Pro- and anti-inflammatory cytokines during acute severe pancreatitis: An early and sustained response, although unpredictable of death

Critical Care Medicine

Volumn 27, Issue 4, 1999, Pages 749-755

  Brivet, François G ^a,c   Emilie, Dominique ^b   Galanaud, Pierre ^a,b  

^a HÔPITAL ANTOINE BÉCLÈRE   (France)

^b INSERM   (France)

^c Dept of Medical Intensive Care Unit Medical Emergency Hôpital   (France)

Author keywords

Acute pancreatitis; Cytokines; Interleukin 1 ; Interleukin 1 receptor antagonist; Interleukin 10; Interleukin 6; Mediators; Multiorgan dysfunction syndrome; Prognosis; Systemic inflammatory response syndrome; Tumor necrosis factor

Indexed keywords

CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ACUTE PANCREATITIS; ADULT; AGED; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CYTOKINE PRODUCTION; DISEASE SEVERITY; FEMALE; HOSPITALIZATION; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; INTENSIVE CARE UNIT; MALE; MORTALITY; MULTIPLE ORGAN FAILURE; PRIORITY JOURNAL; PROGNOSIS; SCORING SYSTEM; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 0032939769     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199904000-00029     Document Type: Article

References (49)

1. Kusske AM, Rongione AJ, Reber HA: Cytokines and acute pancreatitis. Gastroenterology 1996; 110:639-642
2. Lamy M, Deby-Dupont G: Is sepsis a mediator-inhibitor mismatch? Intensive Care Med 1995; 21:S250-S257
3. American College of Chest Physicians/ Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864-874
4. De Waal Malefyt R, Abrams J, Bennett B, et al: Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174:1209-1220
5. Howard M, Muchamuel T, Andrade S, et al: Interleukin 10 protects mice from lethal endotoxemia. J Exp Med 1993; 177:1205-1208
6. Bean AGD, Freiberg RA, Andrade SA, et al: Interleukin 10 protects mice against staphylococcal enterotoxin b-induced lethal shock. Infect Immun 1993; 61:4937-4939
7. Van Laethem JL, Marchant A, Delvaux A, et al: Interleukin 10 prevents necrosis in murine experimental acute pancreatitis. Gastroenterology 1995; 108: 1917-1922
8. Marchant A, Devière J, Byl B, et al: Interleukin 10 production during septicemia. Lancet 1994; 343:707-708
9. Lehmann AK, Halstensen A, Sornes S, et al: High levels of interleukin 10 in serum associated with fatality in meningococcal disease. Infect Immun 1995; 63:2109-2112
10. Doughty LA, Kaplan SS, Carcillo JA: Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure. Crit Care Med 1996; 24: 1137-1143
11. Granowitz EV, Santos AA, Poutsiaka DD, et al: Production of interleukin-1 receptor antagonist during experimental endotoxemia. Lancet 1991; 338: 1423-1424
12. Granowitz EV, Porat R, Mier JW, et al: Hematologic and immunomodulatory effects of an interleukin-1 receptor antagonist coinfusion during low-dose endotoxemia in heathy humans. Blood 193; 82:2985-2990
13. Van Zee KJ, Coyle SM, Calvano SE, et al: Influence of IL-1 receptor antagonist on the human response to endotoxemia. J Immunol 1995; 154:1499-1507
14. Fisher CJ Jr, Slotman GJ, Opal SM, et al: Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of septic syndrom: a randomized, open-label, placebo-controlled, multicenter trial. Crit Care Med 1994; 22:12-21
15. Knaus WA, Zimmerman JE, Wagner DP, et al: APACHE - Acute Physiology and Chronic Health Evaluation: a physiologically based classification system. Crit Care Med 1981; 9:591-597
16. Knaus WA, Draper EA, Wagner DP, et al: APACHE II: A severity of disease classification system. Crit Care Med 1985; 13:818-829
17. Le Gall JR, Lemeshow S, Saulnier F: A new Simplified Acute Physiology Score (SAPS II) based on a European North American multicenter study. JAMA 1993; 270:2957-2963
18. Knaus WA, Draper EA, Wagner DP, et al: Prognosis in acute organ system failure. Ann Surg 1985; 202:685-693
19. Ranson JHC: Etiological and pronosis factors in human acute pancreatitis: a review. Am J Gastroenterol 1982; 77:633-638
20. Ranson JHC, Balthazar E, Caccavale R, et al: Computed tomography and the prediction of pancreatic abcess in acute pancreatitis. Ann Surg 1985; 201: 656-665
21. Dixon WJ, Brown MD, Engelman L, et al (Eds): BMDP Statistical Software Manual. Berkeley, University of California Press, 1988
22. Thijs LG, Hack CE: Time course of cytokine levels in sepsis. Intensive Care Med 1995; 21:S258-S263
23. De Beaux AC, Goldie AS, Ross JA, et al: Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis. Br J Surg 1996; 83:349-353
