Role of Liver in Modulating the Release of Inflammatory Cytokines Involved in Lung and Multiple Organ Dysfunction in Severe Acute Pancreatitis

Cell Biochemistry and Biophysics

Volumn 71, Issue 2, 2015, Pages 765-776

  Wang, Yilin ^a,b   Liu, Weiyan ^b   Liu, Xiqiang ^a   Sheng, Meng ^a   Pei, Yaofei ^a   Lei, Ruoqing ^a   Zhang, Shengdao ^a   Tao, Ran ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b The Central Hospital of Minhang District   (China)

Author keywords

Endotoxin translocation; Hepatic function; Inflammatory cytokine release; NF B; Pancreatitis

Indexed keywords

CYTOKINE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; PYRROLIDINE DERIVATIVE; PYRROLIDINE DITHIOCARBAMIC ACID; THIOCARBAMIC ACID DERIVATIVE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ACUTE DISEASE; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; COMPLICATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; INTESTINE; LIVER; LUNG; MALE; METABOLISM; MULTIPLE ORGAN FAILURE; PANCREATITIS; PATHOPHYSIOLOGY; RAT; SECRETION (PROCESS); SPRAGUE DAWLEY RAT;

ACUTE DISEASE; ANIMALS; CYTOKINES; GENE EXPRESSION REGULATION; INTERLEUKIN-6; INTESTINES; LIPOPOLYSACCHARIDES; LIVER; LUNG; MALE; MULTIPLE ORGAN FAILURE; PANCREATITIS; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; THIOCARBAMATES; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84925487271     PISSN: 10859195     EISSN: 15590283     Source Type: Journal    
DOI: 10.1007/s12013-014-0261-5     Document Type: Article

References (61)

