On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide-alkyne cycloaddition

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 20, 2007, Pages 5590-5594

  Goncalves, Victor ^a,b   Gautier, Benoit ^a,b   Regazzetti, Anne ^a   Coric, Pascale ^a,b   Bouaziz, Serge ^a,b   Garbay, Christiane ^a,b   Vidal, Michel ^a,b   Inguimbert, Nicolas ^a,b  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b INSERM   (France)

Author keywords

Antagonist; Click chemistry; Cyclic peptide; Huisgen reaction; Resin supported synthesis; VEGF receptors

Indexed keywords

1,3 DIPOLAR AZIDE; ALKYNE; AZIDE; CUPROUS ION; RESIN; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 1;

ANALYTIC METHOD; ARTICLE; CYCLIZATION; CYCLOADDITION; PROTEIN ANALYSIS; PROTEIN MODIFICATION; PROTEIN STRUCTURE;

ALKYNES; AMINO ACID SEQUENCE; AZIDES; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COPPER; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 34548566907     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.07.087     Document Type: Article

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