Accelerated intestinal glucose absorption in morbidly obese humans: Relationship to glucose transporters, incretin hormones, and glycemia

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 3, 2015, Pages 968-976

  Nguyen, Nam Q ^a,b   Debreceni, Tamara L ^a   Bambrick, Jenna E ^a   Chia, Bridgette ^c   Wishart, Judith ^b   Deane, Adam M ^a,b   Rayner, Chris K ^a,b   Horowitz, Michael ^b   Young, Richard L ^b,c  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c HANSON INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; GLUCOSE TRANSPORTER 2; INCRETIN; INSULIN; SODIUM GLUCOSE COTRANSPORTER 1; 3 METHYLGLUCOSE; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORTER;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DUODENUM MUCOSA; FEMALE; GLUCAGON BLOOD LEVEL; GLUCOSE ABSORPTION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; LEAN BODY WEIGHT; MALE; MORBID OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TASTE BUD; BLOOD; CONTROLLED CLINICAL TRIAL; GENE EXPRESSION; GENETICS; INTESTINE ABSORPTION; METABOLISM; MIDDLE AGED; TIME;

3-O-METHYLGLUCOSE; ADULT; BLOOD GLUCOSE; FEMALE; GASTRIC INHIBITORY POLYPEPTIDE; GENE EXPRESSION; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; HUMANS; INCRETINS; INSULIN; INTESTINAL ABSORPTION; MALE; MIDDLE AGED; OBESITY, MORBID; TIME FACTORS;

EID: 84925012880     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-3144     Document Type: Article

References (40)

