Inferences from genetically modified mouse models on the skeletal actions of vitamin D

Journal of Steroid Biochemistry and Molecular Biology

Volumn 148, Issue , 2015, Pages 219-224

  Goltzman, D ^a  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

1 25 Dihydroxyvitamin D; 1 Hydroxylase; Bone; Cyp27b1; Extra skeletal effects; Genetic mouse models; Osteoblast; Osteoclasts; Osteocytes; Targeted deletion; Vitamin D; Vitamin D receptor

Indexed keywords

CALCITRIOL; CALCIUM; CYTOCHROME P450; CYTOCHROME P450 27B1; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE; PHOSPHORUS; UNCLASSIFIED DRUG; VITAMIN D; VITAMIN D RECEPTOR; CALCIDIOL 1 MONOOXYGENASE; CALCITRIOL RECEPTOR;

BIOSYNTHESIS; BONE MINERALIZATION; CALCIUM ABSORPTION; CALCIUM BLOOD LEVEL; CATABOLISM; CELL DIFFERENTIATION; CORTICAL BONE; GENE DELETION; GENE EXPRESSION; GENE OVEREXPRESSION; GENETICALLY ENGINEERED MOUSE STRAIN; HOMEOSTASIS; HYPOCALCEMIA; HYPOPHOSPHATEMIA; LOSS OF FUNCTION MUTATION; MINERAL METABOLISM; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; PHENOTYPE; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; BONE; HUMAN; KNOCKOUT MOUSE; METABOLISM; MOUSE; PHYSIOLOGY;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ANIMALS; BONE AND BONES; CALCIFICATION, PHYSIOLOGIC; HUMANS; MICE; MICE, KNOCKOUT; RECEPTORS, CALCITRIOL;

EID: 84925488248     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2014.09.011     Document Type: Review

References (55)

