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Volumn 21, Issue 7, 2011, Pages 1297-1305

Is differentiated vulval intraepithelial neoplasia the precursor lesion of human papillomavirus-negative vulval squamous cell carcinoma?

Author keywords

Cancer; Carcinogenesis; Differentiated; Etiology; Hyperplasia; Squamous; Vulva; Vulval intraepithelial neoplasia

Indexed keywords

CIDOFOVIR; IMIQUIMOD; KI 67 ANTIGEN; PROTEIN P16; PROTEIN P53; T6 ANTIGEN;

EID: 84856076184     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1097/IGC.0b013e31822dbe26     Document Type: Review
Times cited : (47)

References (72)
  • 1
    • 33646809374 scopus 로고    scopus 로고
    • Trends in the incidence of invasive and in situ vulvar carcinoma
    • Judson PL, Habermann EB, Baxter NN, et al. Trends in the incidence of invasive and in situ vulvar carcinoma. Obstet Gynecol. 2006;107:1018-1022.
    • (2006) Obstet Gynecol , vol.107 , pp. 1018-1022
    • Judson, P.L.1    Habermann, E.B.2    Baxter, N.N.3
  • 3
    • 0026573510 scopus 로고
    • In situ and invasive vulvar cancer incidence trends (1973 to 1987)
    • Sturgeon SR, Brinton LA, Devesa SS, et al. In situ and invasive vulvar cancer incidence trends (1973 to 1987). Am J Obstet Gynecol. 1992;166:1482-1485.
    • (1992) Am J Obstet Gynecol , vol.166 , pp. 1482-1485
    • Sturgeon, S.R.1    Brinton, L.A.2    Devesa, S.S.3
  • 4
    • 77958552148 scopus 로고    scopus 로고
    • Vulvodynia: An often-overlooked cause of dyspareunia in the menopausal population
    • Phillips N, Bachmann G. Vulvodynia: an often-overlooked cause of dyspareunia in the menopausal population. Menopausal Med. 2010;18:S1-S5.
    • (2010) Menopausal Med , vol.18
    • Phillips, N.1    Bachmann, G.2
  • 7
    • 0025638973 scopus 로고
    • The epithelial changes associated with squamous cell carcinoma of the vulva: A review of the clinical, histological and viral findings in 78 women
    • Leibowitch M, Neill S, Pelisse M, et al. The epithelial changes associated with squamous cell carcinoma of the vulva: a review of the clinical, histological and viral findings in 78 women. Br J Obstet Gynaecol. 1990;97:1135-1139.
    • (1990) Br J Obstet Gynaecol , vol.97 , pp. 1135-1139
    • Leibowitch, M.1    Neill, S.2    Pelisse, M.3
  • 8
    • 33646013599 scopus 로고    scopus 로고
    • Histopathologic study of thin vulvar squamous cell carcinomas and associated cutaneous lesions: A correlative study of 48 tumors in 44 patients with analysis of adjacent vulvar lntraepithelial neoplasia types and lichen sclerosus
    • DOI 10.1097/01.pas.0000180444.71775.1a, PII 0000047820060300000003
    • Chiesa-Vottero A, Dvoretsky PM, Hart WR. Histopathologic study of thin vulvar squamous cell carcinomas and associated cutaneous lesions: a correlative study of 48 tumors in 44 patients with analysis of adjacent vulvar intraepithelial neoplasia types and lichen sclerosus. Am J Surg Pathol. 2006;30:310-318. (Pubitemid 43740162)
    • (2006) American Journal of Surgical Pathology , vol.30 , Issue.3 , pp. 310-318
    • Chiesa-Vottero, A.1    Dvoretsky, P.M.2    Hart, W.R.3
  • 9
    • 61349151124 scopus 로고    scopus 로고
    • Vulvar squamous cell carcinoma development after diagnosis of VIN increases with age
    • van de Nieuwenhof HP, Massuger LF, van der Avoort IA, et al. Vulvar squamous cell carcinoma development after diagnosis of VIN increases with age. Eur J Cancer. 2009;45:851-856.
    • (2009) Eur J Cancer , vol.45 , pp. 851-856
    • Van De Nieuwenhof, H.P.1    Massuger, L.F.2    Van Der Avoort, I.A.3
  • 11
    • 0024673208 scopus 로고
    • New nomenclature for vulvar disease: International Society for the Study of Vulvar Disease
    • Ridley CM, Frankman O, Jones IS, et al. New nomenclature for vulvar disease: International Society for the Study of Vulvar Disease. Hum Pathol. 1989;20:495-496.
