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Volumn 136, Issue 1, 2015, Pages 143-157

Genetic and epigenetic changes in vulvar squamous cell carcinoma and its precursor lesions: A review of the current literature

Author keywords

Epigenetic; Genetic; Intraepithelial neoplasia; Somatic mutations; Squamous cell carcinoma; Vulva

Indexed keywords

REPETITIVE DNA;

EID: 84925230215     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2014.11.002     Document Type: Review
Times cited : (87)

References (81)
  • 1
    • 84871104861 scopus 로고    scopus 로고
    • Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma
    • Jan
    • Del Pino M, Rodriguez-Carunchio L, Ordi J. Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma. Histopathology Jan 2013;62(1):161-75.
    • (2013) Histopathology , vol.62 , Issue.1 , pp. 161-175
    • Del Pino, M.1    Rodriguez-Carunchio, L.2    Ordi, J.3
  • 2
    • 84862125847 scopus 로고    scopus 로고
    • Clinico-pathological and biological prognostic variables in squamous cell carcinoma of the vulva
    • Jul
    • Gadducci A, Tana R, Barsotti C, Guerrieri ME, Genazzani AR. Clinico-pathological and biological prognostic variables in squamous cell carcinoma of the vulva. Crit Rev Oncol Hematol Jul 2012;83(1):71-83.
    • (2012) Crit Rev Oncol Hematol , vol.83 , Issue.1 , pp. 71-83
    • Gadducci, A.1    Tana, R.2    Barsotti, C.3    Guerrieri, M.E.4    Genazzani, A.R.5
  • 6
    • 84879621727 scopus 로고    scopus 로고
    • Premalignant lesions of the lower female genital tract: Cervix, vagina and vulva
    • Apr
    • McCluggage WG. Premalignant lesions of the lower female genital tract: cervix, vagina and vulva. Pathology Apr 2013;45(3):214-28.
    • (2013) Pathology , vol.45 , Issue.3 , pp. 214-228
    • McCluggage, W.G.1
  • 7
    • 36448935326 scopus 로고    scopus 로고
    • A comparative analysis of lichen sclerosus of the vulva and lichen sclerosus that evolves to vulvar squamous cell carcinoma
    • Dec
    • Raspollini MR, Asirelli G, Moncini D, Taddei GL. A comparative analysis of lichen sclerosus of the vulva and lichen sclerosus that evolves to vulvar squamous cell carcinoma. Am J Obstet Gynecol Dec 2007;197(6):592-5.
    • (2007) Am J Obstet Gynecol , vol.197 , Issue.6 , pp. 592-595
    • Raspollini, M.R.1    Asirelli, G.2    Moncini, D.3    Taddei, G.L.4
  • 8
    • 77649270419 scopus 로고    scopus 로고
    • Differentiated vulvar intraepithelial neoplasia contains Tp53 mutations and is genetically linked to vulvar squamous cell carcinoma
    • Mar
    • Pinto AP, Miron A, Yassin Y, Monte N, Woo TY, Mehra KK, et al. Differentiated vulvar intraepithelial neoplasia contains Tp53 mutations and is genetically linked to vulvar squamous cell carcinoma. Mod Pathol Mar 2010;23(3):404-12.
    • (2010) Mod Pathol , vol.23 , Issue.3 , pp. 404-412
    • Pinto, A.P.1    Miron, A.2    Yassin, Y.3    Monte, N.4    Woo, T.Y.5    Mehra, K.K.6
  • 9
    • 21244505036 scopus 로고    scopus 로고
    • P53 expression in vulvar carcinoma, vulvar intraepithelial neoplasia, squamous cell hyperplasia and lichen sclerosus
    • May
    • Hantschmann P, Sterzer S, Jeschke U, Friese K. P53 expression in vulvar carcinoma, vulvar intraepithelial neoplasia, squamous cell hyperplasia and lichen sclerosus. Anticancer Res May 2005;25(3A):1739-45.
    • (2005) Anticancer Res , vol.25 , Issue.3 , pp. 1739-1745
    • Hantschmann, P.1    Sterzer, S.2    Jeschke, U.3    Friese, K.4
  • 10
    • 27944485746 scopus 로고    scopus 로고
    • Vulvar intraepithelial neoplasia: Aspects of the natural history and outcome in 405 women
    • Dec
    • Jones RW, Rowan DM, Stewart AW. Vulvar intraepithelial neoplasia: aspects of the natural history and outcome in 405 women. Obstet Gynecol Dec 2005;106(6): 1319-26.
    • (2005) Obstet Gynecol , vol.106 , Issue.6 , pp. 1319-1326
    • Jones, R.W.1    Rowan, D.M.2    Stewart, A.W.3
  • 11
    • 0027997037 scopus 로고
    • Vulvar intraepithelial neoplasia III: A clinical study of the outcome in 113 cases with relation to the later development of invasive vulvar carcinoma
    • Nov
    • Jones RW, Rowan DM. Vulvar intraepithelial neoplasia III: a clinical study of the outcome in 113 cases with relation to the later development of invasive vulvar carcinoma. Obstet Gynecol Nov 1994;84(5):741-5.
