메뉴 건너뛰기




Volumn 62, Issue 2, 2014, Pages 94-102

Risk prediction with proprotein convertase subtilisin/kexin type 9 (PCSK9) in patients with stable coronary disease on statin treatment

Author keywords

Coronary artery disease; PCSK9; Risk prediction; Statins; Triglycerides

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; SERINE PROTEINASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; PCSK9 PROTEIN, HUMAN;

EID: 84905012766     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2014.03.004     Document Type: Article
Times cited : (101)

References (40)
  • 1
    • 0037603589 scopus 로고    scopus 로고
    • Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
    • [Epub 2003/05/06]
    • Abifadel M., Varret M., Rabes J.P., Allard D., Ouguerram K., Devillers M., et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet 2003, 34(2):154-156. [Epub 2003/05/06].
    • (2003) Nat Genet , vol.34 , Issue.2 , pp. 154-156
    • Abifadel, M.1    Varret, M.2    Rabes, J.P.3    Allard, D.4    Ouguerram, K.5    Devillers, M.6
  • 2
    • 84855393059 scopus 로고    scopus 로고
    • Proprotein convertases in health and disease
    • [Epub 2011/12/30]
    • Artenstein A.W., Opal S.M. Proprotein convertases in health and disease. N Engl J Med 2011, 365(26):2507-2518. [Epub 2011/12/30].
    • (2011) N Engl J Med , vol.365 , Issue.26 , pp. 2507-2518
    • Artenstein, A.W.1    Opal, S.M.2
  • 3
    • 84872870299 scopus 로고    scopus 로고
    • Cardiovascular endocrinology in 2012: PCSK9-an exciting target for reducing LDL-cholesterol levels
    • [Epub 2013/01/09]
    • Betteridge D.J. Cardiovascular endocrinology in 2012: PCSK9-an exciting target for reducing LDL-cholesterol levels. Nat Rev Endocrinol 2013, 9(2):76-78. [Epub 2013/01/09].
    • (2013) Nat Rev Endocrinol , vol.9 , Issue.2 , pp. 76-78
    • Betteridge, D.J.1
  • 4
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • [Epub 2006/03/24]
    • Cohen J.C., Boerwinkle E., Mosley T.H., Hobbs H.H. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006, 354(12):1264-1272. [Epub 2006/03/24].
    • (2006) N Engl J Med , vol.354 , Issue.12 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley, T.H.3    Hobbs, H.H.4
  • 5
    • 84885447918 scopus 로고    scopus 로고
    • Targeting the proprotein convertase subtilisin/kexin type 9 (PCSK9) for the treatment of dyslipidemia and atherosclerosis
    • Urban D., Pöss J., Böhm M., Laufs U. Targeting the proprotein convertase subtilisin/kexin type 9 (PCSK9) for the treatment of dyslipidemia and atherosclerosis. J Am Coll Cardiol 2013, 62(16):1401-1408.
    • (2013) J Am Coll Cardiol , vol.62 , Issue.16 , pp. 1401-1408
    • Urban, D.1    Pöss, J.2    Böhm, M.3    Laufs, U.4
  • 7
    • 84893230270 scopus 로고    scopus 로고
    • AMG 145, a monoclonal antibody against PCSK9, facilitates achievement of NCEP-ATP III LDL-C goals among high risk patients: an analysis from the LAPLACE-TIMI 57 trial
    • Desai N.R., Giugliano R.P., Zhou J., Kohli P., Somaratne R., Hoffman E., et al. AMG 145, a monoclonal antibody against PCSK9, facilitates achievement of NCEP-ATP III LDL-C goals among high risk patients: an analysis from the LAPLACE-TIMI 57 trial. J Am Coll Cardiol 2014, 63(5):430-433.