1. Ludwig DS, Majzoub JA, Al-Zahrani A, Dallal GE, Blanco I, Roberts SB. High glycemic index foods, overeating, and obesity. Pediatrics. 1999;103:E26.
2. Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr. 2004;79:537-543.
3. Wisén O, Johansson C. Gastrointestinal function in obesity: Motility, secretion, and absorption following a liquid test meal. Metabolism. 1992;41:390-395.
4. Seimon RV, Brennan IM, Russo A, et al. Gastric emptying, mouth-to-cecum transit, and glycemic, insulin, incretin, and energy intake responses to a mixed-nutrient liquid in lean, overweight, and obese males. Am J Physiol Endocrinol Metab. 2013;304:E294-E300.
5. Young RL. Sensing via intestinal sweet taste pathways. Front Neurosci. 2011;5:23.
6. Young RL, Sutherland K, Pezos N, et al. Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes. Gut. 2009;58:337-346.
7. Gorboulev V, Schürmann A, Vallon V, et al. Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes. 2012;61:187-196.
8. Kellett GL, Brot-Laroche E. Apical GLUT2: A major pathway of intestinal sugar absorption. Diabetes. 2005;54:3056-3062.
9. Kokrashvili Z, Mosinger B, Margolskee RF. Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones. Am J Clin Nutr. 2009;90:822S-825S.
10. Reimann F. Molecular mechanisms underlying nutrient detection by incretin-secreting cells. Int Dairy J. 2010;20:236-242.
11. Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S. Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism. 1987;36:54-59.
12. Osswald C, Baumgarten K, Stümpel F, et al. Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity. Mol Cell Biol. 2005;25:78-87.
13. Ait-Omar A, Monteiro-Sepulveda M, Poitou C, et al. GLUT2 accumulation in enterocyte apical and intracellular membranes: A study in morbidly obese human subjects and ob/ob and high fat-fed mice. Diabetes. 2011;60:2598-2607.
14. Wu T, Zhao BR, Bound MJ, et al. Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans. Am J Clin Nutr. 2012;95:78-83.
15. Steinert RE, Gerspach AC, Gutmann H, Asarian L, Drewe J, Beglinger C. The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). Clin Nutr. 2011;30:524-532.
16. Gerspach AC, Steinert RE, Schönenberger L, Graber-Maier A, Beglinger C. The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans. Am J Physiol Endocrinol Metab. 2011;301:E317-25.
17. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-419.
18. Nguyen NQ, Besanko LK, Burgstad C, et al. Delayed enteral feeding impairs intestinal carbohydrate absorption in critically ill patients. Crit Care Med. 2012;40:50-54.
19. Nguyen NQ, Debreceni TL, Bambrick JE, et al. Rapid gastric and intestinal transit is a major determinant of changes in blood glucose, intestinal hormones, glucose absorption, and postprandial symptoms after gastric bypass. Obesity (Silver Spring). 2014;22:2003-2009.
20. Nguyen NQ, Debreceni TL, Bambrick JE, et al. Upregulation of intestinal glucose transporters after Roux-en-Y gastric bypass to prevent carbohydrate malabsorption. Obesity (Silver Spring). 2014;22:164-171.
21. Deane AM, Rayner CK, Keeshan A, et al. The effects of critical illness on intestinal glucose sensing, transporters, and absorption. Crit Care Med. 2014;42:57-65.
22. Young RL, Chia B, Isaacs NJ, et al. Disordered control of intestinal sweet taste receptor expression and glucose absorption in type 2 diabetes. Diabetes. 2013;62:3532-3541.
23. Spector D, Shikora S. Neuro-modulation and bariatric surgery for type 2 diabetes mellitus. Int J Clin Pract Suppl. 2010;(166):53-8.
24. Thomas S, Schauer P. Bariatric surgery and the gut hormone response. Nutr Clin Pract. 2010;25:175-182.
25. Cummings DE. Endocrine mechanisms mediating remission of diabetes after gastric bypass surgery. Int J Obes (Lond). 2009; 33(Suppl 1):S33-S40.
26. Rao RS, Kini S. GIP and bariatric surgery. Obes Surg. 2011;21:244-252.
27. Wisén O, Hellström PM. Gastrointestinal motility in obesity. J Intern Med. 1995;237:411-418.
28. Girard J. The incretins: From the concept to their use in the treatment of type 2 diabetes. Part A: Incretins: Concept and physiological functions. Diabetes Metab. 2008;34:550-559.
29. Deacon CF, Ahrén B. Physiology of incretins in health and disease. Rev Diabet Stud. 2011;8:293-306.
30. Moriya R, Shirakura T, Ito J, Mashiko S, Seo T. Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice. Am J Physiol Endocrinol Metab. 2009;297:E1358-E1365.
31. Cho YM, Kieffer TJ. K-cells and glucose-dependent insulinotropic polypeptide in health and disease. Vitam Horm. 2010;84:111-150.
32. Kim SJ, Nian C, Karunakaran S, Clee SM, Isales CM, McIntosh CH. GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis. PLoS One. 2012; 7:e40156.
33. Nie Y, Ma RC, Chan JC, Xu H, Xu G. Glucose-dependent insulinotropic peptide impairs insulin signaling via inducing adipocyte inflammation in glucose-dependent insulinotropic peptide receptor-overexpressing adipocytes. Faseb J. 2012;26:2383-2393.
34. Egan JM, Meneilly GS, Habener JF, Elahi D. Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state. J Clin Endocrinol Metab. 2002;87:3768-2773.
35. Kuo P, Wishart JM, Bellon M, et al. Effects of physiological hyperglycemia on duodenal motility and flow events, glucose absorption, and incretin secretion in healthy humans. J Clin Endocrinol Metab. 2010;95:3893-3900.
36. Elahi D, Andersen DK, Muller DC, Tobin JD, Brown JC, Andres R. The enteric enhancement of glucose-stimulated insulin release. The role of GIP in aging, obesity, and non-insulin-dependent diabetes mellitus. Diabetes. 1984;33:950-957.
37. Vilsbøll T, Krarup T, Sonne J, et al. Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus. J Clin Endocrinol Metab. 2003;88:2706-2713.
38. Stearns AT, Balakrishnan A, Rhoads DB, Tavakkolizadeh A. Rapid upregulation of sodium-glucose transporter SGLT1 in response to intestinal sweet taste stimulation. Ann Surg. 2010;251:865-871.
39. Færch K, Pacini G, Nolan JJ, Hansen T, Tura A, Vistisen D. Impact of glucose tolerance status, sex, and body size on glucose absorption patterns during OGTTs. Diabetes Care. 2013;36:3691-3697.
40. Anderwald C, Gastaldelli A, Tura A, et al. Mechanism and effects of glucose absorption during an oral glucose tolerance test among females and males. J Clin Endocrinol Metab. 2011;96:515-524.