    • (1994) Obstet Gynecol , vol.84 , Issue.5 , pp. 741-745
    • Jones, R.W.1    Rowan, D.M.2
  • 13
    • 84856076184 scopus 로고    scopus 로고
    • Is differentiated vulval intraepithelial neoplasia the precursor lesion of human papillomavirus-negative vulval squamous cell carcinoma?
    • Oct
    • Kokka F, Singh N, Faruqi A, Gibbon K, Rosenthal AN. Is differentiated vulval intraepithelial neoplasia the precursor lesion of human papillomavirus-negative vulval squamous cell carcinoma? Int J Gynecol Cancer Oct 2011;21(7):1297-305.
    • (2011) Int J Gynecol Cancer , vol.21 , Issue.7 , pp. 1297-1305
    • Kokka, F.1    Singh, N.2    Faruqi, A.3    Gibbon, K.4    Rosenthal, A.N.5
  • 14
    • 20444439843 scopus 로고    scopus 로고
    • Longterm survival and disease recurrence in patients with primary squamous cell carcinoma of the vulva
    • Jun
    • Gonzalez BJ, Magrina JF, Gaffey TA, Hernandez JL, Webb MJ, Cliby WA, et al. Longterm survival and disease recurrence in patients with primary squamous cell carcinoma of the vulva. Gynecol Oncol Jun 2005;97(3):828-33.
    • (2005) Gynecol Oncol , vol.97 , Issue.3 , pp. 828-833
    • Gonzalez, B.J.1    Magrina, J.F.2    Gaffey, T.A.3    Hernandez, J.L.4    Webb, M.J.5    Cliby, W.A.6
  • 15
    • 0141718935 scopus 로고    scopus 로고
    • Local and regional recurrence of vulval cancer: Management dilemmas
    • Aug
    • Coulter J, Gleeson N. Local and regional recurrence of vulval cancer: management dilemmas. Best Pract Res Clin Obstet Gynaecol Aug 2003;17(4):663-81.
    • (2003) Best Pract Res Clin Obstet Gynaecol , vol.17 , Issue.4 , pp. 663-681
    • Coulter, J.1    Gleeson, N.2
  • 17
    • 0025345495 scopus 로고
    • The surgical management of recurrent squamous cell carcinoma of the vulva
    • Jun
    • Hopkins MP, Reid GC, Morley GW. The surgical management of recurrent squamous cell carcinoma of the vulva. Obstet Gynecol Jun 1990;75(6):1001-5.
    • (1990) Obstet Gynecol , vol.75 , Issue.6 , pp. 1001-1005
    • Hopkins, M.P.1    Reid, G.C.2    Morley, G.W.3
  • 19
    • 84869190072 scopus 로고    scopus 로고
    • Epigenetic mechanisms in oral carcinogenesis
    • Nov
    • Gasche JA, Goel A. Epigenetic mechanisms in oral carcinogenesis. Future Oncol Nov 2012;8(11):1407-25.
    • (2012) Future Oncol , vol.8 , Issue.11 , pp. 1407-1425
    • Gasche, J.A.1    Goel, A.2
  • 20
    • 84873719544 scopus 로고    scopus 로고
    • PIK3CA mutational status and overall survival in patients with cervical cancer treated with radical chemoradiotherapy
    • Mar
    • McIntyre JB, Wu JS, Craighead PS, Phan T, Kobel M, Lees-Miller SP, et al. PIK3CA mutational status and overall survival in patients with cervical cancer treated with radical chemoradiotherapy. Gynecol Oncol Mar 2013;128(3):409-14.
    • (2013) Gynecol Oncol , vol.128 , Issue.3 , pp. 409-414
    • McIntyre, J.B.1    Wu, J.S.2    Craighead, P.S.3    Phan, T.4    Kobel, M.5    Lees-Miller, S.P.6
  • 21
    • 84863983915 scopus 로고    scopus 로고
    • Mutation profiling identifies numerous rare drug targets and distinct mutation patterns in different clinical subtypes of breast cancers
    • Jul
    • Santarpia L, Qi Y, Stemke-Hale K, Wang B, Young EJ, Booser DJ, et al. Mutation profiling identifies numerous rare drug targets and distinct mutation patterns in different clinical subtypes of breast cancers. Breast Cancer Res Treat Jul 2012; 134(1):333-43.
    • (2012) Breast Cancer Res Treat , vol.134 , Issue.1 , pp. 333-343
    • Santarpia, L.1    Qi, Y.2    Stemke-Hale, K.3    Wang, B.4    Young, E.J.5    Booser, D.J.6
  • 22
    • 79951491860 scopus 로고    scopus 로고
    • Genetic alterations in the K-Ras gene influence the prognosis in patients with cervical cancer treated by radiotherapy
    • Jan
    • Wegman P, Ahlin C, Sorbe B. Genetic alterations in the K-Ras gene influence the prognosis in patients with cervical cancer treated by radiotherapy. Int J Gynecol Cancer Jan 2011;21(1):86-91.
