-
1
-
-
0037603589
-
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
-
DOI 10.1038/ng1161
-
Abifadel M, Varret M, Rabes JP, Allard D, Ouguerram K, Devillers M, Cruaud C, Benjannet S, Wickham L, Erlich D, Derre A, Villeger L, Farnier M, Beucler I, Bruckert E, Chambaz J, Chanu B, Lecerf JM, Luc G, Moulin P, Weissenbach J, Prat A, Krempf M, Junien C, Seidah NG, Boileau C. 2003. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet 34:154-156. (Pubitemid 36666925)
-
(2003)
Nature Genetics
, vol.34
, Issue.2
, pp. 154-156
-
-
Abifadel, M.1
Varret, M.2
Rabes, J.-P.3
Allard, D.4
Ouguerram, K.5
Devillers, M.6
Cruaud, C.7
Benjannet, S.8
Wickham, L.9
Erlich, D.10
Derre, A.11
Villeger, L.12
Farnier, M.13
Beucler, I.14
Bruckert, E.15
Chambaz, J.16
Chanu, B.17
Lecerf, J.-M.18
Luc, G.19
Moulin, P.20
Weissenbach, J.21
Prat, A.22
Krempf, M.23
Junien, C.24
Seidah, N.G.25
Boileau, C.26
more..
-
2
-
-
69549138572
-
Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents
-
Baass A, Dubuc G, Tremblay M, Delvin EE, O'Loughlin J, Levy E, Davignon J, Lambert M. 2009. Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents. Clin Chem 55:1637-1645.
-
(2009)
Clin Chem
, vol.55
, pp. 1637-1645
-
-
Baass, A.1
Dubuc, G.2
Tremblay, M.3
Delvin, E.E.4
O'Loughlin, J.5
Levy, E.6
Davignon, J.7
Lambert, M.8
-
3
-
-
33750090075
-
The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: Functional consequences of natural mutations and post-translational modifications
-
Benjannet S, Rhainds D, Hamelin J, Nassoury N, Seidah NG. 2006. The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: Functional consequences of natural mutations and post-translational modifications. J Biol Chem 281:30561-30572.
-
(2006)
J Biol Chem
, vol.281
, pp. 30561-30572
-
-
Benjannet, S.1
Rhainds, D.2
Hamelin, J.3
Nassoury, N.4
Seidah, N.G.5
-
4
-
-
0038005018
-
DAVID: Database for annotation, visualization, and integrated discovery
-
Dennis G, Jr., Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA. 2003. DAVID: Database for annotation, visualization, and integrated discovery. Genome Biol 4:P3.
-
(2003)
Genome Biol
, vol.4
-
-
Dennis Jr., G.1
Sherman, B.T.2
Hosack, D.A.3
Yang, J.4
Gao, W.5
Lane, H.C.6
Lempicki, R.A.7
-
6
-
-
0142121516
-
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
-
Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP. 2003. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4:249-264.
-
(2003)
Biostatistics
, vol.4
, pp. 249-264
-
-
Irizarry, R.A.1
Hobbs, B.2
Collin, F.3
Beazer-Barclay, Y.D.4
Antonellis, K.J.5
Scherf, U.6
Speed, T.P.7
-
7
-
-
67651160910
-
PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression
-
Labonte P, Begley S, Guevin C, Asselin MC, Nassoury N, Mayer G, Prat A, Seidah NG. 2009. PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression. Hepatology 50:17-24.
-
(2009)
Hepatology
, vol.50
, pp. 17-24
-
-
Labonte, P.1
Begley, S.2
Guevin, C.3
Asselin, M.C.4
Nassoury, N.5
Mayer, G.6
Prat, A.7
Seidah, N.G.8
-
8
-
-
33750597734
-
Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice
-
Lagace TA, Curtis DE, Garuti R, McNutt MC, Park SW, Prather HB, Anderson NN, Ho YK, Hammer RE, Horton JD. 2006. Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice. J Clin Invest 116:2995-3005.
-
(2006)
J Clin Invest
, vol.116
, pp. 2995-3005
-
-
Lagace, T.A.1
Curtis, D.E.2
Garuti, R.3
McNutt, M.C.4
Park, S.W.5
Prather, H.B.6
Anderson, N.N.7
Ho, Y.K.8
Hammer, R.E.9
Horton, J.D.10
-
9
-
-
44849086762
-
Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment
-
Lambert G, Ancellin N, Charlton F, Comas D, Pilot J, Keech A, Patel S, Sullivan DR, Cohn JS, Rye KA, Barter PJ. 2008. Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment. Clin Chem 54:1038-1045.
