Efficacy of a technique for exposing the mouse lung to particles aspirated from the pharynx

Journal of Toxicology and Environmental Health - Part A

Volumn 66, Issue 15, 2003, Pages 1441-1452

  Rao, G V S ^a   Tinkle, Sally ^a   Weissman, David N ^a   Antonini, James M ^a   Kashon, Michael L ^a   Salmen, Rebecca ^a   Battelli, Lori A ^a   Willard, Patsy A ^a   Hubbs, Ann F ^a,b   Hoover, Mark D ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b M/S 2015 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; BERYLLIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT DYES; IMAGE PROCESSING, COMPUTER-ASSISTED; INHALATION; LUNG; MICE; MICE, INBRED C3H; MICROSCOPY, CONFOCAL; MICROSPHERES; PHARYNX;

VERTEBRATA;

EID: 0042623422     PISSN: 15287394     EISSN: None     Source Type: Journal    
DOI: 10.1080/15287390306417     Document Type: Article

References (15)

1. Baak, J. P. 1987. Analytical and quantitative cytology and histology. Anal. Quant. Cytol. Histol. 9:89-95.
2. Brain, J. D., Knudson, D. E., Sorokin, S. E., and Davis, M. A. 1976. Pulmonary distribution of particles given by intratracheal instillation or by aerosol inhalation. Environ. Res. 11:13-33.
3. Brain, J. D., and Valberg, P. A. 1979. Deposition of aerosol in the respiratory tract. Am. Rev. Respir. Dis. 120:1325-1373.
4. Dorries, A. M., and Valberg, P. A. 1992. Heterogeneity of phagocytosis for inhaled versus instilled material. Am. Rev. Respir. Dis. 146:831-837.
5. Driscoll, K. E., Costa, D. L., Hatch, G., Henderson, R., Oberdorster, G., Salem, H., and Schlesinger, R. B. 2000. Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: Uses and limitations. Toxicol. Sci. 55:24-35.
6. Hatch, G. E., Slade, R., Boykin, E., Hu, P. C., Miller, F. J., and Gardner, D. E. 1981. Correlation of effects of inhaled versus intratracheally injected metals on susceptibility to respiratory infection in mice. Am. Rev. Respir. Dis. 124:67-173.
7. Henderson, R. F., Driscoll, K. E., Harkema, J. R., Lindenschmidt, R. C., Chang, I-Y, Maples, K. R., and Barr, E. B. 1995. A comparison of the inflammatory response of the lung to inhaled versus instilled particles in F344 rats. Fundam. Appl. Toxicol. 24:183-197.
8. Keane-Myers, A. M., Gause, W. C., Finkleman, F. D., Xhou, X.-D., and Wills-Karp, M. 1998. Development of murine allergic asthma is dependent upon B7-2 costimulation. J. Immunol. 160:1036-1043.
9. Leong, B. K. J., Coombs, J. K., Sabitis, C. P., Rop, D. A., and Aaron, C. S. 1998. Quantitative morphometric analysis of pulmonary deposition of aerosol particles inhaled via intratracheal nebulization, intratracheal instillation or nose-only inhalation in rats. J. Appl. Toxicol. 18:49-160.
10. Pritchard, J. N., Holmes, A., Evans, N., Evans, R. J., and Morgan, A. 1985. The distribution of dust in the rat lung following administration by inhalation and by single intratracheal instillation. Environ. Res. 36:268-297.
11. Ritz, H. L, Evans, B. L. B., Bruce, R. D., Fletcher, E. R., Fisher, G. L., and Sarlo, K. 1993. Respiratory and immunological responses of guinea pigs to enzyme-containing detergents: A comparison of intratracheal and inhalation modes of exposure. Fundam. Appl. Toxicol. 21:31-37.
12. Saffiotti, U., Cefis, F., and Kolb, L. H. 1968. A method for the experimental induction of bronchogenic carcinoma. Cancer. Res. 28:104-124.
13. Sherwood, R. L., Thomas, P. T., Kawanishi, C. Y., and Fenters, J. D. 1988. Comparison of Streptococcus zooepidemicus and influenza virus pathogenecity in mice by three exposure routes. Appl. Environ. Microbiol. 54:1744-1751.
14. Sweeney, T. D., and Brain, J. D. 1991. Pulmonary deposition: Determinants and measurement techniques. Toxicol. Pathol. 19:384-397.
15. Zeltner, T. B., Seeney, T. D., Skornik, W. A., Feldman, H. A., and Brain, J. D. 1991. Retention and clearance of 0.9-μm particles inhaled by hamsters during rest or exercise. J. Appl. Physiol. 70:1137-1145.