Modulation of mouse RANKL gene expression by runx2 and vitamin D 3

Journal of Cellular Biochemistry

Volumn 105, Issue 5, 2008, Pages 1289-1297

  Kitazawa, Riko ^a   Mori, Kiyoshi ^a   Yamaguchi, Akira ^b   Kondo, Takeshi ^a   Kitazawa, Sohei ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Chromatin remodeling; Gene promoter; RANKL; Runx2; VDRE

Indexed keywords

CALCITRIOL; COLECALCIFEROL; HISTONE H3; HISTONE H4; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE; STROMAL CELL DERIVED FACTOR 1; TRANSCRIPTION FACTOR RUNX2;

ACETYLATION; ANIMAL CELL; ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN CONDENSATION; CHROMATIN IMMUNOPRECIPITATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; REGULATORY MECHANISM; TRANSACTIVATION; TRANSIENT TRANSFECTION;

ANIMALS; BONE DENSITY CONSERVATION AGENTS; CHOLECALCIFEROL; CORE BINDING FACTOR ALPHA 1 SUBUNIT; MICE; OSTEOBLASTS; RANK LIGAND; RNA, MESSENGER; STROMAL CELLS;

MUS;

EID: 57149120511     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21929     Document Type: Article

References (39)

1. Boyle WJ, Simonet WS, Lacey DL. 2003. Osteoclast differentiation and activation. Nature 423:337-342.
2. Ducy P, Starbuck M, Priemel M, Shen J, Pinero G, Geoffroy V, Amling M, Karsenty G. 1999. A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev 13:1025-1036.
3. Fu Q, Manolagas SC, O'Brien CA. 2006. Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer. Mol Cell Biol 26:6453-6468.
4. Geoffroy V, Kneissel M, Fournier B, Boyde A, Matthias P. 2002. High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage. Mol Cell Biol 22:6222-6233.
5. Kania MA, Bonner AS, Duffy JB, Gergen JP. 1990. The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system. Genes Dev 4:1701-1713.
6. Kawana F, Sasaki T. 2003. Osteoclast differentiation and characteristic trabecular bone formation during growth plate destruction in osteoprotegerin-deficient mice. J Electron Microsc (Tokyo) 52:515-525.
7. Kern B, Shen J, Starbuck M, Karsenty G. 2001. Cbfa1 contributes to the osteoblast-specific expression of type I collagen genes. J Biol Chem 276:7101-7107.
8. Kim S, Yamazaki M, Zella LA, Meyer MB, Fretz JA, Shevde NK, Pike JW. 2007. Multiple enhancer regions located at significant distances upstream of the transcriptional start site mediate RANKL gene expression in response to 1,25-dihydroxyvitamin D3. J Steroid Biochem Mol Biol 103:430-434.
9. Kishimoto K, Kitazawa R, Kurosaka M, Maeda S, Kitazawa S. 2006. Expression profile of genes related to osteoclastogenesis in mouse growth plate and articular cartilage. Histochem Cell Biol 125:593-602.
10. Kitazawa R, Kitazawa S. 2002. Vitamin D(3) augments osteoclastogenesis via vitamin D-responsive element of mouse RANKL gene promoter. Biochem Biophys Res Commun 290:650-655.
11. Kitazawa S, Ross FP, McHugh K, Teitelbaum SL. 1995. Interleukin-4 induces expression of the integrin alpha v beta 3 via transactivation of the beta 3 gene. J Biol Chem 270:4115-4120.
12. Kitazawa R, Kitazawa S, Maeda S. 1999. Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene. Biochim Biophys Acta 1445:134-141.
13. Kitazawa S, Kajimoto K, Kondo T, Kitazawa R. 2003. Vitamin D3 supports osteoclastogenesis via functional vitamin D response element of human RANKL gene promoter. J Cell Biochem 89:771-777.
14. Komori T. 2003. Requisite roles of Runx2 and Cbfb in skeletal development. J Bone Miner Metab 21:193-197.
15. Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T. 1997. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:755-764.
16. Kondo T, Kitazawa R, Yamaguchi A, Kitazawa S. 2008. Dexamethasone promotes osteoclastogenesis by inhibiting osteoprotegerin through multiple levels. J Cell Biochem 103:335-345.
17. Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ. 1998. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165-176.
18. Lamour V, Detry C, Sanchez C, Henrotin Y, Castronovo V, Bellahcene A. 2007. Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression. J Biol Chem 282:36240-36249.
19. Liu W, Toyosawa S, Furuichi T, Kanatani N, Yoshida C, Liu Y, Himeno M, Narai S, Yamaguchi A, Komori T. 2001. Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures. J Cell Biol 155:157-166.