1. Y.C. Li, J. Kong, M. Wei, Z.F. Chen, S.Q. Liu, and L.P. Cao 1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system J. Clin. Invest. 110 2002 229 238
2. C. Zhou, F. Lu, K. Cao, D. Xu, D. Goltzman, and D. Miao Calcium-independent and 1,25(OH) 2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice Kidney Int. 74 2008 170 179
3. Y. Zhu, R. Zhou, R. Yang, Z. Zhang, Y. Bai, F. Chang, L. Li, M. Sokabe, D. Goltzman, D. Miao, and L. Chen Abnormal neurogenesis in the dentate gyrus of adult mice lacking 1,25-dihydroxy vitamin D3 (1,25-(OH) 2 D3) Hippocampus 22 2012 421 433
4. D. Bruce, S. Yu, J.H. Ooi, and M.T. Cantorna Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling Int. Immunol. 23 2011 519 528
5. J. Guo, Z. Ma, Q. Ma, Z. Wu, P. Fan, X. Zhou, L. Chen, S. Zhou, D. Goltzman, D. Miao, and E. Wu 1, 25(OH)2 inhibits inhibits hepatocellular carcinoma development through reducing secretion of inflammatory cytokines from immunocytes Curr. Med. Chem. 20 2013 4131 4141
6. K.H. Yip, N. Kolesnikoff, C. Yu, N. Hauschild, H. Taing, L. Biggs, D. Goltzman, P.A. Gregory, P.H. Anderson, M.S. Samuel, S.J. Galli, A.F. Lopez, and M.A. Grimbaldeston Mechanisms of vitamin D3 metabolite repression of IgE-dependent mast cell activation J. Allergy Clin. Immunol. 133 2014 1356 1364
7. R. Salehi-Tabar, L. Nguyen-Yamamoto, L.E. Tavera-Mendoza, T. Quail, V. Dimitrov, B.S. An, L. Glass, D. Goltzman, and J.H. White Vitamin D receptor as a master regulator of the c-MYC/MXD1 network Proc. Natl. Acad. Sci. U. S. A. 109 2012 18827 18832
8. G.M. Zinser, and J. Welsh Accelerated mammary gland development during pregnancy and delayed postlactational involution in vitamin D3 receptor null mice J. Mol. Endocrinol. 18 2004 2208 2223
9. D.D. Bikle, S. Chang, D. Crumrine, H. Elalieh, M.Q. Man, E.H. Choi, O. Dardenne, Z. Xie, R.S. Arnaud, K. Feingold, and P.M. Elias 25H ydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis J. Invest. Dermatol. 122 2004 984 992
10. M.E. Keith, E. LaPorta, and J. Welsh Stable expression of human VDR in murine VDR-null cells recapitulates vitamin D mediated anti-cancer signaling Mol. Carcinog. 53 2014 286 299
11. G.M. Zinser, J.P. Sundberg, and J. Welsh Vitamin D(3) receptor ablation sensitizes skin to chemically induced tumorigenesis Carcinogenesis 23 2002 2103 2109
12. W. Sun, H. Xie, J. Ji, X. Zhou, D. Goltzman, and D. Miao Defective female reproductive function in 1,25(OH) 2D-deficient mice results from indirect effect mediated by extracellular calcium and/or phosphorus Am. J. Physiol. Endocrinol. Metab. 299 2010 E928 E935
13. P. Pludowski, M.F. Holick, S. Pilz, C.L. Wagner, B.W. Hollis, W.B. Grant, Y. Shoenfeld, E. Lerchbaum, D.J. Llewellyn, K. Kienreich, and M. Soni Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence Autoimmun. Rev. 12 2013 976 989
14. E. Durmaz, M. Zou, R.A. Al-Rijjal, I. Bircan, S. Akçurin, B. Meyer, and Y. Shi Clinical and genetic analysis of patients with vitamin D-dependent rickets type 1A Clin. Endocrinol. 77 2012 363 369
15. D. Feldman, and J. Malloy Mutations in the vitamin D receptor and hereditary vitamin D-resistant rickets Bonekey Rep. 3 2014 510
16. D.K. Panda, D. Miao, M.L. Tremblay, J. Sirois, R. Farookhi, G.N. Hendy, and D. Goltzman Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction Proc. Natl. Acad. Sci. U. S. A. 98 2001 7498 7503
17. D.K. Panda, D. Miao, I. Bolivar, J. Li, R. Huo, G.N. Hendy, and D. Goltzman Inactivation of the 25-hydroxyvitamin D 1alpha-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis J. Biol. Chem. 279 2004 16754 16766
18. Y.C. Li, A.E. Pirro, M. Amling, G. Delling, R. Baron, R. Bronson, and M.B. Demay Targeted ablation of the vitamin D receptor: an animal model of vitamin D - dependent rickets type II with alopecia Proc. Natl. Acad. Sci. U. S. A. 94 1997 9831 9835
19. O. Dardenne, J. Prud'homme, A. Arabian, F.H. Glorieux, and R. St-Arnaud Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D - deficiency rickets Endocrinology 142 2001 3135 3141