    • (2011) Int J Gynecol Cancer , vol.21 , Issue.1 , pp. 86-91
    • Wegman, P.1    Ahlin, C.2    Sorbe, B.3
  • 24
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Jun 30
    • Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med Jun 30 2011;364(26):2507-16.
    • (2011) N Engl J Med , vol.364 , Issue.26 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3    Haanen, J.B.4    Ascierto, P.5    Larkin, J.6
  • 26
    • 0842330369 scopus 로고    scopus 로고
    • TP53 mutations in vulval lichen sclerosus adjacent to squamous cell carcinoma of the vulva
    • Dec 15
    • Rolfe KJ, MacLean AB, Crow JC, Benjamin E, Reid WM, Perrett CW. TP53 mutations in vulval lichen sclerosus adjacent to squamous cell carcinoma of the vulva. Br J Cancer Dec 15 2003;89(12):2249-53.
    • (2003) Br J Cancer , vol.89 , Issue.12 , pp. 2249-2253
    • Rolfe, K.J.1    MacLean, A.B.2    Crow, J.C.3    Benjamin, E.4    Reid, W.M.5    Perrett, C.W.6
  • 28
    • 33846972607 scopus 로고    scopus 로고
    • Inactivation of the CDKN2A and the p53 tumour suppressor genes in external genital carcinomas and their precursors
    • Mar
    • Soufir N, Queille S, Liboutet M, Thibaudeau O, Bachelier F, Delestaing G, et al. Inactivation of the CDKN2A and the p53 tumour suppressor genes in external genital carcinomas and their precursors. Br J Dermatol Mar 2007;156(3):448-53.
    • (2007) Br J Dermatol , vol.156 , Issue.3 , pp. 448-453
    • Soufir, N.1    Queille, S.2    Liboutet, M.3    Thibaudeau, O.4    Bachelier, F.5    Delestaing, G.6
  • 29
    • 84858123458 scopus 로고    scopus 로고
    • Promoter hypermethylation of death-associated protein kinase and p16 genes in vulvar lichen sclerosus
    • Apr
    • Aide S, Lattario FR, Almeida G, do Val IC, Carvalho MG. Promoter hypermethylation of death-associated protein kinase and p16 genes in vulvar lichen sclerosus. J Low Genit Tract Dis Apr 2012;16(2):133-9.
    • (2012) J Low Genit Tract Dis , vol.16 , Issue.2 , pp. 133-139
    • Aide, S.1    Lattario, F.R.2    Almeida, G.3    Do Val, I.C.4    Carvalho, M.G.5
  • 30
    • 79955443513 scopus 로고    scopus 로고
    • Differential hypermethylation of genes in vulvar cancer and lichen sclerosus coexisting or not with vulvar cancer
    • Jun 15
    • Guerrero D, Guarch R, Ojer A, Casas JM, Mendez-Meca C, Esteller M, et al. Differential hypermethylation of genes in vulvar cancer and lichen sclerosus coexisting or not with vulvar cancer. Int J Cancer Jun 15 2011;128(12):2853-64.
    • (2011) Int J Cancer , vol.128 , Issue.12 , pp. 2853-2864
    • Guerrero, D.1    Guarch, R.2    Ojer, A.3    Casas, J.M.4    Mendez-Meca, C.5    Esteller, M.6
  • 31
    • 84885660033 scopus 로고    scopus 로고
    • Differentially methylated loci distinguish ovarian carcinoma histological types: Evaluation of a DNA methylation assay in FFPE tissue 39
    • Kelemen LE, Kobel M, Chan A, Taghaddos S, Dinu I. Differentially methylated loci distinguish ovarian carcinoma histological types: evaluation of a DNA methylation assay in FFPE tissue 39. Biomed Res Int 2013;2013:815894.
    • (2013) Biomed Res Int , vol.2013 , pp. 815894
    • Kelemen, L.E.1    Kobel, M.2    Chan, A.3    Taghaddos, S.4    Dinu, I.5
  • 32
    • 84859910536 scopus 로고    scopus 로고
    • A unique regulatory phase of DNA methylation in the early mammalian embryo
    • Apr 19
    • Smith ZD, Chan MM, Mikkelsen TS, Gu H, Gnirke A, Regev A, et al. A unique regulatory phase of DNA methylation in the early mammalian embryo. Nature Apr 19 2012;484(7394):339-44.
