The effects of critical illness on intestinal glucose sensing, transporters, and absorption

Critical Care Medicine

Volumn 42, Issue 1, 2014, Pages 57-65

  Deane, Adam M ^a,b   Rayner, Chris K ^b,c   Keeshan, Alex ^b   Cvijanovic, Nada ^d   Marino, Zelia ^d   Nguyen, Nam Q ^b   Chia, Bridgette ^d   Summers, Matthew J ^b   Sim, Jennifer A ^a   Van Beek, Theresia ^b   Chapman, Marianne J ^a,b   Horowitz, Michael ^c   Young, Richard L ^d  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b ROYAL ADELAIDE HOSPITAL   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d HANSON INSTITUTE   (Australia)

Author keywords

blood glucose; enteral nutrition; glucose absorption; intensive care; small intestine

Indexed keywords

3 METHYLGLUCOSE; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 2; INSULIN; SODIUM GLUCOSE COTRANSPORTER 1;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; CRITICAL ILLNESS; DUODENUM MUCOSA; ENDOSCOPY; FEMALE; GLUCOSE ABSORPTION; GLUCOSE BLOOD LEVEL; HUMAN; INTENSIVE CARE UNIT; INTESTINE ABSORPTION; LAPAROTOMY; MALE; MIDDLE AGED; MOUSE; NONHUMAN; OBSERVATIONAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; SMALL INTESTINE ABSORPTION; SMALL INTESTINE MUCOSA; SWEETNESS; TASTE BUD; YOUNG ADULT;

EID: 84891540535     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318298a8af     Document Type: Article

References (39)

