; MOUSE; NANOTOXICOLOGY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ADVERSE EFFECTS; ANIMAL; BRONCHOALVEOLAR LAVAGE FLUID; C57BL MOUSE; CHEMICALLY INDUCED; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; EXPOSURE; GENETICS; IMMUNOLOGY; LUNG; LUNG FIBROSIS; METABOLISM; PATHOLOGY; TIME;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; COLLAGEN TYPE I; CYTOKINES; FIBRONECTINS; INHALATION EXPOSURE; LUNG; MALE; MICE, INBRED C57BL; NANOTUBES, CARBON; PULMONARY FIBROSIS; TIME FACTORS;

EID: 84925511027     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1428-y     Document Type: Article

References (40)

1. Blobe GC, Schiemann WP, Lodish HF (2000) Role of transforming growth factor beta in human disease. N Engl J Med 342(18):1350–1358. doi:10.1056/NEJM200005043421807
2. Bonner JC (2004) Regulation of PDGF and its receptors in fibrotic diseases. Cytokine Growth Factor Rev 15(4):255–273. doi:10.1016/j.cytogfr.2004.03.006
3. Brody AR, Roe MW (1983) Deposition pattern of inorganic particles at the alveolar level in the lungs of rats and mice. Am Rev Respir Dis 128(4):724–729
4. Bus JS, Gibson JE (1984) Paraquat: model for oxidant-initiated toxicity. Environ Health Perspect 55:37–46
5. Buzea C, Pacheco II, Robbie K (2007) Nanomaterials and nanoparticles: sources and toxicity. Biointerphases 2(4):MR17–MR71
6. Castranova V, Vallyathan V (2000) Silicosis and coal workers’ pneumoconiosis. Environ Health Perspect 108(Suppl 4):675–684
7. Dales RE, Munt PW (1982) Farmer’s lung disease. Can Fam Physician Med 28:1817–1820
8. De Volder MF, Tawfick SH, Baughman RH, Hart AJ (2013) Carbon nanotubes: present and future commercial applications. Science 339(6119):535–539. doi:10.1126/science.1222453
9. Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G (1993) Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J cell biol 122(1):103–111
10. Donaldson K, Aitken R, Tran L et al (2006) Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety. Toxicol Sci 92(1):5–22. doi:10.1093/toxsci/kfj130
11. Fielding CA, Jones GW, McLoughlin RM et al (2014) Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity 40(1):40–50. doi:10.1016/j.immuni.2013.10.022
12. Gharaee-Kermani M, Denholm EM, Phan SH (1996) Costimulation of fibroblast collagen and transforming growth factor beta1 gene expression by monocyte chemoattractant protein-1 via specific receptors. J Biol Chem 271(30):17779–17784
13. Hasegawa M, Fujimoto M, Kikuchi K, Takehara K (1997) Elevated serum tumor necrosis factor-alpha levels in patients with systemic sclerosis: association with pulmonary fibrosis. J Rheumatol 24(4):663–665
14. He X, Young SH, Schwegler-Berry D, Chisholm WP, Fernback JE, Ma Q (2011) Multiwalled carbon nanotubes induce a fibrogenic response by stimulating reactive oxygen species production, activating NF-kappaB signaling, and promoting fibroblast-to-myofibroblast transformation. Chem Res Toxicol 24(12):2237–2248. doi:10.1021/tx200351d
15. He X, Young SH, Ferback JE, Ma Q (2012) Single-walled carbon nanotubes induce fibrogenic effect by disturbing mitochondrial oxidative stress and activating NF-κB signaling. J Clin Toxicol S5:005. doi:10.4172/2161-0495.S5-005
16. Hubner RH, Gitter W, El Mokhtari NE, et al. (2008) Standardized quantification of pulmonary fibrosis in histological samples. Biotechniques 44(4):507–511, 514–517. doi:10.2144/000112729
17. Kolb M, Margetts PJ, Anthony DC, Pitossi F, Gauldie J (2001) Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis. J Clin Invest 107(12):1529–1536. doi:10.1172/JCI12568
18. Lesur OJ, Mancini NM, Humbert JC, Chabot F, Polu JM (1994) Interleukin-6, interferon-gamma, and phospholipid levels in the alveolar lining fluid of human lungs. Profiles in coal worker’s pneumoconiosis and idiopathic pulmonary fibrosis. Chest 106(2):407–413
