Apical GLUT2: A major pathway of intestinal sugar absorption

Diabetes

Volumn 54, Issue 10, 2005, Pages 3056-3062

  Kellett, George L ^a   Brot Laroche, Edith ^b  

^a UNIVERSITY OF YORK   (United Kingdom)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; GLUCOSE; GLUCOSE TRANSPORTER 2; HORMONE; SODIUM GLUCOSE COTRANSPORTER 1; SUGAR;

APICAL MEMBRANE; CARBOHYDRATE ABSORPTION; CARBOHYDRATE INTAKE; CELL ENERGY; DIABETES MELLITUS; DRUG TARGETING; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT SYSTEM; GLYCEMIC INDEX; INTESTINE ABSORPTION; NONHUMAN; NUTRIENT; POSTPRANDIAL STATE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STRESS; SUGAR INTAKE;

ANIMALS; CARBOHYDRATE METABOLISM; CELL MEMBRANE; DIABETES MELLITUS; DIET; DIETARY CARBOHYDRATES; ENERGY METABOLISM; GLYCEMIC INDEX; HOMEOSTASIS; HUMANS; INTESTINAL ABSORPTION; SODIUM-GLUCOSE TRANSPORTER 1; STRESS;

EID: 25844470444     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.54.10.3056     Document Type: Review

References (50)

