Supervised exercise training reduces oxidative stress and cardiometabolic risk in adults with type 2 diabetes: A randomized controlled trial

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Vinetti, Giovanni ^a   Mozzini, Chiara ^b   Desenzani, Paolo ^c   Boni, Enrico ^c   Bulla, Laura ^a   Lorenzetti, Isabella ^a   Romano, Claudia ^a   Pasini, Andrea ^b   Cominacini, Luciano ^b   Assanelli, Deodato ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

^c SPEDALI CIVILI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1-PALMITOYL-2-(5-OXOVALEROYL)-SN-GLYCERO-3-PHOSPHORYLCHOLINE; 1-PALMITOYL-2-GLUTAROYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE; CHOLESTEROL; ETHER PHOSPHOLIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGED; BLOOD; BODY WEIGHT; CLINICAL TRIAL; CONTROLLED STUDY; CYTOLOGY; EXERCISE TEST; HUMAN; MALE; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; PATHOLOGY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR;

ADULT; AGED; BODY WEIGHT; CHOLESTEROL; CHOLESTEROL, LDL; DIABETES MELLITUS, TYPE 2; EXERCISE TEST; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; OXIDATIVE STRESS; PHOSPHOLIPID ETHERS; RISK FACTORS;

EID: 84924987662     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep09238     Document Type: Article

References (46)