    • (2012) Nature , vol.484 , Issue.7394 , pp. 339-344
    • Smith, Z.D.1    Chan, M.M.2    Mikkelsen, T.S.3    Gu, H.4    Gnirke, A.5    Regev, A.6
  • 33
    • 85047699461 scopus 로고    scopus 로고
    • Coincident inactivation of 14-3-3sigma and p16INK4a is an early event in vulval squamous neoplasia
    • Mar 14
    • Gasco M, Sullivan A, Repellin C, Brooks L, Farrell PJ, Tidy JA, et al. Coincident inactivation of 14-3-3sigma and p16INK4a is an early event in vulval squamous neoplasia. Oncogene Mar 14 2002;21(12):1876-81.
    • (2002) Oncogene , vol.21 , Issue.12 , pp. 1876-1881
    • Gasco, M.1    Sullivan, A.2    Repellin, C.3    Brooks, L.4    Farrell, P.J.5    Tidy, J.A.6
  • 34
    • 0035900819 scopus 로고    scopus 로고
    • p73 is overexpressed in vulval cancer principally as the delta 2 isoform
    • Nov 16
    • O'Nions J, Brooks LA, Sullivan A, Bell A, Dunne B, Rozycka M, et al. p73 is overexpressed in vulval cancer principally as the Delta 2 isoform. Br J Cancer Nov 16 2001;85(10):1551-6.
    • (2001) Br J Cancer , vol.85 , Issue.10 , pp. 1551-1556
    • O'Nions, J.1    Brooks, L.A.2    Sullivan, A.3    Bell, A.4    Dunne, B.5    Rozycka, M.6
  • 35
    • 84896091402 scopus 로고    scopus 로고
    • Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus - Further support for epigenetic mechanisms
    • Oct 27
    • Gambichler T, Terras S, Kreuter A, Skrygan M. Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus - further support for epigenetic mechanisms. Br J Dermatol Oct 27 2013;170(3):687-93.
    • (2013) Br J Dermatol , vol.170 , Issue.3 , pp. 687-693
    • Gambichler, T.1    Terras, S.2    Kreuter, A.3    Skrygan, M.4
  • 37
    • 0027133089 scopus 로고
    • HPV detection and p53 alteration in squamous cell verrucous malignancies of the lower genital tract
    • Dec
    • Pilotti S, Donghi R, D'Amato L, Giarola M, Longoni A, Della TG, et al. HPV detection and p53 alteration in squamous cell verrucous malignancies of the lower genital tract. Diagn Mol Pathol Dec 1993;2(4):248-56.
    • (1993) Diagn Mol Pathol , vol.2 , Issue.4 , pp. 248-256
    • Pilotti, S.1    Donghi, R.2    D'Amato, L.3    Giarola, M.4    Longoni, A.5    Della, T.G.6
  • 38
    • 0028179978 scopus 로고
    • The state of the p53 gene in human papillomavirus (HPV)-positive and HPV-negative genital precancer lesions and carcinomas as determined by single-strand conformation polymorphism analysis and sequencing
    • Jan
    • Kurvinen K, Tervahauta A, Syrjanen S, Chang F, Syrjanen K. The state of the p53 gene in human papillomavirus (HPV)-positive and HPV-negative genital precancer lesions and carcinomas as determined by single-strand conformation polymorphism analysis and sequencing. Anticancer Res Jan 1994;14(1A):177-81.
    • (1994) Anticancer Res , vol.14 , Issue.1 , pp. 177-181
    • Kurvinen, K.1    Tervahauta, A.2    Syrjanen, S.3    Chang, F.4    Syrjanen, K.5
  • 40
    • 0028884967 scopus 로고
    • Presence and persistence of HPV infection and p53 mutation in cancer of the cervix uteri and the vulva
    • Nov 27
    • Milde-Langosch K, Albrecht K, Joram S, Schlechte H, Giessing M, Loning T. Presence and persistence of HPV infection and p53 mutation in cancer of the cervix uteri and the vulva. Int J Cancer Nov 27 1995;63(5):639-45.
    • (1995) Int J Cancer , vol.63 , Issue.5 , pp. 639-645
    • Milde-Langosch, K.1    Albrecht, K.2    Joram, S.3    Schlechte, H.4    Giessing, M.5    Loning, T.6
  • 42
    • 0029975837 scopus 로고    scopus 로고
    • p53 mutations and clonality in vulvar carcinomas and squamous hyperplasias: Evidence suggesting that squamous hyperplasias do not serve as direct precursors of human papillomavirusnegative vulvar carcinomas
    • Apr
    • Kim YT, Thomas NF, Kessis TD, Wilkinson EJ, Hedrick L, Cho KR. p53 mutations and clonality in vulvar carcinomas and squamous hyperplasias: evidence suggesting that squamous hyperplasias do not serve as direct precursors of human papillomavirusnegative vulvar carcinomas. Hum Pathol Apr 1996;27(4):389-95.
