Kupffer cell blockade reduces hepatic and systemic cytokine levels and lung injury in hemorrhagic pancreatitis in rats

Pancreas

Volumn 21, Issue 4, 2000, Pages 414-420

  Gloor, Beat ^a   Blinman, Thane A ^a   Rigberg, David A ^a   Todd, Karen E ^a   Lane, John S ^a   Hines, Oscar J ^a   Reber, Howard A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acute pancreatitis; Cytokines and chemokines; Kupffer cell blockade; Lung injury

Indexed keywords

CYTOKINE; GADOLINIUM CHLORIDE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; SODIUM CHLORIDE; TAUROCHOLIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEMORRHAGIC PANCREATITIS; HEPATIC VEIN; ILIAC ARTERY; KUPFFER CELL; LIVER; LUNG; LUNG INJURY; MORTALITY; NONHUMAN; PANCREAS; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYSTEMIC CIRCULATION;

ACUTE DISEASE; ANIMALS; CYTOKINES; FEMALE; KUPFFER CELLS; LIVER; LUNG; PANCREATITIS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 0033752289     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-200011000-00013     Document Type: Article

References (33)

1. Pancreatitis definitions and classification
2. A clinically based classification system for acute pancreatitis
3. Surgical treatment of infected necrosis
4. Surgical indications and techniques in necrotizing pancreatitis
5. Effects of cytokines, and other inflammatory mediators on human acute pancreatitis
6. The role of cytokines in the pathogenesis of acute pancreatitis
7. Serum profiles of interleukin-6, interleukin-8, and interleukin-10 in patients with severe and mild acute pancreatitis
8. Intrinsic production of pro-inflammatory cytokines by the pancreas during acute pancreatitis
9. Hepatocyte-derived interleukin-6 and tumor-necrosis factor alpha mediate the lipopolysaccharide-induced acute-phase response and nitric oxide release by cultured rat hepatocytes
10. Endotoxin stimulates interleukin-6 production by human Kupffer cells
11. Hepatic Kupffer cell blockade reduces mortality in acute hemorrhagic pancreatitis in mice
12. Interleukin 10 reduces the severity of acute pancreatitis in rats
13. Experimental acute pancreatitis - A quantification of dynamics at enzymic and histomorphologic levels
14. Acute pancreatitis in rats: Effects of sodium taurocholate, CCK-8, and secretin on pancreatic microcirculation
15. Experimental pancreatitis in the rat; sodium taurocholate-induced acute haemorrhagic pancreatitis
16. A better model of acute pancreatitis for evaluating therapy
17. Electron microscopic study of Kupffer cell phagocytosis blockade induced by gadolinium chloride
18. Selective depletion of Kupffer cells after intravenous injection of gadolinium chloride
19. Inhihition of anaphylactic shock by gadolinium chloride-induced Kupffer cell blockade
20. Gadolinium chloride selectively blocks endocytosis by Kupffer cells
21. Effects of the Kupffer cell inactivator gadolinium chloride on rat liver oxygen uptake and content of mitochondrial cytochromes
22. Liposome-encapsulated dichloromethylene diphosphonate induces macrophage apoptosis in vivo and in vitro
23. Induction of tumor necrosis factor in acute pancreatitis and its subsequent reduction after hepatic passage
24. Tissue-specific cytokine production during experimental acute pancreatitis. A probable mechanism for distant organ dysfunction
25. Small molecule inhibition of tumor necrosis factor gene processing during acute pancreatitis prevents cytokine cascade progression and attenuates pancreatitis severity
26. Acute pancreatitis induces cytokine production in endotoxin-resistant mice
27. Tumor necrosis factor stimulates superoxide anion generation by Kupffer cells
28. Mechanism of increased lung injury after acute pancreatitis in IL-10 knockout mice
29. Hepatic involvement in pancreatitis-induced lung damage
30. Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver
31. Lymphatic release of cytokines during acute lung injury complicating severe pancreatitis
32. Neutrophil-dependent, oxygen-radical mediated lung injury associated with acute pancreatitis
33. Anti-neutrophil antibody attenuates the severity of acute lung injury in rats with experimental acute pancreatitis