    • (2014) J Am Coll Cardiol , vol.63 , Issue.5 , pp. 430-433
    • Desai, N.R.1    Giugliano, R.P.2    Zhou, J.3    Kohli, P.4    Somaratne, R.5    Hoffman, E.6
  • 8
    • 84883232230 scopus 로고    scopus 로고
    • AMG145, a monoclonal antibody against proprotein convertase subtilisin kexin type 9, significantly reduces lipoprotein(a) in hypercholesterolemic patients receiving statin therapy: an analysis from the LDL-C assessment with proprotein convertase subtilisin kexin type 9 monoclonal antibody inhibition combined with statin therapy (LAPLACE)-thrombolysis in myocardial infarction (TIMI) 57 trial
    • [Epub 2013/07/26]
    • Desai N.R., Kohli P., Giugliano R.P., O'Donoghue M.L., Somaratne R., Zhou J., et al. AMG145, a monoclonal antibody against proprotein convertase subtilisin kexin type 9, significantly reduces lipoprotein(a) in hypercholesterolemic patients receiving statin therapy: an analysis from the LDL-C assessment with proprotein convertase subtilisin kexin type 9 monoclonal antibody inhibition combined with statin therapy (LAPLACE)-thrombolysis in myocardial infarction (TIMI) 57 trial. Circulation 2013, 128(9):962-969. [Epub 2013/07/26].
    • (2013) Circulation , vol.128 , Issue.9 , pp. 962-969
    • Desai, N.R.1    Kohli, P.2    Giugliano, R.P.3    O'Donoghue, M.L.4    Somaratne, R.5    Zhou, J.6
  • 9
    • 84892679366 scopus 로고    scopus 로고
    • Efficacy and safety of longer-term administration of evolocumab (AMG 145) in patients with hypercholesterolemia: 52-week results from the open-label study of long-term evaluation against LDL-C (OSLER) randomized trial
    • Koren M.J., Giugliano R.P., Raal F.J., Sullivan D., Bolognese M., Langslet G., et al. Efficacy and safety of longer-term administration of evolocumab (AMG 145) in patients with hypercholesterolemia: 52-week results from the open-label study of long-term evaluation against LDL-C (OSLER) randomized trial. Circulation 2014, 129(2):234-243.
    • (2014) Circulation , vol.129 , Issue.2 , pp. 234-243
    • Koren, M.J.1    Giugliano, R.P.2    Raal, F.J.3    Sullivan, D.4    Bolognese, M.5    Langslet, G.6
  • 10
    • 84868689211 scopus 로고    scopus 로고
    • Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia
    • [Epub 2012/11/02]
    • Roth E.M., McKenney J.M., Hanotin C., Asset G., Stein E.A. Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia. N Engl J Med 2012, 367(20):1891-1900. [Epub 2012/11/02].
    • (2012) N Engl J Med , vol.367 , Issue.20 , pp. 1891-1900
    • Roth, E.M.1    McKenney, J.M.2    Hanotin, C.3    Asset, G.4    Stein, E.A.5
  • 11
    • 84863494422 scopus 로고    scopus 로고
    • Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial
    • [Epub 2012/05/29]
    • Stein E.A., Gipe D., Bergeron J., Gaudet D., Weiss R., Dufour R., et al. Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial. Lancet 2012, 380(9836):29-36. [Epub 2012/05/29].
    • (2012) Lancet , vol.380 , Issue.9836 , pp. 29-36
    • Stein, E.A.1    Gipe, D.2    Bergeron, J.3    Gaudet, D.4    Weiss, R.5    Dufour, R.6
  • 12
    • 84858638369 scopus 로고    scopus 로고
    • Effect of a monoclonal antibody to PCSK9 on LDL cholesterol
    • [Epub 2012/03/23]
    • Stein E.A., Mellis S., Yancopoulos G.D., Stahl N., Logan D., Smith W.B., et al. Effect of a monoclonal antibody to PCSK9 on LDL cholesterol. N Engl J Med 2012, 366(12):1108-1118. [Epub 2012/03/23].
