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Volumn 228, Issue 1, 2013, Pages 129-141

The role of Akt/FoxO3a in the protective effect of venlafaxine against corticosterone-induced cell death in PC12 cells

Author keywords

Corticosterone; Neuroprotection; PI3K Akt FoxO3a; Venlafaxine

Indexed keywords

CORTICOSTERONE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHRL1; VENLAFAXINE;

EID: 84879196236     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-013-3017-9     Document Type: Article
Times cited : (57)

References (46)
  • 1
    • 2342496712 scopus 로고    scopus 로고
    • FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
    • 15137936 10.1016/S0092-8674(04)00452-0 1:CAS:528:DC%2BD2cXktlCqtrw%3D
    • Accili D, Arden KC (2004) FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117:421-426
    • (2004) Cell , vol.117 , pp. 421-426
    • Accili, D.1    Arden, K.C.2
  • 3
    • 0035150732 scopus 로고    scopus 로고
    • Overexpression of Akt inhibits NGF-induced growth arrest and neuronal differentiation of PC12 cells
    • 11112692 1:CAS:528:DC%2BD3MXhtVSgs7Y%3D
    • Bang OS, Park EK, Yang SI, Lee SR, Franke TF, Kang SS (2001) Overexpression of Akt inhibits NGF-induced growth arrest and neuronal differentiation of PC12 cells. J Cell Sci 114:81-88
    • (2001) J Cell Sci , vol.114 , pp. 81-88
    • Bang, O.S.1    Park, E.K.2    Yang, S.I.3    Lee, S.R.4    Franke, T.F.5    Kang, S.S.6
  • 4
    • 3042662118 scopus 로고    scopus 로고
    • Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression
    • 15173895
    • Barden N (2004) Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression. J Psychiatry Neurosci 29:185-193
    • (2004) J Psychiatry Neurosci , vol.29 , pp. 185-193
    • Barden, N.1
  • 5
    • 0035014321 scopus 로고    scopus 로고
    • Opposite effects of antidepressants and corticosterone on the sensitivity of hippocampal CA1 neurons to 5-HT1A and 5-HT4 receptor activation
    • 11383709 10.1007/s002100000389 1:CAS:528:DC%2BD3MXivVGhtbc%3D
    • Bijak M, Zahorodna A, Tokarski K (2001) Opposite effects of antidepressants and corticosterone on the sensitivity of hippocampal CA1 neurons to 5-HT1A and 5-HT4 receptor activation. Naunyn Schmiedebergs Arch Pharmacol 363:491-498
    • (2001) Naunyn Schmiedebergs Arch Pharmacol , vol.363 , pp. 491-498
    • Bijak, M.1    Zahorodna, A.2    Tokarski, K.3
  • 6
    • 80051596764 scopus 로고    scopus 로고
    • Neurotoxicity induced by dexamethasone in the human neuroblastoma SH-SY5Y cell line can be prevented by folic acid
    • 21640799 10.1016/j.neuroscience.2011.05.053 1:CAS:528:DC%2BC3MXhtVaju7fL
    • Budni J, Romero A, Molz S, Martín-de-Saavedra MD, Egea J, Del Barrio L, Tasca CI, Rodrigues AL, López MG (2011) Neurotoxicity induced by dexamethasone in the human neuroblastoma SH-SY5Y cell line can be prevented by folic acid. Neuroscience 190:346-353
    • (2011) Neuroscience , vol.190 , pp. 346-353
    • Budni, J.1    Romero, A.2    Molz, S.3    Martín-De-Saavedra, M.D.4    Egea, J.5    Del Barrio, L.6    Tasca, C.I.7    Rodrigues, A.L.8    López, M.G.9
  • 8
    • 0032493304 scopus 로고    scopus 로고
    • Lithium acutely inhibits and chronically up-regulates and stabilizes glutamate uptake by presynaptic nerve endings in mouse cerebral cortex
    • 9653192 10.1073/pnas.95.14.8363 1:CAS:528:DyaK1cXks1SlsLY%3D