    • (1989) Hum Pathol , vol.20 , pp. 495-496
    • Ridley, C.M.1    Frankman, O.2    Jones, I.S.3
  • 12
    • 0032968812 scopus 로고    scopus 로고
    • Ploidy in human papillomavirus positive and negative vulvar squamous cell carcinomas and adjacent skin lesions
    • DOI 10.1046/j.1525-1438.1999.99015.x
    • Scurry J, Hung J, Flowers L, et al. Ploidy in human papillomavirus positive and negative vulvar squamous cell carcinomas and adjacent skin lesions. Int J Gynecol Cancer. 1999;9:187-193. (Pubitemid 29302852)
    • (1999) International Journal of Gynecological Cancer , vol.9 , Issue.3 , pp. 187-193
    • Scurry, J.1    Hung, J.2    Flowers, L.3    Kneafsay, P.4    Gazdar, A.5
  • 14
    • 0026576640 scopus 로고
    • Carcinoma of the vulva: Epidemiology and pathogenesis
    • Crum CP. Carcinoma of the vulva: epidemiology and pathogenesis. Obstet Gynecol. 1992;79:448-454.
    • (1992) Obstet Gynecol , vol.79 , pp. 448-454
    • Crum, C.P.1
  • 15
    • 70350772293 scopus 로고    scopus 로고
    • Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia
    • Kenter GG, Welters MJ, Valentijn AR, et al. Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia. N Engl J Med. 2009;361:1838-1847.
    • (2009) N Engl J Med , vol.361 , pp. 1838-1847
    • Kenter, G.G.1    Welters, M.J.2    Valentijn, A.R.3
  • 16
    • 0037468097 scopus 로고    scopus 로고
    • Immunohistochemical analysis of p53 in vulval intraepithelial neoplasia and vulval squamous cell carcinoma
    • DOI 10.1038/sj.bjc.6600677
    • Rosenthal AN, Hopster D, Ryan A, et al. Immunohistochemical analysis of p53 in vulval intraepithelial neoplasia and vulval squamous cell carcinoma. Br J Cancer. 2003;88:251-256. (Pubitemid 36255844)
    • (2003) British Journal of Cancer , vol.88 , Issue.2 , pp. 251-256
    • Rosenthal, A.N.1    Hopster, D.2    Ryan, A.3    Jacobs, I.J.4
  • 17
    • 43049089744 scopus 로고    scopus 로고
    • Risk factors for invasive squamous cell carcinoma of the vulva and vagina - Population-based case-control study in Denmark
    • DOI 10.1002/ijc.23446
    • Madsen BS, Jensen HL, van den Brule AJ, et al. Risk factors for invasive squamous cell carcinoma of the vulva and vagina - population-based case-control study in Denmark. Int J Cancer. 2008;122:2827-2834. (Pubitemid 351631386)
    • (2008) International Journal of Cancer , vol.122 , Issue.12 , pp. 2827-2834
    • Madsen, B.S.1    Jensen, H.L.2    Van Den, B.A.J.C.3    Wohlfahrt, J.4    Frisch, M.5
  • 18
    • 33646483819 scopus 로고    scopus 로고
    • High-risk human papillomavirus infection of the genital tract of women with a previous history or current high-grade vulvar intraepithelial neoplasia
    • Goffin F, Mayrand MH, Gauthier P, et al. High-risk human papillomavirus infection of the genital tract of women with a previous history or current high-grade vulvar intraepithelial neoplasia. J Med Virol. 2006;78:814-819.
    • (2006) J Med Virol , vol.78 , pp. 814-819
    • Goffin, F.1    Mayrand, M.H.2    Gauthier, P.3
  • 20
    • 18144381041 scopus 로고    scopus 로고
    • Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients
    • van Seters M, van Beurden M, de Craen AJ. Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients. Gynecol Oncol. 2005;97:645-651.
    • (2005) Gynecol Oncol , vol.97 , pp. 645-651
    • Van Seters, M.1    Van Beurden, M.2    De Craen, A.J.3
  • 22
    • 41649084839 scopus 로고    scopus 로고
    • Treatment of vulvar intraepithelial neoplasia with topical imiquimod
    • van Seters M, van Beurden M, de Craen AJ. Treatment of vulvar intraepithelial neoplasia with topical imiquimod. N Engl J Med. 2008;358:1465-1473.
