Inhibitory effect of a dimerization-arm-mimetic peptide on EGF receptor activation

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 12, 2009, Pages 3279-3282

  Mizuguchi, Takaaki ^a   Uchimura, Hiromasa ^b   Kakizawa, Taeko ^a   Kimura, Tooru ^a   Yokoyama, Shigeyuki ^c,d   Kiso, Yoshiaki ^a   Saito, Kazuki ^b,c  

^a Center for Frontier Research in Medicinal Science   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^c RIKEN   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

A431 cells; Autophosphorylation; Dimerization inhibitor; Dimerization arm mimetic peptide; EGF receptor

Indexed keywords

CYCLOPEPTIDE; DETERGENT; DIMER; EPIDERMAL GROWTH FACTOR RECEPTOR; PEPTIDOMIMETIC AGENT;

ARTICLE; AUTOPHOSPHORYLATION; BETA SHEET; CRYSTAL STRUCTURE; DIMERIZATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIGAND BINDING; RECEPTOR UPREGULATION;

CELL LINE, TUMOR; DRUG DESIGN; HUMANS; MOLECULAR MIMICRY; PEPTIDES, CYCLIC; PROTEIN MULTIMERIZATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 65749111884     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.080     Document Type: Article

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