20. Liu T, Gao Y, Sakamoto K, Minamizato T, Furukawa K, Tsukazaki T, Shibata Y, Bessho K, Komori T, Yamaguchi A. 2007. BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines. J Cell Physiol 211:728-735.
21. Mori K, Kitazawa R, Kondo T, Maeda S, Yamaguchi A, Kitazawa S. 2006. Modulation of mouse RANKL gene expression by Runx2 and PKA pathway. J Cell Biochem 98:1629-1644.
22. Notoya M, Otsuka E, Yamaguchi A, Hagiwara H. 2004. Runx-2 is not essential for the vitamin D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells. Biochem Biophys Res Commun 324:655-660.
23. O'Brien CA, Lin SC, Bellido T, Manolagas SC. 2000. Expression levels of gp130 in bone marrow stromal cells determine the magnitude of osteoclastogenic signals generated by IL-6-type cytokines. J Cell Biochem 79:532-541.
24. O'Brien CA, Kern B, Gubrij I, Karsenty G, Manolagas SC. 2002. Cbfa1 does not regulate RANKL gene activity in stromal/osteoblastic cells. Bone 30:453-462.
25. Ogawa M, Nishikawa S, Ikuta K, Yamamura F, Naito M, Takahashi K. 1988. B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, S T2: B cell progenitor develops first in the embryonal body rather than in the yolk sac. EMBO J 7:1337-1343.
26. Ogawa E, Maruyama M, Kagoshima H, Inuzuka M, Lu J, Satake M, Shigesada K, Ito Y. 1993. PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc Natl Acad Sci USA 90:6859-6863.
27. Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, Stamp GW, Beddington RS, Mundlos S, Olsen BR, Selby PB, Owen MJ. 1997. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 89:765-771.
28. Paredes R, Arriagada G, Cruzat F, Villagra A, Olate J, Zaidi K, van Wijnen A, Lian JB, Stein GS, Stein JL, Montecino M. 2004. Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells. Mol Cell Biol 20:8847-8861.
29. Roca H, Phimphilai M, Gopalakrishnan R, Xiao G, Franceschi RT. 2005. Cooperative interactions between RUNX2 and homeodomain protein-binding sites are critical for the osteoblast-specific expression of the bone sialoprotein gene. J Biol Chem 280:30845-30855.
30. Schroeder TM, Westendorf JJ. 2005. Histone deacetylase inhibitors promote osteoblast maturation. J Bone Miner Res 20:2254-2263.
31. Shen J, Montecino M, Lian JB, Stein GS, Van Wijnen AJ, Stein JL. 2002. Histone acetylation in vivo at the osteocalcin locus is functionally linked to vitamin D-dependent, bone tissue-specific transcription. J Biol Chem 277:20284-20292.
32. Shen J, Hovhannisyan H, Lian JB, Montecino MA, Stein GS, Stein JL, Van Wijnen AJ. 2003. Transcriptional induction of the osteocalcin gene during osteoblast differentiation involves acetylation of histones h3 and h4. Mol Endocrinol 17:743-756.
33. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ. 1999. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 20:345-357.
34. Takami M, Takahashi N, Udagawa N, Miyaura C, Suda K, Woo JT, Martin TJ, Nagai K, Suda T. 2000. Intracellular calcium and protein kinase C mediate expression of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in osteoblasts. Endocrinology 141:4711-4719.
35. Takamoto M, Tsuji K, Yamashita T, Sasaki H, Yano T, Taketani Y, Komori T, Nifuji A, Noda M. 2003. Hedgehog signaling enhances core-binding factor a1 and receptor activator of nuclear factor-kappaB ligand (RANKL) gene expression in chondrocytes. J Endocrinol 177:413-421.
36. Teitelbaum SL, Ross FP. 2003. Genetic regulation of osteoclast development and function. Nat Rev Genet 4:638-649.
37. Xiao G, Jiang D, Ge C, Zhao Z, Lai Y, Boules H, Phimphilai M, Yang X, Karsenty G, Franceschi RT. 2005. Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression. J Biol Chem 280:30689-30696.
38. Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, Tomoyasu A, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Higashio K, Udagawa N, Takahashi N, Suda T. 1998. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 95:3597-3602.
39. Yoshida CA, Furuichi T, Fujita T, Fukuyama R, Kanatani N, Kobayashi S, Satake M, Takada K, Komori T. 2002. Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat Genet 32:633-638.