Role of PDGF in fibrotic diseases and systemic sclerosis

Rheumatology

Volumn 47, Issue SUPPL. 5, 2009, Pages

  Trojanowska, M ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Fibrosis; Myofibroblast; Platelet derived growth factor; Platelet derived growth factor receptor; Pulmonary arterial hypertension; Scleroderma; Transforming growth factor

Indexed keywords

IMATINIB; INTERLEUKIN 1ALPHA; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR AA; PLATELET DERIVED GROWTH FACTOR AB; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR BB; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET DERIVED GROWTH FACTOR C; PLATELET DERIVED GROWTH FACTOR D; STI 587; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

AUTOCRINE EFFECT; CELL DIFFERENTIATION; CELL PROLIFERATION; CONFERENCE PAPER; DRUG TARGETING; HUMAN; LUNG FIBROSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PULMONARY HYPERTENSION; SIGNAL TRANSDUCTION; SYSTEMIC SCLEROSIS;

EID: 69949153909     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/ken265     Document Type: Conference Paper

References (15)

1. Betsholtz C. Biology of platelet-derived growth factors in development. Birth Defects Res C Embryo Today 2003;69:272-85.
2. Tallquist M, Kazlauskas A. PDGF signalling in cells and mice. Cytokine Growth Factor Rev 2004;15:205-13.
3. Reigstad LJ, Varhaug JE, Lillehaug JR. Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family. FEBS J 2005;272:5723-41.
4. Alvarez RH, Kantarjian HM, Cortes JE. Biology of platelet-derived growth factor and its involvement in disease. Mayo Clin Proc 2006;81:1241-57.
5. Raines EW. PDGF and cardiovascular disease. Cytokine Growth Factor Rev 2004;15:237-54.
6. Schermuly RT, Dony E, Ghofrani HA et al. Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 2005;115:2811-21.
7. Bonner JC. Regulation of PDGF and its receptors in fibrotic diseases. Cytokine Growth Factor Rev 2004;15:255-73.
8. Floege J, Eitner F, Alpers CE. A new look at platelet-derived growth factor in renal disease. J Am Soc Nephrol 2008;19:12-23.
9. Gay S, Jones RE Jr, Huang GQ, Gay RE. Immunohistologic demonstration of platelet-derived growth factor (PDGF) and sis-oncogene expression in scleroderma. J Invest Dermatol 1989;92:301-3.
10. Klareskog L, Gustafsson R, Scheynius A, Hallgren R. Increased expression of platelet-derived growth factor type B receptors in the skin of patients with systemic sclerosis. Arthritis Rheum 1990;33:1534-41.
11. Yamakage A, Kikuchi K, Smith EA, LeRoy EC, Trojanowska M. Selective upregulation of platelet-derived growth factor alpha receptors by transforming growth factor beta in scleroderma fibroblasts. J Exp Med 1992;175:1227-34.
12. Ludwicka A, Ohba T, Trojanowska M et al. Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma. J Rheumatol 1995;22:1876-83.
13. Kawaguchi Y, Hara M, Wright TM. Endogenous IL-1alpha from systemic sclerosis fibroblasts induces IL-6 and PDGF-A. J Clin Invest 1999;103:1253-60.
14. Baroni SS, Santillo M, Bevilacqua F et al. Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Engl J Med 2006;354:2667-76.
15. Varga JA, Trojanowska M. Fibrosis in systemic sclerosis. Rheum Dis Clin North Am 2008;34:115-43.