Optimization of a PGSS (particles from gas saturated solutions) process for a fenofibrate lipid-based solid dispersion formulation

International Journal of Pharmaceutics

Volumn 485, Issue 1-2, 2015, Pages 295-305

  Pestieau, Aude ^a   Krier, Fabrice ^a   Lebrun, Pierre ^b   Brouwers, Adeline ^c   Streel, Bruno ^c   Evrard, Brigitte ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b Arlenda sa   (Belgium)

^c Galephar M F Research Center   (Belgium)

Author keywords

Biphasic dissolution test; Design of experiments; Fenofibrate; Particles from gas saturated solutions; Solid dispersion; Supercritical carbon dioxide

Indexed keywords

FENOFIBRATE; GELUCIRE; LIPID; ANTILIPEMIC AGENT; CARBON DIOXIDE; DRUG CARRIER; FAT; GAS; GELUCIRE 50-13; OIL;

ARTICLE; DRUG FORMULATION; DRUG MANUFACTURE; DRUG SOLUBILITY; PARTICLE SIZE; POROSITY; PRIORITY JOURNAL; SOLID STATE; VALIDITY; BIOAVAILABILITY; CHEMICAL MODEL; CHEMISTRY; DEVICES; EQUIPMENT DESIGN; GAS; HUMAN; MEDICINAL CHEMISTRY; ORAL DRUG ADMINISTRATION; PHARMACEUTICS; PRESSURE; PROCEDURES; SOLUBILITY; STATISTICAL MODEL; TEMPERATURE;

ADMINISTRATION, ORAL; BIOLOGICAL AVAILABILITY; CARBON DIOXIDE; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; EQUIPMENT DESIGN; FATS; FENOFIBRATE; GASES; HUMANS; HYPOLIPIDEMIC AGENTS; MODELS, CHEMICAL; MODELS, STATISTICAL; OILS; PRESSURE; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE;

EID: 84925325131     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.03.027     Document Type: Article

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