Systems analysis of genetic variation in MPTP neurotoxicity in mice

NeuroToxicology

Volumn 37, Issue , 2013, Pages 26-34

  Jones, Byron C ^a   Miller, Diane B ^b   O'Callaghan, James P ^b   Lu, Lu ^c   Unger, Erica L ^a   Alam, Gelareh ^a   Williams, Robert W ^c  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

BXD; Dopamine; GFAP; Iron; Multivariate analysis; Recombinant inbred strains

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3,4 DIHYDROXYPHENYLACETIC ACID; DOPAMINE; HOMOVANILLIC ACID; SEROTONIN; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; BRAIN TISSUE; CAUDATE NUCLEUS; CHEMICAL ANALYSIS; CHROMOSOME 1; CHROMOSOME 13; CHROMOSOME 15; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE SEVERITY; DOPAMINE BRAIN LEVEL; DOPAMINE METABOLISM; GENE; GENETIC ASSOCIATION; GENETIC DIFFERENCE; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; KANSL1L GENE; LANCL1 GENE; MALE; MOUSE; MTAP2 GENE; NERVE CELL LESION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PUTAMEN; QUANTITATIVE TRAIT LOCUS; RISK FACTOR; SEROTONIN BRAIN LEVEL; SYSTEM ANALYSIS; TELOMERE;

3,4-DIHYDROXYPHENYLACETIC ACID; ANIMALS; BIOLOGICAL MARKERS; BRAIN; DISEASE MODELS, ANIMAL; DOPAMINE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOMICS; GLIAL FIBRILLARY ACIDIC PROTEIN; HOMOVANILLIC ACID; HYDROXYINDOLEACETIC ACID; IRON; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MPTP POISONING; MULTIVARIATE ANALYSIS; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS; RISK FACTORS; SEROTONIN; SPECIES SPECIFICITY; SYSTEMS BIOLOGY; TYROSINE 3-MONOOXYGENASE;

MUS;

EID: 84877025784     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2013.03.010     Document Type: Article

References (21)

1. Berg D., Gerlach M., Youdim M.B., Double K.L., Zecca L., Riederer P., et al. Brain iron pathways and their relevance to Parkinson's disease. J Neurochem 2001, 79:225-236.
2. Boone E.M., Cook M.N., Hou X., Jones B.C. Sex and strain influence the effects of ethanol on central monoamines. J Stud Alcohol 2007, 58:590-599.
3. Cook R., Lu L., Gu J., Williams R.W., Smeyne R.J. Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. Brain Res Mol Brain Res 2003, 110:279-288.
4. Erikson K.M., Pinero D.J., Connor J.R., Beard J.L. Regional brain iron, ferritin and transferrin concentrations during iron deficiency and iron repletion in developing rats. J Nutr 1997, 127:2030-2038.
5. Goldstein L.S., Yang Z. Microtubule-based transport systems in neurons: the roles of kinesins and dyneins. Annu Rev Neurosci 2000, 23:39-71.
6. Jellen L.C., Unger E.L., Lu L., Williams R.W., Rousseau S., Wang X., et al. Systems genetic analysis of the effects of iron deficiency in mouse brain. Neurogenetics 2012, 13:147-157.
7. Kitada T., Tomlinson J.J., Ao H.S., Grimes D.A., Schlossmacher M.G. Considerations regarding the etiology and future treatment of autosomal recessive versus idiopathic Parkinson disease. Curr Treat Options Neurol 2012, 14:230-240.
8. Li A.A., Mink P.J., McIntosh L.J., Teta M.J., Finley B. Evaluation of epidemiologic and animal data associating pesticides with Parkinson's disease. J Occup Environ Med 2005, 47:1059-1087.
9. O'Callaghan J.P., Miller D.B., Reinhard J.F. Characterization of the origins of astrocyte response to injury using the dopaminergic neurotoxicant, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Brain Res 1990, 521:73-80.
10. O'Callaghan J.P. Quantification of glial fibrillary acidic protein: comparison of slot-immunobinding assays with a novel sandwich ELISA. Neurotoxicol Teratol 1991, 13:275-281.
11. O'Callaghan J.P. Measurement of glial fibrillary acidic protein, in Current Protocols in Toxicology 2002, 12.81.1-12.8.12. John Wiley & Sons, New York. L.G. Costa (Ed.).
12. Peirce J.L., Lu L., Gu J., Silve L.M., Williams R.W. A new set of BXD recombinant inbred lines from advanced intercross populations in mice. BMC Genet 2004, 29:5-7.
13. Rosen G.D., Pung C.J., Owens C.B., Caplow J., Kim H., Mozhui K., et al. Genetic modulation of striatal volume by loci on Chrs 6 and 17 in BXD recombinant inbred mice. Genes Brain Behav 2009, 8:296-308.
14. Sandoz G., Tardy M.P., Thummler S., Feliciangeli S., Lazdunski, Lesage F. Mtap2 is a constituent of the protein network that regulates TWIK-related K+ channel expression and trafficking. J Neurosci 2008, 28:8545-8552.
15. Sedelis M., Hofele K., Schwarting R.K., Huston J.P., Belknap J.K. Chromosomal loci influencing the susceptibility to the parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J Neurosci 2003, 23:8247-8253.
16. Smith P.K., Krohn R.I., Hermanson G.T., Mallia A.K., Gartner F.H., Provenzano M.D., et al. Measurement of protein using bicinchoninic acid. Anal Biochem 1985, 150:76-85.
17. Sriram K., Benkovic S.A., Hebert M.A., Miller D.B., O'Callaghan J.P. Induction of gp 130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration: key signaling pathway for astrogliosis in vivo?. J Biol Chem 2004, 275:19936-19947.
18. Taylor B.A., Heiniger H.J., Meier H. Genetic analysis of resistance to cadmium-induced testicular damage in mice. Proc Soc Exp Biol Med 1973, 143:629-633.
19. van der Mark M., Brouwer M., Kromhout H., Nijssen P., Huss A., Vermeulen R. Is pesticide use related to Parkinson disease? Some clues to heterogeneity in study results. Environ Health Perspect 2012, 120:340-347.
20. Yin L., Lu L., Prasad K., Richfield E.K., Unger E.L., Xu J., et al. Genetic-based, differential susceptibility to paraquat neurotoxicity in mice. Neurotoxicol Teratol 2011, 33:415-421.
21. Zhong W.X., Wang Y.B., Peng L., Zhang J., Liu S.S., Zhang X.N., et al. Lanthionine synthase C-like protein 1 interacts with and inhibits cystathionine β-synthase: a target for neuronal antioxidant defense. J Biol Chem 2012, 287:34189-345201.