1. Csaky TZ, Fischer E: Intestinal sugar transport in experimental diabetes. Diabetes 30:568-574, 1981
2. Debnam ES, Ebrahim HY, Swaine DJ: Diabetes mellitus and sugar transport across the brush-border and basolateral membranes of rat jejunal enterocytes. J Physiol 424:13-25, 1990
3. Thomson AB: Uptake of glucose into the intestine of diabetic rats: effects of variations in the effective resistance of the unstirred water layer. Diabetes 30:247-255, 1981
4. Ferraris RP: Dietary and developmental regulation of intestinal sugar transport. Biochem J 360:265-276, 2001
5. Helliwell PA, Richardson M, Affleck J, Kellett GL: Regulation of GLUTS, GLUT2 and intestinal brush-border fructose absorption by the extracellular signal-regulated kinase, p38 mitogen-activated kinase and phosphatidylinositol 3-kinase intracellular signalling pathways: implications for adaptation to diabetes. Biochem J 350:163-169, 2000
6. Helliwell PA, Richardson M, Affleck J, Kellett GL: Stimulation of fructose transport across the intestinal brush-border membrane by PMA is mediated by GLUT2 and dynamically regulated by protein kinase C. Biochem J 350:149-154, 2000
7. Kellett GL, Helliwell PA: The diffusive component of intestinal glucose absorption is mediated by the glucose-induced recruitment of GLUT2 to the brush-border membrane. Biochem J 350:155-162, 2000
8. Corpe CP, Basaleh MM, Affleck J, Gould G, Jess TJ, Kellett GL: The regulation of GLUTS and GLUT2 activity in the adaptation of intestinal brush-border fructose transport in diabetes. Pflugers Arch 432:192-201, 1996
9. Thorens B, Cheng ZQ, Brown D, Lodish HF: Liver glucose transporter: a basolateral protein in hepatocytes and intestine and kidney cells. Am J Physiol 259:C279-C285, 1990
10. Hediger MA, Coady MJ, Ikeda TS, Wright EM: Expression cloning and cDNA sequencing of the Na+/glucose co-transporter. Nature 330:379-381, 1987
11. Burant CF, Takeda J, Brot-Laroche E, Bell GI, Davidson NO: Fructose transporter in human spermatozoa and small intestine is GLUT5. J Biol Chem 267:14523-14526, 1992
12. Cheeseman CI: GLUT2 is the transporter for fructose across the rat intestinal basolateral membrane. Gastroenterology 105:1050-1056, 1993
13. Affleck J, Helliwell PA, Kellett GL: Immunocytochemical detection of GLUT2 at the rat intestinal brush-border membrane. J Histochem Cytochem 51:1567-1574, 2003
14. Au A, Gupta A, Schembri P, Cheeseman CI: Rapid insertion of GLUT2 into the rat jejunal brush-border membrane promoted by glucagon-like peptide 2. Biochem J 367:247-254, 2002
15. Gouyon F, Caillaud L, Carriere V, Klein C, Dalet V, Citadelle D, Kellett GL, Thorens B, Leturque A, Brot-Laroche E: Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption: a study in GLUT2-null mice. J Physiol (Lond) 552:823-832, 2003
16. Thorens B, Deriaz N, Bosco D, DeVos A, Pipeleers D, Schuit F, Meda P, Porret A: Protein kinase A-dependent phosphorylation of GLUT2 in pancreatic beta cells. J Biol Chem 271:8075-8081, 1996
17. Lam NT, Cheung AT, Riedel MJ, Light PE, Cheeseman CI, Kieffer TJ: Leptin reduces glucose transport and cellular ATP levels in INS-1 beta-cells. J Mol Endocrinol 32:415-424, 2004
18. Pappenheimer JR, Reiss KZ: Contribution of solvent drag through intercellular junctions to absorption of nutrients by the small intestine of the rat. J Membr Biol 100:123-136, 1987
19. Kellett GL: The facilitated component of intestinal glucose absorption. J Physiol 531:585-595, 2001
20. Debnam ES, Levin RJ: An experimental method of identifying and quantifying the active transfer electrogenic component from the diffusive component during sugar absorption measured in vivo. J Physiol 246:181-196, 1975
21. Helliwell PA, Kellett GL: The active and passive components of glucose absorption in rat jejunum under low and high perfusion stress. J Physiol 544:579-589, 2002
22. Brot-Laroche E, Serrano MA, Delhomme B, Alvarado F: Different temperature sensitivity and cation specificity of two distinct D-glucose/Na+ cotransport systems in the intestinal brush-border membrane. Ann N Y Acad Sci 456:47-50, 1985
23. Brot-Laroche E, Serrano MA, Delhomme B, Alvarado F: Temperature sensitivity and substrate specificity of two distinct Na+-activated D-glucose transport systems in guinea pig jejunal brush border membrane vesicles. J Biol Chem 261:6168-6176, 1986
24. Brot-Laroche E, Dao MT, Alcalde AI, Delhomme B, Triadou N, Alvarado F: Independent modulation by food supply of two distinct sodium-activated D-glucose transport systems in the guinea pig jejunal brush-border membrane. Proc Natl Acad Sci U S A 85:6370-6373, 1988
25. Brot-Laroche E, Delhomme B, Alvarado F: Absence of effect of two types of essential fatty acid on D-glucose and L-threonine transport systems in piglet intestine: studies with isolated brush-border membrane vesicles. In Biomembrane and Nutrition. Leger CL, Bereziat G, Eds. Paris, Colloqium INSERM, 1989, p. 283-292