24. Stoelben E, Richter A, Scheibenbogen C, et al: Clinical relevance of cytokines IL-6, IL-8 and a TNF in blood of patients with acute pancreatitis. Abstr. Intensive Care Med 1994; 20:S160
25. Calandra T, Gerain J, Heumann D, et al: High circulating levels of interleukin 6 in patients with septic shock: evolution during sepsis, prognostic values and interplay with other cytokines. Am J Med 1991; 91:23-29
26. Damas P, Ledoux P, Nys M, et al: Cytokine serum level during severe sepsis in human IL-6 as a marker of severity. Ann Surg 1992; 215:356-362
27. Pinsky MR, Vincent JL, Deviere J, et al: Serum cytokine levels in human septic shock: relation to multiple-system organ failure and mortality. Chest 1993; 103:565-575
28. Hack CE, De Groot ER, Felt-Bersma RJF, et al: Increased plasma levels of interleukin 6 in sepsis. Blood 1989; 74:1704-1710
29. Friedland JS, Supultamongko PY, Remick DG, et al: Prolonged elevation of interleukin-8 and interleukin-6 concentrations in plasma and of leukocyte interleukin-8 mRna levels during septicemic and localized pseudomonas pseudomallei infection. Infect Immun 1992; 60:2402-2408
30. Kusske AM, Rongione AJ, Ashley SW, et al: Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice. Surgery 1996; 120:284-288
31. Derkx B, Marchant A, Goldman M, et al: High levels of interleukin-10 during the initial phase of fulminant meningococcal septic shock. J Infect Dis 1995; 171:229-232
32. Simonet R, Ballet JJ, Delaunay A, et al: Syndrome de défaillance multiviscérale (SDMV) et évolution des taux sériques de cytokines (IFN, TNF α, IL-8, IL-10) chez les patients atteints du syndrome septique. Abstr. Rean Urg 1995; 4:712
33. Chollet-Martin S, Rousset F, Chastre J, et al: Cytokines in adult respiratory distress syndrome. Lancet 1994; 334:1440
34. Donnelly S, Strieter RM, Reid PT, et al: The association between mortality rates and decreased concentrations of interleukin-10 and interleukin-1 receptor antagonist in the lung fluids of patients with the adult respiratory distress syndrome. Ann Intern Med 1996; 125:191-196
35. Van Deuren M., Van der Ven-JongeKrijg J, Bartelink AKM, et al: Correlation between proinflammatory cytokines and antiinflammatory mediators and the severity of disease in meningococcal infections. J Infect Dis 1995; 172:433-439
36. Norman J, Franz M, Messina J, et al: Interleukin-1 receptor antagonist decreases severity of experimental acute pancreatitis. Surgery 1995; 117:648-655
37. Norman JG, Franz MG, Messina J, et al: Decreased mortality of severe acute pancreatitis after proximal cytokine blockade. Ann Surg 1995; 221:625-631
38. Rogy MA, Coyle SM, Oldenburg HS, et al: Persistently elevated soluble tumor necrosis factor receptor and interleukin-1 receptor antagonist levels in critically ill patients. J Am Coll Surg 1994; 178:132-138
39. Kuhns DB, Alvord G, Gallin JI: Increased circulating cytokines, cytokine antagonists, and E selectin after intravenous administration of endotoxins in humans. J Infect Dis 1995; 171:145-152
40. Bone RC: Immunologic dissonnance: a continuing evolution in our understanding of the systemic inflammtory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS). Ann Intern Med 1996; 125: 680-687
41. Bone RC: Sir Isaac Newton, sepsis, SIRS and CARS. Crit Care Med 1996; 24:1125-1128
42. Bone RC: Sepsis and its complications: the clinical problems. Crit Care Med 1994; 22:S8-S11
43. Casey LC, Balk RA, Bone RC: Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Intern Med 1993; 119:771-778
44. Marty C, Misset B, Tamion F, et al: Circulating interleukin-8 concentrations in patients with multiple organ failure of septic and non-septic origin. Crit Care Med 1994; 22:673-679
45. Kaufmann P, Tilz GP, Luege A, et al: Elevated plasma levels of soluble tumor necrosis factor receptor (STNFR p60) reflect severity of acute pancreatitis. Intensive Care Med 1997; 23: 841-848
46. Damas P, Canivet JL, De Groote D, et al: Sepsis and serum cytokine concentrations. Crit Care Med 1997; 25: 405-412
47. Moscovitz H, Shofer F, Mignott H, et al: Plasma cytokine determinations in emergency departement patients as a predictor of bacteriemia and infectious disease severity. Crit Care Med 1994; 22:1102-1107
48. Friedland JS, Porter JC, Daryananis S, et al: Plasma proinflammatory cytokine concentrations, acute physiology and chronic health evaluation (APACHE) III scores and survival in patients in an intensive care unit. Crit Care Med 1996; 24:1775-1781
49. Matuschak GM: Circulating cytokine concentrations and outcome prediction in Intensive Care Unit patients: still the tip of the iceberg? Crit Care Med 1996; 24:1769-1771