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Volumn 35, Issue 5, 2015, Pages 1381-1387

Dihydroartemisinin inhibits endothelial cell proliferation through the suppression of the ERK signaling pathway

Author keywords

Angiogenesis; Dihydroartemisinin; Endothelial cell; Extracellular signal regulated kinase; Proliferation

Indexed keywords

DIHYDROARTEMISININ; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYC PROTEIN; PROTEIN C FOS; ARTEMISININ DERIVATIVE;

EID: 84925391729     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2015     Document Type: Article
Times cited : (45)

References (39)
  • 1
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J: Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1:27-31, 1995.
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 2
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP and Le Couter J: The biology of VEGF and its receptors. Nat Med 9:669-676, 2003.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Le Couter, J.3
  • 3
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P and Jain RK: Angiogenesis in cancer and other diseases. Nature 407:249-257, 2000.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 4
    • 10444255566 scopus 로고    scopus 로고
    • Angiogenesis: Now and then
    • Costa C, Soares R and Schmitt F Angiogenesis: now and then. APMIS 112:402-412, 2004
    • (2004) APMIS , vol.112 , pp. 402-412
    • Costa, C.1    Soares, R.2    Schmitt, F.3
  • 5
    • 0033179470 scopus 로고    scopus 로고
    • Molecular angiogenesis
    • Klagsbrun M and Moses MA: Molecular angiogenesis. Chem Biol 6:R217-R224, 1999
    • (1999) Chem Biol , vol.6 , pp. R217-R224
    • Klagsbrun, M.1    Moses, M.A.2
  • 6
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W: Mechanisms of angiogenesis. Nature 386:671-674, 1997
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 7
    • 77951622431 scopus 로고    scopus 로고
    • Differential induction of MAP kinase signalling pathways by cadmium in primary cultures of mouse embryo limb bud cells
    • Liu J and Kapron CM: Differential induction of MAP kinase signalling pathways by cadmium in primary cultures of mouse embryo limb bud cells. Reprod Toxicol 29:286-291, 2010.
    • (2010) Reprod Toxicol , vol.29 , pp. 286-291
    • Liu, J.1    Kapron, C.M.2
  • 8
    • 0029964537 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase (MAPK) in cardiac tissues
    • Page C and Doubell AF: Mitogen-activated protein kinase (MAPK) in cardiac tissues. Mol Cell Biochem 157:49-57, 1996.
    • (1996) Mol Cell Biochem , vol.157 , pp. 49-57
    • Page, C.1    Doubell, A.F.2
  • 9
    • 0036590653 scopus 로고    scopus 로고
    • The role of MAP kinases in endothelial activation
    • Hoefen RJ and Berk BC: The role of MAP kinases in endothelial activation. Vascul Pharmacol 38:271-273, 2002.
    • (2002) Vascul Pharmacol , vol.38 , pp. 271-273
    • Hoefen, R.J.1    Berk, B.C.2
  • 10
    • 0032731533 scopus 로고    scopus 로고
    • The development of new antimalarial drugs: Qinghaosu and dihydro-qinghaosu
    • Tu Y: The development of new antimalarial drugs: qinghaosu and dihydro-qinghaosu. Chin Med J (Engl) 112:976-977, 1999
    • (1999) Chin Med J (Engl) , vol.112 , pp. 976-977
    • Tu, Y.1
  • 11
    • 84855554316 scopus 로고    scopus 로고
    • Antitumor activity of artemisinin and its derivatives: From a well-known antimalarial agent to a potential anticancer drug
    • Crespo-Ortiz MP and Wei MQ: Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug. J Biomed Biotechnol 2012:247597, 2012.
    • (2012) J Biomed Biotechnol , vol.2012 , pp. 247597
