Defective female reproductive function in 1,25(OH)2D-deficient mice results from indirect effect mediated by extracellular calcium and/or phosphorus

American Journal of Physiology - Endocrinology and Metabolism

Volumn 299, Issue 6, 2010, Pages

  Sun, Weiwei ^a   Xie, Hui ^a   Ji, Ji ^a   Zhou, Xiaojie ^a   Goltzman, David ^b   Miao, Dengshun ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Corpus luteum formation; Folliculogenesis; Infertility; Ovarian angiogenesis; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D 1ALPHA HYDROXYLASE; ANGIOPOIETIN 1; ANGIOPOIETIN 2; ANGIOPOIETIN RECEPTOR; CALCITRIOL; CALCIUM; ESTROGEN; FOLLITROPIN; GONADOTROPIN; LUTEINIZING HORMONE; OXYGENASE; PHOSPHORUS; PROGESTERONE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; CORPUS LUTEUM; DIETARY INTAKE; EXTRACELLULAR CALCIUM; FEMALE; FERTILITY; GONAD; HISTOPATHOLOGY; HORMONE SYNTHESIS; HYPOCALCEMIA; HYPOPHOSPHATEMIA; HYPOPHYSIS; HYPOPLASIA; HYPOTHALAMUS; INFERTILITY; MOUSE; NONHUMAN; OVARY; OVARY FOLLICLE DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPRODUCTION; UTERUS;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CALCIUM; CALCIUM, DIETARY; ESTROUS CYCLE; FEMALE; FOLLICLE STIMULATING HORMONE; GENOTYPE; INFERTILITY, FEMALE; LUTEINIZING HORMONE; MICE; MICE, KNOCKOUT; OVARIAN FOLLICLE; PHOSPHORUS; PHOSPHORUS, DIETARY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VITAMIN D;

EID: 78649662937     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00378.2010     Document Type: Article

References (30)

1. Adams RH, Alitalo K. Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol 8: 464-478, 2007.
2. Bouillon R, Okamura WH, Norman AW. Structure-function relationships in the vitamin D endocrine system. Endocr Rev 16: 200-257, 1995.
3. 3-1alpha-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets. Endocrinology 142: 3135-3141, 2001.
4. DeLuca HF. The kidney as an endocrine organ for the production of 1,25-dihydroxyvitamin D3, a calcium-mobilizing hormone. N Engl J Med 289: 359-365, 1973.
5. Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol 289: F8-F28, 2005.
6. Erben RG, Soegiarto DW, Weber K, Zeitz U, Lieberherr M, Gniadecki R, Moller G, Adamski J, Balling R. Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D. Mol Endocrinol 16: 1524-1537, 2002. (Pubitemid 34743672)
7. Fraser HM. Regulation of the ovarian follicular vasculature. Reprod Biol Endocrinol 4: 18, 2006.
8. Guzman MA, Navarro MA, Carnicer R, Sarria AJ, Acin S, Arnal C, Muniesa P, Surra JC, Arbones-Mainar JM, Maeda N, Osada J. Cystathionine beta-synthase is essential for female reproductive function. Hum Mol Genet 15: 3168-3176, 2006. (Pubitemid 44605497)
9. Halloran BP, DeLuca HF. Vitamin D deficiency and reproduction in rats. Science 204: 73-74, 1979.
10. Haussler MR, Whitfield GK, Haussler CA, Hsieh JC, Thompson PD, Selznick SH, Dominguez CE, Jurutka PW. The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res 13: 325-349, 1998.
11. Johnson LE, DeLuca HF. Vitamin D receptor null mutant mice fed high levels of calcium are fertile. J Nutr 131: 1787-1791, 2001.
12. Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology 141: 1317-1324, 2000.
13. Kwiecinski GG, Petrie GI, DeLuca HF. Vitamin D is necessary for reproductive functions of the male rat. J Nutr 119: 741-744, 1989.
14. 3 is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 110: 229-238, 2002.
15. Li YC, Pirro AE, Amling M, Delling G, Baron R, Bronson R, Demay MB. Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci USA 94: 9831-9835, 1997.
16. Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, Compton D, McClain J, Aldrich TH, Papadopoulos N, Daly TJ, Davis S, Sato TN, Yancopoulos GD. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277: 55-60, 1997.
17. Panda DK, Miao D, Bolivar I, Li J, Huo R, Hendy GN, Goltzman D. Inactivation of the 25-hydroxyvitamin D 1alpha-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis. J Biol Chem 279: 16754-16766, 2004. (Pubitemid 38509378)
18. Panda DK, Miao D, Tremblay ML, Sirois J, Farookhi R, Hendy GN, Goltzman D. Targeted ablation of the 25-hydroxyvitamin D 1alpha-hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. Proc Natl Acad Sci USA 98: 7498-7503, 2001.
19. Paria BC, Reese J, Das SK, Dey SK. Deciphering the cross-talk of implantation: advances and challenges. Science 296: 2185-2188, 2002.
20. Reddy P, Liu L, Adhikari D, Jagarlamudi K, Rajareddy S, Shen Y, Du C, Tang W, Hamalainen T, Peng SL, Lan ZJ, Cooney AJ, Huhtaniemi I, Liu K. Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool. Science 319: 611-613, 2008.
21. Reynolds LP, Grazul-Bilska AT, Redmer DA. Angiogenesis in the corpus luteum. Endocrine 12: 1-9, 2000.
22. Reynolds LP, Killilea SD, Redmer DA. Angiogenesis in the female reproductive system. FASEB J 6: 886-892, 1992.
23. Shih SC, Robinson GS, Perruzzi CA, Calvo A, Desai K, Green JE, Ali IU, Smith LE, Senger DR. Molecular profiling of angiogenesis markers. Am J Pathol 161: 35-41, 2002.
24. Song X, Bishop JE, Okamura WH, Norman AW. Stimulation of phosphorylation of mitogen-activated protein kinase by 1alpha,25-dihydroxyvitamin D3 in promyelocytic NB4 leukemia cells: a structurefunction study. Endocrinology 139: 457-465, 1998.
25. Stumpf WE, Denny ME. Vitamin D (soltriol), light, and reproduction. Am J Obstet Gynecol 161: 1375-1384, 1989.
26. 3. J Cell Physiol 167: 380-393, 1996.
27. Walters MR. Newly identified actions of the vitamin D endocrine system. Endocr Rev 13: 719-764, 1992.
28. Xue Y, Karaplis AC, Hendy GN, Goltzman D, Miao D. Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development. Hum Mol Genet 14: 1515-1528, 2005. (Pubitemid 40823460)
29. Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K, Yoshihara Y, Kawakami T, Arioka K, Sato H, Uchiyama Y, Masushige S, Fukamizu A, Matsumoto T, Kato S. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet 16: 391-396, 1997.
30. 3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice. Kidney Int 74: 170-179, 2008.