1. Beger, H. G., & Isenmann, R. (1999). Surgical management of necrotizing pancreatitis. Surgical Clinics of North America,79, 783–800.
2. Bradley, E. L, 3rd. (1993). A fifteen year experience with open drainage for infected pancreatic necrosis. Surgery, Gynecology and Obstetrics,177, 215–222.
3. Tsiotos, G. G., Luque-de Leon, E., Soreide, J. A., Bannon, M. P., Zietlow, S. P., Baerga-Varela, Y., & Sarr, M. G. (1998). Management of necrotizing pancreatitis by repeated operative necrosectomy using a zipper technique. AmericanJournal ofSurgery, 175, 91–98.
4. Ronstein, O. D. (2000). Pathogenesis of multiple organ dysfunction syndrome: Gut origin, protection, and decontamination. Surgical Infections,1(3), 217–225.
5. Sharma, M., Garg, D., & Banerjee, P. K. (2007). Characterization of newer subgroups of fulminant and subfulminant pancreatitis associated with a high early mortality. American Journal of Gastroenterology,102, 2688–2695.
6. Isenmann, R., Rau, B., & Beger, H. G. (2001). Early severe acute pancreatitis: characteristics of a new subgroup. Pancreas,22, 274–278.
7. Sadikot, R. T., Wudel, L. J., Jansen, D. E., Debelak, J. P., Yull, F. E., Christman, J. W., et al. (2002). Hepatic cryoablation-induced multisystem injury: Bioluminescent detection of NF-kappaB activation in a transgenic mouse model. Journal of Gastrointestinal Surgery,6, 264–270.
8. Mikami, Y., Takeda, K., Shibuya, K., Qiu-Feng, H., Shimamura, H., Yamauchi, J., et al. (2003). Do peritoneal macrophages play an essential role in the progression of acute pancreatitis in rats? Pancreas,27, 253–260.
9. Harper, S. J. F., & Cheslyn-Curtis, S. (2011). Acute pancreatitis. Annals of Clinical Biochemistry,48, 23.
10. Phillip, V., Steiner, J. M., & Algül, H. (2014). Early phase of acute pancreatitis: Assessment and management. World Journal of Gastrointestinal Pathophysiology,5(3), 158–168.
11. Bhagat, S., Wadhawan, M., Sud, R., & Arora, A. (2008). Hepatitis viruses causing pancreatitis and hepatitis: A case series and review of literature. Pancreas,36, 424–427.
12. Frossard, J. L., Lescuyer, P., & Pastor, C. M. (2009). Experimental evidence of obesity as a risk factor for severe acute pancreatitis. World Journal of Gastroenterology,15, 5260–5265.
13. Dugernier, T., Starkel, P., Laterre, P. F., & Reynaert, M. S. (1996). Severe acute pancreatitis: Pathophysiologic mechanisms underlying pancreatic necrosis and remote organ damage. Acta Gastro-enterologica Belgica,59, 178–185.
14. Regner, S., Manjer, J., Appelros, S., Hjalmarsson, C., Sadic, J., & Borgstrom, A. (2008). Protease activation, pancreatic leakage, and inflammation in acute pancreatitis: Differences between mild and severe cases and changes over the first three days. Pancreatology,8, 600–607.
15. Toouli, J., Brooke-Smith, M., Bassi, C., Carr-Locke, D., Telford, J., Freeny, P., et al. (2002). Guidelines for the management of acute pancreatitis. Journal of Gastroenterology and Hepatology,17(Suppl), S15–S39.
16. Wang, Z. F., Pan, C. E., Lu, Y., Liu, S. G., Zhang, G. J., & Zhang, X. B. (2003). The role of inflammatory mediators in severe acute pancreatitis and regulation of glucocorticoids. Hepatobiliary & Pancreatic Diseases International,2, 458–462.
17. Zhang, X. P., Li, Z. J., & Zhang, J. (2009). Inflammatory mediators and microcirculatory disturbance in acute pancreatitis. Hepatobiliary & Pancreatic Diseases International,8, 351–357.
18. Norman, J. G., Fink, G. W., & Franz, M. G. (1995). Acute pancreatitis induces intrapancreatic tumor necrosis factor gene expression. Archives of Surgery,130, 966–970.
19. Pooran, N., Indaram, A., Singh, P., & Bank, S. (2003). Cytokines (IL-6, IL-8, TNF): Early and reliable predictors of severe acute pancreatitis. Journal of Clinical Gastroenterology,37, 263–266.
20. Sathyanarayan, G., Garg, P. K., Prasad, H., & Tandon, R. K. (2007). Elevated level of interleukin-6 predicts organ failure and severe disease in patients with acute pancreatitis. Journal of Gastroenterology and Hepatology,22, 550–554.
21. Frossard, J. L., Hadengue, A., & Pastor, C. M. (2001). New serum markers for the detection of severe acute pancreatitis in humans. American Journal of Respiratory and Critical Care Medicine,164, 162–170.