    • (2008) N Engl J Med , vol.358 , pp. 1465-1473
    • Van Seters, M.1    Van Beurden, M.2    De Craen, A.J.3
  • 23
    • 27944485746 scopus 로고    scopus 로고
    • Vulvar intraepithelial neoplasia: Aspects of the natural history and outcome in 405 women
    • Jones RW, Rowan DM, Stewart AW. Vulvar intraepithelial neoplasia: aspects of the natural history and outcome in 405 women. Obstet Gynecol. 2005;106:1319-1326. (Pubitemid 41668952)
    • (2005) Obstetrics and Gynecology , vol.106 , Issue.6 , pp. 1319-1326
    • Jones, R.W.1    Rowan, D.M.2    Stewart, A.W.3
  • 24
    • 0031805262 scopus 로고    scopus 로고
    • Intraepithelial and invasive squamous cell neoplasia of the vulva: Trends in incidence, recurrence, and survival rate in Norway
    • DOI 10.1016/S0029-7844(98)00101-X, PII S002978449800101X
    • Iversen T, Tretli S. Intraepithelial and invasive squamous cell neoplasia of the vulva: trends in incidence, recurrence, and survival rate in Norway. Obstet Gynecol. 1998;91:969-972. (Pubitemid 28246933)
    • (1998) Obstetrics and Gynecology , vol.91 , Issue.6 , pp. 969-972
    • Iversen, T.1    Tretli, S.2
  • 25
    • 0036605097 scopus 로고    scopus 로고
    • Molecular evidence of a common clonal origin and subsequent divergent clonal evolution in vulval intraepithelial neoplasia, vulval squamous cell carcinoma and lymph node metastases
    • DOI 10.1002/ijc.10362
    • Rosenthal AN, Ryan A, Hopster D, et al. Molecular evidence of a common clonal origin and subsequent divergent clonal evolution in vulval intraepithelial neoplasia, vulval squamous cell carcinoma and lymph node metastases. Int J Cancer. 2002;99:549-554. (Pubitemid 34461607)
    • (2002) International Journal of Cancer , vol.99 , Issue.4 , pp. 549-554
    • Rosenthal, A.N.1    Ryan, A.2    Hopster, D.3    Jacobs, I.J.4
  • 26
    • 0035892311 scopus 로고    scopus 로고
    • High frequency of loss of heterozygosity in vulval intraepithelial neoplasia (VIN) is associated with invasive vulval squamous cell carcinoma (VSCC)
    • Rosenthal AN, Ryan A, Hopster D, et al. High frequency of loss of heterozygosity in vulval intraepithelial neoplasia (VIN) is associated with invasive vulval squamous cell carcinoma (VSCC). Int J Cancer. 2001;94:896-900.
    • (2001) Int J Cancer , vol.94 , pp. 896-900
    • Rosenthal, A.N.1    Ryan, A.2    Hopster, D.3
  • 30
    • 0037343465 scopus 로고    scopus 로고
    • Recent advances in the pathology of the vulva
    • DOI 10.1046/j.1365-2559.2003.01578.x
    • Fox H, Wells M. Recent advances in the pathology of the vulva. Histopathology. 2003;42:209-216. (Pubitemid 36356852)
    • (2003) Histopathology , vol.42 , Issue.3 , pp. 209-216
    • Fox, H.1    Wells, M.2
  • 31
    • 33750284286 scopus 로고    scopus 로고
    • Review of terminology of precursors of vulvar squamous cell carcinoma
    • DOI 10.1097/00128360-200607000-00008, PII 0012836020060700000008
    • Scurry J, Wilkinson EJ. Review of terminology of precursors of vulvar squamous cell carcinoma. J Low Genit Tract Dis. 2006;10:161-169. (Pubitemid 44618506)
    • (2006) Journal of Lower Genital Tract Disease , vol.10 , Issue.3 , pp. 161-169
    • Scurry, J.1    Wilkinson, E.J.2
  • 33
    • 2642573006 scopus 로고    scopus 로고
    • Pathology and genetics of tumours of the breast and female genital organs
    • Tavassoli FA, Devilee P, eds. Lyon, France: IARC Press
    • Wilkinson EJ, Teixeira MR. Pathology and genetics of tumours of the breast and female genital organs. In: Tavassoli FA, Devilee P, eds. World Health Organization Classification of Tumours. Lyon, France: IARC Press; 2003;230:316-320.