    • (1996) Hum Pathol , vol.27 , Issue.4 , pp. 389-395
    • Kim, Y.T.1    Thomas, N.F.2    Kessis, T.D.3    Wilkinson, E.J.4    Hedrick, L.5    Cho, K.R.6
  • 43
    • 0031013126 scopus 로고    scopus 로고
    • Detection of p53 point mutations in primary human vulvar cancer by PCR and temperature gradient gel electrophoresis
    • Jan
    • Sliutz G, Schmidt W, Tempfer C, Speiser P, Gitsch G, Eder S, et al. Detection of p53 point mutations in primary human vulvar cancer by PCR and temperature gradient gel electrophoresis. Gynecol Oncol Jan 1997;64(1):93-8.
    • (1997) Gynecol Oncol , vol.64 , Issue.1 , pp. 93-98
    • Sliutz, G.1    Schmidt, W.2    Tempfer, C.3    Speiser, P.4    Gitsch, G.5    Eder, S.6
  • 44
  • 45
    • 0032820538 scopus 로고    scopus 로고
    • Genetic changes during the multistage pathogenesis of human papillomavirus positive and negative vulvar carcinomas
    • Jul
    • Flowers LC, Wistuba II, Scurry J, Muller CY, Ashfaq R, Miller DS, et al. Genetic changes during the multistage pathogenesis of human papillomavirus positive and negative vulvar carcinomas. J Soc Gynecol Investig Jul 1999;6(4):213-21.
    • (1999) J Soc Gynecol Investig , vol.6 , Issue.4 , pp. 213-221
    • Flowers, L.C.1    Wistuba, I.I.2    Scurry, J.3    Muller, C.Y.4    Ashfaq, R.5    Miller, D.S.6
  • 46
    • 0033105716 scopus 로고    scopus 로고
    • Abnormal expression or mutation of TP53 and HPV in vulvar cancer
    • Mar
    • Ngan HY, Cheung AN, Liu SS, Yip PS, Tsao SW. Abnormal expression or mutation of TP53 and HPV in vulvar cancer. Eur J Cancer Mar 1999;35(3):481-4.
    • (1999) Eur J Cancer , vol.35 , Issue.3 , pp. 481-484
    • Ngan, H.Y.1    Cheung, A.N.2    Liu, S.S.3    Yip, P.S.4    Tsao, S.W.5
  • 47
    • 0034671556 scopus 로고    scopus 로고
    • Preferential retention of codon 72 arginine p53 in squamous cell carcinomas of the vulva occurs in cancers positive and negative for human papillomavirus
    • Dec 15
    • Brooks LA, Tidy JA, Gusterson B, Hiller L, O'Nions J, Gasco M, et al. Preferential retention of codon 72 arginine p53 in squamous cell carcinomas of the vulva occurs in cancers positive and negative for human papillomavirus. Cancer Res Dec 15 2000; 60(24):6875-7.
    • (2000) Cancer Res , vol.60 , Issue.24 , pp. 6875-6877
    • Brooks, L.A.1    Tidy, J.A.2    Gusterson, B.3    Hiller, L.4    O'Nions, J.5    Gasco, M.6
  • 48
    • 0034063604 scopus 로고    scopus 로고
    • A common polymorphism acts as an intragenic modifier of mutant p53 behaviour
    • May
    • Marin MC, Jost CA, Brooks LA, Irwin MS, O'Nions J, Tidy JA, et al. A common polymorphism acts as an intragenic modifier of mutant p53 behaviour. Nat Genet May 2000; 25(1):47-54.
    • (2000) Nat Genet , vol.25 , Issue.1 , pp. 47-54
    • Marin, M.C.1    Jost, C.A.2    Brooks, L.A.3    Irwin, M.S.4    O'Nions, J.5    Tidy, J.A.6
  • 49
    • 0034508487 scopus 로고    scopus 로고
    • Immunohistochemical localization of telomerase hTERT protein and analysis of clonality in multifocal vulvar intraepithelial neoplasia
    • Sep
    • Wada H, Enomoto T, Yoshino K, Ozaki K, Kurachi H, Nomura T, et al. Immunohistochemical localization of telomerase hTERT protein and analysis of clonality in multifocal vulvar intraepithelial neoplasia. Am J Clin Pathol Sep 2000; 114(3):371-9.
    • (2000) Am J Clin Pathol , vol.114 , Issue.3 , pp. 371-379
    • Wada, H.1    Enomoto, T.2    Yoshino, K.3    Ozaki, K.4    Kurachi, H.5    Nomura, T.6
  • 50
    • 0036697312 scopus 로고    scopus 로고
    • I lichen ed il carcinoma vulvare. Nostra esperienza
    • [Italian] Aug
    • Rampone A, Vozza G, Vozza A, Rampone B, Capuano I, Tirabasso S, et al. Lichen and vulvar cancer. Personal experience. [Italian] I lichen ed il carcinoma vulvare. Nostra esperienza. G Ital Dermatol Venereol Aug 2002;137(4):267-9.