    • Dixon JF, Hokin LE (1998) Lithium acutely inhibits and chronically up-regulates and stabilizes glutamate uptake by presynaptic nerve endings in mouse cerebral cortex. Proc Natl Acad Sci U S A 95:8363-8368
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 8363-8368
    • Dixon, J.F.1    Hokin, L.E.2
  • 9
    • 79956125379 scopus 로고    scopus 로고
    • In search of HPA axis dysregulation in child and adolescent depression
    • 21290178 10.1007/s10567-011-0084-5
    • Guerry JD, Hastings PD (2011) In search of HPA axis dysregulation in child and adolescent depression. Clin Child Fam Psychol Rev 14:135-160
    • (2011) Clin Child Fam Psychol Rev , vol.14 , pp. 135-160
    • Guerry, J.D.1    Hastings, P.D.2
  • 10
    • 46249091103 scopus 로고    scopus 로고
    • The link between childhood trauma and depression: Insights from HPA axis studies in humans
    • 18602762 10.1016/j.psyneuen.2008.03.008 1:CAS:528:DC%2BD1cXosVyjsbk%3D
    • Heim C, Newport DJ, Mletzko T, Miller AH, Nemeroff CB (2008) The link between childhood trauma and depression: insights from HPA axis studies in humans. Psychoneuroendocrinology 33:693-710
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 693-710
    • Heim, C.1    Newport, D.J.2    Mletzko, T.3    Miller, A.H.4    Nemeroff, C.B.5
  • 11
    • 0031015517 scopus 로고    scopus 로고
    • Neurocircuitry of stress: Central control of the hypothalamo-pituitary- adrenocortical axis
    • 9023876 10.1016/S0166-2236(96)10069-2 1:CAS:528:DyaK2sXhtFWqu7c%3D
    • Herman JP, Cullinan WE (1997) Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci 20:78-84
    • (1997) Trends Neurosci , vol.20 , pp. 78-84
    • Herman, J.P.1    Cullinan, W.E.2
  • 12
    • 0032895726 scopus 로고    scopus 로고
    • The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety
    • 10367986 10.1016/S0022-3956(98)90056-5 1:STN:280:DyaK1M3psVCmsA%3D%3D
    • Holsboer F (1999) The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety. J Psychiatr Res 33:181-214
    • (1999) J Psychiatr Res , vol.33 , pp. 181-214
    • Holsboer, F.1
  • 13
    • 32044432128 scopus 로고    scopus 로고
    • Effect of different doses of corticosterone on depression-like behavior and HPA axis responses to a novel stressor
    • 16386319 10.1016/j.bbr.2005.11.019 1:CAS:528:DC%2BD28XhtlCltbg%3D
    • Johnson SA, Fournier NM, Kalynchuk LE (2006) Effect of different doses of corticosterone on depression-like behavior and HPA axis responses to a novel stressor. Behav Brain Res 168:280-288
    • (2006) Behav Brain Res , vol.168 , pp. 280-288
    • Johnson, S.A.1    Fournier, N.M.2    Kalynchuk, L.E.3
  • 14
    • 0742287855 scopus 로고    scopus 로고
    • Proteomic analysis of protein changes developing in rat hippocampus after chronic antidepressant treatment: Implications for depressive disorders and future therapies
    • 14743428 10.1002/jnr.10869 1:CAS:528:DC%2BD2cXhsFKhu7c%3D
    • Khawaja X, Xu J, Liang JJ, Barrett JE (2004) Proteomic analysis of protein changes developing in rat hippocampus after chronic antidepressant treatment: implications for depressive disorders and future therapies. J Neurosci Res 75:451-460
    • (2004) J Neurosci Res , vol.75 , pp. 451-460
    • Khawaja, X.1    Xu, J.2    Liang, J.J.3    Barrett, J.E.4
  • 15
    • 0037305349 scopus 로고    scopus 로고
    • Molecular aspects of glutamate dysregulation: Implications for schizophrenia and its treatment
    • 12559388 10.1016/S0163-7258(02)00328-5 1:CAS:528:DC%2BD3sXmsFaksw%3D%3D
