Insulin-like growth factor-1 secreted by brain microvascular endothelial cells attenuates neuron injury upon ischemia

FEBS Journal

Volumn 280, Issue 15, 2013, Pages 3658-3668

  Wang, Jun ^a   Tang, Yibo ^b   Zhang, Wei ^b   Zhao, Haiping ^c   Wang, Runjun ^b   Yan, Yangyang ^b   Xu, Liwei ^b   Li, Pengtao ^b  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

brain microvascular endothelial cells; insulin like growth factor 1 (IGF 1); ischemia; neuron

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; BRAIN MICROVASCULAR ENDOTHELIAL CELL; BRAIN TISSUE; CELL VIABILITY; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROVASCULAR ENDOTHELIAL CELL; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL LESION; NEUROLOGICAL AND SENSORIAL PROCEDURES; NEUROPROTECTION; NONHUMAN; OXYGEN GLUCOSE DEPRIVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

BRAIN MICROVASCULAR ENDOTHELIAL CELLS; INSULIN-LIKE GROWTH FACTOR-1 (IGF-1); ISCHEMIA; NEURON;

ANIMALS; APOPTOSIS; BRAIN; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; INFARCTION, MIDDLE CEREBRAL ARTERY; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 2; INSULIN-LIKE GROWTH FACTOR I; MALE; MICROVESSELS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, IGF TYPE 1;

RATTUS;

EID: 84880333783     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12359     Document Type: Article

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