    • (2002) G Ital Dermatol Venereol , vol.137 , Issue.4 , pp. 267-269
    • Rampone, A.1    Vozza, G.2    Vozza, A.3    Rampone, B.4    Capuano, I.5    Tirabasso, S.6
  • 52
    • 18744408116 scopus 로고    scopus 로고
    • Overexpression of wild-type p53 in lichen sclerosus adjacent to human papillomavirus-negative vulvar cancer
    • Nov
    • Vanin K, Scurry J, Thorne H, Yuen K, Ramsay RG. Overexpression of wild-type p53 in lichen sclerosus adjacent to human papillomavirus-negative vulvar cancer. J Invest Dermatol Nov 2002;119(5):1027-33.
    • (2002) J Invest Dermatol , vol.119 , Issue.5 , pp. 1027-1033
    • Vanin, K.1    Scurry, J.2    Thorne, H.3    Yuen, K.4    Ramsay, R.G.5
  • 53
    • 7244220252 scopus 로고    scopus 로고
    • Human papillomavirus, Epstein-Barr virus and p53 mutation in vulvar intraepithelial neoplasia
    • Oct
    • Almeida G, do V I, Gondim C, Lima R, Takiya C, Carvalho G. Human papillomavirus, Epstein-Barr virus and p53 mutation in vulvar intraepithelial neoplasia. J Reprod Med Oct 2004;49(10):796-9.
    • (2004) J Reprod Med , vol.49 , Issue.10 , pp. 796-799
    • Almeida, G.1    Do, V.I.2    Gondim, C.3    Lima, R.4    Takiya, C.5    Carvalho, G.6
  • 55
    • 34548133367 scopus 로고    scopus 로고
    • Treatment of squamous cell vulvar cancer with the anti-EGFR tyrosine kinase inhibitor Tarceva
    • Olawaiye A, Lee LM, Krasner C, Horowitz N. Treatment of squamous cell vulvar cancer with the anti-EGFR tyrosine kinase inhibitor Tarceva. Gynecol Oncol 2007; 106(3):628-30.
    • (2007) Gynecol Oncol , vol.106 , Issue.3 , pp. 628-630
    • Olawaiye, A.1    Lee, L.M.2    Krasner, C.3    Horowitz, N.4
  • 56
    • 34249825231 scopus 로고    scopus 로고
    • Characteristics of vulvar squamous cell carcinoma in Japanese women
    • Jun
    • Osakabe M, Hayashi M, Katayama Y, Emura I, Nemoto K, Umezu H, et al. Characteristics of vulvar squamous cell carcinoma in Japanese women. Pathol Int Jun 2007; 57(6):322-7.
    • (2007) Pathol Int , vol.57 , Issue.6 , pp. 322-327
    • Osakabe, M.1    Hayashi, M.2    Katayama, Y.3    Emura, I.4    Nemoto, K.5    Umezu, H.6
  • 57
    • 35348889604 scopus 로고    scopus 로고
    • Single base instability is promoted in vulvar lichen sclerosus
    • Nov
    • Tapp RA, Feng J, Jones JW, Carlson JA, Wilson VL. Single base instability is promoted in vulvar lichen sclerosus. J Invest Dermatol Nov 2007;127(11):2563-76.
    • (2007) J Invest Dermatol , vol.127 , Issue.11 , pp. 2563-2576
    • Tapp, R.A.1    Feng, J.2    Jones, J.W.3    Carlson, J.A.4    Wilson, V.L.5
  • 58
    • 51349100393 scopus 로고    scopus 로고
    • Gains of chromosome region 3q26 in intraepithelial neoplasia and invasive squamous cell carcinoma of the vulva are frequent and independent of HPV status
    • Sep
    • Aulmann S, Schleibaum J, Penzel R, Schirmacher P, Gebauer G, Sinn HP. Gains of chromosome region 3q26 in intraepithelial neoplasia and invasive squamous cell carcinoma of the vulva are frequent and independent of HPV status. J Clin Pathol Sep 2008;61(9):1034-7.
    • (2008) J Clin Pathol , vol.61 , Issue.9 , pp. 1034-1037
    • Aulmann, S.1    Schleibaum, J.2    Penzel, R.3    Schirmacher, P.4    Gebauer, G.5    Sinn, H.P.6
  • 59
    • 79952690921 scopus 로고    scopus 로고
    • PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTOR axis inhibitors
    • Mar
    • Janku F, Tsimberidou AM, Garrido-Laguna I, Wang X, Luthra R, Hong DS, et al. PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTOR axis inhibitors. Mol Cancer Ther Mar 2011;10(3):558-65.
    • (2011) Mol Cancer Ther , vol.10 , Issue.3 , pp. 558-565
    • Janku, F.1    Tsimberidou, A.M.2    Garrido-Laguna, I.3    Wang, X.4    Luthra, R.5    Hong, D.S.6
  • 62
    • 0032967213 scopus 로고    scopus 로고
    • p53 protein expression in squamous cell carcinoma of the vulva
    • Scheistroen M, Trope C, Pettersen EO, Nesland JM. p53 protein expression in squamous cell carcinoma of the vulva. Cancer 1999;85(5):1133-8.
