A cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologies

Neurobiology of Disease

Volumn 84, Issue , 2015, Pages 60-68

  Harris White, Marni E ^a,b   Ferbas, Kathie G ^a,c   Johnson, Ming F ^a   Eslami, Pirooz ^a   Poteshkina, Aleksandra ^a   Venkova, Kalina ^d   Christov, Alexandar ^d   Hensley, Kenneth ^d  

^a VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PEPPERDINE UNIVERSITY   (United States)

^d UNIVERSITY OF TOLEDO MEDICAL CENTER   (United States)

Author keywords

Autophagy; CRMP2; DPYSL2; Lanthionine ketimine; MTOR complex (mTORC)

Indexed keywords

BAFILOMYCIN A1; BECLIN 1; COLLAPSIN RESPONSE MEDIATOR PROTEIN 2; LANTHIONINE KETIMINE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; PROTEIN KINASE; RAPAMYCIN; S6 KINASE; SULFUR AMINO ACID; TUBERIN; UNC 51 LIKE KINASE 1; UNCLASSIFIED DRUG; COLLAPSIN RESPONSE MEDIATOR PROTEIN-2; IMMUNOSUPPRESSIVE AGENT; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; NERVE PROTEIN; NEUROPROTECTIVE AGENT; SIGNAL PEPTIDE; TARGET OF RAPAMYCIN KINASE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DEGENERATIVE DISEASE; GLIOMA CELL LINE; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; LYSOSOME; NEUROBLASTOMA CELL LINE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

AMINO ACIDS, SULFUR; ANIMALS; AUTOPHAGY; CELL LINE, TUMOR; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYSOSOMES; MULTIPROTEIN COMPLEXES; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; RATS; SIROLIMUS; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 84925014376     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2015.03.007     Document Type: Article

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