    • (2012) N Engl J Med , vol.366 , Issue.12 , pp. 1108-1118
    • Stein, E.A.1    Mellis, S.2    Yancopoulos, G.D.3    Stahl, N.4    Logan, D.5    Smith, W.B.6
  • 13
    • 84871326497 scopus 로고    scopus 로고
    • Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: the GAUSS randomized trial
    • [Epub 2012/11/07]
    • Sullivan D., Olsson A.G., Scott R., Kim J.B., Xue A., Gebski V., et al. Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: the GAUSS randomized trial. JAMA 2012, 308(23):2497-2506. [Epub 2012/11/07].
    • (2012) JAMA , vol.308 , Issue.23 , pp. 2497-2506
    • Sullivan, D.1    Olsson, A.G.2    Scott, R.3    Kim, J.B.4    Xue, A.5    Gebski, V.6
  • 14
    • 65549116032 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia
    • [Epub 2009/03/07]
    • Le May C., Kourimate S., Langhi C., Chetiveaux M., Jarry A., Comera C., et al. Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia. Arterioscler Thromb Vasc Biol 2009, 29(5):684-690. [Epub 2009/03/07].
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , Issue.5 , pp. 684-690
    • Le May, C.1    Kourimate, S.2    Langhi, C.3    Chetiveaux, M.4    Jarry, A.5    Comera, C.6
  • 15
    • 38949109659 scopus 로고    scopus 로고
    • Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9
    • [Epub 2007/11/24]
    • Careskey H.E., Davis R.A., Alborn W.E., Troutt J.S., Cao G., Konrad R.J. Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9. J Lipid Res 2008, 49(2):394-398. [Epub 2007/11/24].
    • (2008) J Lipid Res , vol.49 , Issue.2 , pp. 394-398
    • Careskey, H.E.1    Davis, R.A.2    Alborn, W.E.3    Troutt, J.S.4    Cao, G.5    Konrad, R.J.6
  • 16
    • 77956230636 scopus 로고    scopus 로고
    • Plasma PCSK9 is increased by fenofibrate and atorvastatin in a non-additive fashion in diabetic patients
    • [Epub 2010/07/14]
    • Costet P., Hoffmann M.M., Cariou B., Guyomarc'h Delasalle B., Konrad T., Winkler K. Plasma PCSK9 is increased by fenofibrate and atorvastatin in a non-additive fashion in diabetic patients. Atherosclerosis 2010, 212(1):246-251. [Epub 2010/07/14].
    • (2010) Atherosclerosis , vol.212 , Issue.1 , pp. 246-251
    • Costet, P.1    Hoffmann, M.M.2    Cariou, B.3    Guyomarc'h Delasalle, B.4    Konrad, T.5    Winkler, K.6
  • 17
    • 77956797294 scopus 로고    scopus 로고
    • High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol
    • [Epub 2010/06/08]
    • Welder G., Zineh I., Pacanowski M.A., Troutt J.S., Cao G., Konrad R.J. High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol. J Lipid Res 2010, 51(9):2714-2721. [Epub 2010/06/08].
    • (2010) J Lipid Res , vol.51 , Issue.9 , pp. 2714-2721
    • Welder, G.1    Zineh, I.2    Pacanowski, M.A.3    Troutt, J.S.4    Cao, G.5    Konrad, R.J.6
  • 18
    • 84889822869 scopus 로고    scopus 로고
    • ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines
    • [Epub 2013/11/14]
    • Stone N.J., Robinson J., Lichtenstein A.H., Merz C.N., Blum C.B., Eckel R.H., et al. ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. Circulation 2013, 2013. [Epub 2013/11/14].
    • (2013) Circulation , vol.2013
    • Stone, N.J.1    Robinson, J.2    Lichtenstein, A.H.3    Merz, C.N.4    Blum, C.B.5    Eckel, R.H.6
  • 19
    • 84859184996 scopus 로고    scopus 로고
    • Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis
    • [Epub 2012/03/29]
    • Boekholdt S.M., Arsenault B.J., Mora S., Pedersen T.R., LaRosa J.C., Nestel P.J., et al. Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis. JAMA 2012, 307(12):1302-1309. [Epub 2012/03/29].