26. Levine GM, Shiau YF, Deren JA: Characteristics of intestinal glucose secretion in normal and diabetic rats. Am J Physiol 242:G456-G459, 1982
27. Pappenheimer JR: On the coupling of membrane digestion with intestinal absorption of sugars and amino acids. Am J Physiol 265:G409-G417, 1993
28. Ferraris RP, Yasharpour S, Lloyd KC, Mirzayan R, Diamond JM: Luminal glucose concentrations in the gut under normal conditions. Am J Physiol 259:G822-G837, 1990
29. Stempel F, Burcelin R, Jungermann K, Thorens B: Normal kinetics of intestinal glucose absorption in the absence of GLUT2: evidence for a transport pathway requiring glucose phosphorylation and transfer into the endoplasmic reticulum. Proc Natl Acad Sci U S A 98:11330-11335, 2001
30. Santer R, Hillebrand G, Steinmann B, Schaub J: Intestinal glucose transport: evidence for a membrane traffic-based pathway in humans. Gastroenterology 124:34-39, 2003
31. Dyer J, Wood IS, Palejwala A, Ellis A, Shirazi-Beechey SP: Expression of monosaccharide transporters in intestine of diabetic humans. Am J Physiol Gastrointest Liver Physiol 282:G241-G248, 2002
32. Habold C, Foltzer-Jourdainne C, Le Maho Y, Lignot JH, Oudart H: Intestinal gluconeogenesis and glucose transport according to body fuel availability in rats. J Physiol 566:575-586, 2005
33. Morgan EL, Mace OJ, Helliwell PA, Affleck J, Kellett GL: A role for Ca(v)1.3 in rat intestinal calcium absorption. Biochem Biophys Res Commun 312:487-493, 2003
34. Liu G, Dilmac N, Hilliard N, Hockerman GH: Ca v 1.3 is preferentially coupled to glucose-stimulated insulin secretion in the pancreatic beta-cell line INS-1. J Pharmacol Exp Ther 305:271-278, 2003
35. Gobble FM, Williams L, Simpson AK, Reimann F: A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line. Diabetes 52:1147-1154, 2003
36. Diez-Sampedro A, Hirayama BA, Osswald C, Gorboulev V, Baumgarten K, Volk C, Wright EM, Koepsell H: A glucose sensor hiding in a family of transporters. Proc Natl Acad Sci U S A 100:11753-11758, 2003
37. Walker J, Jijon HB, Diaz H, Salehi P, Churchill T, Madsen K: 5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK. Biochem J 385:485-491, 2004
38. Zou MH, Kirkpatrick SS, Davis BJ, Nelson JS, Wiles WG, Schlattner U, Neumann D, Brownlee M, Freeman MB, Goldman MH: Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo: role of mitochondrial reactive nitrogen species. J Biol Chem 279:43940-43951, 2004
39. Bailey CJ, Mynett KJ, Page T: Importance of the intestine as a site of metformin-stimulated glucose utilization. Br J Pharmacol 112:671-675, 1994
40. O'Donovan DG, Doran S, Feinle-Bisset C, Jones KL, Meyer JH, Wishart JM, Morris HA, Horowitz M: Effect of variations in small intestinal glucose delivery on plasma glucose, insulin, and incretin hormones in healthy subjects and type 2 diabetes. J Clin Endocrinol Metab 89:3431-3435, 2004
41. Lostao MP, Urdaneta E, Martinez-Anso E, Barber A, Martinez JA: Presence of leptin receptors in rat small intestine and leptin effect on sugar absorption. FEBS Lett 423:302-306, 1998
42. Hirsh AJ, Cheeseman CI: Cholecystokinin decreases intestinal hexose absorption by a parallel reduction in SGLT1 abundance in the brush-border membrane. J Biol Chem 273:14545-14549, 1998
43. Rosmond R: Role of stress in the pathogenesis of the metabolic syndrome. Psychoneuroendocrinology 30:1-10, 2005
44. Shepherd EJ, Helliwell PA, Lister N, Mace OJ, Morgan EL, Patel N, Kellett GL: Stress and glucocorticoid inhibit apical GLUT2-trafficking and intestinal glucose absorption in rat small intestine. J Physiol 560:281-290, 2004
45. Dimitriadis G, Leighton B, Parry-Billings M, Sasson S, Young M, Krause U, Bevan S, Piva T, Wegener G, Newsholme EA: Effects of glucocorticoid excess on the sensitivity of glucose transport and metabolism to insulin in rat skeletal muscle. Biochem J 321:707-712, 1997
46. Thomson AB, Keelan M, Clandinin MT, Walker K: A high linoleic acid diet diminishes enhanced intestinal uptake of sugars in diabetic rats. Am J Physiol 252:G262-G271, 1987
47. Mooradian AD, Thurman JE: Drug therapy of postprandial hyperglycaemia. Drugs 57:19-29, 1999
48. Ramaswamy K, Malathi P, Caspary WF, Crane RK: Studies on the transport of glucose from disaccharides by hamster small intestine in vitro. II. Characteristics of the disaccharidase-related transport system. Biochim Biophys Acta 345:39-48, 1974
49. Marks J, Carvou NJ, Debnam ES, Srai SK, Unwin RJ: Diabetes increases facultative glucose uptake and GLUT2 expression at the rat proximal tubule brush border membrane. J Physiol 553:137-145, 2003
50. Cheeseman CI: Intestinal hexose absorption: transcellular or paracellular fluxes. J Physiol 544:336, 2002