20. Y.C. Li, M. Amling, A.E. Pirro, M. Priemel, J. Meuse, R. Baron, G. Delling, and M.B. Demay Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor - ablated mice Endocrinology 139 1998 4391 4396
21. R. Gopalakrishnan, S. Suttamanatwong, A.E. Carlson, and R.T. Franceschi Role of matrix gla protein in parathyroid hormone inhibition of osteoblast mineralization Cell Tissue Organ 181 2005 166 175
22. S. Christakos Recent advances in our understanding of 1,25-dihydroxyvitamin D(3) regulation of intestinal calcium absorption Arch. Biochem. Biophys. 523 July (1) 2012 73 76
23. J.C. Fleet, and R.D. Schoch Molecular mechanisms for regulation of intestinal calcium absorption by vitamin D and other factors Crit. Rev. Clin. Lab. Sci. 47 August (4) 2010 181 195
24. S. Kido, I. Kaneko, S. Tatsumi, H. Segawa, and K. Miyamoto Vitamin D and type II sodium-dependent phosphate cotransporters Contrib. Nephrol. 180 2013 86 97
25. D. Tiosano, S. Hadad, Z. Chen, A. Nemirovsky, V. Gepstein, D. Militianu, Y. Weisman, and S.A. Abrams Calcium absorption, kinetics, bone density, and bone structure in patients with hereditary vitamin D-resistant rickets J. Clin. Endocrinol. Metab. 96 2011 3701 3709
26. J. Mitchell, A. Tenenhouse, M. Warner, and D. Goltzman Parathyroid hormone desensitization in renal membranes of vitamin D-deficient rats is associated with a postreceptor defect Endocrinology 122 5 1988 1834 1841
27. G. Turner, C. Coureau, M.R. Rabin, B. Escoubet, M. Hruby, O. Walrant, and C. Silve Parathyroid hormone (PTH)/PTH-related protein receptor messenger ribonucleic acid expression and PTH response in a rat model of secondary hyperparathyroidism associated with vitamin D deficiency Endocrinology 136 1995 3751 3758
28. C. Richard, R. Huo, R. Samadfam, I. Bolivar, D. Miao, E.M. Brown, G.N. Hendy, and D. Goltzman The calcium-sensing receptor and 25-hydroxyvitamin D-1alpha-hydroxylase interact to modulate skeletal growth and bone turnover J. Bone Miner. Res. 25 2010 1627 1636
29. M.M. Dvorak, T.H. Chen, B. Orwoll, C. Garvey, W. Chang, D.D. Bikle, and D.M. Shoback Constitutive activity of the osteoblast Ca2-sensing receptor promotes loss of cancellous bone Endocrinology 148 2007 3156 3163
30. Z. Bar-Shavit, A.J. Kahn, and S.L. Teitelbaum Defective binding of macrophages to bone in rodent osteomalacia and vitamin D deficiency: in vitro evidence for a cellular defect and altered saccharides in the bone matrix J. Clin. Invest. 72 1983 526 534
31. R. Suzumoto, M. Takami, and T. Sasaki Differentiation and function of osteoclasts cultured on bone and cartilage J. Electron. Microsc. (Tokyo) 54 2005 529 540
32. O. Dardenne, J. Prud'homme, S.A. Hacking, F.H. Glorieux, and R. St-Arnaud Correction of the abnormal mineral ion homeostasis with a high-calcium, high-phosphorus, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1) Bone 32 2003 332 340
33. M. Amling, M. Priemel, T. Holzmann, K. Chapin, J.M. Rueger, R. Baron, and M.B. Demay Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses Endocrinology 140 1999 4982 4987
34. Y. Xue, A.C. Karaplis, G.N. Hendy, D. Goltzman, and D. Miao Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development Hum. Mol. Genet. 14 2005 1515 1528
35. B.C. Heng, T. Cao, L.W. Stanton, P. Robson, and B. Olsen Strategies for directing the differentiation of stem cells into the osteogenic lineage in vitro J. Bone Miner. Res. 19 2004 1379 1394
36. E.M. Gardiner, P.A. Baldock, G.P. Thomas, N.A. Sims, N.K. Henderson, B. Hollis, C.P. White, K.L. Sunn, N.A. Morrison, W.R. Walsh, and J.A. Eisman Increased formation and decreased resorption of bone in mice with elevated vitamin D receptor in mature cells of the osteoblastic lineage FASEB J. 14 2000 1908 1916
37. N.N. Lam, R. Triliana, R.K. Sawyer, G.J. Atkins, H.A. Morris, P.D. O'Loughlin, and P.H. Anderson Vitamin D receptor overexpression in osteoblasts and osteocytes prevents bone loss during vitamin D-deficiency J. Steroid Biochem. Mol. Biol. 144PA 2014 128 131
