Maintaining biological activity by using triazoles as disufide bond mimetics

Angewandte Chemie - International Edition

Volumn 50, Issue 22, 2011, Pages 5204-5206

  Holland Nell, Kai ^b   Meldal, Morten ^a  

^a CARLSBERG LABORATORY   (Denmark)

^b Leibniz Insitut für Molekulare Pharmakologie ^*  (Germany)

Author keywords

antibacterial activity; click chemistry; cyclization; nitrogen heterocycles; peptidomimetics

Indexed keywords

ANTI-BACTERIAL ACTIVITY; BIOLOGICAL ACTIVITIES; CLICK CHEMISTRY; CYSTEINE RESIDUES; DISULFIDE BRIDGE; MIMETICS; NITROGEN HETEROCYCLES; OPTIMIZED STRUCTURES; PEPTIDOMIMETICS;

AMINO ACIDS; COVALENT BONDS;

IODINE;

ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; BIOMIMETIC MATERIAL; CYCLOPEPTIDE; DISULFIDE; DNA BINDING PROTEIN; PEPTIDOMIMETIC AGENT; TACHYPLESIN PEPTIDE, TACHYPLEUS TRIDENTATUS; TRIAZOLE DERIVATIVE;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; CLICK CHEMISTRY; CYCLIZATION; MICROBIOLOGICAL EXAMINATION; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BIOMIMETIC MATERIALS; CLICK CHEMISTRY; CYCLIZATION; DISULFIDES; DNA-BINDING PROTEINS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PEPTIDES, CYCLIC; PEPTIDOMIMETICS; TRIAZOLES;

EID: 79956131018     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201005846     Document Type: Article

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