    • (2003) World Health Organization Classification of Tumours , vol.230 , pp. 316-320
    • Wilkinson, E.J.1    Teixeira, M.R.2
  • 34
    • 18144401653 scopus 로고    scopus 로고
    • Early vulvar squamous neoplasia: Advances in classification, diagnosis, and differential diagnosis
    • DOI 10.1097/01.pqp.0000151268.72556.f3
    • Medeiros F, Nascimento AF, Crum CP. Early vulvar squamous neoplasia: advances in classification, diagnosis, and differential diagnosis. Adv Anat Pathol. 2005;12:20-26. (Pubitemid 40614486)
    • (2005) Advances in Anatomic Pathology , vol.12 , Issue.1 , pp. 20-26
    • Medeiros, F.1    Nascimento, A.F.2    Crum, C.P.3
  • 36
    • 33751311959 scopus 로고    scopus 로고
    • The distribution of low and high-risk HPV types in vulvar and vaginal intraepithelial neoplasia (VIN and VaIN)
    • DOI 10.1097/01.pas.0000213291.96401.48, PII 0000047820061200000003
    • Srodon M, Stoler MH, Baber GB, et al. The distribution of low and high-risk HPV types in vulvar and vaginal intraepithelial neoplasia (VIN and VaIN). Am J Surg Pathol. 2006;30:1513-1518. (Pubitemid 44808787)
    • (2006) American Journal of Surgical Pathology , vol.30 , Issue.12 , pp. 1513-1518
    • Srodon, M.1    Stoler, M.H.2    Baber, G.B.3    Kurman, R.J.4
  • 37
    • 0000034013 scopus 로고
    • Intraepithelial carcinomas of epidermis and squamous mucosa of vulva and perineum
    • Abell MR. Intraepithelial carcinomas of epidermis and squamous mucosa of vulva and perineum. Surg Clin North Am. 1965;45:1179-1198.
    • (1965) Surg Clin North Am , vol.45 , pp. 1179-1198
    • Abell, M.R.1
  • 38
    • 0035153342 scopus 로고    scopus 로고
    • Vulvar intraepithelial neoplasia: Historical aspects and current status
    • Hart WR. Vulvar intraepithelial neoplasia: historical aspects and current status. Int J Gynecol Pathol. 2001;20:16-30. (Pubitemid 32041755)
    • (2001) International Journal of Gynecological Pathology , vol.20 , Issue.1 , pp. 16-30
    • Hart, W.R.1
  • 40
    • 58649089614 scopus 로고    scopus 로고
    • Recent developments in vulvovaginal pathology
    • McCluggage WG. Recent developments in vulvovaginal pathology. Histopathology. 2009;54:156-173.
    • (2009) Histopathology , vol.54 , pp. 156-173
    • McCluggage, W.G.1
  • 41
    • 79551644108 scopus 로고    scopus 로고
    • Differentiated vulvar intraepithelial neoplasia is often found in lesions, previously diagnosed as lichen sclerosus, which have progressed to vulvar squamous cell carcinoma
    • van de Nieuwenhof HP, Bulten J, Hollema H, et al. Differentiated vulvar intraepithelial neoplasia is often found in lesions, previously diagnosed as lichen sclerosus, which have progressed to vulvar squamous cell carcinoma. Mod Pathol. 2011;24:297-305.
    • (2011) Mod Pathol , vol.24 , pp. 297-305
    • Van De Nieuwenhof, H.P.1    Bulten, J.2    Hollema, H.3
  • 42
    • 39349086765 scopus 로고    scopus 로고
    • Differentiated intraepithelial neoplasia of the vulva
    • DOI 10.1097/pgp.0b0318134ea34, PII 0000434720080100000023
    • Mulvany NJ, Allen DG. Differentiated intraepithelial neoplasia of the vulva. Int J Gynecol Pathol. 2008;27:125-135. (Pubitemid 351627985)
    • (2008) International Journal of Gynecological Pathology , vol.27 , Issue.1 , pp. 125-135
    • Mulvany, N.J.1    Allen, D.G.2
  • 44
    • 0028882273 scopus 로고
    • The natural history of vulvar intraepithelial neoplasia
    • Jones RW. The natural history of vulvar intraepithelial neoplasia. Br J Obstet Gynaecol. 1995;102:764-766.