    • Crespo-Ortiz, M.P.1    Wei, M.Q.2
  • 13
    • 33750007435 scopus 로고    scopus 로고
    • In vivo and in vitro investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos
    • Longo M, Zanoncelli S, Torre PD, et al: In vivo and in vitro investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos. Reprod Toxicol 22:797-810, 2006.
    • (2006) Reprod Toxicol , vol.22 , pp. 797-810
    • Longo, M.1    Zanoncelli, S.2    Torre, P.D.3
  • 14
    • 0038689359 scopus 로고    scopus 로고
    • Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro
    • Chen HH, Zhou HJ and Fang X: Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro. Pharmacol Res 48:231-236, 2003.
    • (2003) Pharmacol Res , vol.48 , pp. 231-236
    • Chen, H.H.1    Zhou, H.J.2    Fang, X.3
  • 15
    • 11844281505 scopus 로고    scopus 로고
    • Apoptosis of human umbilical vein endothelial cells induced by artesunate
    • Wu GD, Zhou HJ and Wu XH: Apoptosis of human umbilical vein endothelial cells induced by artesunate. Vascul Pharmacol 41:205-212, 2004
    • (2004) Vascul Pharmacol , vol.41 , pp. 205-212
    • Wu, G.D.1    Zhou, H.J.2    Wu, X.H.3
  • 16
    • 79960906401 scopus 로고    scopus 로고
    • Hypoxia modulates the effect of dihydroartemisinin on endothelial cells
    • D'Alessandro S, Basilico N, Corbett Y, et al: Hypoxia modulates the effect of dihydroartemisinin on endothelial cells. Biochem Pharmacol 82:476-484, 2011.
    • (2011) Biochem Pharmacol , vol.82 , pp. 476-484
    • D'Alessandro, S.1    Basilico, N.2    Corbett, Y.3
  • 17
    • 84871325625 scopus 로고    scopus 로고
    • Induction of neurite outgrowth in PC12 cells by artemisinin through activation of ERK and p38 MAPK signaling pathways
    • Sarina, Yagi Y, Nakano O, et al: Induction of neurite outgrowth in PC12 cells by artemisinin through activation of ERK and p38 MAPK signaling pathways. Brain Res 1490:61-71, 2013.
    • (2013) Brain Res , vol.1490 , pp. 61-71
    • Sarina1    Yagi, Y.2    Nakano, O.3
  • 18
    • 78650652371 scopus 로고    scopus 로고
    • Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase C5/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages
    • Wang Y, Huang ZQ, Wang CQ, et al: Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase C5/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages. Clin Exp Pharmacol Physiol 38:11-18, 2011.
    • (2011) Clin Exp Pharmacol Physiol , vol.38 , pp. 11-18
    • Wang, Y.1    Huang, Z.Q.2    Wang, C.Q.3
  • 19
    • 56149102126 scopus 로고    scopus 로고
    • Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species
    • Lu JJ, Meng LH, Cai YJ, et al: Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen species. Cancer Biol Ther 7:1017-1023, 2008.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1017-1023
    • Lu, J.J.1    Meng, L.H.2    Cai, Y.J.3
  • 20
    • 84908206790 scopus 로고    scopus 로고
    • Dihydroartemisinin inhibits VEGF-induced endothelial cell migration by a p38 MAPK-independent pathway
    • Guo L, Dong FY, Hou YL, et al: Dihydroartemisinin inhibits VEGF-induced endothelial cell migration by a p38 MAPK-independent pathway. Exp Ther Med 8:1707-1712, 2014
    • (2014) Exp Ther Med , vol.8 , pp. 1707-1712
    • Guo, L.1    Dong, F.Y.2    Hou, Y.L.3
  • 21
    • 79956328903 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical applications of angiogenesis
    • Carmeliet P and Jain RK: Molecular mechanisms and clinical applications of angiogenesis. Nature 473:298-307, 2011.
    • (2011) Nature , vol.473 , pp. 298-307
    • Carmeliet, P.1    Jain, R.K.2
  • 22
    • 0028786336 scopus 로고