    • Konradi C, Heckers S (2003) Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment. Pharmacol Ther 97:153-179
    • (2003) Pharmacol Ther , vol.97 , pp. 153-179
    • Konradi, C.1    Heckers, S.2
  • 16
    • 0141926465 scopus 로고    scopus 로고
    • Cytoprotective effect is one of common action pathways for antidepressants
    • 14531941 1:CAS:528:DC%2BD3sXotFSlu7g%3D
    • Li YF, Liu YQ, Huang WC, Luo ZP (2003) Cytoprotective effect is one of common action pathways for antidepressants. Acta Pharmacol Sin 24:996-1000
    • (2003) Acta Pharmacol Sin , vol.24 , pp. 996-1000
    • Li, Y.F.1    Liu, Y.Q.2    Huang, W.C.3    Luo, Z.P.4
  • 17
    • 3142738003 scopus 로고    scopus 로고
    • The cytoprotective effect of inulin-type hexasaccharide extracted from Morinda officinalis on PC12 cells against the lesion induced by corticosterone
    • 15261759 10.1016/j.lfs.2004.02.029 1:CAS:528:DC%2BD2cXlsl2mtr8%3D
    • Li YF, Liu YQ, Yang M, Wang HL, Huang WC, Zhao YM (2004) The cytoprotective effect of inulin-type hexasaccharide extracted from Morinda officinalis on PC12 cells against the lesion induced by corticosterone. Life Sci 75:1531-1538
    • (2004) Life Sci , vol.75 , pp. 1531-1538
    • Li, Y.F.1    Liu, Y.Q.2    Yang, M.3    Wang, H.L.4    Huang, W.C.5    Zhao, Y.M.6
  • 18
    • 41549114129 scopus 로고    scopus 로고
    • Elevation of plasma corticosterone levels and hippocampal glucocorticoid receptor translocation in rats: A potential mechanism for cognition impairment following chronic low-power-density microwave exposure
    • 18198477 10.1269/jrr.07063 1:CAS:528:DC%2BD1cXntVOkur4%3D
    • Li M, Wang Y, Zhang Y, Zhou Z, Yu Z (2008) Elevation of plasma corticosterone levels and hippocampal glucocorticoid receptor translocation in rats: a potential mechanism for cognition impairment following chronic low-power-density microwave exposure. J Radiat Res 49:163-170
    • (2008) J Radiat Res , vol.49 , pp. 163-170
    • Li, M.1    Wang, Y.2    Zhang, Y.3    Zhou, Z.4    Yu, Z.5
  • 19
    • 33751434331 scopus 로고    scopus 로고
    • Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses
    • 17141627 10.1016/j.cmet.2006.11.004 1:CAS:528:DC%2BD2sXmslQ%3D
    • Liang B, Moussaif M, Kuan CJ, Gargus JJ, Sze JY (2006) Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses. Cell Metab 4:429-440
    • (2006) Cell Metab , vol.4 , pp. 429-440
    • Liang, B.1    Moussaif, M.2    Kuan, C.J.3    Gargus, J.J.4    Sze, J.Y.5
  • 20
    • 79952948880 scopus 로고    scopus 로고
    • The role of corticotropin-releasing hormone in the pathophysiology of depression: Therapeutic implications
    • 21261589 10.2174/1568026611109060609 1:CAS:528:DC%2BC3MXkslSnu7k%3D
    • Lloyd RB, Nemeroff CB (2011) The role of corticotropin-releasing hormone in the pathophysiology of depression: therapeutic implications. Curr Top Med Chem 11:609-617
    • (2011) Curr Top Med Chem , vol.11 , pp. 609-617
    • Lloyd, R.B.1    Nemeroff, C.B.2
  • 21
    • 78649685457 scopus 로고    scopus 로고
    • Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle
    • 20864533 10.1074/jbc.M110.160218 1:CAS:528:DC%2BC3cXhsVOku7zO
    • Lotz GP, Legleiter J, Aron R, Mitchell EJ, Huang SY, Ng C, Glabe C, Thompson LM, Muchowski PJ (2010) Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle. J Biol Chem 285:38183-38193
    • (2010) J Biol Chem , vol.285 , pp. 38183-38193
    • Lotz, G.P.1    Legleiter, J.2    Aron, R.3    Mitchell, E.J.4    Huang, S.Y.5    Ng, C.6    Glabe, C.7    Thompson, L.M.8    Muchowski, P.J.9