    • (1999) Cancer , vol.85 , Issue.5 , pp. 1133-1138
    • Scheistroen, M.1    Trope, C.2    Pettersen, E.O.3    Nesland, J.M.4
  • 63
    • 3042689408 scopus 로고    scopus 로고
    • The most common chromosome aberration detected by high-resolution comparative genomic hybridization in vulvar intraepithelial neoplasia is not seen in vulvar squamous cell carcinoma
    • Bryndorf T, Kirchhoff M, Larsen J, Andreasson B, Bjerregaard B, Westh H, et al. The most common chromosome aberration detected by high-resolution comparative genomic hybridization in vulvar intraepithelial neoplasia is not seen in vulvar squamous cell carcinoma. Cytogenet Genome Res 2004;106(1):43-8.
    • (2004) Cytogenet Genome Res , vol.106 , Issue.1 , pp. 43-48
    • Bryndorf, T.1    Kirchhoff, M.2    Larsen, J.3    Andreasson, B.4    Bjerregaard, B.5    Westh, H.6
  • 65
    • 0031923589 scopus 로고    scopus 로고
    • Patterns of allelic loss (LOH) in vulvar squamous carcinomas and adjacent noninvasive epithelia 1
    • May
    • Lin MC, Mutter GL, Trivijisilp P, Boynton KA, Sun D, Crum CP. Patterns of allelic loss (LOH) in vulvar squamous carcinomas and adjacent noninvasive epithelia 1. Am J Pathol May 1998;152(5):1313-8.
    • (1998) Am J Pathol , vol.152 , Issue.5 , pp. 1313-1318
    • Lin, M.C.1    Mutter, G.L.2    Trivijisilp, P.3    Boynton, K.A.4    Sun, D.5    Crum, C.P.6
  • 66
    • 0032943577 scopus 로고    scopus 로고
    • Allelic loss in human papillomavirus-positive and -negative vulvar squamous cell carcinomas
    • Apr
    • Pinto AP, Lin M-C, Mutter GL, Sun D, Villa LL, Crum CP. Allelic loss in human papillomavirus-positive and -negative vulvar squamous cell carcinomas. Am J Pathol Apr 1999;154(4):1009-15.
    • (1999) Am J Pathol , vol.154 , Issue.4 , pp. 1009-1015
    • Pinto, A.P.1    Lin, M.-C.2    Mutter, G.L.3    Sun, D.4    Villa, L.L.5    Crum, C.P.6
  • 67
    • 0034492981 scopus 로고    scopus 로고
    • Chromosome 17 aneusomy detected by fluorescence in situ hybridization in vulvar squamous cell carcinomas and synchronous vulvar skin
    • Carlson JA, Healy K, Tran TA, Malfetano J, Wilson VL, Rohwedder A, et al. Chromosome 17 aneusomy detected by fluorescence in situ hybridization in vulvar squamous cell carcinomas and synchronous vulvar skin. Am J Pathol 2000;157(3): 973-83.
    • (2000) Am J Pathol , vol.157 , Issue.3 , pp. 973-983
    • Carlson, J.A.1    Healy, K.2    Tran, T.A.3    Malfetano, J.4    Wilson, V.L.5    Rohwedder, A.6
  • 68
    • 0343898134 scopus 로고    scopus 로고
    • Loss in 3p and 4p and gain of 3q are concomitant aberrations in squamous cell carcinoma of the vulva
    • Jee KJ, Kim YT, Kim KR, Kim HS, Yan A, Knuutila S. Loss in 3p and 4p and gain of 3q are concomitant aberrations in squamous cell carcinoma of the vulva. Mod Pathol 2001;14(5):377-81.
    • (2001) Mod Pathol , vol.14 , Issue.5 , pp. 377-381
    • Jee, K.J.1    Kim, Y.T.2    Kim, K.R.3    Kim, H.S.4    Yan, A.5    Knuutila, S.6
  • 69
    • 0037128671 scopus 로고    scopus 로고
    • Genetic aberrations detected by comparative genomic hybridisation in vulvar cancers
    • Mar 18
    • Allen DG, Hutchins AM, Hammet F, White DJ, Scurry JP, Tabrizi SN, et al. Genetic aberrations detected by comparative genomic hybridisation in vulvar cancers. Br J Cancer Mar 18 2002;86(6):924-8.
    • (2002) Br J Cancer , vol.86 , Issue.6 , pp. 924-928
    • Allen, D.G.1    Hutchins, A.M.2    Hammet, F.3    White, D.J.4    Scurry, J.P.5    Tabrizi, S.N.6
  • 70
    • 0035892311 scopus 로고    scopus 로고
    • High frequency of loss of heterozygosity in vulval intraepithelial neoplasia (VIN) is associated with invasive vulval squamous cell carcinoma (VSCC)
    • Dec 15
    • Rosenthal AN, Ryan A, Hopster D, Surentheran T, Jacobs IJ. High frequency of loss of heterozygosity in vulval intraepithelial neoplasia (VIN) is associated with invasive vulval squamous cell carcinoma (VSCC). Int J Cancer Dec 15 2001; 94(6):896-900.
