Inhibiting EGFR dimerization using triazolyl-bridged dimerization arm mimics

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Hanold, Laura E ^a   Oruganty, Krishnadev ^b   Ton, Norman T ^a   Beedle, Aaron M ^a   Kannan, Natarajan ^a   Kennedy, Eileen J ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b Department of Biochemistry and Molecular Biology University of Georgia ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBENE; CHEMICAL COMPOUND; EDA1 PEPTIDE; EDA2 PEPTIDE; EDA2 SCR PEPTIDE; EDA3 PEPTIDE; EDA4 PEPTIDE; EDA5 PEPTIDE; EDA6 PEPTIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; PEPTIDE DERIVATIVE; TRIAZOLYL; UNCLASSIFIED DRUG; ECTODYSPLASIN A; TRIAZOLE DERIVATIVE;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DIMERIZATION; DRUG DESIGN; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG STABILITY; DRUG STRUCTURE; DRUG TARGETING; HUMAN; HUMAN CELL; PROTEIN DEGRADATION; PROTEIN STABILITY; RECEPTOR DOWN REGULATION; BIOSYNTHESIS; CARCINOMA; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MOLECULAR DYNAMICS; PHYSIOLOGY; PROCEDURES; PROTEIN ENGINEERING;

ALLOSTERIC REGULATION; CARCINOMA; DIMERIZATION; ECTODYSPLASINS; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN ENGINEERING; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRIAZOLES;

EID: 84925431232     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0118796     Document Type: Article

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