    • Transcriptional regulation by MAP kinases
    • Davis RJ: Transcriptional regulation by MAP kinases. Mol Reprod Dev 42:459-467, 1995
    • (1995) Mol Reprod Dev , vol.42 , pp. 459-467
    • Davis, R.J.1
  • 23
    • 0026912870 scopus 로고
    • The immediate early genes of human cytomegalovirus upregulate expression of the cellular genes myc and fos
    • Monick MM, Geist LJ, Stinski MF and Hunninghake GW: The immediate early genes of human cytomegalovirus upregulate expression of the cellular genes myc and fos. Am J Respir Cell Mol Biol 7:251-256, 1992.
    • (1992) Am J Respir Cell Mol Biol , vol.7 , pp. 251-256
    • Monick, M.M.1    Geist, L.J.2    Stinski, M.F.3    Hunninghake, G.W.4
  • 25
    • 78650461227 scopus 로고    scopus 로고
    • Electrical cell-substrate impedance sensing as a non-invasive tool for cancer cell study
    • Hong J, Kandasamy K, Marimuthu M, Choi CS and Kim S: Electrical cell-substrate impedance sensing as a non-invasive tool for cancer cell study. Analyst 136:237-245, 2011.
    • (2011) Analyst , vol.136 , pp. 237-245
    • Hong, J.1    Kandasamy, K.2    Marimuthu, M.3    Choi, C.S.4    Kim, S.5
  • 26
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N and Kerbel RS: Angiogenesis as a therapeutic target. Nature 438:967-974, 2005.
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 27
    • 0141545134 scopus 로고    scopus 로고
    • Growth inhibition activity of thioacetal artemisinin derivatives against human umbilical vein endothelial cells
    • Oh S, Jeong IH, Shin WS and Lee S: Growth inhibition activity of thioacetal artemisinin derivatives against human umbilical vein endothelial cells. Bioorg Med Chem Lett 13:3665-3668, 2003.
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 3665-3668
    • Oh, S.1    Jeong, I.H.2    Shin, W.S.3    Lee, S.4
  • 28
    • 0033094007 scopus 로고    scopus 로고
    • Pathways of macromolecular extravasation across microvascular endothelium in response to VPF/VEGF and other vasoactive mediators
    • Feng D, Nagy JA, Pyne K, Hammel I, Dvorak HF and Dvorak AM: Pathways of macromolecular extravasation across microvascular endothelium in response to VPF/VEGF and other vasoactive mediators. Microcirculation 6:23-44, 1999.
    • (1999) Microcirculation , vol.6 , pp. 23-44
    • Feng, D.1    Nagy, J.A.2    Pyne, K.3    Hammel, I.4    Dvorak, H.F.5    Dvorak, A.M.6
  • 29
    • 0026165752 scopus 로고
    • Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies
    • Boulton TG and Cobb MH: Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. Cell Regul 2:357-371, 1991.
    • (1991) Cell Regul , vol.2 , pp. 357-371
    • Boulton, T.G.1    Cobb, M.H.2
  • 30
    • 0032524644 scopus 로고    scopus 로고
    • Molecular cloning and characterization of the human p44 mitogen-activated protein kinase gene
    • García F, Zalba G, Páez G, Encío I and De Miguel C: Molecular cloning and characterization of the human p44 mitogen-activated protein kinase gene. Genomics 50:69-78, 1998.
    • (1998) Genomics , vol.50 , pp. 69-78
    • García, F.1    Zalba, G.2    Páez, G.3    Encío, I.4    De Miguel, C.5
  • 31
    • 0026578183 scopus 로고
    • Extracellular signal-regulated kinases in T cells: Characterization of human ERK1 and ERK2 cDNAs
    • Owaki H, Makar R, Boulton TG, Cobb MH and Geppert TD: Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs. Biochem Biophys Res Commun 182:1416-1422, 1992.
    • (1992) Biochem Biophys Res Commun , vol.182 , pp. 1416-1422
    • Owaki, H.1    Makar, R.2    Boulton, T.G.3    Cobb, M.H.4    Geppert, T.D.5
  • 32
    • 78751582382 scopus 로고    scopus 로고