    • (2001) Int J Cancer , vol.94 , Issue.6 , pp. 896-900
    • Rosenthal, A.N.1    Ryan, A.2    Hopster, D.3    Surentheran, T.4    Jacobs, I.J.5
  • 72
    • 37749051880 scopus 로고    scopus 로고
    • Genetic imbalance and human papillomavirus states in vulvar squamous cell carcinomas
    • Yangling O, Shulang Z, Rongli C, Bo L, Lili C, Xin W. Genetic imbalance and human papillomavirus states in vulvar squamous cell carcinomas. Eur J Gynaecol Oncol 2007;28(6):442-6.
    • (2007) Eur J Gynaecol Oncol , vol.28 , Issue.6 , pp. 442-446
    • Yangling, O.1    Shulang, Z.2    Rongli, C.3    Bo, L.4    Lili, C.5    Xin, W.6
  • 75
    • 0034049662 scopus 로고    scopus 로고
    • Allelic imbalance in lichen sclerosus, hyperplasia, and intraepithelial neoplasia of the vulva
    • Apr
    • Pinto AP, Lin MC, Sheets EE, Muto MG, Sun D, Crum CP. Allelic imbalance in lichen sclerosus, hyperplasia, and intraepithelial neoplasia of the vulva. Gynecol Oncol Apr 2000;77(1):171-6.
    • (2000) Gynecol Oncol , vol.77 , Issue.1 , pp. 171-176
    • Pinto, A.P.1    Lin, M.C.2    Sheets, E.E.3    Muto, M.G.4    Sun, D.5    Crum, C.P.6
  • 76
    • 77958141125 scopus 로고    scopus 로고
    • Promoter hypermethylation patterns of death-associated protein kinase and p16 genes in vulvar lichen sclerosus
    • Oct
    • Aide S, Lattario FR, Almeida G, do Val IC, Carvalho MG. Promoter hypermethylation patterns of death-associated protein kinase and p16 genes in vulvar lichen sclerosus. J Low Genit Tract Dis Oct 2010;14(4):282-6.
    • (2010) J Low Genit Tract Dis , vol.14 , Issue.4 , pp. 282-286
    • Aide, S.1    Lattario, F.R.2    Almeida, G.3    Do Val, I.C.4    Carvalho, M.G.5
  • 78
    • 0036826901 scopus 로고    scopus 로고
    • Alterations of the p16 (INK4a)/Rb/Cyclin-D1 pathway in vulvar carcinoma, vulvar intraepithelial neoplasia, and lichen sclerosus
    • Lerma E, Esteller M, Herman JG, Prat J. Alterations of the p16 (INK4a)/Rb/Cyclin-D1 pathway in vulvar carcinoma, vulvar intraepithelial neoplasia, and lichen sclerosus. Hum Pathol 2002;33(11):1120-5.
    • (2002) Hum Pathol , vol.33 , Issue.11 , pp. 1120-1125
    • Lerma, E.1    Esteller, M.2    Herman, J.G.3    Prat, J.4
  • 79
    • 84859615616 scopus 로고    scopus 로고
    • Identification of inguinofemoral lymph node metastases by methylation markers in vulvar cancer
    • May
    • Oonk MH, Eijsink JJ, Volders HH, Hollema H, Wisman GB, Schuuring E, et al. Identification of inguinofemoral lymph node metastases by methylation markers in vulvar cancer. Gynecol Oncol May 2012;125(2):352-7.
    • (2012) Gynecol Oncol , vol.125 , Issue.2 , pp. 352-357
    • Oonk, M.H.1    Eijsink, J.J.2    Volders, H.H.3    Hollema, H.4    Wisman, G.B.5    Schuuring, E.6
  • 80
    • 0037468097 scopus 로고    scopus 로고
    • Immunohistochemical analysis of p53 in vulval intraepithelial neoplasia and vulval squamous cell carcinoma
    • Jan 27
    • Rosenthal AN, Hopster D, Ryan A, Jacobs IJ. Immunohistochemical analysis of p53 in vulval intraepithelial neoplasia and vulval squamous cell carcinoma. Br J Cancer Jan 27 2003;88(2):251-6.
    • (2003) Br J Cancer , vol.88 , Issue.2 , pp. 251-256
    • Rosenthal, A.N.1    Hopster, D.2    Ryan, A.3    Jacobs, I.J.4
  • 81
    • 79952384705 scopus 로고    scopus 로고
    • Cancer epigenetics reaches mainstream oncology
    • Mar
    • Rodriguez-Paredes M, Esteller M. Cancer epigenetics reaches mainstream oncology. Nat Med Mar 2011;17(3):330-9.
    • (2011) Nat Med , vol.17 , Issue.3 , pp. 330-339
    • Rodriguez-Paredes, M.1    Esteller, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.