19. Maynard AM, Kuempel ED (2005) Airborne nanostructured particles and occupational health. J Nanopart Res 7:587–614
20. Mercer RR, Hubbs AF, Scabilloni JF et al (2010) Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes. Part Fibre Toxicol 7:28. doi:10.1186/1743-8977-7-28
21. Mercer RR, Hubbs AF, Scabilloni JF et al (2011) Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes. Part Fibre Toxicol 8:21. doi:10.1186/1743-8977-8-21
22. Mercer RR, Scabilloni JF, Hubbs AF et al (2013a) Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes. Part Fibre Toxicol 10(1):33. doi:10.1186/1743-8977-10-33
23. Mercer RR, Scabilloni JF, Hubbs AF et al (2013b) Extrapulmonary transport of MWCNT following inhalation exposure. Part Fibre Toxicol 10(1):38. doi:10.1186/1743-8977-10-38
24. Miyazaki Y, Araki K, Vesin C et al (1995) Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis. J Clin Invest 96(1):250–259. doi:10.1172/JCI118029
25. Moore BB, Hogaboam CM (2008) Murine models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 294(2):L152–L160. doi:10.1152/ajplung.00313.2007
26. Mouratis MA, Aidinis V (2011) Modeling pulmonary fibrosis with bleomycin. Curr Opin Pulm Med 17(5):355–361. doi:10.1097/MCP.0b013e328349ac2b
27. NIOSH (2013) Current strategies for engineering controls in nanomaterial production and downstream handling processes, vol HDDS (NIOSH) Publication No. 2014-102. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati
28. O’Reilly KM, McLaughlin AM, Beckett WS, Sime PJ (2007) Asbestos-related lung disease. Am Fam Physician 75(5):683–688
29. Porter DW, Sriram K, Wolfarth MG et al (2008) A biocompatible medium for nanoparticle dispersion. Nanotoxicology 2:144–154
30. Porter DW, Hubbs AF, Mercer RR et al (2010) Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes. Toxicology 269(2–3):136–147. doi:10.1016/j.tox.2009.10.017
31. Porter DW, Hubbs AF, Chen BT et al (2013) Acute pulmonary dose-responses to inhaled multi-walled carbon nanotubes. Nanotoxicology 7(7):1179–1194. doi:10.3109/17435390.2012.719649
32. Rao GV, Tinkle S, Weissman DN et al (2003) Efficacy of a technique for exposing the mouse lung to particles aspirated from the pharynx. J Toxicol Environ Health Part A 66(15):1441–1452. doi:10.1080/15287390306417
33. Rom WN (2007) Environmental and occupational medicine, 4th edn. Lippincott Williams and Wilkins, Philadelphia
34. Ryman-Rasmussen JP, Cesta MF, Brody AR et al (2009) Inhaled carbon nanotubes reach the subpleural tissue in mice. Nat Nanotechnol 4(11):747–751. doi:10.1038/nnano.2009.305
35. Shvedova AA, Kisin ER, Mercer R et al (2005) Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 289(5):L698–L708. doi:10.1152/ajplung.00084.2005
36. Suwara MI, Green NJ, Borthwick LA et al (2014) IL-1alpha released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts. Mucosal Immunol 7(3):684–693. doi:10.1038/mi.2013.87
37. Trojanowska M (2008) Role of PDGF in fibrotic diseases and systemic sclerosis. Rheumatology 47(Suppl 5):v2–v4. doi:10.1093/rheumatology/ken265
38. Wynn TA (2011) Integrating mechanisms of pulmonary fibrosis. J Exp Med 208(7):1339–1350. doi:10.1084/jem.20110551
39. Zhang Y, Lee TC, Guillemin B, Yu MC, Rom WN (1993) Enhanced IL-1 beta and tumor necrosis factor-alpha release and messenger RNA expression in macrophages from idiopathic pulmonary fibrosis or after asbestos exposure. J Immunol 150(9):4188–4196
40. Zhang Q, Huang JQ, Qian WZ, Zhang YY, Wei F (2013) The road for nanomaterials industry: a review of carbon nanotube production, post-treatment, and bulk applications for composites and energy storage. Small 9(8):1237–1265. doi:10.1002/smll.201203252