The gut is a motor of organ system dysfunction

Surgery

Volumn 141, Issue 5, 2007, Pages 563-569

  Leaphart, Cynthia L ^a   Tepas III, J J ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MORPHINE; PROTON PUMP INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

BACTERIAL COLONIZATION; BACTERIAL TRANSLOCATION; CLINICAL FEATURE; DEFENSE MECHANISM; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE EXACERBATION; ENDOTOXEMIA; ENTEROPATHY; ENVIRONMENTAL STRESS; HEMORRHAGIC SHOCK; HUMAN; INCIDENCE; ISCHEMIA; MORTALITY; MUCOSAL DISEASE; MULTIPLE ORGAN FAILURE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; REPERFUSION INJURY; REVIEW; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; THERMAL INJURY;

BACTERIAL TRANSLOCATION; GASTROINTESTINAL TRACT; HUMANS; MULTIPLE ORGAN FAILURE;

EID: 34247267648     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.surg.2007.01.021     Document Type: Review

References (44)

1. Deitch E.A., Morrison J., Berg R., and Specian R.D. Effect of hemorrhagic shock on bacterial translocation, intestinal morphology, and intestinal permeability in conventional and antibiotic-decontaminated rats. Crit Care Med 18 (1990) 529-536
2. Mainous M.R., Ertel W., Chaudry I.H., and Deitch E.A. The gut: a cytokine-generating organ in systemic inflammation?. Shock 4 (1995) 193-199
3. MacFie J., Reddy B.S., Gatt M., Jain P.K., Sowdi R., and Mitchell C.J. Bacterial translocation studied in 927 patients over 13 years. Br J Surg 93 (2006) 87-93
4. Marshall J.C., and Nathens A.B. The gut in critical illness: evidence from human studies. Shock 6 Suppl 1 (1996) S10-S16
5. de Jonge E., Schultz M.J., Spanjaard L.K., Bossuyt P.M., Vroom M.B., Dankert J., and Kesecioglu J. Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomized control trial. Lancet 362 (2003) 1011-1016
6. Muenzer J.T., Davis C.G., Dunne B.S., Unsinger J., Dunne W.M., and Hotchkiss R.S. Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis. Shock 26 (2006) 565-570
7. Cobb J.P., Buchman T.G., Karl I.E., and Hotchkiss R.S. Molecular biology of multiple organ dysfunction syndrome: injury, adaptation, and apoptosis. Surg Infect (Larchmt) 3 (2000) 207-213
8. Plank L.D., and Hill G.L. Sequential metabolic changes following induction of systemic inflammatory response in patients with severe sepsis or major blunt trauma. World J Surg 24 (2000) 630-638
9. Moore F.A. The role of the gastrointestinal tract in postinjury multiple organ failure. Am J Surg 178 (1999) 449-453
10. Fairies P.L., Simon R., and Martella A. Intestinal permeability correlates with severity of injury in trauma patients. J Trauma 44 (1998) 1031-1035
11. Fink M.P., and Delude R.L. Epithelial barrier dysfunction: a unifying theme to explain the pathogenesis of multiple organ dysfunction at the cellular level. Crit Care Clin 21 (2005) 177-196
12. MacFie J. Current status of bacterial translocation as a cause of surgical sepsis. Brit Med Bull 17 (2004) 1-11
13. Kataylima M., Xu D., Specian R.D., and Deitch E.A. The role of bacterial adherence and the mucus barrier on bacterial translocation: effects of protein malnutrition and endotoxin in rats. Ann Surg 225 (1997) 317-326
14. Albanese C.T., Smith S.D., Watkins S., Kurkchubusche A., Simmons R.L., and Rowe M.I. The effect of secretory IgA on transepithelial passage of bacteria across the intact ileum in vitro. J Am Coll Surg 179 (1994) 679-688
15. Albanese C.T., Cardona M., Smith S.D., Watkins S., Kurkchubusche A., Ulman I., et al. The role of intestinal mucus in transepithelial passage of bacteria across the intact ileum in vitro. Surgery 116 (1994) 76-82
16. Corfield A.P., Myerscough N., Longman R., Sylvester P., Arul S., and Pignatelli M. Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease. Gut 47 (2000) 589-594
17. Magnotti L.J., and Deitch E.A. Burns, bacterial translocation, gut barrier function, and failure. J Burn Care Rehab 26 (2005) 383-391
18. Shimizu K., Ogura H., Goto M., Asahara T., Nomoto K., Morotomi M., et al. Altered gut flora and environment in patients with severe SIRS. J Trauma 60 (2006) 126-133
19. Rotstein O.D. Pathogenesis of multiple organ dysfunction syndrome: gut origin, protection, and decontamination. Surg Infect (Larchmt) 1 (2000) 217-225