    • The anti-malaria agent artesunate inhibits expression of vascular endothelial growth factor and hypoxia-inducible factor-1α in human rheumatoid arthritis fbroblast-like synoviocyte
    • He Y, Fan J, Lin H, et al: The anti-malaria agent artesunate inhibits expression of vascular endothelial growth factor and hypoxia-inducible factor-1α in human rheumatoid arthritis fbroblast-like synoviocyte. Rheumatol Int 31:53-60, 2011.
    • (2011) Rheumatol Int , vol.31 , pp. 53-60
    • He, Y.1    Fan, J.2    Lin, H.3
  • 33
    • 28844487481 scopus 로고    scopus 로고
    • Dihydroartemisinin downregulates vascular endothelial growth factor expression and induces apoptosis in chronic myeloid leukemia K562 cells
    • Lee J, Zhou HJ and Wu XH: Dihydroartemisinin downregulates vascular endothelial growth factor expression and induces apoptosis in chronic myeloid leukemia K562 cells. Cancer Chemother Pharmacol 57:213-220, 2006.
    • (2006) Cancer Chemother Pharmacol , vol.57 , pp. 213-220
    • Lee, J.1    Zhou, H.J.2    Wu, X.H.3
  • 34
    • 48749121296 scopus 로고    scopus 로고
    • VEGF blockade decelerates the growth of a murine experimental osteosarcoma
    • Yin D, Jia T, Gong W, et al: VEGF blockade decelerates the growth of a murine experimental osteosarcoma. Int J Oncol 33:253-259, 2008.
    • (2008) Int J Oncol , vol.33 , pp. 253-259
    • Yin, D.1    Jia, T.2    Gong, W.3
  • 35
    • 0035157982 scopus 로고    scopus 로고
    • All-trans retinoic acid inhibits vascular smooth muscle cell proliferation targeting multiple genes for cyclins and cyclin-dependent kinases
    • Kosaka C, Sasaguri T, Komiyama Y and Takahashi H: All-trans retinoic acid inhibits vascular smooth muscle cell proliferation targeting multiple genes for cyclins and cyclin-dependent kinases. Hypertens Res 24:579-588, 2001.
    • (2001) Hypertens Res , vol.24 , pp. 579-588
    • Kosaka, C.1    Sasaguri, T.2    Komiyama, Y.3    Takahashi, H.4
  • 36
    • 77952266182 scopus 로고    scopus 로고
    • Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells
    • Lu JJ, Meng LH, Shankavaram UT, et al: Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells. Biochem Pharmacol 80:22-30, 2010.
    • (2010) Biochem Pharmacol , vol.80 , pp. 22-30
    • Lu, J.J.1    Meng, L.H.2    Shankavaram, U.T.3
  • 37
    • 77957225011 scopus 로고    scopus 로고
    • Adropin is a novel regulator of endothelial function
    • Lovren F, Pan Y, Quan A, et al: Adropin is a novel regulator of endothelial function. Circulation 122(Suppl 11):S185-S192, 2010.
    • (2010) Circulation , vol.122 , pp. S185-S192
    • Lovren, F.1    Pan, Y.2    Quan, A.3
  • 38
    • 84863394792 scopus 로고    scopus 로고
    • The effects of adiponectin and leptin on human endothelial cell proliferation: A live-cell study
    • Alvarez G, Visitación Bartolomé M, Miana M, et al: The effects of adiponectin and leptin on human endothelial cell proliferation: a live-cell study. J Vasc Res 49:111-122, 2012.
    • (2012) J Vasc Res , vol.49 , pp. 111-122
    • Alvarez, G.1    Visitación Bartolomé, M.2    Miana, M.3
  • 39
    • 84855794830 scopus 로고    scopus 로고
    • Ghrelin stimulates angiogenesis via GHSR1a-dependent MEK/ERK and PI3K/Akt signal pathways in rat cardiac microvascular endothelial cells
    • Wang L, Chen Q, Li G and Ke D: Ghrelin stimulates angiogenesis via GHSR1a-dependent MEK/ERK and PI3K/Akt signal pathways in rat cardiac microvascular endothelial cells. Peptides 33:92-100, 2012.
    • (2012) Peptides , vol.33 , pp. 92-100
    • Wang, L.1    Chen, Q.2    Li, G.3    Ke, D.4


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