    • (1995) Br J Obstet Gynaecol , vol.102 , pp. 764-766
    • Jones, R.W.1
  • 45
    • 0034089176 scopus 로고    scopus 로고
    • Vulvar intraepithelial neoplasia of the simplex (differentiated) type: A clinicopathologic study including analysis of HPV and p53 expression
    • DOI 10.1097/00000478-200003000-00013
    • Yang B, Hart WR. Vulvar intraepithelial neoplasia of the simplex (differentiated) type: a clinicopathologic study including analysis of HPVand p53 expression. Am J Surg Pathol. 2000;24:429-441. (Pubitemid 30127480)
    • (2000) American Journal of Surgical Pathology , vol.24 , Issue.3 , pp. 429-441
    • Yang, B.1    Hart, W.R.2
  • 46
    • 57349115531 scopus 로고    scopus 로고
    • A panel of p16(INK4A), MIB1 and p53 proteins can distinguish between the 2 pathways leading to vulvar squamous cell carcinoma
    • Hoevenaars BM, van der Avoort IA, deWilde PC, et al. A panel of p16(INK4A), MIB1 and p53 proteins can distinguish between the 2 pathways leading to vulvar squamous cell carcinoma. Int J Cancer. 2008;123:2767-2773.
    • (2008) Int J Cancer , vol.123 , pp. 2767-2773
    • Hoevenaars, B.M.1    Van Der Avoort, I.A.2    DeWilde, P.C.3
  • 48
    • 35348917434 scopus 로고    scopus 로고
    • Topical imiquimod can reverse vulvar intraepithelial neoplasia: A randomised, double-blinded study
    • DOI 10.1016/j.ygyno.2007.06.003, PII S0090825807004167
    • Mathiesen O, Buus SK, Cramers M. Topical imiquimod can reverse vulvar intraepithelial neoplasia: a randomised, double-blinded study. Gynecol Oncol. 2007;107:219-222. (Pubitemid 47575715)
    • (2007) Gynecologic Oncology , vol.107 , Issue.2 , pp. 219-222
    • Mathiesen, O.1    Buus, S.K.2    Cramers, M.3
  • 49
    • 34548137811 scopus 로고    scopus 로고
    • Final results of a phase 2 study using continuous 5% Imiquimod cream application in the primary treatment of high-grade vulva intraepithelial neoplasia
    • DOI 10.1016/j.ygyno.2007.05.019, PII S0090825807003496
    • Le T, Menard C, Hicks-Boucher W, et al. Final results of a phase 2 study using continuous 5% imiquimod cream application in the primary treatment of high-grade vulva intraepithelial neoplasia. Gynecol Oncol. 2007;106:579-584. (Pubitemid 47302478)
    • (2007) Gynecologic Oncology , vol.106 , Issue.3 , pp. 579-584
    • Le, T.1    Menard, C.2    Hicks-Boucher, W.3    Hopkins, L.4    Weberpals, J.5    Fung-Kee-Fung, M.6
  • 50
    • 28144438815 scopus 로고    scopus 로고
    • Clinical responses to Cidofovir applied topically to women with high grade vulval intraepithelial neoplasia
    • DOI 10.1016/j.ygyno.2005.07.127, PII S0090825805005986
    • Tristram A, Fiander A. Clinical responses to cidofovir applied topically to women with high grade vulval intraepithelial neoplasia. Gynecol Oncol. 2005;99:652-655. (Pubitemid 41693335)
    • (2005) Gynecologic Oncology , vol.99 , Issue.3 , pp. 652-655
    • Tristram, A.1    Fiander, A.2
  • 51
    • 77949275772 scopus 로고    scopus 로고
    • Photodynamic therapy for intraepithelial neoplasia of the lower genital tract
    • Soergel P, Hillemanns P. Photodynamic therapy for intraepithelial neoplasia of the lower genital tract. Photodiagnosis Photodyn Ther. 2010;7:10-14.