    • (2012) JAMA , vol.307 , Issue.12 , pp. 1302-1309
    • Boekholdt, S.M.1    Arsenault, B.J.2    Mora, S.3    Pedersen, T.R.4    LaRosa, J.C.5    Nestel, P.J.6
  • 20
    • 84859809935 scopus 로고    scopus 로고
    • On-treatment non-high-density lipoprotein cholesterol, apolipoprotein B, triglycerides, and lipid ratios in relation to residual vascular risk after treatment with potent statin therapy: JUPITER (justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin)
    • [Epub 2012/04/21]
    • Mora S., Glynn R.J., Boekholdt S.M., Nordestgaard B.G., Kastelein J.J., Ridker P.M. On-treatment non-high-density lipoprotein cholesterol, apolipoprotein B, triglycerides, and lipid ratios in relation to residual vascular risk after treatment with potent statin therapy: JUPITER (justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin). J Am Coll Cardiol 2012, 59(17):1521-1528. [Epub 2012/04/21].
    • (2012) J Am Coll Cardiol , vol.59 , Issue.17 , pp. 1521-1528
    • Mora, S.1    Glynn, R.J.2    Boekholdt, S.M.3    Nordestgaard, B.G.4    Kastelein, J.J.5    Ridker, P.M.6
  • 21
    • 84860128369 scopus 로고    scopus 로고
    • Determinants of residual risk in secondary prevention patients treated with high- versus low-dose statin therapy: the treating to new targets (TNT) study
    • Epub 2012/03/31
    • Mora S., Wenger N.K., Demicco D.A., Breazna A., Boekholdt S.M., Arsenault B.J., et al. Determinants of residual risk in secondary prevention patients treated with high- versus low-dose statin therapy: the treating to new targets (TNT) study. Circulation 2012, 125(16):1979-1987. Epub 2012/03/31.
    • (2012) Circulation , vol.125 , Issue.16 , pp. 1979-1987
    • Mora, S.1    Wenger, N.K.2    Demicco, D.A.3    Breazna, A.4    Boekholdt, S.M.5    Arsenault, B.J.6
  • 22
    • 78651315324 scopus 로고    scopus 로고
    • Executive summary: standards of medical care in diabetes-2011
    • [Epub 2011/01/14], American Diabetes Association
    • American Diabetes Association Executive summary: standards of medical care in diabetes-2011. Diabetes Care 2011, 34(Suppl. 1):S4-S10. [Epub 2011/01/14].
    • (2011) Diabetes Care , vol.34 , Issue.SUPPL. 1
  • 23
    • 70350245011 scopus 로고    scopus 로고
    • Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
    • [Epub 2009/10/07]
    • Alberti K.G., Eckel R.H., Grundy S.M., Zimmet P.Z., Cleeman J.I., Donato K.A., et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009, 120(16):1640-1645. [Epub 2009/10/07].
    • (2009) Circulation , vol.120 , Issue.16 , pp. 1640-1645
    • Alberti, K.G.1    Eckel, R.H.2    Grundy, S.M.3    Zimmet, P.Z.4    Cleeman, J.I.5    Donato, K.A.6
  • 24
    • 0034471041 scopus 로고    scopus 로고
    • Obesity: preventing and managing the global epidemic. Report of a WHO consultation
    • [Epub 2001/03/10], World Health Organization
    • World Health Organization Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser 2000, 894(i-xii):1-253. [Epub 2001/03/10].
    • (2000) World Health Organ Tech Rep Ser , vol.894 , Issue.1-12 , pp. 1-253
  • 25
    • 36548998846 scopus 로고    scopus 로고
    • Universal definition of myocardial infarction
    • [Epub 2007/10/24], Joint ESCAAHAWHFTFftRoMI
    • Thygesen K., Alpert J.S., White H.D., Joint ESCAAHAWHFTFftRoMI, Jaffe A.S., Apple F.S., et al. Universal definition of myocardial infarction. Circulation 2007, 116(22):2634-2653. [Epub 2007/10/24].