-
(2008)
Clin Chem
, vol.54
, pp. 1038-1045
-
-
Lambert, G.1
Ancellin, N.2
Charlton, F.3
Comas, D.4
Pilot, J.5
Keech, A.6
Patel, S.7
Sullivan, D.R.8
Cohn, J.S.9
Rye, K.A.10
Barter, P.J.11
-
10
-
-
34548163845
-
Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity
-
Li J, Tumanut C, Gavigan JA, Huang WJ, Hampton EN, Tumanut R, Suen KF, Trauger JW, Spraggon G, Lesley SA, Liau G, Yowe D, Harris JL. 2007. Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity. Biochem J 406:203-207.
-
(2007)
Biochem J
, vol.406
, pp. 203-207
-
-
Li, J.1
Tumanut, C.2
Gavigan, J.A.3
Huang, W.J.4
Hampton, E.N.5
Tumanut, R.6
Suen, K.F.7
Trauger, J.W.8
Spraggon, G.9
Lesley, S.A.10
Liau, G.11
Yowe, D.12
Harris, J.L.13
-
11
-
-
13844310887
-
Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment
-
Maxwell KN, Fisher EA, Breslow JL. 2005. Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. Proc Natl Acad Sci USA 102:2069-2074.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 2069-2074
-
-
Maxwell, K.N.1
Fisher, E.A.2
Breslow, J.L.3
-
12
-
-
45549096493
-
Plasma PCSK9 levels are significantly modified by statins and fibrates in humans
-
Mayne J,Dewpura T, Raymond A, Cousins M, Chaplin A, Lahey KA, Lahaye SA, Mbikay M, Ooi TC, Chretien M. 2008. Plasma PCSK9 levels are significantly modified by statins and fibrates in humans. Lipids Health Dis 7:22.
-
(2008)
Lipids Health Dis
, vol.7
, pp. 22
-
-
Mayne, J.1
Dewpura, T.2
Raymond, A.3
Cousins, M.4
Chaplin, A.5
Lahey, K.A.6
Lahaye, S.A.7
Mbikay, M.8
Ooi, T.C.9
Chretien, M.10
-
13
-
-
34547137377
-
Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells
-
McNutt MC, Lagace TA, Horton JD. 2007. Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells. J Biol Chem 282:20799-20803.
-
(2007)
J Biol Chem
, vol.282
, pp. 20799-20803
-
-
McNutt, M.C.1
Lagace, T.A.2
Horton, J.D.3
-
14
-
-
66449114033
-
P62 at the crossroads of autophagy, apoptosis, and cancer
-
Moscat J, Diaz-Meco MT. 2009. p62 at the crossroads of autophagy, apoptosis, and cancer. Cell 137:1001-1004.
-
(2009)
Cell
, vol.137
, pp. 1001-1004
-
-
Moscat, J.1
Diaz-Meco, M.T.2
-
15
-
-
34548175537
-
Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis
-
Qian YW, Schmidt RJ, Zhang Y, Chu S, Lin A, Wang H, Wang X, Beyer TP, Bensch WR, Li W, Ehsani ME, Lu D, Konrad RJ, Eacho PI, Moller DE, Karathanasis SK, Cao G. 2007. Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. J Lipid Res 48(7):1488-1498.
-
(2007)
J Lipid Res
, vol.48
, Issue.7
, pp. 1488-1498
-
-
Qian, Y.W.1
Schmidt, R.J.2
Zhang, Y.3
Chu, S.4
Lin, A.5
Wang, H.6
Wang, X.7
Beyer, T.P.8
Bensch, W.R.9
Li, W.10
Ehsani, M.E.11
Lu, D.12
Konrad, R.J.13
Eacho, P.I.14
Moller, D.E.15
Karathanasis, S.K.16
Cao, G.17
-
16
-
-
51449103813
-
Genome-wide expression analysis of cells expressing gain of function mutant D374YPCSK9
-
Ranheim T, Mattingsdal M, Lindvall JM, Holla OL, Berge KE, Kulseth MA, Leren TP. 2008. Genome-wide expression analysis of cells expressing gain of function mutant D374YPCSK9. J Cell Physiol 217:459-467.
-
(2008)
J Cell Physiol
, vol.217
, pp. 459-467
-
-
Ranheim, T.1
Mattingsdal, M.2
Lindvall, J.M.3
Holla, O.L.4
Berge, K.E.5
Kulseth, M.A.6
Leren, T.P.7
-
18
-
-
61449444418
-
PCSK9 as a therapeutic target of dyslipidemia
-
Seidah NG. 2009. PCSK9 as a therapeutic target of dyslipidemia. Expert Opin Ther Targets 13:19-28.
-
(2009)
Expert Opin Ther Targets
, vol.13
, pp. 19-28
-
-
Seidah, N.G.1
-
19
-
-
67650092919
-
LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor
-
Zelcer N, Hong C, Boyadjian R, Tontonoz P. 2009. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science 325:100-104.
-
(2009)
Science
, vol.325
, pp. 100-104
-
-
Zelcer, N.1
Hong, C.2
Boyadjian, R.3
Tontonoz, P.4
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