Inflammatory mediators in human acute pancreatitis: Clinical and pathophysiological implications

Gut

Volumn 47, Issue 4, 2000, Pages 546-552

  Mayer, J ^a   Rau, B ^a   Gansauge, F ^a   Beger, H G ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Cytokines; Lymphocyte activation; Organ complications; Pancreatic necrosis; Pancreatitis

Indexed keywords

AMYLASE; C REACTIVE PROTEIN; CATECHOLAMINE; CYTOKINE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 8; LACTATE DEHYDROGENASE; TRIACYLGLYCEROL LIPASE;

ACUTE PANCREATITIS; ADULT; AGED; ARTICLE; ASCITES; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; KIDNEY FAILURE; LUNG INSUFFICIENCY; LYMPHOCYTE ACTIVATION; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MULTIPLE ORGAN FAILURE; PANCREAS NECROSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; SHOCK; SYSTOLIC BLOOD PRESSURE;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1; INTERLEUKIN-10; INTERLEUKIN-6; INTERLEUKIN-8; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; PANCREATITIS; PROGNOSIS; PROSPECTIVE STUDIES; RECEPTORS, INTERLEUKIN-1; RECEPTORS, INTERLEUKIN-2; SEVERITY OF ILLNESS INDEX;

EID: 0033804768     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.47.4.546     Document Type: Article

References (44)