  • 23
    • 33750473749 scopus 로고    scopus 로고
    • The dynamic pattern of glucocorticoid receptor-mediated transcriptional responses in neuronal PC12 cells
    • 17026526 10.1111/j.1471-4159.2006.04187.x 1:CAS:528:DC%2BD28Xht1yks7jF
    • Morsink MC, Joëls M, Sarabdjitsingh RA, Meijer OC, De Kloet ER, Datson NA (2006) The dynamic pattern of glucocorticoid receptor-mediated transcriptional responses in neuronal PC12 cells. J Neurochem 99:1282-1298
    • (2006) J Neurochem , vol.99 , pp. 1282-1298
    • Morsink, M.C.1    Joëls, M.2    Sarabdjitsingh, R.A.3    Meijer, O.C.4    De Kloet, E.R.5    Datson, N.A.6
  • 24
    • 0025882570 scopus 로고
    • Steroids and depression
    • 1645586 10.1016/0960-0760(91)90312-S 1:STN:280:DyaK3M3kvVOlsA%3D%3D
    • Murphy BE (1991) Steroids and depression. J Steroid Biochem Mol Biol 38:537-559
    • (1991) J Steroid Biochem Mol Biol , vol.38 , pp. 537-559
    • Murphy, B.E.1
  • 25
    • 0030866035 scopus 로고    scopus 로고
    • Antiglucocorticoid therapies in major depression: A review
    • 9264159 10.1016/S0306-4530(97)00021-8
    • Murphy BE (1997) Antiglucocorticoid therapies in major depression: a review. Psychoneuroendocrinology 22:S125-S132
    • (1997) Psychoneuroendocrinology , vol.22
    • Murphy, B.E.1
  • 27
    • 84858379189 scopus 로고    scopus 로고
    • The bed nucleus of stria terminalis and the amygdala as targets of antenatal glucocorticoids: Implications for fear and anxiety responses
    • 10.1007/s00213-011-2494-y 1:CAS:528:DC%2BC3MXhtF2isbvI
    • Oliveira M, Rodrigues AJ, Leão P, Cardona D, Pêgo JM, Sousa N (2012) The bed nucleus of stria terminalis and the amygdala as targets of antenatal glucocorticoids: implications for fear and anxiety responses. Psychopharmacology (Berl) 220:443-453
    • (2012) Psychopharmacology (Berl) , vol.220 , pp. 443-453
    • Oliveira, M.1    Rodrigues, A.J.2    Leão, P.3    Cardona, D.4    Pêgo, J.M.5    Sousa, N.6
  • 28
    • 0033565418 scopus 로고    scopus 로고
    • 2+-Permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons
    • 10407026 1:CAS:528:DyaK1MXksVyktLk%3D
    • 2+-Permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons. J Neurosci 19:5861-5874
    • (1999) J Neurosci , vol.19 , pp. 5861-5874
    • Perkinton, M.S.1    Sihra, T.S.2    Williams, R.J.3
  • 30
    • 0035023610 scopus 로고    scopus 로고
    • The role of corticotropin-releasing factor in drug addiction
    • 11356984 1:CAS:528:DC%2BD3MXkt1Gnurk%3D
    • Sarnyai Z, Shaham Y, Heinrichs SC (2001) The role of corticotropin- releasing factor in drug addiction. Pharmacol Rev 53:209-243
    • (2001) Pharmacol Rev , vol.53 , pp. 209-243
    • Sarnyai, Z.1    Shaham, Y.2    Heinrichs, S.C.3
  • 31
    • 0028970281 scopus 로고
    • Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus
    • 7891134 1:CAS:528:DyaK2MXksVegu7k%3D
    • Smith MA, Makino S, Kvetnansky R, Post RM (1995) Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci 15:1768-1777
    • (1995) J Neurosci , vol.15 , pp. 1768-1777
    • Smith, M.A.1    Makino, S.2    Kvetnansky, R.3    Post, R.M.4
  • 32
    • 79951514630 scopus 로고    scopus 로고
    • Depression and hypothalamic-pituitary-adrenal activation: A quantitative summary of four decades of research
    • 21257974 10.1097/PSY.0b013e31820ad12b
    • Stetler C, Miller GE (2011) Depression and hypothalamic-pituitary-adrenal activation: a quantitative summary of four decades of research. Psychosom Med 73:114-126
