Pancreatic elastase induces liver injury by activating cytokine production within kupffer cells via nuclear factor-kappa B

Journal of Gastrointestinal Surgery

Volumn 6, Issue 3, 2002, Pages 474-480

  Murr, Michel M ^a,c   Yang, Jun ^a   Fier, Adam ^a   Kaylor, Pam ^a   Mastorides, Stephen ^b   Norman, James G ^b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c TAMPA GENERAL HOSPITAL   (United States)

Author keywords

Cytokines; Kupffer cells; Liver injury; Pancreatic enzymes; Pancreatitis

Indexed keywords

GADOLINIUM; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIVER ENZYME; MESSENGER RNA; PANCREATIC ELASTASE; PYRROLIDINE DITHIOCARBAMATE; TUMOR NECROSIS FACTOR; CYTOKINE; TUMOR NECROSIS FACTOR ALPHA;

ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; KUPFFER CELL; LIVER CELL; LIVER INJURY; LIVER PARENCHYMA; MALE; NONHUMAN; RAT; STATISTICAL SIGNIFICANCE; AGAR GEL ELECTROPHORESIS; ANIMAL; CELL CULTURE; EVALUATION; GEL MOBILITY SHIFT ASSAY; IN VITRO STUDY; LIVER; METABOLISM; PHYSIOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALS; CELLS, CULTURED; CYTOKINES; ELECTROPHORESIS, AGAR GEL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HEPATOCYTES; KUPFFER CELLS; LIVER; MALE; NF-KAPPA B; PANCREATIC ELASTASE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036582349     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1091-255X(01)00071-3     Document Type: Article

References (18)

1. Norman J. Role of cytokines in the pathogenesis of acute pancreatitis. Am J Surg 1998;175:76-83.
2. Norman J, Fink G, Franz M. Acute pancreatitis induces intrapancreatic tumor necrosis factor gene expression. Arch Surg 1995;130:966-970.
3. Norman J, Franz M, Riker A, Gower W. Rapid elevation of cytokines during acute pancreatitis and their origination within the pancreas. Surg Forum 1994;45:148-150.
4. Yang J, Jaffray C, Carter G, Norman J. Pancreatic elastase-induced lung injury mimics pancreatitis-associated ARDS. Dig Dis Sci (submitted for publication).
5. Jaffray C, Yang J, Norman J. Elastase mimics pancreatitis-induced hepatic injury via inflammatory mediators. J Surg Res 2000;90:95-101.
6. Gloor B, Todd K, Lane J, Lewis M, Reber H. Hepatic Kupffer cell blockade reduces mortality of acute hemorrhagic pancreatitis in mice. J GASTROINTEST SURG 1998;2: 430-435.
7. Zhu X, Zellweger R, Ayala A, Chaudry I. Cytokine gene expression in Kupffer cells following hemorrhage. Cytokine 1996;8:134-140.
8. Koo D, Chaudry I, Wang P. Kuppfer cells are responsible for producing inflammatory cytokines and hepatocellular dysfunction during early sepsis. J Surg Res 1999;83:151-157.
9. Hems R, Ross BD, Berry MN, Krebs HA. Gluconeogenesis in the perfused rat liver. Biochem J 1966;101:284-292.
10. Kamimura S, Tsukamoto H. Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease. Hepatology 1995;21:1304-1309.
11. Lee SJ, Friedman SL, Whalen R, Boyer TD. Cellular sources of glutathione S-transferase P in primary cultured rat hepatocytes: Localization by in situ hybridization. Biochem J 1994;229:79-83.
12. Yang J, Denham W, Carter G, Tracey KJ, Norman J. Macrophage pacification reduces pancreatitis-induced hepato-cellular injury through downregulation of hepatic TNF and IL-1. Hepatology 1998;28:1282-1288.
13. Denham W, Yang J, Fink G, Zervos EE, Carter G, Norman J. Pancreatic ascites as a powerful inducer of inflammatory cytokines: The role of known vs. unknown factors. Arch Surg 1997;132:1231-1236.
14. Jaffray C, Mendez C, Denham W, Carter G, Norman J. Specific pancreatic enzymes activate macrophages to produce TNF-alpha: Role of Nuclear Factor Kappa B and Inhibitory-Kappa B proteins. J GASTROINTEST SURG 2000;4:370-378.
15. Pahl HL. Activation and target genes of Rel/NF-κB transcription factors. Oncogene 1999;18:8653-8666.
16. Husztik E, Lazar G, Parducz A. Electron microscope study of Kupffer cell phagocytosis blockade induced by gadolinium chloride. Br J Exp Pathol 1980;61:624-630.
17. 2 synthesis and septic mortality. Hepatology 1999,29:756-765.
18. Mizgerd J, Molina R, Stearns R, Brain J, Warner A. Gadolinium induces macrophage apoptosis. J Leukocyte Biol 1996;59:189-195.