    • (2007) Circulation , vol.116 , Issue.22 , pp. 2634-2653
    • Thygesen, K.1    Alpert, J.S.2    White, H.D.3    Jaffe, A.S.4    Apple, F.S.5
  • 26
    • 84878709786 scopus 로고    scopus 로고
    • 2012 ACCF/AHA focused update incorporated into the ACCF/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines
    • [Epub 2013/05/04]
    • Anderson J.L., Adams C.D., Antman E.M., Bridges C.R., Califf R.M., Casey D.E., et al. 2012 ACCF/AHA focused update incorporated into the ACCF/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. J Am Coll Cardiol 2013, 61(23):e179-e347. [Epub 2013/05/04].
    • (2013) J Am Coll Cardiol , vol.61 , Issue.23
    • Anderson, J.L.1    Adams, C.D.2    Antman, E.M.3    Bridges, C.R.4    Califf, R.M.5    Casey, D.E.6
  • 27
    • 24344442873 scopus 로고    scopus 로고
    • Circulating endothelial progenitor cells and cardiovascular outcomes
    • [Epub 2005/09/09]
    • Werner N., Kosiol S., Schiegl T., Ahlers P., Walenta K., Link A., et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 2005, 353(10):999-1007. [Epub 2005/09/09].
    • (2005) N Engl J Med , vol.353 , Issue.10 , pp. 999-1007
    • Werner, N.1    Kosiol, S.2    Schiegl, T.3    Ahlers, P.4    Walenta, K.5    Link, A.6
  • 28
    • 9644266673 scopus 로고    scopus 로고
    • Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver
    • [Epub 2004/09/24]
    • Park S.W., Moon Y.A., Horton J.D. Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver. J Biol Chem 2004, 279(48):50630-50638. [Epub 2004/09/24].
    • (2004) J Biol Chem , vol.279 , Issue.48 , pp. 50630-50638
    • Park, S.W.1    Moon, Y.A.2    Horton, J.D.3
  • 29
    • 79953317222 scopus 로고    scopus 로고
    • Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9
    • [Epub 2011/01/26]
    • Ason B., Tep S., Davis H.R., Xu Y., Tetzloff G., Galinski B., et al. Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9. J Lipid Res 2011, 52(4):679-687. [Epub 2011/01/26].
    • (2011) J Lipid Res , vol.52 , Issue.4 , pp. 679-687
    • Ason, B.1    Tep, S.2    Davis, H.R.3    Xu, Y.4    Tetzloff, G.5    Galinski, B.6
  • 30
    • 79953760698 scopus 로고    scopus 로고
    • Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue
    • [Epub 2011/01/29]
    • Roubtsova A., Munkonda M.N., Awan Z., Marcinkiewicz J., Chamberland A., Lazure C., et al. Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue. Arterioscler Thromb Vasc Biol 2011, 31(4):785-791. [Epub 2011/01/29].
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , Issue.4 , pp. 785-791
    • Roubtsova, A.1    Munkonda, M.N.2    Awan, Z.3    Marcinkiewicz, J.4    Chamberland, A.5    Lazure, C.6
  • 31
    • 85027929193 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor
    • [Epub 2012/05/15]
    • Sun H., Samarghandi A., Zhang N., Yao Z., Xiong M., Teng B.B. Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor. Arterioscler Thromb Vasc Biol 2012, 32(7):1585-1595. [Epub 2012/05/15].