    • (2011) Psychosom Med , vol.73 , pp. 114-126
    • Stetler, C.1    Miller, G.E.2
  • 33
    • 33644665002 scopus 로고    scopus 로고
    • Glucocorticoid sensitivity: The hypothalamic-pituitary-adrenal-tissue axis
    • 16076979 10.1038/oby.2005.132 1:CAS:528:DC%2BD2MXhtVSltrrP
    • Syed AA, Weaver JU (2005) Glucocorticoid sensitivity: the hypothalamic-pituitary-adrenal-tissue axis. Obes Res 13:1131-1133
    • (2005) Obes Res , vol.13 , pp. 1131-1133
    • Syed, A.A.1    Weaver, J.U.2
  • 34
    • 0026062606 scopus 로고
    • Glucocorticoids inhibit glucose transport and glutamate uptake in hippocampal astrocytes: Implications for glucocorticoid neurotoxicity
    • 1680166 10.1111/j.1471-4159.1991.tb08309.x 1:CAS:528:DyaK3MXlvFyqsL4%3D
    • Virgin CE Jr, Ha TP, Packan DR, Tombaugh GC, Yang SH, Horner HC, Sapolsky RM (1991) Glucocorticoids inhibit glucose transport and glutamate uptake in hippocampal astrocytes: implications for glucocorticoid neurotoxicity. J Neurochem 57:1422-1428
    • (1991) J Neurochem , vol.57 , pp. 1422-1428
    • Virgin Jr., C.E.1    Ha, T.P.2    Packan, D.R.3    Tombaugh, G.C.4    Yang, S.H.5    Horner, H.C.6    Sapolsky, R.M.7
  • 35
    • 84855974464 scopus 로고    scopus 로고
    • The roles of neurotrophic factor and Wnt signaling in depression
    • 22205198 10.1038/clpt.2011.296 1:CAS:528:DC%2BC38Xht1WktLc%3D
    • Voleti B, Duman RS (2012) The roles of neurotrophic factor and Wnt signaling in depression. Clin Pharmacol Ther 91:333-338
    • (2012) Clin Pharmacol Ther , vol.91 , pp. 333-338
    • Voleti, B.1    Duman, R.S.2
  • 36
    • 0036247091 scopus 로고    scopus 로고
    • Neuroprotective effects of antidepressant and mood stabilizing drugs
    • 11836978
    • Young LT (2002) Neuroprotective effects of antidepressant and mood stabilizing drugs. J Psychiatry Neurosci 27:8-9
    • (2002) J Psychiatry Neurosci , vol.27 , pp. 8-9
    • Young, L.T.1
  • 37
    • 68849124726 scopus 로고    scopus 로고
    • Neuroprotective treatment strategies for poststroke mood disorders: A minireview on atypical neuroleptic drugs and selective serotonin re-uptake inhibitors
    • 19576272 10.1016/j.brainresbull.2009.06.013 1:CAS:528:DC%2BD1MXhtVentbfF
    • Yulug B (2009) Neuroprotective treatment strategies for poststroke mood disorders: a minireview on atypical neuroleptic drugs and selective serotonin re-uptake inhibitors. Brain Res Bull 80:95-99
    • (2009) Brain Res Bull , vol.80 , pp. 95-99
    • Yulug, B.1
  • 38
    • 2542473205 scopus 로고    scopus 로고
    • Comparative signaling pathways of insulin-like growth factor-1 and brain-derived neurotrophic factor in hippocampal neurons and the role of the PI3 kinase pathway in cell survival
    • 15140184 10.1111/j.1471-4159.2004.02350.x 1:CAS:528:DC%2BD2cXksVyksL0%3D
    • Zheng WH, Quirion R (2004) Comparative signaling pathways of insulin-like growth factor-1 and brain-derived neurotrophic factor in hippocampal neurons and the role of the PI3 kinase pathway in cell survival. J Neurochem 89:844-852
    • (2004) J Neurochem , vol.89 , pp. 844-852
    • Zheng, W.H.1    Quirion, R.2
  • 39
    • 59449095272 scopus 로고    scopus 로고
    • Glutamate acting on N-methyl-D-aspartate receptors attenuates insulin-like growth factor-1 receptor tyrosine phosphorylation and its survival signaling properties in rat hippocampal neurons
    • 18981172 10.1074/jbc.M807914200 1:CAS:528:DC%2BD1MXhsV2nsg%3D%3D