20. Hotchkiss R.S., and Karl I.E. The pathophysiology and treatment of sepsis. New Engl J Med 348 (2003) 138-150
21. Niess J.H., and Reinecker H.C. Dendritic cells in the recognition of intestinal microbiota. Cell Microbiol 8 (2006) 558-564
22. Niess J.H., and Reinecker H.C. Lamina propria dendritic cells in the physiology and pathology of the gastrointestinal tract. Curr Opin Gastroenterol 21 (2005) 687-691
23. Efron P.A., Martins A., Minnich D., Tinsley K., Ungaro R., Bahjat F.R., et al. Characterization of the systemic loss of dendritic cells in murine lymph odes during polymicrobial sepsis. J Immunol 173 (2004) 3035-3043
24. Sousa R., Sher A., and Kaye P. The role of dendritic cells in the induction and regulation of immunity to microbial infection. Curr Opin Immunol 11 (1999) 392-399
25. De Smedt T., Pajak B., Muraille E., Lespagnard L., Heinen E., De Baetselier P., et al. Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo. J Exp Med 184 (1996) 1413-1424
26. Nieuwenhuijzen G.A., Haskel Y., Lu Q., Berg R.D., van Rooijen N., Goris R.J., et al. Macrophage elimination increases bacterial translocation and gut-origin septicemia but attenuates symptoms and mortality rate in a model of systemic inflammation. Ann Surg 218 (1993) 791-799
27. Sansonetti P.J., and Phalipon A. M cells as ports of entry for enteroinvasive pathogens: mechanisms of interaction, consequences for the disease process. Semin Immunol 11 (1999) 193-203
28. Janssens S., and Beyaert R. Role of Toll-like receptors in pathogen recognition. Clin Microbiol Rev 16 (2003) 637-646
29. Neal M.D., Leaphart C., Levy R., Prince J., Billiar T.R., Watkins S., et al. Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. J Immunol 175 (2006) 3070-3079
30. Prince J.M., Levy R.M., Yang R., Mollen K.P., Fink M.P., Vodovotz Y., et al. Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock. J Am Coll Surg 202 (2006) 407-417
31. Seely A.J., Pascual J.L., and Christou N.V. Science review: Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance. Crit Care 7 (2003) 291-307
32. Majetscha K.M., Borgermann J., Waydhas C., Obertacke U., Nast-Kolb D., et al. Whole blood TNF-alpha production and its relation to systemic concentration of interleukin 4, interleukin 10, and transforming growth factor-beta1 in multiply injured blunt trauma victims. Crit Care Med 28 (2000) 1847-1853
33. Pinsky M.R. Sepsis: a proinflammatory and anti-inflammatory disequilibrium syndrome. Contrib Nephrol 132 (2001) 354-366
34. Madge L.A., and Pober J.S. Tumor necrosis factor signaling in vascular endothelial cells. Experimental Molecular Pathology 70 (2001) 317-325
35. Dinarello C.A. Proinflammatory cytokines. Chest 118 (2000) 503-508
36. Dinarello C.A. Biologic basis for interleukin-1 in disease. Blood 87 (1996) 2095-2147
37. Pugin J., Ricou B., Steinberg K.P., Suter D.M., and Martin T.R. Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS, a prominent role for interleukin-1. Am J Resp Crit Care Med 153 (1996) 1850-1856
38. Liener U.C., Bruckner U.B., Knoferl M.W., Steinbach G., Kinzl L., and Gebhard F. Chemokine activation within 24 hours after blunt accident trauma. Shock 17 (2002) 169-172
39. Patrick D.A., Moore F.A., Moore E.E., Biffl W.L., Sauaia A., and Barnett C.C. The inflammatory profile of interleukin-6, interleukin-8, and soluble intercellular adhesion molecule-1 in postinjury multiple organ failure. Am J Surg 172 (1996) 425-431
40. Roumen R.M.H., Hendriks T., van der Ven-Jongekrijg, Nieuwenhuijzen G.A., Sauerwein R.W., van der Meer J.W., et al. Cytokine patterns in patients after major vascular surgery, hemorrhagic shock, and severe blunt trauma: relation with subsequent ARDS and multiple organ failure. Ann Surg 6 (1993) 769-776
41. Raeburn C.D., Sheppard F., Barsness K.A., Arya J., and Harken A.H. Cytokines for surgeons. Am J Surg 183 (2002) 268-273
42. Ford H.R. Mechanism of nitric oxide-mediated intestinal barrier failure: insight into the pathogenesis of necrotizing enterocolitis. J Ped Surg 41 (2006) 294-299
43. Holmes C.L., Russel J.A., and Walley K.R. Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy. Chest 124 (2003) 1103-1115
44. Licheng W., Holbrook C., Zaborina O., Ploplys E., Rocera F., et al. The role of epithelial cell contact and molecules: quorum sensing signaling system. Ann Surg 238 (2003) 754-764