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , Issue.7 , pp. 1585-1595
    • Sun, H.1    Samarghandi, A.2    Zhang, N.3    Yao, Z.4    Xiong, M.5    Teng, B.B.6
  • 32
    • 84860735288 scopus 로고    scopus 로고
    • Plasma PCSK9 levels and clinical outcomes in the TNT (treating to new targets) trial: a nested case-control study
    • [Epub 2012/05/12]
    • Huijgen R., Boekholdt S.M., Arsenault B.J., Bao W., Davaine J.M., Tabet F., et al. Plasma PCSK9 levels and clinical outcomes in the TNT (treating to new targets) trial: a nested case-control study. J Am Coll Cardiol 2012, 59(20):1778-1784. [Epub 2012/05/12].
    • (2012) J Am Coll Cardiol , vol.59 , Issue.20 , pp. 1778-1784
    • Huijgen, R.1    Boekholdt, S.M.2    Arsenault, B.J.3    Bao, W.4    Davaine, J.M.5    Tabet, F.6
  • 34
    • 79957923056 scopus 로고    scopus 로고
    • Unexpected roles for PCSK9 in lipid metabolism
    • [Epub 2011/04/16]
    • Soutar A.K. Unexpected roles for PCSK9 in lipid metabolism. Curr Opin Lipidol 2011, 22(3):192-196. [Epub 2011/04/16].
    • (2011) Curr Opin Lipidol , vol.22 , Issue.3 , pp. 192-196
    • Soutar, A.K.1
  • 36
    • 69549138572 scopus 로고    scopus 로고
    • Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents
    • [Epub 2009/07/25]
    • Baass A., Dubuc G., Tremblay M., Delvin E.E., O'Loughlin J., Levy E., et al. Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents. Clin Chem 2009, 55(9):1637-1645. [Epub 2009/07/25].
    • (2009) Clin Chem , vol.55 , Issue.9 , pp. 1637-1645
    • Baass, A.1    Dubuc, G.2    Tremblay, M.3    Delvin, E.E.4    O'Loughlin, J.5    Levy, E.6
  • 37
    • 78649755606 scopus 로고    scopus 로고
    • Serum PCSK9 is associated with multiple metabolic factors in a large Han Chinese population
    • [Epub 2010/11/03]
    • Cui Q., Ju X., Yang T., Zhang M., Tang W., Chen Q., et al. Serum PCSK9 is associated with multiple metabolic factors in a large Han Chinese population. Atherosclerosis 2010, 213(2):632-636. [Epub 2010/11/03].
    • (2010) Atherosclerosis , vol.213 , Issue.2 , pp. 632-636
    • Cui, Q.1    Ju, X.2    Yang, T.3    Zhang, M.4    Tang, W.5    Chen, Q.6
  • 39
    • 77955046691 scopus 로고    scopus 로고
    • Fenofibrate concomitantly decreases serum proprotein convertase subtilisin/kexin type 9 and very-low-density lipoprotein particle concentrations in statin-treated type 2 diabetic patients
    • [Epub 2010/07/24]
    • Chan D.C., Hamilton S.J., Rye K.A., Chew G.T., Jenkins A.J., Lambert G., et al. Fenofibrate concomitantly decreases serum proprotein convertase subtilisin/kexin type 9 and very-low-density lipoprotein particle concentrations in statin-treated type 2 diabetic patients. Diabetes Obes Metab 2010, 12(9):752-756. [Epub 2010/07/24].
    • (2010) Diabetes Obes Metab , vol.12 , Issue.9 , pp. 752-756
    • Chan, D.C.1    Hamilton, S.J.2    Rye, K.A.3    Chew, G.T.4    Jenkins, A.J.5    Lambert, G.6
  • 40
    • 77649274263 scopus 로고    scopus 로고
    • PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities
    • [Epub 2009/12/23]
    • Mbikay M., Sirois F., Mayne J., Wang G.S., Chen A., Dewpura T., et al. PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities. FEBS Lett 2010, 584(4):701-706. [Epub 2009/12/23].
    • (2010) FEBS Lett , vol.584 , Issue.4 , pp. 701-706
    • Mbikay, M.1    Sirois, F.2    Mayne, J.3    Wang, G.S.4    Chen, A.5    Dewpura, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.