    • (2010) Photodiagnosis Photodyn Ther , vol.7 , pp. 10-14
    • Soergel, P.1    Hillemanns, P.2
  • 53
    • 30444457914 scopus 로고    scopus 로고
    • 2 laser vaporization, photodynamic therapy, excision and vulvectomy
    • DOI 10.1016/j.ygyno.2005.08.012, PII S0090825805007109
    • Hillemanns P, Wang X, Staehle S, et al. Evaluation of different treatment modalities for vulvar intraepithelial neoplasia (VIN): CO(2) laser vaporization, photodynamic therapy, excision and vulvectomy. Gynecol Oncol. 2006;100:271-275. (Pubitemid 43075260)
    • (2006) Gynecologic Oncology , vol.100 , Issue.2 , pp. 271-275
    • Hillemanns, P.1    Wang, X.2    Staehle, S.3    Michels, W.4    Dannecker, C.5
  • 54
    • 0036176847 scopus 로고    scopus 로고
    • High-grade vulval intraepithelial neoplasia (VIN 3): A retrospective analysis of patient characteristics, management, outcome and relationship to squamous cell carcinoma of the vulva 1989-1999
    • Sykes P, Smith N, McCormick P, et al. High-grade vulval intraepithelial neoplasia (VIN 3): a retrospective analysis of patient characteristics, management, outcome and relationship to squamous cell carcinoma of the vulva 1989-1999. Aust N Z J Obstet Gynaecol. 2002;42:69-74. (Pubitemid 34173094)
    • (2002) Australian and New Zealand Journal of Obstetrics and Gynaecology , vol.42 , Issue.1 , pp. 69-74
    • Sykes, P.1    Smith, N.2    McCormick, P.3    Frizelle, F.A.4
  • 55
    • 0021846620 scopus 로고
    • Intraepithelial neoplasia in the vulvar region
    • DOI 10.1016/0090-8258(85)90267-7
    • Andreasson B, Bock JE. Intraepithelial neoplasia in the vulvar region. Gynecol Oncol. 1985;21:300-305. (Pubitemid 15059966)
    • (1985) Gynecologic Oncology , vol.21 , Issue.3 , pp. 300-305
    • Andreasson, B.1    Bock, J.E.2
  • 56
    • 0023109155 scopus 로고
    • Skinning vulvectomy for the treatment of multifocal vulvar intraepithelial neoplasia
    • Rettenmaier MA, Berman ML, DiSaia PJ. Skinning vulvectomy for the treatment of multifocal vulvar intraepithelial neoplasia. Obstet Gynecol. 1987;69:247-250. (Pubitemid 17015542)
    • (1987) Obstetrics and Gynecology , vol.69 , Issue.2 , pp. 247-250
    • Rettenmaier, M.A.1    Berman, M.L.2    DiSaia, P.J.3
  • 58
    • 0026509461 scopus 로고
    • Sexual function and somatopsychic reactions after local excision of vulvar intra-epithelial neoplasia
    • Thuesen B, Andreasson B, Bock JE. Sexual function and somatopsychic reactions after local excision of vulvar intra-epithelial neoplasia. Acta Obstet Gynecol Scand. 1992;71:126-128.
    • (1992) Acta Obstet Gynecol Scand , vol.71 , pp. 126-128
    • Thuesen, B.1    Andreasson, B.2    Bock, J.E.3
  • 60
    • 70350435208 scopus 로고    scopus 로고
    • HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: An unrecognized variant of simplex (differentiated) VIN
    • Ordi J, Alejo M, Fusté V, et al. HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN. Am J Surg Pathol. 2009;33:1659-1665.
    • (2009) Am J Surg Pathol , vol.33 , pp. 1659-1665
    • Ordi, J.1    Alejo, M.2    Fusté, V.3
  • 61
    • 0031012973 scopus 로고    scopus 로고
    • Monoclonal origin of vulvar intraepithelial neoplasia and some vulvar hyperplasias
    • Tate JE, Mutter GL, Boynton KA, et al. Monoclonal origin of vulvar intraepithelial neoplasia and some vulvar hyperplasias. Am J Pathol. 1997;150:315-322. (Pubitemid 27027120)
    • (1997) American Journal of Pathology , vol.150 , Issue.1 , pp. 315-322
    • Tate, J.E.1    Mutter, G.L.2    Boynton, K.A.3    Crum, C.P.4
  • 62
    • 34249904396 scopus 로고    scopus 로고
    • In the absence of (early) invasive carcinoma, vulvar intraepithelial neoplasia associated with lichen sclerosus is mainly of undifferentiated type: New insights in histology and aetiology
    • van Seters M, ten Kate FJ, van Beurden M, et al. In the absence of (early) invasive carcinoma, vulvar intraepithelial neoplasia associated with lichen sclerosus is mainly of undifferentiated type: new insights in histology and aetiology. J Clin Pathol. 2007;60:504-509.
