Evaluation of dimerization-inhibitory activities of cyclic peptides containing a β-hairpin loop sequence of the EGF receptor

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 19, 2012, Pages 5730-5737

  Mizuguchi, Takaaki ^a   Ohara, Naho ^a   Iida, Mika ^a   Ninomiya, Ryunosuke ^a   Wada, Shinji ^a   Kiso, Yoshiaki ^a   Saito, Kazuki ^a,b   Akaji, Kenichi ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

A431 cell; Cyclic peptide; Dimerization; EGF receptor; Inhibitor; Retro Inverso modification

Indexed keywords

CYCLOPEPTIDE; CYSTEINE; EPIDERMAL GROWTH FACTOR RECEPTOR;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; AUTOPHOSPHORYLATION; BETA HAIRPIN LOOP STRUCTURE; CONTROLLED STUDY; DIMERIZATION; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84866373458     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.08.013     Document Type: Article

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