22. Oruc, N., Ozutemiz, A. O., Yukselen, V., Nart, D., Celik, H. A., Yuce, G., et al. (2004). Infliximab: a new therapeutic agent in acute pancreatitis? Pancreas,28, e1–e8.
23. Reding, T., Bimmler, D., Perren, A., Sun, L. K., Fortunato, F., Storni, F., et al. (2006). A selective COX-2 inhibitor suppresses chronic pancreatitis in an animal model (WBN/Kob rats): Significant reduction of macrophage infiltration and fibrosis. Gut,55, 1165–1173.
24. Closa, D., Bardaji, M., Hotter, G., Prats, N., Gelpi, E., Fernandez-Cruz, L., et al. (1996). Hepatic involvement in pancreatitis-induced lung damage. American Journal of Physiology,270, G6–G13.
25. Closa, D., Sabater, L., Fernandez-Cruz, L., Prats, N., Gelpi, E., & Rosello-Catafau, J. (1999). Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver. Annals of Surgery,229, 230–236.
26. Folch-Puy, E. (2007). Importance of the liver in systemic complications associated with acute pancreatitis: the role of Kupffer cells. The Journal of Pathology,211, 383–388.
27. Liu, H. B., Cui, N. Q., Li, D. H., & Chen, C. (2006). Role of Kupffer cells in acute hemorrhagic necrotizing pancreatitis-associated lung injury of rats. World Journal of Gastroenterology,12, 403–407.
28. Shifrin, A. L., Chirmule, N., Zhang, Y., & Raper, S. E. (2005). Macrophage ablation attenuates adenoviral vector-induced pancreatitis. Surgery,137, 545–551.
29. Wang, Y. L., Zheng, Y. J., Zhang, Z. P., Su, J. Y., Lei, R. Q., Tang, Y. Q., et al. (2009). Effects of gut barrier dysfunction and NF-kappaB activation on aggravating mechanism of severe acute pancreatitis. Journal of Digestive Diseases,10, 30–34.
30. Aho, H. J., Suonpaa, K., Ahola, R. A., & Nevalainen, T. J. (1984). Experimental pancreatitis in the rat. Ductal factors in sodium taurocholate-induced acute pancreatitis. Experimental Pathology,25, 73–79.
31. Huang, W., Xue, P., Liu, T. T., Huang, L., Xiang, D. K., Wang, L., & Xia, Q.(2007). Clinical study on 100 cases of severe acute pancreatitis in aged patients. Zhong Xi Yi Jie He Xue Bao, 5, 268–271.
32. Zhu, H. H., & Jiang, L. L. (2012). Serum inter-cellular adhesion molecule 1 is an early marker of diagnosis and prediction of severe acute pancreatitis. The World Journal of Gastroenterology,18, 2554–2560.
33. Su, K. H., Cuthbertson, C., & Christophi, C. (2006). Review of experimental animal models of acute pancreatitis. HPB (Oxford),8, 264–286.
34. Ryan, C. M., Schmidt, J., Lewandrowski, K., Compton, C. C., Rattner, D. W., Warshaw, A. L., et al. (1993). Gut macromolecular permeability in pancreatitis correlates with severity of disease in rats. Gastroenterology,104, 890–895.
35. Ammori, B. J., Fitzgerald, P., Hawkey, P., & McMahon, M. J. (2003). The early increase in intestinal permeability and systemic endotoxin exposure in patients with severe acute pancreatitis is not associated with systemic bacterial translocation: molecular investigation of microbial DNA in the blood. Pancreas,26, 18–22.
36. Kazantsev, G. B., Hecht, D. W., Rao, R., Fedorak, I. J., Gattuso, P., Thompson, K., et al. (1994). Plasmid labeling confirms bacterial translocation in pancreatitis. The American Journal of Surgery,167, 201–206. discussion 206–207.
37. Wang, X. D., Wang, Q., Andersson, R., & Ihse, I. (1996). Alterations in intestinal function in acute pancreatitis in an experimental model. British Journal of Surgery,83, 1537–1543.
38. Qiao, S. F., Lu, T. J., Sun, J. B., & Li, F. (2005). Alterations of intestinal immune function and regulatory effects of l-arginine in experimental severe acute pancreatitis rats. World Journal of Gastroenterology,11, 6216–6218.
39. Bonham, M. J., Abu-Zidan, F. M., Simovic, M. O., & Windsor, J. A. (1997). Gastric intramucosal pH predicts death in severe acute pancreatitis. British Journal of Surgery,84, 1670–1674.
40. Soong, C. V., Lewis, H. G., Halliday, M. I., & Rowlands, B. J. (1999). Intramucosal acidosis and the inflammatory response in acute pancreatitis. American Journal of Gastroenterology,94, 2423–2429.
41. Ammori, B. J., Cairns, A., Dixon, M. F., Larvin, M., & McMahon, M. J. (2002). Altered intestinal morphology and immunity in patients with acute necrotizing pancreatitis. Journal of Hepatobiliary Pancreatic Surgery,9, 490–496.