1. Martindale RG, McClave SA, Vanek VW, et al; American College of Critical Care Medicine; A.S.P.E.N. Board of Directors: Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition: Executive Summary. Crit Care Med 2009; 37:1757-1761
2. Wierdsma NJ, Peters JH, Weijs PJ, et al: Malabsorption and nutritional balance in the ICU: Fecal weight as a biomarker: A prospective observational pilot study. Crit Care 2011; 15:R264
3. Reintam A, Parm P, Kitus R, et al: Gastrointestinal symptoms in intensive care patients. Acta Anaesthesiol Scand 2009; 53:318-324
4. Deane AM, Summers MJ, Zaknic AV, et al: Glucose absorption and small intestinal transit in critical illness. Crit Care Med 2011; 39:1282-1288
5. Burgstad CM, Besanko LK, Deane AM, et al: Sucrose malabsorption and impaired mucosal integrity in enterally fed critically ill patients: A prospective cohort observational study. Crit Care Med 2013; 41:1221-1228
6. Fordtran JS, Clodi PH, Soergel KH, et al: Sugar absorption tests, with special reference to 3-0-methyl-d-glucose and d-xylose. Ann Intern Med 1962; 57:883-891
7. Uhing MR, Kimura RE: Active transport of 3-O-methyl-glucose by the small intestine in chronically catheterized rats. J Clin Invest 1995; 95:2799-2805
8. Deane AM, Chapman MJ, Fraser RJ, et al: Effects of exogenous glucagon-like peptide-1 on gastric emptying and glucose absorption in the critically ill: Relationship to glycemia. Crit Care Med 2010; 38:1261-1269
9. Deane AM, Wong GL, Horowitz M, et al: Randomized double-blind crossover study to determine the effects of erythromycin on small intestinal nutrient absorption and transit in the critically ill. Am J Clin Nutr 2012; 95:1396-1402
10. Margolskee RF, Dyer J, Kokrashvili Z, et al: T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter. Proc Natl Acad Sci USA 2007; 104:15075-15080
11. Moran AW, Al-Rammahi MA, Arora DK, et al: Expression of Na+/glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners. Br J Nutr 2010; 104:637-646
12. Stearns AT, Balakrishnan A, Rhoads DB, et al: Rapid upregulation of sodium-glucose transporter SGLT1 in response to intestinal sweet taste stimulation. Ann Surg 2010; 251:865-871
13. Shirazi-Beechey SP, Moran AW, Batchelor DJ, et al: Glucose sensing and signalling; regulation of intestinal glucose transport. Proc Nutr Soc 2011; 70:185-193
14. Jang HJ, Kokrashvili Z, Theodorakis MJ, et al: Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci USA 2007; 104:15069-15074
15. Young RL, Sutherland K, Pezos N, et al: Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes. Gut 2009; 58:337-346
16. Dungan KM, Braithwaite SS, Preiser JC: Stress hyperglycaemia. Lancet 2009; 373:1798-1807
17. Deane AM, Horowitz M: Dysglycaemia in the critically ill-Significance and management. Diabetes Obes Metab 2013; 15:792-801
18. Steinert RE, Gerspach AC, Gutmann H, et al: The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). Clin Nutr 2011; 30:524-532
19. Doi K, Leelahavanichkul A, Yuen PS, et al: Animal models of sepsis and sepsis-induced kidney injury. J Clin Invest 2009; 119:2868-2878
20. Sim JA, Horowitz M, Summers MJ, et al: Mesenteric blood flow, glucose absorption and blood pressure responses to small intestinal glucose in critically ill patients older than 65 years. Intensive Care Med 2013; 39:258-266
21. Liliensiek B, Weigand MA, Bierhaus A, et al: Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response. J Clin Invest 2004; 113:1641-1650
22. Wishart J, Morris HA, Horowitz M: Radioimmunoassay of gastric inhibitory polypeptide in plasma. Clin Chem 1992; 38:2156-2157
23. Sutherland K, Young RL, Cooper NJ, et al: Phenotypic characterization of taste cells of the mouse small intestine. Am J Physiol Gastrointest Liver Physiol 2007; 292:G1420-G1428
24. Rittirsch D, Huber-Lang MS, Flierl MA, et al: Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc 2009; 4:31-36
25. Dyer J, Daly K, Salmon KS, et al: Intestinal glucose sensing and regulation of intestinal glucose absorption. Biochem Soc Trans 2007; 35(Part 5):1191-1194
26. Arabi YM, Tamim HM, Dhar GS, et al: Permissive underfeeding and intensive insulin therapy in critically ill patients: A randomized controlled trial. Am J Clin Nutr 2011; 93:569-577
27. Rice TW, Wheeler AP, Thompson BT, et al: Initial trophic vs full enteral feeding in patients with acute lung injury: The EDEN randomized trial. JAMA 2012; 307:795-803
28. Rice TW, Mogan S, Hays MA, et al: Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit Care Med 2011; 39:967-974
29. Heyland DK, Cahill N, Day AG: Optimal amount of calories for critically ill patients: Depends on how you slice the cake! Crit Care Med 2011; 39:2619-2626
30. Singer P, Anbar R, Cohen J, et al: The tight calorie control study (TICACOS): A prospective, randomized, controlled pilot study of nutritional support in critically ill patients. Intensive Care Med 2011; 37:601-609
31. Amador P, Marca MC, García-Herrera J, et al: Lipopolysaccharide induces inhibition of galactose intestinal transport in rabbits in vitro. Cell Physiol Biochem 2008; 22:715-724
32. Gorboulev V, Schürmann A, Vallon V, et al: Na(+)-d-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucosedependent incretin secretion. Diabetes 2012; 61:187-196
33. Parker HE, Adriaenssens A, Rogers G, et al: Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion. Diabetologia 2012; 55:2445-2455
34. Deane A, Chapman MJ, Fraser RJ, et al: Bench-to-bedside review: The gut as an endocrine organ in the critically ill. Crit Care 2010; 14:228
35. Knop FK: Bile-induced secretion of glucagon-like peptide-1: Pathophysiological implications in type 2 diabetes Am J Physiol Endocrinol Metab 2010; 299:E10-E13
36. Deane AM, Nguyen NQ, Stevens JE, et al: Endogenous glucagonlike peptide-1 slows gastric emptying in healthy subjects, attenuating postprandial glycemia. J Clin Endocrinol Metab 2010; 95:215-221
37. Deane AM, Fraser RJ, Chapman MJ: Prokinetic drugs for feed intolerance in critical illness: Current and potential therapies. Crit Care Resusc 2009; 11:132-143
38. Schwartz MP, Samsom M, Renooij W, et al: Small bowel motility affects glucose absorption in a healthy man. Diabetes Care 2002; 25:1857-1861
39. Santos A, Gonçalves P, Araújo JR, et al: Intestinal permeability to glucose after experimental traumatic brain injury: Effect of gadopentetate dimeglumine administration. Basic Clin Pharmacol Toxicol 2008; 103:247-254