    • (2007) J Clin Pathol , vol.60 , pp. 504-509
    • Van Seters, M.1    Ten Kate, F.J.2    Van Beurden, M.3
  • 63
    • 0028991396 scopus 로고
    • Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia
    • Cordon-Cardo C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol. 1995;147:545-560.
    • (1995) Am J Pathol , vol.147 , pp. 545-560
    • Cordon-Cardo, C.1
  • 64
    • 77649270419 scopus 로고    scopus 로고
    • Differentiated vulvar intraepithelial neoplasia contains Tp53 mutations and is genetically linked to vulvar squamous cell carcinoma
    • Pinto AP, Miron A, Yassin Y, et al. Differentiated vulvar intraepithelial neoplasia contains Tp53 mutations and is genetically linked to vulvar squamous cell carcinoma. Mod Pathol. 2010;23:404-412.
    • (2010) Mod Pathol , vol.23 , pp. 404-412
    • Pinto, A.P.1    Miron, A.2    Yassin, Y.3
  • 65
    • 34250826011 scopus 로고    scopus 로고
    • Progression of simplex (differentiated) vulvar intraepithelial neoplasia to invasive squamous cell carcinoma: A prospective case study confirming its precursor role in the pathogenesis of vulvar cancer
    • DOI 10.1097/01.pgp.0000236944.36593.d0, PII 0000434720070700000008
    • Roma AA, Hart WR. Progression of simplex (differentiated) vulvar intraepithelial neoplasia to invasive squamous cell carcinoma: a prospective case study confirming its precursor role in the pathogenesis of vulvar cancer. Int J Gynecol Pathol. 2007;26:248-253. (Pubitemid 46986057)
    • (2007) International Journal of Gynecological Pathology , vol.26 , Issue.3 , pp. 248-253
    • Roma, A.A.1    Hart, W.R.2
  • 66
    • 51349100393 scopus 로고    scopus 로고
    • Gains of chromosome region 3q26 in intraepithelial neoplasia and invasive squamous cell carcinoma of the vulva are frequent and independent of HPV status
    • Aulmann S, Schleibaum J, Penzel R, et al. Gains of chromosome region 3q26 in intraepithelial neoplasia and invasive squamous cell carcinoma of the vulva are frequent and independent of HPV status. J Clin Pathol. 2008;61:1034-1037.
    • (2008) J Clin Pathol , vol.61 , pp. 1034-1037
    • Aulmann, S.1    Schleibaum, J.2    Penzel, R.3
  • 69
    • 20644455963 scopus 로고    scopus 로고
    • Simplex (differentiated) type VIN: Absence of p16INK4 supports its weak association with HPV and its probable precursor role in non-HPV related vulvar squamous cancers [7]
    • DOI 10.1111/j.1365-2559.2005.02036.x
    • Ruhul Quddus M, Xu C, Steinhoff MM, et al. Simplex (differentiated) type VIN: absence of p16INK4 supports its weak association with HPV and its probable precursor role in non-HPV related vulvar squamous cancers. Histopathology. 2005;46:718-720. (Pubitemid 40834838)
    • (2005) Histopathology , vol.46 , Issue.6 , pp. 718-720
    • Ruhul, Q.M.1    Xu, C.2    Steinhoff, M.M.3    Zhang, C.4    Lawrence, W.D.5    Sung, C.J.6
  • 72
    • 0034049662 scopus 로고    scopus 로고
    • Allelic imbalance in lichen sclerosus, hyperplasia, and intraepithelial neoplasia of the vulva
    • DOI 10.1006/gyno.2000.5739
    • Pinto AP, Lin MC, Sheets EE, et al. Allelic imbalance in lichen sclerosus, hyperplasia, and intraepithelial neoplasia of the vulva. Gynecol Oncol. 2000;77:171-176. (Pubitemid 30217321)
    • (2000) Gynecologic Oncology , vol.77 , Issue.1 , pp. 171-176
    • Pinto, A.P.1    Lin, M.-C.2    Sheets, E.E.3    Muto, M.G.4    Sun, D.5    Crum, C.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.