42. Mayerle, J., Hlouschek, V., & Lerch, M. M. (2005). Current management of acute pancreatitis. Nature Clinical Practice Gastroenterology & Hepatology,2, 473–483.
43. Leaphart, C. L., & Tepas, J. J, 3rd. (2007). The gut is a motor of organ system dysfunction. Surgery,141, 563–569.
44. Gloor, B., Todd, K. E., Lane, J. S., Lewis, M. P., & Reber, H. A. (1998). Hepatic Kupffer cell blockade reduces mortality of acute hemorrhagic pancreatitis in mice. The Journal of Gastrointestinal Surgery,2, 430–435.
45. Folch, E., Prats, N., Hotter, G., Lopez, S., Gelpi, E., Rosello-Catafau, J., et al. (2000). P-selectin expression and Kupffer cell activation in rat acute pancreatitis. Digestive Diseases and Sciences,45, 1535–1544.
46. Gloor, B., Blinman, T. A., Rigberg, D. A., Todd, K. E., Lane, J. S., Hines, O. J., et al. (2000). Kupffer cell blockade reduces hepatic and systemic cytokine levels and lung injury in hemorrhagic pancreatitis in rats. Pancreas,21, 414–420.
47. Murr, M. M., Yang, J., Fier, A., Kaylor, P., Mastorides, S., & Norman, J. G. (2002). Pancreatic elastase induces liver injury by activating cytokine production within Kupffer cells via nuclear factor-Kappa B. The Journal of Gastrointestinal Surgery,6, 474–480.
48. Miyahara, S., & Isaji, S. (2001). Liver injury in acute pancreatitis and mitigation by continuous arterial infusion of an antibiotic via the superior mesenteric artery. Pancreas,23, 204–211.
49. Peng, Y., Gallagher, S. F., Haines, K., et al. (2006). Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL. Journal of Surgical Research,130, 58–65.
50. Parbhoo, S. P., Welch, J., & Sherlock, S. (1973). Acute pancreatitis in patients with fulminant hepatic failure. Gut,14, 428.
51. Kuo, P. C., Plotkin, J. S., & Johnson, L. B. (1998). Acute pancreatitis and fulminant hepatic failure. Journal of the American College of Surgeons,187, 522–528.
52. Grewal, H. P., Kotb, M., el Din, A. M., Ohman, M., Salem, A., Gaber, L., et al. (1994). Induction of tumor necrosis factor in severe acute pancreatitis and its subsequent reduction after hepatic passage. Surgery,115, 213–221.
53. Gathiram, P., Wells, M. T., Raidoo, D., Brock-Utne, J. G., & Gaffin, S. L. (1989). Changes in lipopolysaccharide concentrations in hepatic portal and systemic arterial plasma during intestinal ischemia in monkeys. Circulatory Shock,27, 103–109.
54. Jacob, A. I., Goldberg, P. K., Bloom, N., Degenshein, G. A., & Kozinn, P. J. (1977). Endotoxin and bacteria in portal blood. Gastroenterology,72, 1268–1270.
55. Brivet, F. G., Emilie, D., & Galanaud, P. (1999). Pro- and anti-inflammatory cytokines during acute severe pancreatitis: an early and sustained response, although unpredictable of death. Parisian Study Group on Acute Pancreatitis. Critical Care Medicine,27, 749–755.
56. Mayer, J., Rau, B., Gansauge, F., & Beger, H. G. (2000). Inflammatory mediators in human acute pancreatitis: Clinical and pathophysiological implications. Gut,47, 546–552.
57. Lancaster, L. H., Christman, J. W., Blackwell, T. R., et al. (2001). Suppression of lung inflammation in rats by prevention of NF-kappaB activation in the liver. Inflammation,25, 25–31.
58. Ethridge, R. T., Hashimoto, K., Chung, D. H., Ehlers, R. A., Rajaraman, S., & Evers, B. M. (2002). Selective inhibition of NF-kappaB attenuates the severity of cerulein-induced acute pancreatitis. Journal of the American College of Surgeons,195, 497–505.
59. Altavilla, D., Famulari, C., Passaniti, M., Galeano, M., Macri, A., Seminara, P., et al. (2003). Attenuated cerulein-induced pancreatitis in nuclear factor-kappaB-deficient mice. Laboratory Investigation,83, 1723–1732.
60. Letoha, T., Somlai, C., Takacs, T., Szabolcs, A., Jarmay, K., Rakonczay, Z, Jr, et al. (2005). A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis. World Journal of Gastroenterology,11, 990–999.
61. Letoha, T., Kusz, E., Papai, G., Szabolcs, A., Kaszaki, J., Varga, I., et al. (2006). In vitro and in vivo nuclear factor-kappaB inhibitory effects of the cell-penetrating penetratin peptide. Molecular Pharmacology,69, 2027–2036.