High frequency of loss of heterozygosity in vulval intraepithelial neoplasia (VIN) is associated with invasive vulval squamous cell carcinoma (VSCC)

International Journal of Cancer

Volumn 94, Issue 6, 2001, Pages 896-900

  Wijnhoven, Bas P L ^a   Lindstedt, Eric Wim ^a   Abbou, Mustaffa ^a   Ijzendoorn, Ynske ^a   De Krijger, Ronald R ^b   Tilanus, Hugo W ^b   Dinjens, Winand N M ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

Author keywords

Cancer; HPV; LOH; VIN; Vulval

Indexed keywords

ARTICLE; CANCER GROWTH; CANCER STAGING; CHROMOSOMAL LOCALIZATION; CHROMOSOME 11P; CHROMOSOME 17P; CHROMOSOME 3P; CHROMOSOME 4Q; CHROMOSOME 5P; CHROMOSOME 9P; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DNA SEQUENCE; FEMALE; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; VULVA CARCINOMA; VULVA TUMOR;

CARCINOMA, SQUAMOUS CELL; FEMALE; GENES, P16; HUMANS; LOSS OF HETEROZYGOSITY; PRECANCEROUS CONDITIONS; TUMOR SUPPRESSOR PROTEIN P53; VULVAR NEOPLASMS;

EID: 0035892311     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.1549     Document Type: Article

References (22)

1. Basaloid and warty carcinomas of the vulva. Distinctive types of squamous cell carcinoma frequently associated with human papillomaviruses
2. Vulvar squamous cell carcinoma and papillomaviruses: Indications for two different etiologies
3. Invasive vulvar tumours in young women: A disease of the immunocompromised?
4. Absence of p53 protein overexpression in precancerous lesions of the vulva
5. Monoclonal origin of vulvar intraepithelial neoplasia and some vulval hyperplasias
6. Unrecognised invasive carcinoma in vulvar intra-epithelial neoplasia (VIN)
7. Vulvar intraepithelial neoplasia III: A clinical study of the outcome of 113 cases with relation to the later development of invasive vulvar carcinoma
8. Patterns of allelic loss (LOH) in vulvar squamous carcinomas and adjacent non-invasive epithelia
9. Allelic loss in human papillomavirus-positive and -negative vulvar squamous cell carcinomas
10. Genetic changes during the multistage pathogenesis of human papillomavirus positive and negative vulvar carcinomas
11. Allelic imbalance in lichen sclerosus, hyperplasia and intraepithelial neoplasia of the vulva
12. Molecular damage in the bronchial epithelium of current and former smokers
13. p53 overexpression is common and independent of human papillomavirus infection in squamous cell carcinoma of the vulva
14. p-53 protein expression in a population-based series of primary vulval squamous cell carcinoma and immediate adjacent field-change
15. Sequential loss of heterozygosity at microsatellite motifs in preinvasive and invasive head and neck squamous carcinoma
16. Frequent loss of chromosome 9p21-22 early in head and neck cancer progression
17. Allelic loss at chromosomes 3p, 8p and 17p associated with poor prognosis in head and neck cancer
18. INK4 and retinoblastoma protein Rb in vulvar lesions of Chinese women
19. Allelotype analysis of cervical carcinoma
20. Genetic alterations accumulate during cervical tumorigenesis and indicate a common origin in multifocal lesions
21. Ploidy in human papillomavirus positive and negative vulvar squamous cell carcinomas and adjacent skin lesions
22. Monoclonality and surface lesion-specific microsatellite alterations in premalignant and malignant neoplasia of uterine cervix: A local field effect of genomic instability and clonal evolution