    • Zheng WH, Quirion R (2009) Glutamate acting on N-methyl-D-aspartate receptors attenuates insulin-like growth factor-1 receptor tyrosine phosphorylation and its survival signaling properties in rat hippocampal neurons. J Biol Chem 284:855-861
    • (2009) J Biol Chem , vol.284 , pp. 855-861
    • Zheng, W.H.1    Quirion, R.2
  • 40
    • 0034518163 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 (IGF-1): A neuroprotective trophic factor acting via the Akt kinase pathway
    • 11205145
    • Zheng WH, Kar S, Dore S, Quirion R (2000a) Insulin-like growth factor-1 (IGF-1): a neuroprotective trophic factor acting via the Akt kinase pathway. J Neural Transm Suppl 60:261-272
    • (2000) J Neural Transm Suppl , vol.60 , pp. 261-272
    • Zheng, W.H.1    Kar, S.2    Dore, S.3    Quirion, R.4
  • 41
    • 0034671848 scopus 로고    scopus 로고
    • Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells
    • 10788447 10.1074/jbc.275.18.13377 1:CAS:528:DC%2BD3cXjtFyksbk%3D
    • Zheng WH, Kar S, Quirion R (2000b) Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells. J Biol Chem 275:13377-13385
    • (2000) J Biol Chem , vol.275 , pp. 13377-13385
    • Zheng, W.H.1    Kar, S.2    Quirion, R.3
  • 42
    • 0036328592 scopus 로고    scopus 로고
    • FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signaling
    • 11953455 10.1046/j.0022-3042.2002.00783.x 1:CAS:528:DC%2BD38XisVKgsLc%3D
    • Zheng WH, Kar S, Quirion R (2002a) FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signaling. J Neurochem 80:1049-1061
    • (2002) J Neurochem , vol.80 , pp. 1049-1061
    • Zheng, W.H.1    Kar, S.2    Quirion, R.3
  • 43
    • 0036078618 scopus 로고    scopus 로고
    • Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons
    • 12130673 10.1124/mol.62.2.225 1:CAS:528:DC%2BD38XlslOrsr8%3D
    • Zheng WH, Kar S, Quirion R (2002b) Insulin-like growth factor-1-induced phosphorylation of transcription factor FKHRL1 is mediated by phosphatidylinositol 3-kinase/Akt kinase and role of this pathway in insulin-like growth factor-1-induced survival of cultured hippocampal neurons. Mol Pharmacol 62:225-233
    • (2002) Mol Pharmacol , vol.62 , pp. 225-233
    • Zheng, W.H.1    Kar, S.2    Quirion, R.3
  • 44
    • 79955559390 scopus 로고    scopus 로고
    • Protective effects of flavonoid extract from Apocynum venetum leaves against corticosterone-induced neurotoxicity in PC12 cells
    • 21170580 10.1007/s10571-010-9635-4 1:CAS:528:DC%2BC3MXjvFOjsb4%3D
    • Zheng M, Liu C, Pan F, Shi D, Ma F, Zhang Y, Zhang Y (2011) Protective effects of flavonoid extract from Apocynum venetum leaves against corticosterone-induced neurotoxicity in PC12 cells. Cell Mol Neurobiol 31:421-428
    • (2011) Cell Mol Neurobiol , vol.31 , pp. 421-428
    • Zheng, M.1    Liu, C.2    Pan, F.3    Shi, D.4    Ma, F.5    Zhang, Y.6    Zhang, Y.7
  • 46
    • 60349106599 scopus 로고    scopus 로고
    • Curcumin protects PC12 cells from corticosterone-induced cytotoxicity: Possible involvement of the ERK1/2 pathway
    • 19175364 10.1111/j.1742-7843.2008.00348.x
    • Zhou H, Li X, Gao M (2009) Curcumin protects PC12 cells from corticosterone-induced cytotoxicity: possible involvement of the ERK1/2 pathway. Basic Clin Pharmacol Toxicol 104:236-240
    • (2009) Basic Clin Pharmacol Toxicol , vol.104 , pp. 236-240
    • Zhou, H.1    Li, X.2    Gao, M.3


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