1. Dröge, W. Free radicals in the physiological control of cell function. Physiol. Rev. 82, 47-95 (2002).
2. Chang, Y.-C. & Chuang, L.-M. The role of oxidative stress in the pathogenesis of type 2 diabetes: from molecular mechanism to clinical implication. Am. J. Transl. Res. 2, 316-31 (2010).
3. Fruhwirth, G. O., Loidl, A. & Hermetter, A. Oxidized phospholipids: from molecular properties to disease. Biochim. Biophys. Acta 1772, 718-36 (2007).
4. González, F., Rote, N. S., Minium, J. & Kirwan, J. P. Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 91, 336-40 (2006).
5. Ferretti, G. Maximal oxygen consumption in healthy humans: theories and facts. Eur. J. Appl. Physiol. (2014) doi:10.1007/s00421-014-2911-0
6. Florez, H. & Castillo-Florez, S. Beyond the obesity paradox in diabetes: fitness, fatness, and mortality. JAMA 308, 619-20 (2012).
7. Fang, Z. Y., Sharman, J., Prins, J. B. & Marwick, T. H. Determinants of exercise capacity in patients with type 2 diabetes. Diabetes Care 28, 1643-8 (2005).
8. Thomas, D. E., Elliott, E. J.&Naughton, G.A. Exercise for type 2 diabetes mellitus. Cochrane database Syst. Rev. CD002968 (2006). doi:10.1002/14651858.CD002968.pub2
9. Balducci, S. et al. Changes in physical fitness predict improvements in modifiable cardiovascular risk factors independently of body weight loss in subjects with type 2 diabetes participating in the Italian Diabetes and Exercise Study (IDES). Diabetes Care 35, 1347-54 (2012).
10. Colberg, S. R. et al . Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes Care 33, e147-67 (2010).
11. Ji, L. L. Exercise-induced modulation of antioxidant defense. Ann. N. Y. Acad. Sci. 959, 82-92 (2002).
12. Fatouros, I. G. et al. Oxidative stress responses in older men during endurance training and detraining. Med. Sci. Sports Exerc. 36, 2065-72 (2004).
13. Elosua, R. et al. Response of oxidative stress biomarkers to a 16-week aerobic physical activity program, and to acute physical activity, in healthy young men and women. Atherosclerosis 167, 327-34 (2003).
14. De Lemos, E. T., Oliveira, J., Pinheiro, J. P. & Reis, F. Regular physical exercise as a strategy to improve antioxidant and anti-inflammatory status: benefits in type 2 diabetes mellitus. Oxid. Med. Cell. Longev. 2012, 741545 (2012).
15. Kelly, K. R. et al. A low-glycemic index diet and exercise intervention reduces TNF(alpha) in isolated mononuclear cells of older, obese adults. J. Nutr. 141, 1089-94 (2011).
16. Weisman, I.M. et al . ATS/ACCP Statement on cardiopulmonary exercise testing. Am. J. Respir. Crit. Care Med. 167, 211-77 (2003).
17. Solomon, T. P. J. et al. Pancreatic b-cell function is a stronger predictor of changes in glycemic control after an aerobic exercise intervention than insulin sensitivity. J. Clin. Endocrinol. Metab. 98, 4176-86 (2013).
18. Church, T. S. et al. Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial. JAMA 304, 2253-62 (2010).
19. Vanhees, L. et al. Importance of characteristics and modalities of physical activity and exercise in the management of cardiovascular health in individuals with cardiovascular risk factors: recommendations from the EACPR. Part II. Eur. J. Prev. Cardiol. 19, 1005-33 (2012).
20. Boulé, N. G., Haddad, E., Kenny, G. P., Wells, G. A. & Sigal, R. J. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA 286, 1218-27 (2001).
21. Boulé, N. G., Kenny, G. P., Haddad, E., Wells, G. A. & Sigal, R. J. Meta-analysis of the effect of structured exercise training on cardiorespiratory fitness in Type 2 diabetes mellitus. Diabetologia 46, 1071-81 (2003).
22. Umpierre, D. et al. Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes: a systematic review and meta-analysis. JAMA 305, 1790-9 (2011).
23. Associazione Medici Diabetologi & Societá Italiana di Diabetologia. Italian Standards of Care for Diabetes Mellitus 2009-2010. (2010). at 〈http://www.aemmedi.it/files/Linee-guida-Raccomandazioni/2010/2010-2010-linee-guida.pdf〉
24. Alberti, K. G. M. M., Zimmet, P. & Shaw, J. The metabolic syndrome - a new worldwide definition. Lancet 366, 1059-62 (2005).
25. Pisani, P. et al . Relative validity and reproducibility of a food frequency dietary questionnaire for use in the Italian EPIC centres. Int. J. Epidemiol. 26 Suppl 1, S152-60 (1997).
26. Pala, V. et al. Diet in the Italian EPIC cohorts: presentation of data and methodological issues. Tumori 89, 594-607 (2003).
27. Gurka, M. J., Lilly, C. L., Oliver, M. N. &DeBoer, M. D. An examination of sex and racial/ethnic differences in the metabolic syndrome among adults: a confirmatory factor analysis and a resulting continuous severity score. Metabolism. 63, 218-25 (2014).
28. Pasini, A. F. et al. Enhanced levels of oxidized low-density lipoprotein prime monocytes to cytokine overproduction via upregulation of CD14 and toll-like receptor 4 in unstable angina. Arterioscler. Thromb. Vasc. Biol. 27, 1991-7 (2007).
29. Gruber, F. et al. Photooxidation generates biologically active phospholipids that induce heme oxygenase-1 in skin cells. J. Biol. Chem. 282, 16934-41 (2007).
30. Beaver, W. L., Wasserman, K. & Whipp, B. J. A new method for detecting anaerobic threshold by gas exchange. J. Appl. Physiol. 60, 2020-7 (1986).
31. Poole, D. C. & Jones, A. M. Oxygen Uptake Kinetics in Sport, Exercise and Medicine. (Routledge, 2005).
32. Wasserman, K., Beaver, W. L., Sun, X.-G. & Stringer, W. W. Arterial H+ regulation during exercise in humans. Respir. Physiol. Neurobiol. 178, 191-5 (2011).
33. Atalay, M. & Laaksonen, D. E. Diabetes, oxidative stress and physical exercise. J. Sports Sci. Med. 1, 1-14 (2002).
34. Vincent, H. K. & Taylor, A. G. Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. Int. J. Obes. (Lond). 30, 400-18 (2006).
35. Rains, J. L.&Jain, S.K.Oxidative stress, insulin signaling, and diabetes. Free Radic. Biol. Med. 50, 567-75 (2011).
36. Dandona, P. et al. Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect? J. Clin. Endocrinol. Metab. 86, 3257-65 (2001).
37. Monnier, L. et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA 295, 1681-7 (2006).
38. Donnelly, J. E. et al. American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med. Sci. Sports Exerc. 41, 459-71 (2009).
39. Durstine, J. L. et al. Blood lipid and lipoprotein adaptations to exercise: a quantitative analysis. Sports Med. 31, 1033-62 (2001).
40. Boyden, T. W. et al. Resistance exercise training is associated with decreases in serum low-density lipoprotein cholesterol levels in premenopausal women. Arch. Intern. Med. 153, 97-100 (1993).
41. Blair, S. N. et al. Changes in physical fitness and all-cause mortality. A prospective study of healthy and unhealthy men. JAMA 273, 1093-8 (1995).
42. Malin, S. K. & Braun, B. Effect of metformin on substrate utilization after exercise training in adults with impaired glucose tolerance. Appl. Physiol. Nutr. Metab. 38, 427-30 (2013).
43. Malin, S. K., Gerber, R., Chipkin, S. R. & Braun, B. Independent and combined effects of exercise training and metformin on insulin sensitivity in individuals with prediabetes. Diabetes Care 35, 131-6 (2012).
44. Ortega, J. F. et al.Metformin does not attenuate the acute insulin-sensitizing effect of a single bout of exercise in individuals with insulin resistance. Acta Diabetol. (2014) doi:10.1007/s00592-014-0580-4
45. Boulé, N. G. et al. Metformin and exercise in type 2 diabetes: examining treatment modality interactions. Diabetes Care 34, 1469-74 (2011).
46. Plotnikoff, R. C. et al. The Alberta Diabetes and Physical Activity Trial (ADAPT): a randomized trial evaluating theory-based interventions to increase physical activity in adults with type 2 diabetes. Ann. Behav. Med. 45, 45-56 (2013).