IGF-1 Signaling via the PI3K/Akt Pathway Confers Neuroprotection in Human Retinal Pigment Epithelial Cells Exposed to Sodium Nitroprusside Insult

Journal of Molecular Neuroscience

Volumn 55, Issue 4, 2015, Pages 931-940

  Wang, Haitao ^a   Liao, Sufen ^a   Geng, Ruojun ^a   Zheng, Yongxin ^a   Liao, Rifang ^a   Yan, Fengxia ^a   Thrimawithana, Thilini ^b   Little, Peter J ^b   Feng, Zhong Ping ^c   Lazarovici, Philip ^d   Zheng, Wenhua ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b RMIT UNIVERSITY   (Australia)

^c UNIVERSITY OF TORONTO   (Canada)

^d HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Akt; Apoptosis; Insulin like growth factor 1; MAP kinase; Nitric oxide; Protection; Retinal pigment epithelium

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITROPRUSSIDE SODIUM; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN C; VISUAL PIGMENT; NEUROPROTECTIVE AGENT;

APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LIPID PEROXIDATION; METHYL THIAZOLYL TETRAZOLIUM ASSAY; MTT ASSAY; NEUROPROTECTION; OXIDATIVE STRESS; PIGMENT EPITHELIUM; RETINA PIGMENT CELL; RETINOPATHY; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL LINE; CYTOLOGY; DRUG EFFECTS; METABOLISM;

APOPTOSIS; CELL LINE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LIPID PEROXIDATION; MAP KINASE SIGNALING SYSTEM; NEUROPROTECTIVE AGENTS; NITROPRUSSIDE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RETINAL PIGMENT EPITHELIUM;

EID: 84925505883     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-014-0448-7     Document Type: Article

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