1. 1 Norman J. The role of cytokines in the pathogenesis of acute pancreatitis. Am J Surg 1998;175:76-83.
2. 2 Norman JG, Franz MG, Fink GS, et al. Decreased mortality of severe acute pancreatitis after proximal cytokine blockade. Ann Surg 1995;221:625-34.
3. 3 Norman JG, Fink GW, Sexton C, Carter G. Transgenic animals demonstrate a role for the IL-1 receptor in regulating IL-1 beta gene expression at steady-state and during the systemic stress induced by acute pancreatitis. J Surg Res 1996;63:231-6.
4. 4 Rongione AJ, Kusske AM, Kwan K, Ashley SW, Reber HA, McFadden DW. Interleukin 10 reduces the severity of acute pancreatitis in rats. Gastroenterology 1997;112:960-7.
5. 5 Kusske AM, Rongione AJ, Ashley SW, McFadden DW, Reber HA. Interleukin-10 prevents death in lethal necrotizing pancreatitis in mice. Surgery 1996;120:284-8.
6. 6 Bradley E. A clinically based classification system for acute pancreatitis: Summary of the international symposium on acute pancreatitis. Arch Surg 1993;128:586-90.
7. 7 ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/ Society of Critical Care Medicine Consensus Conference: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992;20:864-74.
8. 8 Fink GW, Norman J. Specific changes in the pancreatic expression of the interleukin 1 family of genes during experimental acute pancreatitis. Cytokine 1997;9:1023-7.
9. 9 Denham W, Yang J, Fink G, et al. Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis. Gastroenterology 1997;113:1741-6.
10. 10 Fink GW, Norman J. Intrapancreatic interleukin 1beta gene expression by specific leukocyte populations during acute pancreatitis. J Surg Res 1996;63:369-73.
11. 11 Norman J, Fink GW, Denham W, et al. Tissue-specific cytokine production during experimental acute pancreatitis. A probable mechanism for distant organ dysfunction. Dig Dis Sci 1997;42:1783-8.
12. 12 Geissler K. Current status of clinical development of interleukin 10. Curr Opin Hematol 1996;3:203-8.
13. 13 Heath DI, Cruickshank A, Gudgeon AM, Jehanli AM, Shenkin A, Imrie CW. The relationship between pancreatic enzyme release and activation and the acute phase protein response in patients with acute pancreatitis. Pancreas 1995; 10:347-53.
14. 14 Uhl W, Buechler M, Malfertheiner P, Martini M, Beger HG. PMN-elastase in comparison with CRP, antiproteases and LDH as indicators of necrosis in human acute pancreatitis. Pancreas 1991;6:253-9.
15. 15 Berney T, Gasche Y, Robert J, et al. Serum profiles of interleukin-6, interleukin-8 and interleukin-10 in patients with severe and mild acute pancreatitis. Pancreas 1999;18: 371-7.
16. 16 Brivet FG, Emilie D, Galanaud P. Pro-and antiinflammatory cytokines during acute pancreatitis: an early and sustained response although unpredictive of death. Parisian Study Group on acute pancreatitis. Crit Care Med 1999;27: 749-55.
17. 17 Heresbach D, Letourneur JP, Bahon I, et al. Value of early blood Th-1 cytokine determination in predicting severity of acute pancreatitis. Scand J Gastroenterol 1998;33:554-60.
18. 18 Inagaki T, Hoshino M, Hayakawa T, et al. Interleukin 6 is a useful marker for early prediction of the severity of acute pancreatitis. Pancreas 1997;14:1-8.
19. 19 Formela LJ, Galloway SW, Kingsnorth AN. Inflammatory mediators in acute pancreatitis. Br J Surg 1995;82:6-13.
20. 20 Viedma JA, Perez-Mateo M, Dominguez JE, Carballo F. Role of interleukin 6 in acute pancreatitis - Comparison with CRP and phospholipase A. Gut 1992;33:1264-7.
21. 21 Pezzilli R, Billi P, Miniero R, et al. Serum interleukin-6, interleukin-8 and beta2-microglobulin in early assessment of severity of acute pancreatitis - Comparison with serum CRP. Dig Dis Sci 1995;40:2341-8.
22. 22 Pezzilli R, Morselli-Labate AM, Miniero R, Barakat B, Fiocchi M, Cappelletti O. Simultaneous serum assays of lipase and interleukin 6 for early diagnosis and prognosis of acute pancreatitis. Clin Chem 1999;45:1762-7.
23. 23 Gross V, Andreesen R, Leser HG, et al. Interleukin 8 and neutrophil activation in acute pancreatitis. Eur J Clin Invest 1992;22:200-3.
24. 24 Rau B, Steinbach G, Gansauge F, Mayer J, Grunert A, Beger HG. The potential role of procalcitonin and interleukin 8 in the prediction of infected necrosis in acute pancreatitis. Gut 1997;41:832-40.
25. 25 McKay CJ, Gallagher G, Brooks B, Imrie CW, Baxter JN. Increased monocyte cytokine production in association with systemic complications in acute pancreatitis. Br J Surg 1996;83:919-23.
26. 26 De Beaux AC, Ross J, Maingay JP, Fearon KCH, Carter DC. Proinflammatory cytokine release by peripheral blood mononuclear cells from patients with acute pancreatitis. Br J Surg 1996;83:1071-5.
27. 27 Norman J, Yang J, Fink G, et al. Severity and mortality of experimental pancreatitis are dependent on interleukin-1 converting enzyme (ICE). J Interferon Cytokine Res 1997;17:113-18.
28. 28 Tanaka K, Murata A, Uda K, et al. Interleukin 1 receptor antagonist modifies the changes in vital organs induced by acute necrotizing pancreatitis in a rat experimental model. Crit Care Med 1995;23:901-8.
29. 29 Norman J, Franz M, Messina J, et al. Interleukin-1 receptor antagonist decreases severity of experimental acute pancreatitis. Surgery 1995;117:648-55.
30. 30 Hynninen M, Valtonen M, Markkanen H, et al. Interleukin-1 receptor antagonist and E- selectin concentrations: A comparison in patients with severe acute pancreatitis and severe sepsis. J Crit Care 1999;14:63-8.
31. 31 Tompkins RG. The role of proinflammatory cytokines in inflammatory and metabolic responses. Ann Surg 1997; 225:243-5.
32. 32 Kingsnorth AN. Role of cytokines and their inhibitors in acute pancreatitis. Gut 1997;40:1-4.
33. 33 Farkas G, Marton J, Nagy Z, et al. Experimental acute pancreatitis results in increased blood-brain barrier permeability in the rat: A potential role for tumor necrosis factor and interleukin 6. Neurosci Lett 1998;242:147-50.
34. 34 Donnelly SC, Strieter R, Kunkel ST, et al. Interleukin 6 and development of adult respiratory distress syndrome in at-risk groups. Lancet 1993;341:643-7.
35. 35 Van Laethem JL, Marchant A, Delvaux A, et al. Interleukin 10 prevents necrosis in murine experimental acute pancreatitis. Gastroenterology 1995;108:1917-22.
36. 36 Denham W, Denham D, Yang J, et al. Transient human gene therapy: A novel cytokine regulatory strategy for experimental pancreatitis. Ann Surg 1998;227:812-20.
37. 37 Pezzilli R, Billi P, Miniero R, Barakat B. Serum interleukin 10 in human acute pancreatitis. Dig Dis Sci 1997;42:1469-72.
38. 38 Chen CC, Wang SS, Lu RH, Chang FY, Lee SD. Serum interleukin 10 and interleukin 11 in patients with acute pancreatitis. Gut 1999;45:895-9.
39. 39 Pezzilli R, Billi P, Beltrandi E, et al. Behavior of serum soluble interleukin 2 receptor, soluble CD8 and soluble CD4 in the early phases of acute pancreatitis. Digestion 1994;55: 268-73.
40. 40 Curley P, McMahon RF, Lancaster F, et al. Reduction in circulating levels of CD4-positive lymphocytes in acute pancreatitis: Relationship to endotoxin, interleukin 6 and disease severity. Br J Surg 1993;80:1312-15.
41. 41 Chaloner C, Laing I, Heath DI, Imrie C, Braganza JM. Dysregulation of T cell-macrophage network in severe acute pancreatitis. Biochem Soc Transact 1993;21:451.
42. 42 Widdison AL, Cunningham S. Immune function early in acute pancreatitis. Br J Surg 1996;83:633-6.
43. 43 Mayer J, Laine VJO, Rau B, et al. Systemic lymphocyte activation modulates the severity of diet-induced acute pancreatitis in mice. Pancreas 1999;19:62-8.
44. 44 Mayer J, Laine VJO, Gezgin A, et al. Single shot FK506 and OKT3 reduces early severity in experimental acute pancreatitis. Eur J Surg 2000;166: