메뉴 건너뛰기




Volumn 22, Issue 3, 2015, Pages 221-230

PCSK9: A key factor modulating atherosclerosis

Author keywords

Atherosclerosis; Coronary artery disease; Hyperlipidemia; Proprotein convertase subtilisin kexin type 9

Indexed keywords

APOLIPOPROTEIN B; KEXIN TYPE 9; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; PROPROTEIN CONVERTASE SUBTILISIN; PROTEINASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; PCSK9 PROTEIN, HUMAN; SERINE PROTEINASE;

EID: 84925344911     PISSN: 13403478     EISSN: 18803873     Source Type: Journal    
DOI: 10.5551/jat.27615     Document Type: Review
Times cited : (39)

References (73)
  • 1
    • 84897365678 scopus 로고    scopus 로고
    • The global burden of cardiovascular diseases: A challenge to improve
    • Mendis S, Chestnov O: The global burden of cardiovascular diseases: a challenge to improve. Curr Cardiol Rep, 2014; 16: 486
    • (2014) Curr Cardiol Rep , vol.16 , pp. 486
    • Mendis, S.1    Chestnov, O.2
  • 2
    • 84863667325 scopus 로고    scopus 로고
    • Aging and atherosclerosis: Mechanisms, functional consequences, and potential therapeutics for cellular senescence
    • Wang JC, Bennett M: Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence. Circ Res, 2012; 111: 245-259
    • (2012) Circ Res , vol.111 , pp. 245-259
    • Wang, J.C.1    Bennett, M.2
  • 3
    • 84878108892 scopus 로고    scopus 로고
    • Interactions between inflammation and lipid metabolism: Relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis
    • van Diepen JA, Berbee JF, Havekes LM, Rensen PC: Interactions between inflammation and lipid metabolism: relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis. Atherosclerosis, 2013; 228: 306-315
    • (2013) Atherosclerosis , vol.228 , pp. 306-315
    • van Diepen, J.A.1    Berbee, J.F.2    Havekes, L.M.3    Rensen, P.C.4
  • 7
    • 84885447918 scopus 로고    scopus 로고
    • Targeting the proprotein convertase subtilisin/kexin type 9 for the treatment of dyslipidemia and atherosclerosis
    • Urban D, Poss J, Bohm M, Laufs U: Targeting the proprotein convertase subtilisin/kexin type 9 for the treatment of dyslipidemia and atherosclerosis. J Am Coll Cardiol, 2013; 62: 1401-1408
    • (2013) J Am Coll Cardiol , vol.62 , pp. 1401-1408
    • Urban, D.1    Poss, J.2    Bohm, M.3    Laufs, U.4
  • 8
    • 84883245777 scopus 로고    scopus 로고
    • Acute myocardial infarction in an 8-year old male child with homozygous familiar hypercholesterolemia: Laboratory findings and response to lipid-lowering drugs
    • Wu NQ, Guo YL, Xu RX, Liu J, Zhu CG, Jiang LX, Li JJ: Acute myocardial infarction in an 8-year old male child with homozygous familiar hypercholesterolemia: laboratory findings and response to lipid-lowering drugs. Clin Lab, 2013; 59: 901-907
    • (2013) Clin Lab , vol.59 , pp. 901-907
    • Wu, N.Q.1    Guo, Y.L.2    Xu, R.X.3    Liu, J.4    Zhu, C.G.5    Jiang, L.X.6    Li, J.J.7
  • 9
    • 84896694715 scopus 로고    scopus 로고
    • PCSK9 gene mutations and low-density lipoprotein cholesterol
    • Wu NQ, Li JJ: PCSK9 gene mutations and low-density lipoprotein cholesterol. Clin Chim Acta, 2014; 431:148- 153
    • (2014) Clin Chim Acta , vol.431 , pp. 148-153
    • Wu, N.Q.1    Li, J.J.2
  • 13
    • 84900854191 scopus 로고    scopus 로고
    • Association of plasma PCSK9 levels with white blood cell count and its subsets in patients with stable coronary artery disease
    • Li S, Guo YL, Xu RX, Zhang Y, Zhu CG, Sun J, Qing P, Wu NQ, Jiang LX, Li JJ: Association of plasma PCSK9 levels with white blood cell count and its subsets in patients with stable coronary artery disease. Atherosclerosis, 2014; 234: 441-445
    • (2014) Atherosclerosis , vol.234 , pp. 441-445
    • Li, S.1    Guo, Y.L.2    Xu, R.X.3    Zhang, Y.4    Zhu, C.G.5    Sun, J.6    Qing, P.7    Wu, N.Q.8    Jiang, L.X.9    Li, J.J.10
  • 15
    • 81255188900 scopus 로고    scopus 로고
    • Atherosclerosis: Current pathogenesis and therapeutic options
    • Weber C, Noels H: Atherosclerosis: current pathogenesis and therapeutic options. Nat Med, 2011; 17: 1410-1422
    • (2011) Nat Med , vol.17 , pp. 1410-1422
    • Weber, C.1    Noels, H.2
  • 16
    • 44649153859 scopus 로고    scopus 로고
    • Contribution of macromolecular structure to the retention of low-density lipoprotein at arterial branch points
    • Kwon GP, Schroeder JL, Amar MJ, Remaley AT, Balaban RS: Contribution of macromolecular structure to the retention of low-density lipoprotein at arterial branch points. Circulation, 2008; 117: 2919-2927
    • (2008) Circulation , vol.117 , pp. 2919-2927
    • Kwon, G.P.1    Schroeder, J.L.2    Amar, M.J.3    Remaley, A.T.4    Balaban, R.S.5
  • 17
    • 0033877211 scopus 로고    scopus 로고
    • Blood pressure, LDL cholesterol, and intima-media thickness: A test of the "response to injury" hypothesis of atherosclerosis
    • Sun P, Dwyer KM, Merz CN, Sun W, Johnson CA, Shircore AM, Dwyer JH: Blood pressure, LDL cholesterol, and intima-media thickness: a test of the "response to injury" hypothesis of atherosclerosis. Arterioscler Thromb Vasc Biol, 2000; 20: 2005-2010
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 2005-2010
    • Sun, P.1    Dwyer, K.M.2    Merz, C.N.3    Sun, W.4    Johnson, C.A.5    Shircore, A.M.6    Dwyer, J.H.7
  • 19
    • 84855964405 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels
    • Ferri N, Tibolla G, Pirillo A, Cipollone F, Mezzetti A, Pacia S, Corsini A, Catapano AL: Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels. Atherosclerosis, 2012; 220: 381-386
    • (2012) Atherosclerosis , vol.220 , pp. 381-386
    • Ferri, N.1    Tibolla, G.2    Pirillo, A.3    Cipollone, F.4    Mezzetti, A.5    Pacia, S.6    Corsini, A.7    Catapano, A.L.8
  • 20
    • 26944489690 scopus 로고    scopus 로고
    • Dual regulation of the LDL receptor-- some clarity and new questions
    • Attie AD, Seidah NG: Dual regulation of the LDL receptor-- some clarity and new questions. Cell Metab, 2005; 1: 290-292
    • (2005) Cell Metab , vol.1 , pp. 290-292
    • Attie, A.D.1    Seidah, N.G.2
  • 21
    • 84879287631 scopus 로고    scopus 로고
    • Serum proprotein convertase subtilisin/ kexin type 9 and cell surface low-density lipoprotein receptor: Evidence for a reciprocal regulation
    • Tavori H, Fan D, Blakemore JL, Yancey PG, Ding L, Linton MF, Fazio S: Serum proprotein convertase subtilisin/ kexin type 9 and cell surface low-density lipoprotein receptor: evidence for a reciprocal regulation. Circulation, 2013; 127: 2403-2413
    • (2013) Circulation , vol.127 , pp. 2403-2413
    • Tavori, H.1    Fan, D.2    Blakemore, J.L.3    Yancey, P.G.4    Ding, L.5    Linton, M.F.6    Fazio, S.7
  • 22
    • 2342451128 scopus 로고    scopus 로고
    • Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype
    • Maxwell KN, Breslow JL: Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype. Proc Natl Acad Sci U S A, 2004; 101: 7100-7105
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 7100-7105
    • Maxwell, K.N.1    Breslow, J.L.2
  • 24
    • 57649129016 scopus 로고    scopus 로고
    • Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels
    • Mayer G, Poirier S, Seidah NG: Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels. J Biol Chem, 2008; 283: 31791-31801
    • (2008) J Biol Chem , vol.283 , pp. 31791-31801
    • Mayer, G.1    Poirier, S.2    Seidah, N.G.3
  • 25
    • 85027929193 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor
    • Sun H, Samarghandi A, Zhang N, Yao Z, Xiong M, Teng BB: Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor. Arterioscler Thromb Vasc Biol, 2012; 32: 1585-1595
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 1585-1595
    • Sun, H.1    Samarghandi, A.2    Zhang, N.3    Yao, Z.4    Xiong, M.5    Teng, B.B.6
  • 26
    • 18144406186 scopus 로고    scopus 로고
    • Evidence for effect of mutant PCSK9 on apolipoprotein B secretion as the cause of unusually severe dominant hypercholesterolaemia
    • Sun XM, Eden ER, Tosi I, Neuwirth CK, Wile D, Naoumova RP, Soutar AK: Evidence for effect of mutant PCSK9 on apolipoprotein B secretion as the cause of unusually severe dominant hypercholesterolaemia. Hum Mol Genet, 2005; 14: 1161-1169
    • (2005) Hum Mol Genet , vol.14 , pp. 1161-1169
    • Sun, X.M.1    Eden, E.R.2    Tosi, I.3    Neuwirth, C.K.4    Wile, D.5    Naoumova, R.P.6    Soutar, A.K.7
  • 28
    • 38349117118 scopus 로고    scopus 로고
    • The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2
    • Poirier S, Mayer G, Benjannet S, Bergeron E, Marcinkiewicz J, Nassoury N, Mayer H, Nimpf J, Prat A, Seidah NG: The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2. J Biol Chem, 2008; 283: 2363-2372
    • (2008) J Biol Chem , vol.283 , pp. 2363-2372
    • Poirier, S.1    Mayer, G.2    Benjannet, S.3    Bergeron, E.4    Marcinkiewicz, J.5    Nassoury, N.6    Mayer, H.7    Nimpf, J.8    Prat, A.9    Seidah, N.G.10
  • 29
    • 84877675332 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1)
    • Canuel M, Sun X, Asselin MC, Paramithiotis E, Prat A, Seidah NG: Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1). PLoS One, 2013; 8: e64145
    • (2013) PLoS One , vol.8
    • Canuel, M.1    Sun, X.2    Asselin, M.C.3    Paramithiotis, E.4    Prat, A.5    Seidah, N.G.6
  • 32
    • 84862219022 scopus 로고    scopus 로고
    • Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy
    • McKenney JM, Koren MJ, Kereiakes DJ, Hanotin C, Ferrand AC, Stein EA: Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy. J Am Coll Cardiol, 2012; 59: 2344- 2353
    • (2012) J Am Coll Cardiol , vol.59 , pp. 2344-2353
    • McKenney, J.M.1    Koren, M.J.2    Kereiakes, D.J.3    Hanotin, C.4    Ferrand, A.C.5    Stein, E.A.6
  • 34
    • 84866499818 scopus 로고    scopus 로고
    • PCSK9 siRNA suppresses the inflammatory response induced by oxLDL through inhibition of NF-kappaB activation in THP-1-derived macrophages
    • Tang Z, Jiang L, Peng J, Ren Z, Wei D, Wu C, Pan L, Jiang Z, Liu L: PCSK9 siRNA suppresses the inflammatory response induced by oxLDL through inhibition of NF-kappaB activation in THP-1-derived macrophages. Int J Mol Med, 2012; 30: 931-938
    • (2012) Int J Mol Med , vol.30 , pp. 931-938
    • Tang, Z.1    Jiang, L.2    Peng, J.3    Ren, Z.4    Wei, D.5    Wu, C.6    Pan, L.7    Jiang, Z.8    Liu, L.9
  • 35
    • 84913595062 scopus 로고    scopus 로고
    • The Relationship between the Plasma PCSK9 Levels and Platelet Indices in Patients with Stable Coronary Artery Disease
    • [Epub ahead of print]
    • Li S, Zhu CG, Guo YL, Xu RX, Zhang Y, Sun J, Li JJ: The Relationship between the Plasma PCSK9 Levels and Platelet Indices in Patients with Stable Coronary Artery Disease. J Atheroscler Thromb, 2014; [Epub ahead of print]
    • (2014) J Atheroscler Thromb
    • Li, S.1    Zhu, C.G.2    Guo, Y.L.3    Xu, R.X.4    Zhang, Y.5    Sun, J.6    Li, J.J.7
  • 42
    • 69549138572 scopus 로고    scopus 로고
    • Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents
    • Baass A, Dubuc G, Tremblay M, Delvin EE, O'Loughlin J, Levy E, Davignon J, Lambert M: Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents. Clin Chem, 2009; 55: 1637-1645
    • (2009) Clin Chem , vol.55 , pp. 1637-1645
    • Baass, A.1    Dubuc, G.2    Tremblay, M.3    Delvin, E.E.4    O'Loughlin, J.5    Levy, E.6    Davignon, J.7    Lambert, M.8
  • 46
    • 34447299120 scopus 로고    scopus 로고
    • The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population
    • Hooper AJ, Marais AD, Tanyanyiwa DM, Burnett JR: The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population. Atherosclerosis, 2007; 193: 445-448
    • (2007) Atherosclerosis , vol.193 , pp. 445-448
    • Hooper, A.J.1    Marais, A.D.2    Tanyanyiwa, D.M.3    Burnett, J.R.4
  • 48
    • 84861728908 scopus 로고    scopus 로고
    • Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)
    • Sharotri V, Collier DM, Olson DR, Zhou R, Snyder PM: Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9). J Biol Chem, 2012; 287: 19266-19274
    • (2012) J Biol Chem , vol.287 , pp. 19266-19274
    • Sharotri, V.1    Collier, D.M.2    Olson, D.R.3    Zhou, R.4    Snyder, P.M.5
  • 49
    • 77953309816 scopus 로고    scopus 로고
    • PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses
    • Benn M, Nordestgaard BG, Grande P, Schnohr P, Tybjaerg- Hansen A: PCSK9 R46L, low-density lipoprotein cholesterol levels, and risk of ischemic heart disease: 3 independent studies and meta-analyses. J Am Coll Cardiol, 2010; 55: 2833-2842
    • (2010) J Am Coll Cardiol , vol.55 , pp. 2833-2842
    • Benn, M.1    Nordestgaard, B.G.2    Grande, P.3    Schnohr, P.4    Tybjaerg-Hansen, A.5
  • 50
    • 33646443979 scopus 로고    scopus 로고
    • Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy
    • Berge KE, Ose L, Leren TP: Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy. Arterioscler Thromb Vasc Biol, 2006; 26: 1094-1100
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 1094-1100
    • Berge, K.E.1    Ose, L.2    Leren, T.P.3
  • 51
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • Cohen JC, Boerwinkle E, Mosley TH, Jr., Hobbs HH: Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med, 2006; 354: 1264-1272
    • (2006) N Engl J Med , vol.354 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley, T.H.3    Hobbs, H.H.4
  • 53
    • 77956262162 scopus 로고    scopus 로고
    • The influence of PCSK9 polymorphisms on serum low-density lipoprotein cholesterol and risk of atherosclerosis
    • Davignon J, Dubuc G, Seidah NG: The influence of PCSK9 polymorphisms on serum low-density lipoprotein cholesterol and risk of atherosclerosis. Curr Atheroscler Rep, 2010; 12: 308-315
    • (2010) Curr Atheroscler Rep , vol.12 , pp. 308-315
    • Davignon, J.1    Dubuc, G.2    Seidah, N.G.3
  • 54
    • 84902177497 scopus 로고    scopus 로고
    • Genetics of coronary artery disease
    • Roberts R: Genetics of coronary artery disease. Circ Res, 2014; 114: 1890-1903
    • (2014) Circ Res , vol.114 , pp. 1890-1903
    • Roberts, R.1
  • 55
    • 18944392912 scopus 로고    scopus 로고
    • A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis
    • Chen SN, Ballantyne CM, Gotto AM, Jr., Tan Y, Willerson JT, Marian AJ: A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis. J Am Coll Cardiol, 2005; 45: 1611-1619
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1611-1619
    • Chen, S.N.1    Ballantyne, C.M.2    Gotto, A.M.3    Tan, Y.4    Willerson, J.T.5    Marian, A.J.6
  • 57
    • 84878013844 scopus 로고    scopus 로고
    • Association of serum proprotein convertase subtilisin/kexin type 9 with carotid intima media thickness in hypertensive subjects
    • Lee CJ, Lee YH, Park SW, Kim KJ, Park S, Youn JC, Lee SH, Kang SM, Jang Y: Association of serum proprotein convertase subtilisin/kexin type 9 with carotid intima media thickness in hypertensive subjects. Metabolism, 2013; 62: 845-850
    • (2013) Metabolism , vol.62 , pp. 845-850
    • Lee, C.J.1    Lee, Y.H.2    Park, S.W.3    Kim, K.J.4    Park, S.5    Youn, J.C.6    Lee, S.H.7    Kang, S.M.8    Jang, Y.9
  • 59
    • 84860128369 scopus 로고    scopus 로고
    • Determinants of residual risk in secondary prevention patients treated with high- versus low-dose statin therapy: The Treating to New Targets (TNT) study
    • Mora S, Wenger NK, Demicco DA, Breazna A, Boekholdt SM, Arsenault BJ, Deedwania P, Kastelein JJ, Waters DD: Determinants of residual risk in secondary prevention patients treated with high- versus low-dose statin therapy: the Treating to New Targets (TNT) study. Circulation, 2012; 125: 1979-1987
    • (2012) Circulation , vol.125 , pp. 1979-1987
    • Mora, S.1    Wenger, N.K.2    Demicco, D.A.3    Breazna, A.4    Boekholdt, S.M.5    Arsenault, B.J.6    Deedwania, P.7    Kastelein, J.J.8    Waters, D.D.9
  • 61
    • 84905012766 scopus 로고    scopus 로고
    • Risk prediction with proprotein convertase subtilisin/ kexin type 9 (PCSK9) in patients with stable coronary disease on statin treatment
    • Werner C, Hoffmann MM, Winkler K, Bohm M, Laufs U: Risk prediction with proprotein convertase subtilisin/ kexin type 9 (PCSK9) in patients with stable coronary disease on statin treatment. Vascul Pharmacol, 2014; 62: 94-102
    • (2014) Vascul Pharmacol , vol.62 , pp. 94-102
    • Werner, C.1    Hoffmann, M.M.2    Winkler, K.3    Bohm, M.4    Laufs, U.5
  • 62
    • 3943060193 scopus 로고    scopus 로고
    • Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis- regulated convertase-1 implicated in familial hypercholesterolemia
    • Dubuc G, Chamberland A, Wassef H, Davignon J, Seidah NG, Bernier L, Prat A: Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis- regulated convertase-1 implicated in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol, 2004; 24: 1454-1459
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1454-1459
    • Dubuc, G.1    Chamberland, A.2    Wassef, H.3    Davignon, J.4    Seidah, N.G.5    Bernier, L.6    Prat, A.7
  • 64
    • 77956797294 scopus 로고    scopus 로고
    • High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol
    • Welder G, Zineh I, Pacanowski MA, Troutt JS, Cao G, Konrad RJ: High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol. J Lipid Res, 2010; 51: 2714-2721
    • (2010) J Lipid Res , vol.51 , pp. 2714-2721
    • Welder, G.1    Zineh, I.2    Pacanowski, M.A.3    Troutt, J.S.4    Cao, G.5    Konrad, R.J.6
  • 65
    • 84876801739 scopus 로고    scopus 로고
    • The safety of therapeutic monoclonal antibodies: Implications for cardiovascular disease and targeting the PCSK9 pathway
    • Catapano AL, Papadopoulos N: The safety of therapeutic monoclonal antibodies: implications for cardiovascular disease and targeting the PCSK9 pathway. Atherosclero- sis, 2013; 228: 18-28
    • (2013) Atherosclero- sis , vol.228 , pp. 18-28
    • Catapano, A.L.1    Papadopoulos, N.2
  • 67
    • 84899899100 scopus 로고    scopus 로고
    • Enhanced circulating PCSK9 concentration by berberine through SREBP-2 pathway in high fat diet-fed rats
    • Jia YJ, Xu RX, Sun J, Tang Y, Li JJ: Enhanced circulating PCSK9 concentration by berberine through SREBP-2 pathway in high fat diet-fed rats. J Transl Med, 2014; 12: 103
    • (2014) J Transl Med , vol.12 , pp. 103
    • Jia, Y.J.1    Xu, R.X.2    Sun, J.3    Tang, Y.4    Li, J.J.5
  • 68
    • 77952684555 scopus 로고    scopus 로고
    • Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: Mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters
    • Dong B, Wu M, Li H, Kraemer FB, Adeli K, Seidah NG, Park SW, Liu J: Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters. J Lipid Res, 2010; 51: 1486- 1495
    • (2010) J Lipid Res , vol.51 , pp. 1486-1495
    • Dong, B.1    Wu, M.2    Li, H.3    Kraemer, F.B.4    Adeli, K.5    Seidah, N.G.6    Park, S.W.7    Liu, J.8
  • 69
    • 84901199916 scopus 로고    scopus 로고
    • Beyond statins: New lipid lowering strategies to reduce cardiovascular risk
    • Noto D, Cefalu AB, Averna MR: Beyond statins: new lipid lowering strategies to reduce cardiovascular risk. Curr Atheroscler Rep, 2014; 16: 414
    • (2014) Curr Atheroscler Rep , vol.16 , pp. 414
    • Noto, D.1    Cefalu, A.B.2    Averna, M.R.3
  • 71
    • 84878388937 scopus 로고    scopus 로고
    • The next generation of novel low-density lipoprotein cholesterol-lowering agents: Proprotein convertase subtilisin/kexin 9 inhibitors
    • Shen L, Peng H, Xu D, Zhao S: The next generation of novel low-density lipoprotein cholesterol-lowering agents: proprotein convertase subtilisin/kexin 9 inhibitors. Pharmacol Res, 2013; 73: 27-34
    • (2013) Pharmacol Res , vol.73 , pp. 27-34
    • Shen, L.1    Peng, H.2    Xu, D.3    Zhao, S.4
  • 73
    • 84897889156 scopus 로고    scopus 로고
    • PCSK9: A Key Modulator of Cardiovascular Health
    • Seidah NG, Awan Z, Chretien M, Mbikay M: PCSK9: A Key Modulator of Cardiovascular Health. Circ Res, 2014; 114: 1022-1036
    • (2014) Circ Res , vol.114 , pp. 1022-1036
    • Seidah, N.G.1    Awan, Z.2    Chretien, M.3    Mbikay, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.