38. J.A. Fretz, L.A. Zella, S. Kim, N.K. Shevde, and J.W. Pike 1,25-Dihydroxyvitamin D3 regulates the expression of low-density lipoprotein receptor-related protein 5 via deoxyribonucleic acid sequence elements located downstream of the start site of transcription Mol. Endocrinol. 20 2006 2215 2230
39. T. Suda, N. Takahashi, N. Udagawa, E. Jimi, M.T. Gillespie, and T.J. Martin Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families Endocr. Rev. 20 1999 345 357
40. W.J. Boyle, W.S. Simonet, and D.L. Lacey Osteoclast differentiation and activation Nature 423 2003 337 342
41. R. Kitazawa, K. Mori, A. Yamaguchi, T. Kondo, and S. Kitazawa Modulation of mouse RANKL gene expression by Runx2 and vitamin D3 J. Cell Biochem. 105 2008 1289 1297
42. S. Kim, M. Yamazaki, L.A. Zella, N.K. Shevde, and J.W. Pike Activation of receptor activator of NF-kappaB ligand gene expression by 1,25-dihydroxyvitamin D3 is mediated through multiple long-range enhancers Mol. Cell Biol. 26 2006 6469 6486
43. R. Lin, N. Amizuka, T. Sasaki, M.M. Aarts, H. Ozawa, D. Goltzman, J.E. Henderson, and J.H. White 1Alpha,25-dihydroxyvitamin D3 promotes vascularization of the chondro-osseous junction by stimulating expression of vascular endothelial growth factor and matrix metalloproteinase 9 J. Bone Miner. Res. 17 2002 1604 1612
44. L. Lieben, R. Masuyama, S. Torrekens, R. Van Looveren, J. Schrooten, P. Baatsen, M.H. Lafage-Proust, T. Dresselaers, J.Q. Feng, L.F. Bonewald, M.B. Meyer, J.W. Pike, R. Bouillon, and G. Carmeliet Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization J. Clin. Invest. 122 2012 1803 1815
45. K.E. White, T.E. Larsson, and M.J. Econs The roles of specific genes implicated as circulating factors involved in normal and disordered phosphate homeostasis: frizzled related protein-4, matrix extracellular phosphoglycoprotein, and fibroblast growth factor 23 Endocr. Rev. 27 2006 221 241
46. O.I. Kolek, E.R. Hines, M.D. Jones, L.K. Lesueur, M.A. Lipko, P.R. Kiela, J.F. Collins, M.R. Haussler, and F.K. Ghishan 1alpha,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport Am. J. Physiol. Gastrointest. Liver Physiol. 289 2005 G1036 G1042
47. C. Turner, N. Dalton, R. Inaoui, I. Fogelman, W.D. Fraser, and G. Hampson Effect of a 300 000-IU loading dose of ergocalciferol (Vitamin D2) on circulating 1,25(OH) 2-vitamin D and fibroblast growth factor-23 (FGF-23) in vitamin D insufficiency J. Clin. Endocrinol. Metab. 98 2013 550 556
48. S.J. Quinn, A.R. Thomsen, J.L. Pang, L. Kantham, H. Bräuner-Osborne, M. Pollak, D. Goltzman, and E.M. Brown Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo Am. J. Physiol. Endocrinol. Metab. 304 3 2013 E310 E320
49. L. Lieben, and G. Carmeliet Vitamin D signaling in osteocytes: effects on bone and mineral homeostasis Bone 54 2013 237 243
50. R. St-Arnaud, A. Arabian, R. Travers, F. Barletta, M. Raval-Pandya, K. Chapin, J. Depovere, C. Mathieu, S. Christakos, M.B. Demay, and F.H. Glorieux Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D Endocrinology 141 2000 2658 2666
51. R. Dacquin, M. Starbuck, T. Schinke, and G. Karsenty Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast Dev. Dyn. 224 2002 245 251
52. Y. Yamamoto, T. Yoshizawa, T. Fukuda, Y. Shirode-Fukuda, T. Yu, K. Sekine, T. Sato, H. Kawano, K. Aihara, Y. Nakamichi, T. Watanabe, M. Shindo, K. Inoue, E. Inoue, N. Tsuji, M. Hoshino, G. Karsenty, D. Metzger, P. Chambon, S. Kato, and Y. Imai Vitamin D receptor in osteoblasts is a negative regulator of bone mass control Endocrinology 154 2013 1008 1020
53. M.B. Meyer, N.A. Benkusky, C.H. Lee, and J.W. Pike Genomic determinants of gene regulation by 1,25-dihydroxyvitamin D3 during osteoblast-lineage cell differentiation J. Biol. Chem. 289 2014 19539 19554
54. J. van de Peppel, and J.P. van Leeuwen Vitamin D and gene networks in human osteoblasts Front. Physiol. 5 2014 137
55. P.A. Baldock, G.P. Thomas, J.M. Hodge, S.U. Baker, U. Dressel, P.D. O'Loughlin, G.C. Nicholson, K.H. Briffa, J.A. Eisman, and E.M. Gardiner Vitamin D action and regulation of bone remodeling: suppression of osteoclastogenesis by the mature osteoblast J. Bone Miner. Res. 21 October (10) 2006 1618 1626